The in vitro antiosteoporotic activity of some glycosides in Dioscorea spongiosa.

abstract：:The oral cavity contains almost half of the commensal bacterial population present in the human body. An increase in the number of these microorganisms may result in systemic diseases such as infective endocarditis and aspiration pneumonia as well as oral infections. It is essential to control the total numbers of the...

journal_title：Biological & pharmaceutical bulletin

authors： Tamura M,Saito H,Kikuchi K,Ishigami T,Toyama Y,Takami M,Ochiai K

更新日期：2011-01-01 00:00:00

abstract：:We investigated the changes (increase or decrease in peak intensity) in the expression of plasma proteins in spontaneously diabetic WBN/Kob rats that were with complicated diabetic nephropathy, to determine multiple biomarkers in the plasma of diabetic rats. The present study using surface enhanced laser desorption/io...

journal_title：Biological & pharmaceutical bulletin

authors： Kiga C,Nakagawa T,Koizumi K,Sakurai H,Shibagaki Y,Ogawa K,Goto H,Saiki I

更新日期：2005-06-01 00:00:00

abstract：:Povidone-iodine (PVP-I), an antibacterial medicine, was infiltrated in sepiolite (SPL). The available iodine content in this new pharmaceutical product, a sepiolite preparation containing povidone-iodine (PVP-I-SPL), was retained at 98.9 and 98.3% during storage at 40 degrees C for 3 and 6 months, respectively. The ef...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Nagai K,Maruyama M,Inoue H,Katsuyama Y,Atobe O,Ogata H,Yamato S,Tachikawa E,Zenda H

更新日期：1999-01-01 00:00:00

abstract：:Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosi...

journal_title：Biological & pharmaceutical bulletin

authors： Baek SH,Piao XL,Lee UJ,Kim HY,Park JH

更新日期：2006-10-01 00:00:00

abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized therapeutic gene editing by providing researchers with a new method to study and cure diseases previously considered untreatable. While the full range and power of CRISPR technology for t...

journal_title：Biological & pharmaceutical bulletin

authors： Çiçek YA,Luther DC,Kretzmann JA,Rotello VM

更新日期：2019-01-01 00:00:00

abstract：:In Parkinson's disease, while dopamine (DA) replacement therapy, such as with L-DOPA (levodopa), improves the symptoms, it does not inhibit the degeneration of DA neurons in the substantia nigra. Numerous studies have suggested that both endogenous and environmental neurotoxins and oxidative stress may participate in ...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura Y,Kakimura J,Taniguchi T

更新日期：2002-03-01 00:00:00

abstract：:An extract of the leaves of Apocynum venetum L. (Apocynaceae) markedly shortened the immobility time of male rats in a forced swimming test (FST) in a dose range of 30-125 mg/kg, indicating a possible antidepressant activity. This effect was comparable to that of the tricyclic antidepressant imipramine (20 mg/kg). Nei...

journal_title：Biological & pharmaceutical bulletin

authors： Butterweck V,Nishibe S,Sasaki T,Uchida M

更新日期：2001-07-01 00:00:00

abstract：:The effects of a liquid nutritive and tonic drug (NTD) selected from a modification of the "Kai-xin-shou-yu-shen-qi-wan" prescription, on scopolamine-induced amnesia in mice were investigated using the passive avoidance and water-maze tasks. A popular NTD in Japan that contains 17 crude (natural) drug extracts togethe...

journal_title：Biological & pharmaceutical bulletin

authors： Sakata Y,Chida R,Ishige K,Edagawa Y,Tadano T,Ito Y

更新日期：2005-10-01 00:00:00

abstract：:A series of anthracene derivatives have been synthesized, and their potential individual cytotoxicity was evaluated using Jurkat T cells and peripheral blood mononuclear cells (PBMCs) in vitro. These compounds, except for 2l, showed less cytotoxicity in PBMCs than mitoxantrone. We also analyzed the antiproliferative a...

journal_title：Biological & pharmaceutical bulletin

authors： Chen RF,Chou CL,Wang MR,Chen CF,Liao JF,Ho LK,Tao CW,Huang HS

更新日期：2004-06-01 00:00:00

abstract：:We previously screened the anti-itching activities of 33 herbal medicines in substance P (SP)-induced itching model mice. One of the most potent antipruritogenic extracts, the methanol extract of fruits of Cnidium monnieri (Cnidii Fructus) was studied further. The chloroform-soluble fraction of the methanol extract ma...

