Association of Protein and Endotoxin in Outdoor Air with Emergency Department Visits for Children and Adults with Asthma in Fukuoka, Japan.

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:Polygonum multiflorum is widely used in the prevention and treatment of hyperlipidemia in traditional Chinese Medicine. In this study, the effects and relevant mechanisms of lipid-regulation by raw Polygonum multiflorum (RPM) were investigated. The results indicated that the basal plasma lipids, such as low-density li...

journal_title：Biological & pharmaceutical bulletin

authors： Xian Z,Liu Y,Xu W,Duan F,Guo Z,Xiao H

更新日期：2017-01-01 00:00:00

abstract：:To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin ...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tatsumoto T,Kozuka M,Kasai R,Tanaka O,Nie RL,Tokuda H,Nishino H,Iwashima A

更新日期：1994-05-01 00:00:00

abstract：:In order to clarify that squalene monohydroperoxide (SQOOH) correlates with changes in morphology through cytotoxicity and establish in vitro evaluation of the cytotoxicity of lipid hydroperoxide, the effect of SQOOH on cytotoxicity and morphology in normal human epidermal keratinocytes (NHEK(B)) and the Gunze three-d...

journal_title：Biological & pharmaceutical bulletin

authors： Uchino T,Tokunaga H,Onodera H,Ando M

更新日期：2002-05-01 00:00:00

abstract：:We investigated whether peripherally administered aconitine increases spontaneous acetylcholine (ACh) release from the frontal cerebral cortex in freely moving rats using in vivo microdialysis, as it relates to aconitine-induced bradycardia estimated by a tail-artery cuff technique in unilateral anterior hypothalamus ...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Takada M,Nojima H,Kimura M

更新日期：1996-11-01 00:00:00

abstract：:Electrets are polymeric discs that carry semi permanent electrostatic charge. These provide electrostatic potentials in the range of 500 to 3,000 V. In the current work, the effect of electret exposure on the skin permeability was investigated. Transdermal transport studies were carried out across porcine epidermis in...

journal_title：Biological & pharmaceutical bulletin

authors： Narasimha Sathyanarayana Murthy NS,Boguda VA,Payasada K

更新日期：2008-01-01 00:00:00

abstract：:Biomacromolecules (>40 kDa) have been developed as drug delivery system (DDS) carriers of low-molecular weight drugs to promote these drugs' uptake by cancer tissues via enhanced permeability and retention (EPR) effects. Human serum albumin (HSA) has been found to accumulate in cancer tissues via this EPR effect. HSA ...

journal_title：Biological & pharmaceutical bulletin

authors： Ishima Y

更新日期：2017-01-01 00:00:00

abstract：:All living organisms on earth are composed of L-amino acids and D-sugars. Therefore the presence and function of D-amino acids in living organisms have not been studied. Recently, however, D-aspartic acid (D-Asp) which is a D-amino acid, has been detected in various proteins from human tissue samples such as eye lens,...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii N

更新日期：2005-09-01 00:00:00

abstract：:Hyphal growth of Candida albicans was observed at neutral condition, whereas the yeast growth was increased below pH 5. Eight out of 12 strains of C. albicans grow in hyphal form at pH 7, and hyphal formation was inhibited in all strains at pH 4. The addition of GMP, an alternative oxidase (AOX) activator, induced the...

journal_title：Biological & pharmaceutical bulletin

authors： Konno N,Ishii M,Nagai A,Watanabe T,Ogasawara A,Mikami T,Matsumoto T

更新日期：2006-05-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:The effects of alpha(1)-acid glycoprotein (AGP) on human erythrocyte membrane were examined in vitro. Bovine and dog AGP, in addition to human AGP or asialo human AGP were used, and the collected data were compared with that for human serum albumin (HSA). A new technique developed by Kikuchi was used to investigate er...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto K,Nishi K,Tokutomi Y,Irie T,Suenaga A,Otagiri M

