Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix.

abstract：:The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 microM, and 19 of ...

journal_title：Biological & pharmaceutical bulletin

authors： Takahira M,Kusano A,Shibano M,Kusano G,Koizumi K,Suzuki R,Kim HS,Wataya Y

更新日期：1998-08-01 00:00:00

abstract：:Oyaksungisan, the herbal prescription composed of eleven herbs, has been widely used in treatment of cerebral infarct in Oriental Medicine. However, the mechanisms by which the herbal formula affects on the production of pro- and anti-inflammatory cytokines in cerebral infarction patients remain unknown yet. The secre...

journal_title：Biological & pharmaceutical bulletin

authors： Kim Y,So HS,Kim JK,Park C,Lee JH,Woo WH,Cho KH,Moon BS,Park R

更新日期：2007-06-01 00:00:00

abstract：:Many anti-epileptic drugs (AEDs) that mainly target ion channels or post-synaptic receptors are in clinical use, but a proportion of patients are resistant to these traditional AEDs and experience repeated severe break-out seizures. Given its involvement in the etiology of epilepsy, the neurotransmitter glycine may se...

journal_title：Biological & pharmaceutical bulletin

authors： Zhao J,Tao H,Xian W,Cai Y,Cheng W,Yin M,Liang G,Li K,Cui L,Zhao B

更新日期：2016-01-01 00:00:00

abstract：:Coffee is a popular beverage worldwide with various nutritional benefits. Diterpene cafestol, one of the major components of coffee, contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Shen T,Lee J,Lee E,Kim SH,Kim TW,Cho JY

更新日期：2010-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality worldwide. Traditional chemotherapy for HCC is not widely accepted by clinical practitioners because of its toxic side effects. Thus, there is a need to identify chemotherapeutic drugs against HCC. AMP-activated protein kinase (...

journal_title：Biological & pharmaceutical bulletin

authors： Sul YH,Lee MS,Cha EY,Thuong PT,Khoi NM,Song IS

更新日期：2013-01-01 00:00:00

abstract：:Polyethyleneglycol (PEG) compounds have a large hydrogen bonding capability and possess various functions that depend on the length of the chain and conformational diversity. Modification of a drug with PEG is a well-known technology for improving the physicochemical properties and biological responses of a drug. Ther...

journal_title：Biological & pharmaceutical bulletin

authors： Ishihara H

更新日期：2013-01-01 00:00:00

abstract：:Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary fibrosis is a common complication in these interstitial lung diseases, and PF always has a poor prognosis and short survival. To date, there ...

journal_title：Biological & pharmaceutical bulletin

authors： Hao Y,Liu Y

更新日期：2016-01-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) exert beneficial effects in non-small cell lung cancer (NSCLC) patients. However, ICIs are only advantageous for a limited population of NSCLC patients. Therefore to enhance their effects, combination therapies with ICIs have been developed. To identify preferable chemotherapy to co...

journal_title：Biological & pharmaceutical bulletin

authors： Haruna M,Hirata M,Iwahori K,Kanazawa T,Yamamoto Y,Goto K,Kawashima A,Morimoto-Okazawa A,Funaki S,Shintani Y,Kumanogoh A,Wada H

更新日期：2020-01-01 00:00:00

abstract：:The mechanism of inactivation of cholinesterase (EC 3.1.1.8) by the Cu2+ -ascorbic acid (AsA) system was investigated. Incubation of the enzyme with the Cu2+ -AsA system under aerobic conditions resulted in an irreversible loss of enzyme activity. At low concentrations of Cu2+, the extent of inactivation showed the sa...

journal_title：Biological & pharmaceutical bulletin

authors： Kanazawa H,Fujimoto S,Ohara A

更新日期：1995-09-01 00:00:00

abstract：:The prostacyclin I1 (PGI1) analogue, SM-10906 and its methyl ester, SM-10902, have been compared with the PGI2 analogue, iloprost, with respect to binding to the PGI2 receptor, stimulation of adenylate cyclase activity and inhibition of thrombin-induced Ca2+ mobilization in mastocytoma P-815 cells. SM-10906 displaced ...