journal_title：Biological & pharmaceutical bulletin

authors： Basnet P,Yasuda I,Kumagai N,Tohda C,Nojima H,Kuraishi Y,Komatsu K

更新日期：2001-09-01 00:00:00

abstract：:T cells play a principal role in cellular immunity and govern the regulatory mechanism in humoral immunity. Therefore, T cells play a key role as either effectors or regulators in the immune network. Mizoribine (MZR), an immunosuppressive agent, suppresses both humoral and cellular immunity by acting on both T cells a...

journal_title：Biological & pharmaceutical bulletin

authors： Kamada H,Inoue N,Takaoka Y,Nakagami K,Mori H,Nagai H

更新日期：1996-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the accuracy of the recommended theophylline therapeutic range in the treatment of acute airway obstruction. Twenty seven patients (20 to 64 years) with acute asthma attack were given aminophylline intravenously to obtain a theophylline concentration between 10 and 20 microgra...

journal_title：Biological & pharmaceutical bulletin

authors： Nakahara Y,Murata M,Suzuki T,Ohtsu F,Nagasawa K

更新日期：1996-05-01 00:00:00

abstract：:We have found a new compound from thermophile extracts which inhibits antigen presentation on mouse macrophages. The substance inhibits the expression of the class II major histocompatibility molecule (Ia). It was extracted from Bacillus stearothermophilus UBT8038 and purified by silica gel column chromatography. The ...

journal_title：Biological & pharmaceutical bulletin

authors： Kohama Y,Itoh M,Tanaka K,Senba T,Itoh S,Mimura T

更新日期：1994-07-01 00:00:00

abstract：:Mucus on the nasal mucosa is translocated to the pharynx by ciliary beating, which is an important nonspecific defense mechanism called mucociliary clearance (MC). MC is one of the important factors determining the rate and extent of drug absorption after nasal application. The purpose of this study is to evaluate MC ...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue D,Furubayashi T,Ogawara K,Kimura T,Higaki K,Katsumi H,Sakane T,Yamamoto A,Higashi Y

更新日期：2012-01-01 00:00:00

abstract：:Morinda citrifolia L., known as noni, originated from Indonesia exhibits various pharmacological activities including anti-inflammatory properties. However, the validity of noni fruit juice as a treatment for rheumatoid arthritis (RA), an autoimmune disorder, has not been confirmed yet. Therefore, the main purpose of ...

journal_title：Biological & pharmaceutical bulletin

authors： Kustiarini DA,Nishigaki T,Kanno H,To H

更新日期：2019-01-01 00:00:00

abstract：:Beta-D-Xylosidase (EC 3.2.1.37) has been purified from ginsenoside Ra-metabolizing Bifidobacterium breve K-110, which was isolated from human intestinal microflora. beta-D-Xylosidase was purified to apparent homogeneity by a combination of ammonium sulfate precipitation, QAE-cellulose, butyl-toyopearl, hydroxyapatit a...

journal_title：Biological & pharmaceutical bulletin

authors： Shin HY,Lee JH,Lee JY,Han YO,Han MJ,Kim DH

更新日期：2003-08-01 00:00:00

abstract：:Pneumolysin (PLY) is a devastating bacterial protein toxin of Streptococcus pneumoniae that punctures the cytomembrane, leading to pathological reactions, such as cell disruption and inflammation. Drugs capable of closely impacting the toxin are considered advantageous in the treatment of bacterial infections. Amentof...

journal_title：Biological & pharmaceutical bulletin

authors： Zhao X,Liu B,Liu S,Wang L,Wang J

更新日期：2017-01-01 00:00:00

abstract：:We examined the effects of ginseng total saponin (GTS) and several ginsenosides injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the antinociception induced by cold water swimming. The tail-flick response was used as an antinociceptive parameter. We found that i.t. injection of GTS time- and dose...

journal_title：Biological & pharmaceutical bulletin

authors： Choi SS,Lee JK,Suh HW

更新日期：2003-06-01 00:00:00

abstract：:The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2'-methyl ether (1), and three aromatic compounds, 4-O-methylsappanol (4), caesalpin...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong GS,Lee DS,Kwon TO,Lee HS,An RB,Kim YC

更新日期：2009-05-01 00:00:00

abstract：:We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated recepto...

