The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice.

abstract：:A pharmacokinetic analysis program based on a tank-in-series model, MULTI(TIS), was developed for the evaluation of dose-dependency in the local disposition of a drug. The program written in FORTRAN was constructed by expanding MULTI(RUNGE). The reliability of MULTI(TIS) was verified by analyzing the experimental data...

journal_title：Biological & pharmaceutical bulletin

authors： Fukumura K,Yamaoka K,Higashimori M,Nakagawa T

更新日期：1998-12-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:In vitro studies were conducted to identify human drug-metabolizing enzymes involved in the metabolism of SNI-2011 ((+/-)-cis-2-methylspiro [1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline hydrochloride hydrate). When 14C-SNI-2011 was incubated with human liver microsomes, SNI-2011 trans-s...

journal_title：Biological & pharmaceutical bulletin

authors： Washio T,Arisawa H,Kohsaka K,Yasuda H

更新日期：2001-11-01 00:00:00

abstract：:Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β(2)-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaire...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara S,Fukuda H,Abe T,Arisaka O

更新日期：2010-01-01 00:00:00

abstract：:We recently suggested that the transferrin (Tf)-gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (111In) and iron-59 (59Fe) with ...

journal_title：Biological & pharmaceutical bulletin

authors： Sato R,Abe S,Yamada Y,Toyama D,Ohtake Y,Sato N,Ohkubo Y

更新日期：2004-08-01 00:00:00

abstract：:Accumulation of β-amyloid peptide (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). Previous studies have demonstrated the neuroprotective role of osthole against oxygen and glucose deprivation in cortical neurons. However, the effects of osthole on Aβ-induced neurotoxicity in ...

journal_title：Biological & pharmaceutical bulletin

authors： Hu Y,Wen Q,Liang W,Kang T,Ren L,Zhang N,Zhao D,Sun D,Yang J

更新日期：2013-01-01 00:00:00

abstract：:Calcium channel blockers have become important tools in the treatment of cardiovascular disorders and other diseases. Hybridization of well established calcium antagonist subclasses was an attempt to optimize their pharmacological profile. The intension of this study was to investigate the electrophysiological propert...

journal_title：Biological & pharmaceutical bulletin

authors： Schade B,Erker T,Weber M,Studenik C

更新日期：2004-09-01 00:00:00

abstract：:Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. In this study, we investigated its neuroprotection in permanent focal cerebral ischemia model in rats, and in an in vitro model of ischemia. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the ons...

journal_title：Biological & pharmaceutical bulletin

authors： Li R,Guo M,Zhang G,Xu X,Li Q

更新日期：2006-09-01 00:00:00

abstract：:The improvement of diabetic complications such as lipid lowering and anti-oxidative potential of Hydrangea Dulcis Folium (HDF) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into 3 groups after induction of streptozotocin (STZ)-diabetes: normal control; diabetic control; dia...

journal_title：Biological & pharmaceutical bulletin

authors： Kim HK,Kim MJ,Lyu ES,Shin DH

更新日期：2009-01-01 00:00:00

abstract：:This study was performed to examine the effects of the antifibrotic agents TJN-331 and tranilast on mesangial expansion in a rat model of anti-Thy1 nephritis. We first investigated the effects of TJN-331 and tranilast on mesangial expansion induced by anti-Thy1 serum in rats, and determined the counts of glomerular ce...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Kase Y,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:Thyroid hormone, thyroxine (T4) binding to glycosylated human serum albumin (G-HSA), and native human serum albumin (HSA) were studied as a function of pH using the fluorescence method. T4 binding affinity for G-HSA was remarkably reduced in an alkaline pH as compared with the native HSA. The thermodynamic parameters ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe N,Yoshida S

更新日期：1995-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang JY,Leu YL,Hwang TL,Cheng HC

更新日期：2004-11-01 00:00:00

abstract：:We describe herein the development of a high affinity and specific DNA aptamer as a new ligand for use in liposomal nanoparticles to target cultured mouse tumor endothelial cells (mTECs). Active targeted nanotechnology based drug delivery systems are currently of great interest, due to their potential for reducing sid...

journal_title：Biological & pharmaceutical bulletin

authors： Ara MN,Matsuda T,Hyodo M,Sakurai Y,Ohga N,Hida K,Harashima H

更新日期：2014-01-01 00:00:00

abstract：:The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like,...

journal_title：Biological & pharmaceutical bulletin

authors： Lee BM,Kim HS,Jeohn GH

更新日期：2000-07-01 00:00:00

abstract：:A plasmid-cured strain of the marine Vibrio alginolyticus 138-2 retains a respiration-driven Na+ pump. Examinations of several strains of V. alginolyticus and V. parahaemolyticus revealed that these murine Vibrio always possessed the respiration-driven Na+ pump irrespective of the presence or absence of plasmids. Thes...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura T,Hayashi S,Yamanaka R,Hamashima H,Arai T,Unemoto T

更新日期：1993-08-01 00:00:00

abstract：:Mitogenicity and the production of tumor necrosis factor (TNF) by a chemically synthesized lipotetrapeptide analog (KAB-8), S-[2,3-bis(palmitoyloxy)-2R-propyl]-N-[(2,2,2)-trichloro- ethoxycarbonyl: Troc group]-(R)-cysteinyl-(S)-seryl-(S)-seryl-(S)-asparagine, the amino acid sequence of which corresponds to that of the...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu T,Iwamoto Y,Yanagihara Y,Kurimura M,Achiwa K

更新日期：1994-07-01 00:00:00

abstract：:Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ is absorbed when a topical preparation is applied to cancerous tissue r...

journal_title：Biological & pharmaceutical bulletin

authors： Iida J,Kudo T,Shimada K,Yatsuno Y,Yamagishi S,Hasegawa S,Ike H,Sato T,Kagaya H,Ito K