journal_title：Biological & pharmaceutical bulletin

authors： Oka M,Negishi M,Yamamoto T,Satoh K,Hirohashi T,Ichikawa A

更新日期：1994-01-01 00:00:00

abstract：:Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concent...

journal_title：Biological & pharmaceutical bulletin

authors： Iida S,Kamiya H,Nakaya A,Hayashi Y,Sawada A,Kaji N,Baba Y,Harashima H

更新日期：2013-01-01 00:00:00

abstract：:Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals, including humans. In the present study, we demonstrated the anti-inflammatory effects of MSM in lipopolysaccharide (LPS...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YH,Kim DH,Lim H,Baek DY,Shin HK,Kim JK

更新日期：2009-04-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264.7 cells. Aimed at evaluating the mechanism of action by whi...

journal_title：Biological & pharmaceutical bulletin

authors： Lu Y,Hong TG,Jin M,Yang JH,Suh SJ,Piao DG,Ko HK,Seo CS,Chang YC,Kim CH,Son JK,Chang HW

更新日期：2010-01-01 00:00:00

abstract：:Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced p...

journal_title：Biological & pharmaceutical bulletin

authors： Chen F,Chen Y,Kang X,Zhou Z,Zhang Z,Liu D

更新日期：2012-01-01 00:00:00

abstract：:Defining a quantitative and reliable relationship between in vitro drug release and in vivo absorption is highly desired for rational development, optimization, and evaluation of controlled-release dosage forms and manufacturing process. During the development of once daily extended-release (ER) tablet of glipizide, a...

journal_title：Biological & pharmaceutical bulletin

authors： Ghosh A,Bhaumik UK,Bose A,Mandal U,Gowda V,Chatterjee B,Chakrabarty US,Pal TK

更新日期：2008-10-01 00:00:00

abstract：:Two kinds of dosage forms (tablets and retarded capsules) of furosemide (F) were compared in vitro dissolution profile and in vivo absorption studies. The dissolution of F from retarded capsules was extremely restricted in the first fluid of the JP XII disintegration test (within 0.8%), while the dissolution of F from...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Kiuchi T,Satoh H,Terashima Y,Kenmotsu H,Sekikawa H,Takada M

更新日期：1996-04-01 00:00:00

abstract：:Low molecular weight metabolites produced by the intestinal microbiome that have been associated with health and disease as metabolites need to be constantly absorbed from the intestinal lumen and transported to intestinal epithelial cells and blood. Polyamines, especially spermidine and spermine, are bioactive chemic...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto M

更新日期：2020-01-01 00:00:00

abstract：:Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic m...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Sun X,Xie Y,Tian F,Hu H,Tan W

更新日期：2018-01-01 00:00:00

abstract：:The radioprotective effects of propolis and polyphenolic compounds from propolis on the radiation-induced mortality of mice exposed to 9 Gy of gamma-irradiation were studied. Intraperitoneal (i.p.) treatment of mice at doses of 100 mg kg(-1) body weight of propolis (water or ethanolic extract; WSDP or EEP) or its poly...

journal_title：Biological & pharmaceutical bulletin

authors： Orsolić N,Benković V,Horvat-Knezević A,Kopjar N,Kosalec I,Bakmaz M,Mihaljević Z,Bendelja K,Basić I

更新日期：2007-05-01 00:00:00

abstract：:P2X7 receptor (P2X7R), a purinergic receptor, is involved in pathophysiological events such as inflammation and cell death, and thus is an attractive target for therapeutic approaches. It is reported that divalent metal cations (DMCs) inhibit P2X7R activation and that there are species differences in their inhibitory ...