journal_title：Biological & pharmaceutical bulletin

authors： Kotani H,Tanabe H,Mizukami H,Amagaya S,Inoue M

更新日期：2012-01-01 00:00:00

abstract：:The interaction of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist YM90K with the competitive N-methyl-D-aspartate (NMDA) antagonist CGS19755 or with the NMDA channel blocker MK801 on the spatial memory of rats was examined by the 4-arm-baited radial maze task. When administered alone, t...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Matsumoto K,Watanabe H

更新日期：1998-11-01 00:00:00

abstract：:The effects of Cu, Zn-superoxide disumutase (SOD) delivered by genetically modified skin fibroblasts on cold-induced skin edema were studied in rats. Cold-induced skin edema was induced on the dorsal skin following transplantation of ILSOD cells, genetically modified skin fibroblasts which release secretable SOD prote...

journal_title：Biological & pharmaceutical bulletin

authors： Nishiguchi K,Komada F,Tanigawara Y,Sakai Y,Iwakawa S,Okumura K

更新日期：1998-12-01 00:00:00

abstract：:Recently we showed significance of biosurfactants in the field of non-viral vectors for gene transfection. There, a biosurfactant, mannosylerythritol lipid A (MEL-A), especially increased the efficiency of gene transfection mediated with cationic liposomes. However, the molecular mechanism has not been well-understood...

journal_title：Biological & pharmaceutical bulletin

authors： Ueno Y,Hirashima N,Inoh Y,Furuno T,Nakanishi M

更新日期：2007-01-01 00:00:00

abstract：:In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda H,Fujita R

更新日期：2004-07-01 00:00:00

abstract：:When carbohydrate metabolism is impaired, fatty acid metabolism is activated. Excess acetyl-coenzyme A (CoA) is generated from fatty acids by β-oxidation and is used for the formation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and subsequently for acetoacetate. High levels of secreted ketone bodies (acetoacetate and ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa S,Kojima Y,Sekino K,Yamato S

更新日期：2013-01-01 00:00:00

abstract：:The study revealed that high molecular polyvinyl sulfate (PVP) or sulfonate (PVS), and low molecular alkyldisulfonates (NaO3S(CH2)nSO3Na, n = 2--5: EDS, TDS, BDS and PDS) can alleviate acute toxicity of the herbicide, paraquat dichloride (PQ) in mice. Their activity as antidotes and the mode of the action varied depen...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuchiya T,Yoshida T,Imaeda A,Kiho T,Ukai S

更新日期：1995-04-01 00:00:00

abstract：:To clarify the pathogenicity and the pathogenic factors of Candida tropicalis strains, five strains, IFO 0199, IFO 0587, IFO 0589, IFO 1400, and IFO 1647, of C. tropicalis were tested for their lethality to mice, adherence to Hela cells, hydrophobicity, cell growth under acidic conditions (pH 2.0-5.9), and sucrose ass...

journal_title：Biological & pharmaceutical bulletin

authors： Okawa Y,Miyauchi M,Kobayashi H

更新日期：2008-08-01 00:00:00

abstract：:Astilbin, a dihydroflavonol rhamnoside isolated from the leaves of Engelhardtia chrysolepis, enhanced the vanadate-stimulated release of lipoprotein lipase (LPL) activity from rat isolated fat pads. N-[2-(Methyl-amino)ethyl]-5-isoquinolinesulfonamide (H-8), a potent inhibitor of cAMP-dependent protein kinase (PKA), ma...

journal_title：Biological & pharmaceutical bulletin

authors： Motoyashiki T,Miyake M,Morita T,Mizutani K,Masuda H,Ueki H

更新日期：1998-05-01 00:00:00

abstract：:Although distigmine is known to sometimes cause severe adverse drug reactions (ADRs), such as cholinergic crisis, there are limited data on the risk factors for these ADRs. In this study, we defined a serum cholinesterase (sChE) cutoff level for early detection of ADRs to distigmine and sought to identify risk factors...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuboshi S,Nagai K,Okajima H

更新日期：2020-01-01 00:00:00

abstract：:Two carboxylesterases with pI 6.0 and 6.2 derived from rat liver microsomes were purified. The two isozymes were remarkably different in substrate specificity, but they had equal enzymatic activity for alpha-naphthyl acetate and were inhibited equally by phenylmethylsulfonyl fluoride (PMSF) and bis-(4-nitrophenyl) pho...

journal_title：Biological & pharmaceutical bulletin

authors： Luan L,Sugiyama T,Takai S,Usami Y,Adachi T,Katagiri Y,Hirano K

更新日期：1997-01-01 00:00:00