更新日期：2003-01-01 00:00:00

abstract：:A protein was purified from rabbit seminal plasma using preparative acrylamide disc electrophoresis, ammonium sulfate precipitation and gel filtration. The protein inhibited the in vitro fertilization of mouse ova inseminated with epididymal sperm and with capacitated sperm. The inhibition was not observed, however, w...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe M,Kishi Y,Ying X,Kohama Y,Mimura T,Li SS

更新日期：1993-05-01 00:00:00

abstract：:Chitooligosaccharides, the oligomers made up of beta-1,4-linked D-glucosamine, are obtained by partial hydrolysis of chitosan, a deacetylation product of chitin. The antioxidant activity of various chitooligosaccharides was tested in vitro with aminoguanidine, pyridoxamine, and Trolox as reference compounds. Hydroxyla...

journal_title：Biological & pharmaceutical bulletin

authors： Chen AS,Taguchi T,Sakai K,Kikuchi K,Wang MW,Miwa I

更新日期：2003-09-01 00:00:00

abstract：:Small interfering RNAs (siRNAs) are expected to offer a means of treating rheumatoid arthritis (RA) because they allow the specific silencing of genes related to RA pathogenesis. In our previous study, we reported that the siRNA targeted against RelA (anti-RelA siRNA), an important nuclear factor-kappaB (NF-κB) subdom...

journal_title：Biological & pharmaceutical bulletin

authors： Kanazawa T,Tamano K,Sogabe K,Endo T,Ibaraki H,Takashima Y,Seta Y

更新日期：2017-01-01 00:00:00

abstract：:Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the principal source of reducing power in numerous processes of physiological importance. We examined the influence of oxidative stress on the relative amounts of NADPH in human red blood cells (RBCs). To determine the homeostasis of the NADPH existing in ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogasawara Y,Funakoshi M,Ishii K

更新日期：2009-11-01 00:00:00

abstract：:The immunoreactivity (specific binding) of three Gly(A1)-sulfobenzoxadiazole-labeled insulins which have different spacer groups, Gly(A1)-[3-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin , Gly(A1)-[2-(4-sulfobenzoxadiazol-7-ylthio)acetyl]-insulin, Gly(A1)-[3-carboxy-2(or 3)-(4-sulfobenzoxadiazol-7-ylthio)propanoyl...

journal_title：Biological & pharmaceutical bulletin

authors： Nanami M,Zaitsu K,Ohkura Y

更新日期：1993-05-01 00:00:00

abstract：:In this study, the effects of N-acyl taurates (NATs) on the intestinal absorption of curcumin (CUR), a water-insoluble and poorly absorbed compound, were examined in rats. Sodium methyl lauroyl taurate (LMT) and sodium methyl cocoyl taurate (CMT) were the most effective in increasing the solubility and intestinal abso...

journal_title：Biological & pharmaceutical bulletin

authors： Li X,Kawamura A,Sato Y,Morishita M,Kusamori K,Katsumi H,Sakane T,Yamamoto A

更新日期：2017-01-01 00:00:00

abstract：:In the investigation of chemical constituents in antiosteoporotic active fraction, 90% ethanol fraction of water extract of the rhizomes of Dioscorea spongiosa, twenty-two glycosides were isolated and their structures were elucidated. In order to know the role of each compound played in the fraction and to find the ex...

journal_title：Biological & pharmaceutical bulletin

authors： Yin J,Han N,Liu Z,Song S,Kadota S

更新日期：2010-01-01 00:00:00

abstract：:An alkaloid piperine isolated from the Piper Nigrum was found to inhibit lipid droplet accumulation in mouse macrophages, and especially inhibited cholesteryl ester (CE) synthesis (IC50: 25 microM). The metabolism of cholesterol from lysosome to lipid droplet was inhibited with a similar IC50 (18 microM), indicating t...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda D,Ohte S,Ohshiro T,Jiang W,Rudel L,Hong B,Si S,Tomoda H

更新日期：2008-06-01 00:00:00

abstract：:Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosi...