journal_title：Biological & pharmaceutical bulletin

authors： Fujiwara M,Ohbori K,Ohishi A,Nishida K,Uozumi Y,Nagasawa K

更新日期：2017-01-01 00:00:00

abstract：:Rats stressed by specific alternation of rhythm in temperature (SART) show various symptoms of disautonomia, increased pulse rates, continuous hypotension, and severe orthostatic hypotension (OH) when they are subjected to postural change. The OH symptoms are improved by muscarinic M2-receptor blockers. In the present...

journal_title：Biological & pharmaceutical bulletin

authors： Funakami Y,Hata T,Itoh E,Itano S

更新日期：2007-02-01 00:00:00

abstract：:Seven flavonoids of Stachys chrysantha and Stachys candida have been isolated. The structures of the compounds were elucidated by spectroscopic methods, particularly highfield NMR spectroscopy. The effects of the methanol extracts of these two endemic Greek Stachys sp. and their main flavonoids were examined on arachi...

journal_title：Biological & pharmaceutical bulletin

authors： Skaltsa H,Bermejo P,Lazari D,Silvan AM,Skaltsounis AL,Sanz A,Abad MJ

更新日期：2000-01-01 00:00:00

abstract：:Using a plaque reduction assay, treatment of human influenza A viruses with the fruit-juice concentrate of Japanese plum (Prunus mume SIEB. et ZUCC) showed strong in vitro anti-influenza activity against human influenza A viruses before viral adsorption, but not after viral adsorption, with 50% inhibitory concentratio...

journal_title：Biological & pharmaceutical bulletin

authors： Yingsakmongkon S,Miyamoto D,Sriwilaijaroen N,Fujita K,Matsumoto K,Jampangern W,Hiramatsu H,Guo CT,Sawada T,Takahashi T,Hidari K,Suzuki T,Ito M,Ito Y,Suzuki Y

更新日期：2008-03-01 00:00:00

abstract：:We previously reported that kiwi fruit is rich in polyphenols and has immunostimulatory activity. Polyphenols are widely known for having anti-oxidant effects. We also revealed potential anti-oxidant effects of kiwi fruit in vivo by oral administration to mice. Here, we compared the anti-oxidant effects of kiwi fruit ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwasawa H,Morita E,Yui S,Yamazaki M

更新日期：2011-01-01 00:00:00

abstract：:UDP-N-acetylglucosaminyl transferase (OGT) resides in both cytosolic and nuclear compartments and catalyzes O-linked glycosylation of various proteins. In the current study, we have extracted protein from nuclear DNA (chromatin protein) using 0.2% NP-40 detergent. Addition of chromatin protein to either cytosolic or n...

journal_title：Biological & pharmaceutical bulletin

authors： Okuyama R,Marshall S

更新日期：2004-08-01 00:00:00

abstract：:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

更新日期：2014-01-01 00:00:00

abstract：:To elucidate molecular mechanisms of adipocyte differentiation, we previously isolated TC10-like/TC10betaLong (TCL/TC10betaL), regulators of G protein signaling 2 (RGS2), factor for adipocyte differentiation (fad) 104 and fad158, which were transiently expressed in the early phase of adipogenesis. These four genes see...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaji A,Nishizuka M,Osada S,Imagawa M

更新日期：2010-01-01 00:00:00

abstract：:In a previous report, we had demonstrated the antioxidant activity of the sialic acid N-acetylneuraminic acid (Neu5Ac, NANA). This activity can counteract the cytotoxicity of hydrogen peroxide (H2O2), and the antitoxicity is a result of a direct chemical reaction, whereby NANA reduces H2O2 in the culture media. The in...

journal_title：Biological & pharmaceutical bulletin

authors： Iijima R,Takahashi H,Ikegami S,Yamazaki M

更新日期：2007-03-01 00:00:00

abstract：:The availability and applicability of the combination of paramagnetic nitroxyl contrast agent and T(1)-weighted gradient echo (GE)-based dynamic magnetic resonance imaging (MRI) measurement for redox imaging are described. The time courses of T(1)-weighted GE MRI signal intensities according to first-order paramagneti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto K

更新日期：2009-04-01 00:00:00