Protective effects of benidipine against myocardial damage following ischemia and reperfusion in the isolated perfused rat heart.

abstract：:Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited m...

journal_title：Biological & pharmaceutical bulletin

authors： Oh KB,Mar W,Kim S,Kim JY,Lee TH,Kim JG,Shin D,Sim CJ,Shin J

更新日期：2006-03-01 00:00:00

abstract：:Granisetron (GRN) is widely used for patients with various cancers who suffer from chemotherapy-induced vomiting and nausea. The, pharmacokinetics of GRN has not been fully evaluated in such patients, however, and its dosage regimen is still controversial. In this study, we determined GRN levels in serum and urine fro...

journal_title：Biological & pharmaceutical bulletin

authors： Wada I,Takeda T,Sato M,Saitoh H,Nakabayashi T,Mino K,Honma T,Takada M,Hirano K

更新日期：2001-04-01 00:00:00

abstract：:The riboflavin sensitized oxidation of cysteine under an aerobic condition was investigated. The effects of various scavengers, such as superoxide dismutase, catalase, mannitol, sodium azide and potassium ferrocyanide (an electron donor), on the photooxidation were determined. A reaction mechanism involving the supero...

journal_title：Biological & pharmaceutical bulletin

authors： Sarkar B,Das U,Bhattacharyya S,Bose SK

更新日期：1997-08-01 00:00:00

abstract：:The study revealed that high molecular polyvinyl sulfate (PVP) or sulfonate (PVS), and low molecular alkyldisulfonates (NaO3S(CH2)nSO3Na, n = 2--5: EDS, TDS, BDS and PDS) can alleviate acute toxicity of the herbicide, paraquat dichloride (PQ) in mice. Their activity as antidotes and the mode of the action varied depen...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuchiya T,Yoshida T,Imaeda A,Kiho T,Ukai S

更新日期：1995-04-01 00:00:00

abstract：:The lactose transport system of Citrobacter freundii was characterized. Both the lactose transport system and beta-galactosidase were induced with either lactose or isopropyl-beta-D-thiogalactopyranoside (IPTG), the latter being the better inducer. The Km values for methyl-beta-D-thiogalactopyranoside (TMG) transport ...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki N,Tsuda M,Wilson TH,Tsuchiya T

更新日期：1994-06-01 00:00:00

abstract：:The objectives of the present study were to assess pharmacokinetics, pharmacodynamics, tolerability and safety of intravenous administration of bivalirudin, a direct thrombin inhibitor, in healthy Chinese subjects. 48 subjects were equally divided into 4 groups (0.5 mg/kg, 0.75 mg/kg, 1.05 mg/kg intravenous bolus, and...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang D,Wang Z,Zhao X,Lu W,Gu J,Cui Y

更新日期：2011-01-01 00:00:00

abstract：:Regulating γ-aminobutyric acid (GABA) uptake transport on the plasma membranes is required for its efficient clearance from the brain interstitial fluid. The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na+-H+ exchanger regulatory fac...

journal_title：Biological & pharmaceutical bulletin

authors： Tachikawa M,Yokoyama R,Akanuma SI,Hosoya KI

更新日期：2018-01-01 00:00:00

abstract：:Cynanchum wilfordii is one of most widely used medicinal plants in Oriental medicine for the treatment of various conditions. In the present study, we isolated cynandione A (CA) from an extract of Cynanchum wilfordii roots (CWE) and investigated the effects of CA on the expression of inducible nitric oxide synthase (i...

journal_title：Biological & pharmaceutical bulletin

authors： Yang SB,Lee SM,Park JH,Lee TH,Baek NI,Park HJ,Lee H,Kim J

更新日期：2014-01-01 00:00:00

abstract：:Epidermis is one of the well-known estrogen target tissues. Information regarding estrogen metabolism in epidermis is still very limited compared to that of estrogen action. In the breast cancer tissue, 17β-estradiol (E(2)) is inactivated by sulfation and the expression level of estrogen sulfotransferase (SULT1E1) is ...

journal_title：Biological & pharmaceutical bulletin

authors： Kushida A,Hattori K,Yamaguchi N,Kobayashi T,Date A,Tamura H

更新日期：2011-01-01 00:00:00

abstract：:Swallowing involves several motor processes such as bolus formation and intraoral transport of a food bolus (oral stage) and a series of visceral events that occur in a relatively fixed timed sequence but are to some degree modifiable (pharyngeal stage or swallow reflex). Reflecting the progressive aging of society, p...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamura K,Kitagawa J,Kurose M,Sugino S,Takatsuji H,Mostafeezur RM,Zakir HM,Yamada Y

