Abstract:
:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, dog and mouse liver microsomes followed the Michaelis-Menten model, whereas the kinetics by monkey and rat liver microsomes fitted the Hill model. The kinetics for MBzP formation fitted the Hill model for all liver microsomes. The Vmax and in vitro clearance (CLint or CLmax) ratios of MBP/MBzP formation varied among animal species, although the Km for MBP and MBzP formation in each liver microsomes were generally comparable. The hydrolysis of BBzP to monoester phthalates in mammalian liver microsomes could be classified into two types: MBzP>MBP type for humans and dogs, and MBP>MBzP type for monkeys, rats and mice. These findings suggest that the formation profile of MBzP and MBP from BBzP by liver microsomes differs extensively among animal species.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka Ndoi
10.1248/bpb.b14-00002subject
Has Abstractpub_date
2014-01-01 00:00:00pages
703-6issue
4eissn
0918-6158issn
1347-5215pii
DN/JST.JSTAGE/bpb/b14-00002journal_volume
37pub_type
杂志文章abstract::Small interfering RNAs (siRNAs) are expected to offer a means of treating rheumatoid arthritis (RA) because they allow the specific silencing of genes related to RA pathogenesis. In our previous study, we reported that the siRNA targeted against RelA (anti-RelA siRNA), an important nuclear factor-kappaB (NF-κB) subdom...
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journal_title:Biological & pharmaceutical bulletin
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