Effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on plasma glucose and glucagon levels of rats.

abstract：:We have previously proposed a novel deconvolution method, which can estimate first-pass metabolism of orally administered drugs. In the present study, we examined whether this deconvolution method is useful for evaluating oral dosage forms. The absorption and first-pass metabolism of orally administered aspirin formul...

journal_title：Biological & pharmaceutical bulletin

authors： Wu X,Yamashita F,Hashida M

更新日期：1999-11-01 00:00:00

abstract：:A significant sex-related difference was observed for the pharmacokinetics of acetohexamide in Wistar-Imamichi (Wistar-IM) rats. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. Testectomy was found to decrease the plasma clearance (CLp) o...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Kaneko M,Mori Y,Otagiri M

更新日期：1999-04-01 00:00:00

abstract：:The effects of various disinfectants and hot water on planktonic cells and biofilm cells of Burkholderia cepacia were investigated. The survival rate of viable B. cepacia cells in suspension decreased to 0.001% or lower within 15 s of exposure to 0.5% benzalkonium chloride, within 30 s of exposure to 0.5% alkyldiamino...

journal_title：Biological & pharmaceutical bulletin

authors： Miyano N,Oie S,Kamiya A

更新日期：2003-05-01 00:00:00

abstract：:The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measure...

journal_title：Biological & pharmaceutical bulletin

authors： Teramachi H,Hatakeyama H,Matsushita R,Imai Y,Miyamoto K,Tsuji A

更新日期：2002-10-01 00:00:00

abstract：:Oxidative stress is recognized as an important mediator of brain disorders. Nevertheless, there are few antioxidants approved for brain diseases. There are two types of mechanisms as antioxidant systems in vivo, antioxidants and antioxidant enzymes. Antioxidants are consumed by the reaction with reactive oxygen specie...

journal_title：Biological & pharmaceutical bulletin

authors： Kume T

更新日期：2017-01-01 00:00:00

abstract：:A convenient and sensitive high performance liquid chromatographic method with post-column platinum catalyst reduction and electrochemical detection was applied to the simultaneous determination of oxidized and reduced coenzyme Q (CoQ and CoQH2) and alpha-tocopherol (alpha-TP) in human and rat samples. After the separ...

journal_title：Biological & pharmaceutical bulletin

authors： Wakabayashi H,Yamato S,Nakajima M,Shimada K

更新日期：1994-08-01 00:00:00

abstract：:Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associat...

journal_title：Biological & pharmaceutical bulletin

authors： Yanagihara S,Taniguchi Y,Hosono M,Yoshioka E,Ishikawa R,Shimada Y,Kadoya T,Kutsukake K

更新日期：2010-01-01 00:00:00

abstract：:Analgesic activities of Randia siamensis CRAIB (R. siamensis) extract and pseudoginsenoside-RP1, a constituent of the extract, were examined in the writhing test, hot plate test and Randall-Selitto test. Oral administration of R. siamensis extract dose-dependently decreased the number of writhings and stretchings indu...

journal_title：Biological & pharmaceutical bulletin

authors： Reanmongkol W,Matsumoto K,Itharat A,Watanabe H

更新日期：1994-09-01 00:00:00

abstract：:Regulating γ-aminobutyric acid (GABA) uptake transport on the plasma membranes is required for its efficient clearance from the brain interstitial fluid. The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na+-H+ exchanger regulatory fac...

journal_title：Biological & pharmaceutical bulletin

authors： Tachikawa M,Yokoyama R,Akanuma SI,Hosoya KI

更新日期：2018-01-01 00:00:00

abstract：:The induction of a mutant DnaA protein (DnaA E204Q) with decreased intrinsic ATPase activity in cells causes a lethal phenotype. Based on our results that the decreased ATPase activity of DnaA E204Q is activated to the level of a wild-type protein in the presence of partially purified stimulating factors for DnaA ATPa...

