Highly acidic C-terminal domain of pp32 is required for the interaction with histone chaperone, TAF-Ibeta.

abstract：:Agaricus blazei is a medicinal mushroom native to Brazil. It used to be a source of anti-tumor and immunmoactive compounds and considered a health food in many countries. However, its specific effect against mast cell-mediated anaphylactic reactions is still unknown. In the present study, we investigated the effect of...

journal_title：Biological & pharmaceutical bulletin

authors： Choi YH,Yan GH,Chai OH,Choi YH,Zhang X,Lim JM,Kim JH,Lee MS,Han EH,Kim HT,Song CH

更新日期：2006-07-01 00:00:00

abstract：:Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel encoded by K(Ca)1.1 plays an important role in the control of smooth muscle tone by modulating membrane potential and intracellular Ca(2+) mobilization. BK(Ca) channel is functionally expressed in prostatic smooth muscle cells, and is activated by α(1)-adrenocep...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa S,Ohya S,Kojima Y,Sasaki S,Yamamura H,Sakuragi M,Kohri K,Imaizumi Y

更新日期：2012-01-01 00:00:00

abstract：:Liposomes were prepared from hydrogenated lecithin (H-PC) by sonication (S) or injection (I) of H-PC dissolved in ethanol containing dl-tocopherol acetate (VEA). The effects of liposomes on the dermal absorption of VEA were studied. The particle diameter of S-liposomes was smaller than that of I-liposomes. The penetra...

journal_title：Biological & pharmaceutical bulletin

authors： Natsuki R,Morita Y,Osawa S,Takeda Y

更新日期：1996-05-01 00:00:00

abstract：:We developed a novel fluorometric assay method for the measurement of glycosyltransferase activities using mono- and di-saccharides aminated and tagged with 7-hydroxycoumarin-3-carboxylic acid (coumarin) as substrates, N-acetylglucosamine (GlcNAc)-coumarin for beta1,4-galactosyltransferase from bovine milk and Gal bet...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Masuda D,Matsuzawa Y,Satoh T,Matsumoto K

更新日期：1999-04-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:A plasmid, pEP2104 (23.9 kilobase pairs), from Staphylococcus aureus carries a gene that specifies inducible resistance to 14-membered (erythromycin, EM, and oleandomycin, OL) and 16-membered macrolide (mycinamicin I and II), but not to all of the latter, and to streptogramin type B antibiotics (partial macrolide- and...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuoka M,Jánosi L,Endou K,Saitoh S,Hashimoto H,Nakajima Y

更新日期：1993-12-01 00:00:00

abstract：:In most species, solar light is both a DNA-damaging agent and the key entraining stimulus for the endogenous circadian clock. The zebrafish is an attractive vertebrate system in which to study the influence of light on gene expression because the DNA repair proteins and circadian oscillators in this species are light-...

journal_title：Biological & pharmaceutical bulletin

authors： Osaki T,Uchida Y,Hirayama J,Nishina H

更新日期：2011-01-01 00:00:00

abstract：:We investigated the possible protective effects of benidipine (Coniel), a calcium antagonist, on mechanical dysfunction, metabolic damage and changes in vascular reactivity during ischemia and reperfusion in the Langendorff-perfused rat heart. The responses of perfusion pressure to U-46619, a vasoconstrictor, and acet...

journal_title：Biological & pharmaceutical bulletin

authors： Yao K,Karasawa A

更新日期：1994-04-01 00:00:00

abstract：:Among the eight inbred mouse strains employed in our preceding report, 12-O-tetradecanoylphorbol 13-acetate (TPA) painting alone induced CD4+ regulatory T (Tr) cells in four strains (e.g., C3H/He) at 6-8 weeks of age, but not in the remaining strains (e.g., C57BL/6, BALB/c). In the present study, the effect of growth ...

journal_title：Biological & pharmaceutical bulletin

authors： Negoro T,Satoh K,Iinuma F,Tobe T,Watanabe M

更新日期：2002-02-01 00:00:00

abstract：:Arsenicals are known to be toxic and carcinogenic in humans. Inorganic arsenicals are enzymatically methylated to monomethylarsonic acid (MMAsV) and dimethylarsinic acid (DMAsV), which are the major pentavalent methyl arsenic metabolites. Recent reports indicate that trivalent methyl arsenicals are produced through me...