更新日期：2010-01-01 00:00:00

abstract：:Nafamostat mesilate, an ester drug with extensive hydrolysis in vivo, exhibits species difference in the relative contribution for its hydrolysis in blood and tissues. For the rat, the main hydrolysis site may be blood and human may be tissue (mainly by liver). The paper gave in vivo evidence that human tissue may giv...

journal_title：Biological & pharmaceutical bulletin

authors： Cao YG,Chen YC,Hao K,Zhang M,Liu XQ

更新日期：2008-11-01 00:00:00

abstract：:Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

journal_title：Biological & pharmaceutical bulletin

authors： de Allori MC,Jure MA,Romero C,de Castillo ME

更新日期：2006-08-01 00:00:00

abstract：:The present work aimed to investigate the vasorelaxant effect of isotirumalin, a dihydroflavonol isolated from Derris urucu (Leguminosae). The vasorelaxant effect of isotirumalin was investigated in the rat aorta, in the presence and in the absence of a functional endothelium. The production of nitric oxide (NO) induc...

journal_title：Biological & pharmaceutical bulletin

authors： Mendes LJ,Capettini LS,Lôbo LT,da Silva GA,Arruda MS,Lemos VS,Côrtes SF

更新日期：2011-01-01 00:00:00

abstract：:Uridine 5'-diphosphate-glucuronosyltransferase (UGT) catalyzes a major phase II reaction in a drug-metabolizing enzyme system. Although the UGT1A subfamily is expressed mainly in the liver, it is also expressed in the brain. The purpose of the present study was to elucidate the effect of β-naphthoflavone (BNF), one of...

journal_title：Biological & pharmaceutical bulletin

authors： Sakakibara Y,Katoh M,Kondo Y,Nadai M

更新日期：2016-01-01 00:00:00

abstract：:When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Ba...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Bae EA,Han MJ,Park HJ,Choi JW

更新日期：2002-01-01 00:00:00

abstract：:LAT1 (L-type amino acid transporter 1), one of the L-type amino acid transporters, transports the branched and aromatic amino acids. LAT1 requires the heavy chain of 4F2 antigen (4F2hc) for the functional expression as an amino acid transporter. The expression of this transporter is up-regulated in tumor cells and rap...

journal_title：Biological & pharmaceutical bulletin

authors： Asano S,Kameyama M,Oura A,Morisato A,Sakai H,Tabuchi Y,Chairoungdua A,Endou H,Kanai Y

更新日期：2007-03-01 00:00:00

abstract：:The 70% ethanol extract (KS-ext) from Kochiae Fructus (dried fruits of Kochia scoparia L.) was screened for its activity on nociceptive and inflammatory responses in experimental animals. Although KS-ext at an oral administration of 500 mg/kg had an antinociceptive effect on writhing responses induced by acetic acid, ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Dai Y,Ido Y,Ko S,Yoshikawa M,Kubo M

更新日期：1997-10-01 00:00:00

abstract：:DJ-927, currently undergoing Phase I clinical trial, is a new orally effective taxane with potent antitumor effects. The absorption, tissue distribution, and excretion of DJ-927 were investigated in mice, dogs, and monkeys after a single oral administration. After oral administration of [14C]DJ-927, radioactivity was ...

journal_title：Biological & pharmaceutical bulletin

authors： Ono C,Takao A,Atsumi R

更新日期：2004-03-01 00:00:00

abstract：:Extracellular nucleotides have multiple biological actions in processes such as proliferation, differentiation, chemotaxis, and cytokine secretion through P2X receptors on the cell surface. To determine the biological activity of adenosine triphosphate (ATP) and the expression of P2 nucleotide receptors in murine bone...

journal_title：Biological & pharmaceutical bulletin

authors： Yoon MJ,Lee HJ,Lee YS,Kim JH,Park JK,Chang WK,Shin HC,Kim DK

更新日期：2007-04-01 00:00:00

abstract：:Treatment with antipsychotic drugs has been associated with hyperprolactinemia. The same antipsychotic drugs have also been associated with side effects such as menstruation disorders. The aim of this study was to evaluate the prevalence of hyperprolactinemia and menstruation disorders in women undergoing antipsychoti...

journal_title：Biological & pharmaceutical bulletin

authors： Takechi K,Yoshioka Y,Kawazoe H,Tanaka M,Takatori S,Kobayashi M,Matsuoka I,Yanagawa H,Zamami Y,Imanishi M,Ishizawa K,Tanaka A,Araki H

更新日期：2017-01-01 00:00:00

abstract：:Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been ...