journal_title：Biological & pharmaceutical bulletin

authors： Makise M,Sakamoto K,Tsuchiya T,Mizushima T

更新日期：1999-09-01 00:00:00

abstract：:We developed a novel fluorometric assay method for the measurement of glycosyltransferase activities using mono- and di-saccharides aminated and tagged with 7-hydroxycoumarin-3-carboxylic acid (coumarin) as substrates, N-acetylglucosamine (GlcNAc)-coumarin for beta1,4-galactosyltransferase from bovine milk and Gal bet...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Masuda D,Matsuzawa Y,Satoh T,Matsumoto K

更新日期：1999-04-01 00:00:00

abstract：:The phylogenetic relationship of Cistanche deserticola, C. salsa and C. tubulosa was analyzed by comparing the nucleotide sequences of the plastid rps2 gene and the intergenic spacer region between rpl16 and rpl14. By comparison of sequence data, the Cistanche samples were distinguishable from each other. The results ...

journal_title：Biological & pharmaceutical bulletin

authors： Tomari N,Ishizuka Y,Moriya A,Kojima S,Deyama T,Mizukami H,Tu P

更新日期：2002-02-01 00:00:00

abstract：:Two C-type lectins (OLLafs and OLLafl) were isolated from Osmerus (Spirinchus) lanceolatus eggs using asialofetuin-Sepharose column. OLLafs and OLLafl were eluted with 0.2 M sucrose and 0.2 M lactose from the same column, respectively. OLLafl has been estimated to be a heterodimeric protein composed of H- and L-subuni...

journal_title：Biological & pharmaceutical bulletin

authors： Sugawara S,Hosono M,Ogawa Y,Takayanagi M,Nitta K

更新日期：2005-05-01 00:00:00

abstract：:It is known that female rats are resistant to ischemic acute renal failure (ARF), compared with male rats. To elucidate sex differences in ischemic ARF, we searched global protein expression in post-ischemic kidneys using proteomic techniques. Ischemic ARF was induced by 45-min ischemia followed by reperfusion. By pro...

journal_title：Biological & pharmaceutical bulletin

authors： Takayama J,Takaoka M,Sugino Y,Yamamoto Y,Ohkita M,Matsumura Y

更新日期：2007-10-01 00:00:00

abstract：:Effects of epidermal growth factor (EGF) on the expression of alpha(2)-adrenergic responses were examined in primary cultures of adult rat hepatocytes. The alpha(2)-responses were assessed by the inhibition of the rate of forskolin-stimulated cAMP formation by the selective alpha(2)-adrenergic agonists, oxymetazoline ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogihara M

更新日期：1996-04-01 00:00:00

abstract：:Salazosulfapyridine (SASP) is widely used orally and rectally in the treatment of ulcerative colitis. SASP is mainly metabolized by hydrolysis and the main active metabolite, 5-aminosalicylic acid (5-ASA), has an antiinflammatory effect. In the present study, we prepared suppositories containing 6.5 mmol of SASP and a...

journal_title：Biological & pharmaceutical bulletin

authors： Tokui K,Asai Y,Arakawa T,Matsumoto T,Nabeshima T

更新日期：2002-02-01 00:00:00

abstract：:The effects of erythromycin, clarithromycin and rokitamycin on the metabolism of nifedipine were studied in vitro and in situ. Erythromycin, clarithromycin or rokitamycin added to nifedipine did not inhibit the formation of metabolite, M-1, of nifedipine, whereas pretreatment with erythromycin or clarithromycin signif...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuruta S,Nakamura K,Arimori K,Nakano M

更新日期：1997-04-01 00:00:00

abstract：:Cannabinoids are the active ingredients in marijuana, which is among the most widely used addictive drugs despite the well-documented harmfulness related to its abuse. The mechanism underlying cannabinoid addiction remains unclear, which is attributed partially to the difficulty in behavioral testing of high-dose cann...

journal_title：Biological & pharmaceutical bulletin

authors： Liu T,Zheng Q,Qian Z,Wang H,Liu Z,Ren W,Zhang X,Han J

更新日期：2016-05-01 00:00:00

abstract：:Two acidic polysaccharides, called ginsenan S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. Meyer. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6 x 10(4) and 1.0 x 10(5), respectively. Ginsenan S-IA is composed of L-arabi...