journal_title：Biological & pharmaceutical bulletin

authors： Kojima C,Sakurai T,Waalkes MP,Himeno S

更新日期：2005-10-01 00:00:00

abstract：:N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous peptide released from its precursor (thymosin-β4) by prolyl oligopeptidase. AcSDKP is a natural inhibitor of pluripotent hematopoietic stem cell proliferation and is normally found in human plasma. AcSDKP has been shown to be a potent angiogenic factor an...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Katagiri F,Sato F,Fujioka K,Sato Y,Fujioka T,Sato Y,Mimata H,Itoh H

更新日期：2014-01-01 00:00:00

abstract：:Orally disintegrating tablets (ODTs) are formulated to disintegrate upon contact with saliva, allowing administration without water. Olopatadine hydrochloride, a second-generation antihistamine, is widely used for treating allergic rhinitis. However, it has a bitter taste; therefore, the development of taste-masked ol...

journal_title：Biological & pharmaceutical bulletin

authors： Sotoyama M,Uchida S,Tanaka S,Hakamata A,Odagiri K,Inui N,Watanabe H,Namiki N

更新日期：2017-01-01 00:00:00

abstract：:Hepatic organic anion transporters OATP1B1 and OATP1B3 are expressed at the sinusoidal membrane of hepatocytes and contribute to the hepatic uptake of a wide variety of clinically used drugs. To identify the antibiotics that interact with the human organic anion transporters OATP1B1 and OATP1B3, we applied a screening...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi H,Takeuchi T,Okada M,Kobayashi M,Unno M,Abe T,Goto J,Hishinuma T,Shimada M,Mano N

更新日期：2011-01-01 00:00:00

abstract：:Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitte...

journal_title：Biological & pharmaceutical bulletin

authors： Sato-Masumoto N,Uchikura T,Sugiwaki H,Yoshimura M,Masada S,Atsumi T,Watanabe M,Tanaka N,Uchiyama N,Amakura Y,Hakamatsuka T

更新日期：2017-01-01 00:00:00

abstract：:In an effort to develop potent cyclooxygenase-1 (COX-1) inhibitors used as anticancer agent, a series of 2',5'-dimethoxychalcones was screened to evaluate their antiplatelet effect on human washed platelets suspension. Compound 2 exhibited potent inhibition of human washed platelet aggregation induced by collagen, sig...

journal_title：Biological & pharmaceutical bulletin

authors： Wu CM,Lin KW,Teng CH,Huang AM,Chen YC,Yen MH,Wu WB,Pu YS,Lin CN

更新日期：2014-01-01 00:00:00

abstract：:The major physiologic effect of thyroid hormone is thought to be initiated by the binding of T3 to the DNA binding thyroid hormone receptor (TR). The aim of this study has been to characterize the organ specific expression of thyroid hormone receptor mRNA, as well as its protein distribution and molecular weight in ma...

journal_title：Biological & pharmaceutical bulletin

authors： Shahrara S,Drvota V,Sylvén C

更新日期：1999-10-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis. Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solu...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Zhang K,Li Z,Zhao J,Zhang Y,Feng N

更新日期：2017-01-01 00:00:00

abstract：:The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like,...

journal_title：Biological & pharmaceutical bulletin

authors： Lee BM,Kim HS,Jeohn GH

更新日期：2000-07-01 00:00:00

abstract：:The discovery that angiogenesis is a key condition for the growth of a tumor beyond a millimeter or two, brings about a new approach in the treatment of tumors using drugs able to inhibit the formation of new blood vessels. Also, it has been realized that antiangiogenic drugs can be useful in the treatment of other pa...