journal_title：Biological & pharmaceutical bulletin

authors： Baek SH,Piao XL,Lee UJ,Kim HY,Park JH

更新日期：2006-10-01 00:00:00

abstract：:The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda T,Yokomizo K,Okawa M,Tsuchihashi R,Kinjo J,Nohara T,Uyeda M

更新日期：2005-09-01 00:00:00

abstract：:The inhibitory effects of five angiotensin-converting enzyme (ACE) inhibitors on the uptake of an aminocephalosporin antibiotic, cefroxadine, by rabbit small intestinal brush-border membrane vesicles were examined in the presence of an inward H+ gradient. Dixon plot analysis showed that all these ACE inhibitors inhibi...

journal_title：Biological & pharmaceutical bulletin

authors： Kitagawa S,Takeda J,Sato S

更新日期：1999-07-01 00:00:00

abstract：:A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14alpha-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal orga...

journal_title：Biological & pharmaceutical bulletin

authors： Vasanthanathan P,Lakshmi M,Arockia Babu M,Kaskhedikar SG

更新日期：2006-06-01 00:00:00

abstract：:Hypericum perforatum extract (St. John's wort, SJW), Harpagophytum procumbens extract (HPE) and Grape seed proanthocyanidin extract (GSPE) have a broad spectrum of biological activities including antidepressant, anti-inflammatory or anti-oxidant effects. The aim of this study was to clarify antinociceptive properties ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida S,Hirai K,Hatanaka J,Hanato J,Umegaki K,Yamada S

更新日期：2008-02-01 00:00:00

abstract：:The oligopeptide transporter PEPT1 (SLC15A1) is responsible for absorption of peptidic nutrients in the small intestine. Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transp...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuoka K,Tamai I,Morohashi Y,Kubo Y,Saitoh R,Tsuji A,Kato Y

更新日期：2009-08-01 00:00:00

abstract：:(1-->3)-beta-D-Glucans exhibit a variety of biological and immunopharmacological activities, and the degree of these activities depends on the nature of the individual glucans e.q. molecular weight, degree of branching and conformation. Based on the generally accepted evidence that the conformation of Sonifilan (SPG) ...

journal_title：Biological & pharmaceutical bulletin

authors： Miura NN,Ohno N,Adachi Y,Aketagawa J,Tamura H,Tanaka S,Yadomae T

更新日期：1995-01-01 00:00:00

abstract：:The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2'-methyl ether (1), and three aromatic compounds, 4-O-methylsappanol (4), caesalpin...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong GS,Lee DS,Kwon TO,Lee HS,An RB,Kim YC

更新日期：2009-05-01 00:00:00

abstract：:The accumulation of amyloid β(1-42) peptide (Aβ(1-42)) in retina is implicated in the development of retinal ganglion cell apoptosis and diabetic retinopathy. In this study we demonstrate that spontaneous diabetes mellitus Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be used as an animal model in studies to iden...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai N,Ito Y,Tanino T

更新日期：2015-01-01 00:00:00

abstract：:Among the calcium-binding proteins from chicken gizzard smooth muscle, smooth muscle calcium-binding protein 11 (SMCaBP 11), which is an EF-hand type calcium-binding protein, can prevent Ca2+ dependent histamine release from permeabilized rat peritoneal mast cells. This activity appears to be specific since other calc...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii T,Kuzumaki N,Ogoma Y,Kondo Y

更新日期：1994-05-01 00:00:00

abstract：:Agaricus blazei is a medicinal mushroom native to Brazil. It used to be a source of anti-tumor and immunmoactive compounds and considered a health food in many countries. However, its specific effect against mast cell-mediated anaphylactic reactions is still unknown. In the present study, we investigated the effect of...

journal_title：Biological & pharmaceutical bulletin

authors： Choi YH,Yan GH,Chai OH,Choi YH,Zhang X,Lim JM,Kim JH,Lee MS,Han EH,Kim HT,Song CH

更新日期：2006-07-01 00:00:00