journal_title：Biological & pharmaceutical bulletin

authors： Tomoda M,Hirabayashi K,Shimizu N,Gonda R,Ohara N,Takada K

更新日期：1993-11-01 00:00:00

abstract：:The inhibitory effects of tetrandrine (an alkaloid isolated from the Chinese medicine Stephania tetrandrae S. Moore) were investigated in terms of the angiogenesis in an adjuvant-induced chronic inflammation model of mouse and tube formation of rat vascular endothelial cells (EC). Tetrandrine (7.5-30 mg/kg) reduced th...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi S,Inaba K,Kimura I,Kimura M

更新日期：1998-04-01 00:00:00

abstract：:The promoting effect of d-limonene and l-menthol on the percutaneous absorption of nonionized and ionized diclofenac (DF) was investigated employing a pretreatment method. After the pretreatment of hairless rat skin with an ethanol buffer solution containing terpenes, the permeation study was performed in vitro. The p...

journal_title：Biological & pharmaceutical bulletin

authors： Obata Y,Takayama K,Maitani Y,Machida Y,Nagai T

更新日期：1993-03-01 00:00:00

abstract：:As a study to assess the potential application of milk fat-globule membrane (MFGM), which is of natural origin and expected to be a safer alternative to synthetic emulsifiers, to pharmaceutical dosage forms, the oral absorption of alpha-linolenic acid was evaluated by the analysis of gastrointestinal disposition after...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-09-01 00:00:00

abstract：:Schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has been shown to enhance mitochondrial antioxidant status in liver, heart and brain tissues in rodents. Whether or not long-term Sch B treatment can protect against oxidative stress-induced cerebral damage remai...

journal_title：Biological & pharmaceutical bulletin

authors： Chen N,Chiu PY,Ko KM

更新日期：2008-07-01 00:00:00

abstract：:The effects of dietary supplementation of L-carnosine (beta-alanyl-L-histidine) on ischemia/reperfusion-induced acute renal failure (ARF) in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal fun...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii T,Takaoka M,Tsuruoka N,Kiso Y,Tanaka T,Matsumura Y

更新日期：2005-02-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) plays an important role in the development of glomerulonephritis. The study of experimental glomerulonephritis in rats was performed to examine the antinephritic effects of TJN-331, a new herbally-derived chemical compound. To clarify the action of TJN-331 ((E)-N-(3,4-dimet...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:We established a highly sensitive method for evaluating P-glycoprotein activity in Caco-2 cells. Using time-lapse confocal laser-scanning microscopy, we measured the change in fluorescence of residual rhodamine 123 in Caco-2 cells. Horizontal fluorescence images of rhodamine 123 in the apical and central parts of thes...

journal_title：Biological & pharmaceutical bulletin

authors： Wakuda H,Nejime N,Tada Y,Kagota S,Umegaki K,Yamada S,Shinozuka K

更新日期：2010-01-01 00:00:00

abstract：:Microsomal enzyme inducers are known to influence the expression of many transporter proteins and mRNA. In this study, we examined the effects of microsomal enzyme inducers on the mRNA expression of Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Associated Protein 2 (MRP2) in BALB/c mice. mRNA expres...

journal_title：Biological & pharmaceutical bulletin

authors： Han Y,Sugiyama Y

更新日期：2006-05-01 00:00:00

abstract：:The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2'-methyl ether (1), and three aromatic compounds, 4-O-methylsappanol (4), caesalpin...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong GS,Lee DS,Kwon TO,Lee HS,An RB,Kim YC

更新日期：2009-05-01 00:00:00

abstract：:Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antib...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui E,Takayama K,Sato E,Okamura N

更新日期：2011-01-01 00:00:00

abstract：:Periodontitis is initiated by accumulation of microbial plaque and activation of gingival inflammation through overexpression of matrix metalloproteinases (MMPs), leading to tissue destruction. Natural MMP inhibitors may be developed as therapeutic agents against periodontitis. In this study, panduratin A, a natural b...

journal_title：Biological & pharmaceutical bulletin

authors： Yanti,Oh HI,Anggakusuma,Hwang JK

更新日期：2009-01-01 00:00:00