Abstract:
:A significant sex-related difference was observed for the pharmacokinetics of acetohexamide in Wistar-Imamichi (Wistar-IM) rats. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. Testectomy was found to decrease the plasma clearance (CLp) of acetohexamide in male rats, whereas ovariectomy had no effect on the CLp of acetohexamide in female animals, suggesting that androgens regulate the pharmacokinetics of acetohexamide. The co-administration of sulfamethazine, which is known to be metabolized by a male-specific cytochrome P450 (CYP) isoform (CYP2C11), significantly decreased the CLp of acetohexamide in male Wistar-IM rats. Based on these results, it is reasonable to assume that the sex-dependent pharmacokinetics of acetohexamide observed in Wistar-IM rats is associated with the male-specific hydroxylation catalyzed by CYP2C11.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Imamura Y,Kaneko M,Mori Y,Otagiri Mdoi
10.1248/bpb.22.435subject
Has Abstractpub_date
1999-04-01 00:00:00pages
435-8issue
4eissn
0918-6158issn
1347-5215journal_volume
22pub_type
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