更新日期：2013-01-01 00:00:00

abstract：:Biotin-binding human immunoglobulin G (B-IgG) was quantitatively measured using an F(ab')2anti-human IgG-coated multi-well microplate for the first time. B-IgG was caught by F(ab')2anti-human IgG and was detected by the following detecting reagents: Peroxidase-labeled streptavidin, avidin and peroxidase-biotin, or avi...

journal_title：Biological & pharmaceutical bulletin

authors： Muratsugu M,Muramoto E,Fukui T

更新日期：2003-11-01 00:00:00

abstract：:The mitochondrial ADP/ATP carrier (AAC) has 6 transmembrane regions and 3 matrix loops. Our previous mutational study on the Cys residue in the LM1s of chimeric bovine type 1 AAC (yN-bAAC1), in which the N-terminal 11 amino acids of bovine type 1 AAC are substituted with the corresponding 26 amino acids of yeast type ...

journal_title：Biological & pharmaceutical bulletin

authors： Kihira Y,Ueno M,Terada H

更新日期：2007-05-01 00:00:00

abstract：:The aim of the present study is to discover multidrug resistance-associated protein (MRP) inhibitors with neuroblastoma-selective cytotoxicity by means of fluorescence assay with a membrane-permeable fluorescent dye, Fluo-8 AM, based on our observation that gene expression of Mrp3 in neuroblastoma Neuro2a cells was re...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamichi N,Ishimoto T,Yamauchi Y,Masuo Y,Kato Y

更新日期：2016-01-01 00:00:00

abstract：:One hundred and fifteen synthesized mono, di, and trihydroxybenzamide and thiobenzamide derivatives having structures related to euglobals were examined for their inhibitory effects on Epstein-Barr virus (EBV) activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) as a primary screening test for anti-tumor-promoters...

journal_title：Biological & pharmaceutical bulletin

authors： Takasaki M,Konoshima T,Kozuka M,Yoneyama K,Yoshida S,Tokuda H,Nishino H,Iwashima A

更新日期：1995-02-01 00:00:00

abstract：:In this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, Leishmania major, Leishmania tropica and Leishmania infantum (Pakistani isolate). Curcumin has shown an average IC5...

journal_title：Biological & pharmaceutical bulletin

authors： Saleheen D,Ali SA,Ashfaq K,Siddiqui AA,Agha A,Yasinzai MM

更新日期：2002-03-01 00:00:00

abstract：:There exist limitations in the detection of exogenous oligosaccharides due to their polydisperse and diversiform nature, and particularly the interference of endogenous glycosaminoglycans (GAGs). Herein, a surface plasmon resonance (SPR) assay for detecting acidic oligosaccharide sugar chain (AOSC), an anti-Alzheimer'...

journal_title：Biological & pharmaceutical bulletin

authors： Guo X,Xin X,Gan L,Nie Q,Geng M

更新日期：2006-01-01 00:00:00

abstract：:Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Ni Q,Wang Y,Fan H,Li Y

更新日期：2018-08-01 00:00:00

abstract：:Oral tolerance is thought to have a role in preventing allergic responses and immune-mediated diseases. Modulation of this tolerance by drugs and chemicals can cause or suppress them. An improved model of oral tolerance to ovalbumin (OVA) in mice was developed to detect modulators of the tolerance and to apply it to s...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Ohsawa M

更新日期：1995-06-01 00:00:00

abstract：:Chitooligosaccharides, the oligomers made up of beta-1,4-linked D-glucosamine, are obtained by partial hydrolysis of chitosan, a deacetylation product of chitin. The antioxidant activity of various chitooligosaccharides was tested in vitro with aminoguanidine, pyridoxamine, and Trolox as reference compounds. Hydroxyla...

journal_title：Biological & pharmaceutical bulletin

authors： Chen AS,Taguchi T,Sakai K,Kikuchi K,Wang MW,Miwa I

更新日期：2003-09-01 00:00:00

abstract：:The effect of permeation enhancers on the percutaneous absorption of pentazocine (PTZ) was investigated in excised hairless mice using Franz diffusion cells in vitro. The enhancing effect on the percutaneous absorption of PTZ from the isopropyl myristate (IPM) solution system was improved with glyceryl monocaprylate (...

journal_title：Biological & pharmaceutical bulletin

authors： Furuishi T,Oda S,Saito H,Fukami T,Suzuki T,Tomono K

更新日期：2007-07-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is the most frequent cause of liver dysfunction and a common global problem. Gypenosides can decrease pathological modifications of high-fat diet-induced rat atherosclerosis; however, its effect and mechanism on NASH remain unclear. In this study, rats were randomly divided into nor...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Ying H,Hu A,Hu Y,Li D

更新日期：2017-01-01 00:00:00

abstract：:Puerarin (daidzein 8-C-glucoside) is an isoflavone C-glucoside contained in the roots of Pueraria lobata OHWI. We have previously isolated the human intestinal bacterium, strain PUE, which metabolizes puerarin to daidzein, though the enzyme which cleaves C-glycosidic bond has not been clarified. Here, we identified on...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura K,Zhu S,Komatsu K,Hattori M,Iwashima M

更新日期：2019-03-01 00:00:00

abstract：:An increase in the number of glucocorticoid-induced tumor necrosis factor receptor-family related gene/protein (GITR)+CD25- (or fork-head box protein 3: Foxp3-) CD4+ T cells, after treating a mouse model of arthritis with fingolimod (FTY720), and a pathogenic antigen may play a key role in the establishment of immune ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida Y,Mikami N,Nakanishi Y,Saimoto M,Nagaike A,Shimono H,Nakano S,Tsuji T,Kohno T

更新日期：2021-01-26 00:00:00