journal_title：Biological & pharmaceutical bulletin

authors： González RP,Leyva A,Moraes MO

更新日期：2001-10-01 00:00:00

abstract：:In this study, the effects of N-acyl taurates (NATs) on the intestinal absorption of curcumin (CUR), a water-insoluble and poorly absorbed compound, were examined in rats. Sodium methyl lauroyl taurate (LMT) and sodium methyl cocoyl taurate (CMT) were the most effective in increasing the solubility and intestinal abso...

journal_title：Biological & pharmaceutical bulletin

authors： Li X,Kawamura A,Sato Y,Morishita M,Kusamori K,Katsumi H,Sakane T,Yamamoto A

更新日期：2017-01-01 00:00:00

abstract：:The model penetrants oxaprozin, nimesulide, gliclazide, and ribavirin, because of their different lipophilicities, were selected to assess the enhancing activity of pre-treatment solutions consisting of isopropyl palmitate (IP) in ethanol (5%, 10%, 15%and 20%, w/w, respectively) across excised rat skin using Franz dif...

journal_title：Biological & pharmaceutical bulletin

authors： Guo H,Liu Z,Li J,Nie S,Pan W

更新日期：2006-11-01 00:00:00

abstract：:This study investigated both morphologically and biochemically whether parsley (Petroselinum crispum), which is used as a folk remedy to decrease blood glucose, has any antidiabetic effect on pancreatic B cells of rats. Parsley extract was given to male diabetic rats. In the diabetic group given parsley extract, it wa...

journal_title：Biological & pharmaceutical bulletin

authors： Yanardağ R,Bolkent S,Tabakoğlu-Oğuz A,Ozsoy-Saçan O

更新日期：2003-08-01 00:00:00

abstract：:The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in Tmax indicated that simultaneous ...

journal_title：Biological & pharmaceutical bulletin

authors： Chen LC,Chen YF,Chou MH,Lin MF,Yang LL,Yen KY

更新日期：2002-04-01 00:00:00

abstract：:Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) trigger...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CS,Won C,Yoo H,Yi EH,Cho Y,Maeng JW,Sung SH,Ye SK,Chung MH

更新日期：2009-11-01 00:00:00

abstract：:Two kinds of dosage forms (tablets and retarded capsules) of furosemide (F) were compared in vitro dissolution profile and in vivo absorption studies. The dissolution of F from retarded capsules was extremely restricted in the first fluid of the JP XII disintegration test (within 0.8%), while the dissolution of F from...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Kiuchi T,Satoh H,Terashima Y,Kenmotsu H,Sekikawa H,Takada M

更新日期：1996-04-01 00:00:00

abstract：:The objectives of the present study were to assess pharmacokinetics, pharmacodynamics, tolerability and safety of intravenous administration of bivalirudin, a direct thrombin inhibitor, in healthy Chinese subjects. 48 subjects were equally divided into 4 groups (0.5 mg/kg, 0.75 mg/kg, 1.05 mg/kg intravenous bolus, and...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang D,Wang Z,Zhao X,Lu W,Gu J,Cui Y

更新日期：2011-01-01 00:00:00

abstract：:To elucidate molecular mechanisms of adipocyte differentiation, we previously isolated TC10-like/TC10betaLong (TCL/TC10betaL), regulators of G protein signaling 2 (RGS2), factor for adipocyte differentiation (fad) 104 and fad158, which were transiently expressed in the early phase of adipogenesis. These four genes see...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaji A,Nishizuka M,Osada S,Imagawa M

更新日期：2010-01-01 00:00:00

abstract：:Oligodeoxyribonucleotides containing 8-hydroxyguanine and 2-hydroxyadenine, purine lesions produced in cells by reactive oxygen species, were synthesized and inserted into vector DNAs to introduce each lesion at a predetermined site. The manipulated DNAs were transfected into living cells, and the mutants induced by e...

journal_title：Biological & pharmaceutical bulletin

authors： Kamiya H

更新日期：2004-04-01 00:00:00

abstract：:The degradation of 125I-endothelin-1 (125I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of E...

journal_title：Biological & pharmaceutical bulletin

authors： Edano T,Arai K,Koshi T,Torii T,Ohshima T,Hirata M,Ohkuchi M,Okabe T

更新日期：1994-03-01 00:00:00