journal_title：Biological & pharmaceutical bulletin

authors： O'Leary R,Rerek M,Wood EJ

更新日期：2004-02-01 00:00:00

abstract：:The present study was to study the hepatoprotective effects of phloridzin (PHL) on hepatic fibrosis induced by carbon tetrachloride (CCl₄) in rats, on the basis of this investigation, the possible mechanism of PHL was elucidated. Male Sprague Dawley (SD) rats were randomly divided into six groups: control, model, PHL-...

journal_title：Biological & pharmaceutical bulletin

authors： Deng G,Wang J,Zhang Q,He H,Wu F,Feng T,Zhou J,Zou K,Hattori M

更新日期：2012-01-01 00:00:00

abstract：:Prunella vulgaris L., commonly known as "self-heal" or "heal-all," is a perennial herb with a long history of medicinal use. Phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H), and 4-coumarate:coenzyme-A (CoA) ligase (4CL) are important enzymes in the phenylpropanoid pathway and in the accumulation of ro...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YB,Shin Y,Tuan PA,Li X,Park Y,Park NI,Park SU

更新日期：2014-01-01 00:00:00

abstract：:Cannabinoids are the active ingredients in marijuana, which is among the most widely used addictive drugs despite the well-documented harmfulness related to its abuse. The mechanism underlying cannabinoid addiction remains unclear, which is attributed partially to the difficulty in behavioral testing of high-dose cann...

journal_title：Biological & pharmaceutical bulletin

authors： Liu T,Zheng Q,Qian Z,Wang H,Liu Z,Ren W,Zhang X,Han J

更新日期：2016-05-01 00:00:00

abstract：:Hypericum perforatum extract (St. John's wort, SJW), Harpagophytum procumbens extract (HPE) and Grape seed proanthocyanidin extract (GSPE) have a broad spectrum of biological activities including antidepressant, anti-inflammatory or anti-oxidant effects. The aim of this study was to clarify antinociceptive properties ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida S,Hirai K,Hatanaka J,Hanato J,Umegaki K,Yamada S

更新日期：2008-02-01 00:00:00

abstract：:Tyrosinase is a key enzyme in the synthesis of melanin and is widely distributed in animals, plants, and microorganisms. As excessive melanin production causes not only hyperpigmenting effects on human skin but also melanosis in various foods, an inhibitor of tyrosinase has become of interest lately from a practical p...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuchiya T,Yamada K,Minoura K,Miyamoto K,Usami Y,Kobayashi T,Hamada-Sato N,Imada C,Tsujibo H

更新日期：2008-08-01 00:00:00

abstract：:The present study investigated whether Astragalus polysaccharide (APS) possessed immunotherapeutic effects on type 1 diabetes mellitus. Diabetic mice induced by multiple low dose streptozotocin (MLD-STZ) were administered either APS (100, 200, 400 mg/kg body weight) or saline intraperitoneally daily, and sacrificed af...

journal_title：Biological & pharmaceutical bulletin

authors： Li RJ,Qiu SD,Chen HX,Tian H,Wang HX

更新日期：2007-03-01 00:00:00

abstract：:An increase in the number of glucocorticoid-induced tumor necrosis factor receptor-family related gene/protein (GITR)+CD25- (or fork-head box protein 3: Foxp3-) CD4+ T cells, after treating a mouse model of arthritis with fingolimod (FTY720), and a pathogenic antigen may play a key role in the establishment of immune ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida Y,Mikami N,Nakanishi Y,Saimoto M,Nagaike A,Shimono H,Nakano S,Tsuji T,Kohno T

更新日期：2021-01-26 00:00:00

abstract：:The antitumour activity of the methanolic extract of Glinus lotoides (MGL) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean survival time of tumour bearing mice and peritoneal cell count in normal mice was observed with respect to the control group. Whe...

journal_title：Biological & pharmaceutical bulletin

authors： Kavimani S,Manisenthilkumar KT,Ilango R,Krishnamoorthy G

更新日期：1999-11-01 00:00:00

abstract：:Prophylactic oral administration of a novel immunomodulator (immunosuppressant), FTY720 (1 mg/kg, three times a week), completely prevented the development of experimental autoimmune myasthenia gravis (EAMG) in C57BL/6 mice. EAMG has been used as an animal model for human myasthenia gravis, and was established by immu...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno T,Tsuji T,Hirayama K,Iwatsuki R,Hirose M,Watabe K,Yoshikawa H,Kohno T,Matsumoto A,Fujita T,Hayashi M

更新日期：2005-04-01 00:00:00