Preparation and characteristics of antibacterial sepiolite containing povidone-iodine as a useful pharmaceutical product for patient care.

abstract：:Methylmercury (MeHg) is a causative agent of Minamata disease and an environmental pollutant that comprises a large portion of organically occurring mercury. Many aspects of the biological defense mechanisms against MeHg toxicity remain unclear. Recently, nuclear factor-E2-related factor 2 (Nrf2), heat shock factor pr...

journal_title：Biological & pharmaceutical bulletin

authors： Hwang GW

更新日期：2012-01-01 00:00:00

abstract：:Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

journal_title：Biological & pharmaceutical bulletin

authors： Ariga H

更新日期：2015-01-01 00:00:00

abstract：:There are many important considerations in the interactions among the herbal constituents in a prescription of traditional Chinese medicine (TCM). Ephedra Herb [Chinese characters: see text] (Eph) is described a warm and acrid agent in TCM. The combination of Eph and Gypsum [Chinese characters: see text] (Eph-Gyp) sho...

journal_title：Biological & pharmaceutical bulletin

authors： Yuan D,Sunouchi H,Sakurai T,Saito K,Kano Y

更新日期：2002-07-01 00:00:00

abstract：:Reprogramming differentiated cells toward stem cells may have long-term applications in stem-cell research and regenerative medicine. Here we report on the dedifferentiation of human epidermal keratinocytes into their precursor cells in vitro with basic fibroblast growth factor (bFGF) but not external gene interventio...

journal_title：Biological & pharmaceutical bulletin

authors： Sun X,Fu X,Han W,Zhao Y,Liu H,Sheng Z

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to investigate the characteristics of arachidonic acid-induced peripheral vascular disease in rats. Injecting arachidonic acid (2 mg/leg) into the femoral artery caused hind limb gangrene. Histopathological examination revealed occlusive thrombi and marked vascular injury, including denud...

journal_title：Biological & pharmaceutical bulletin

authors： Tanaka T,Takei M,Fukuta Y,Higashino R,Fukuda Y,Nomura Y,Ito S,Tamaki H,Kurimoto T,Suzuki Y

更新日期：1999-03-01 00:00:00

abstract：:A deconvolution method for estimating the first-pass metabolism of orally administered drugs is proposed. This analysis can be carried out without assuming any pharmacokinetic models. The applicability of the deconvolution method was evaluated by application to the plasma concentration-time courses of aspirin and its ...

journal_title：Biological & pharmaceutical bulletin

authors： Yamashita F,Bando H,Takakura Y,Hashida M

更新日期：1995-12-01 00:00:00

abstract：:Using the par to rep region of the 24653 bp plasmid pN315, which is present in Staphylococcus aureus strain N315, we constructed three vectors that can be shuttled between Escherichia coli and S. aureus and maintained stably in S. aureus. Due to plasmid incompatibility, the resident plasmid in S. aureus cells can be r...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo M,Kurokawa K,Lee BL,Sekimizu K

更新日期：2010-01-01 00:00:00

abstract：:Polyporus (P.) umbellatus, an endangered medicinal fungus in China, is distributed throughout most areas of the country. Thirty-seven natural P. umbellatus samples collected from 12 provinces in China were subjected to the inter-simple sequence repeat (ISSR) assay to investigate the genetic diversity within and among ...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MM,Xing YM,Guo SX

更新日期：2015-01-01 00:00:00

abstract：:Costunolide, isolated from the stem bark of Magnolia sieboldii, is a sesquiterpene lactone that exhibits various biological and immunological actions. We investigated the induction mechanism of apoptosis by costunolide in a human B cell leukemia NALM-6 cell culture system. Costunolide (10 microM)-induced apoptosis tim...

journal_title：Biological & pharmaceutical bulletin

authors： Kanno S,Kitajima Y,Kakuta M,Osanai Y,Kurauchi K,Ujibe M,Ishikawa M

更新日期：2008-05-01 00:00:00

abstract：:LAT1 (L-type amino acid transporter 1), one of the L-type amino acid transporters, transports the branched and aromatic amino acids. LAT1 requires the heavy chain of 4F2 antigen (4F2hc) for the functional expression as an amino acid transporter. The expression of this transporter is up-regulated in tumor cells and rap...

journal_title：Biological & pharmaceutical bulletin

authors： Asano S,Kameyama M,Oura A,Morisato A,Sakai H,Tabuchi Y,Chairoungdua A,Endou H,Kanai Y

更新日期：2007-03-01 00:00:00

abstract：:Virus entry, assembly, and budding are important processes in the replication cycle of a virus. Viruses are dependent on host living cells for their replication. Viruses use the proliferative mechanism of host cells for replication of viral components. Lipid rafts, specific membrane microdomains play a critical role i...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki T,Suzuki Y

更新日期：2006-08-01 00:00:00

abstract：:The total alkaloid fractions of the methanolic extracts of the leaves, ripe fruits, roots, seeds and stem of Solanum pseudocapsicum were subjected to in-vitro cytotoxicity, short-term toxicity and long-term survival studies. All the five fractions exhibited potent activity. The total alkaloid fraction of leaves was fo...

journal_title：Biological & pharmaceutical bulletin

authors： Vijayan P,Vijayaraj P,Setty PH,Hariharpura RC,Godavarthi A,Badami S,Arumugam DS,Bhojraj S

更新日期：2004-04-01 00:00:00

abstract：:4-Acetyltropolone, a minor component of Thujopsis dolabrata SIEB. et Zucc. hondai MAKINO, showed antimicrobial activity against various microorganisms including wood-rotting fungi, a phytogrowth-inhibitory effect with chlorophyll biosynthesis inhibition, cytotoxic effect and inhibitory activity on metalloproteases. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Morita Y,Matsumura E,Tsujibo H,Yasuda M,Okabe T,Sakagami Y,Kumeda Y,Ishida N,Inamor Y

更新日期：2002-08-01 00:00:00

abstract：:The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and...

journal_title：Biological & pharmaceutical bulletin

authors： Abe F,Nagafuji S,Okabe H,Higo H,Akahane H

更新日期：2003-12-01 00:00:00

abstract：:When carbohydrate metabolism is impaired, fatty acid metabolism is activated. Excess acetyl-coenzyme A (CoA) is generated from fatty acids by β-oxidation and is used for the formation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and subsequently for acetoacetate. High levels of secreted ketone bodies (acetoacetate and ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa S,Kojima Y,Sekino K,Yamato S

更新日期：2013-01-01 00:00:00

abstract：:We developed a novel fluorometric assay method for the measurement of glycosyltransferase activities using mono- and di-saccharides aminated and tagged with 7-hydroxycoumarin-3-carboxylic acid (coumarin) as substrates, N-acetylglucosamine (GlcNAc)-coumarin for beta1,4-galactosyltransferase from bovine milk and Gal bet...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Masuda D,Matsuzawa Y,Satoh T,Matsumoto K

更新日期：1999-04-01 00:00:00

abstract：:We recently suggested that the transferrin (Tf)-gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (111In) and iron-59 (59Fe) with ...

journal_title：Biological & pharmaceutical bulletin

authors： Sato R,Abe S,Yamada Y,Toyama D,Ohtake Y,Sato N,Ohkubo Y

更新日期：2004-08-01 00:00:00

abstract：:TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory neurons (OSNs). We carried out histochemical analyses of TRPV2 and i...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui H,Noguchi T,Takakusaki K,Kashiwayanagi M

更新日期：2014-01-01 00:00:00

abstract：:The pharmacological characteristics of Ryokan-kyomi-shinge-nin-to (RKS), a traditional oriental herbal (Kampo) medicine which has been used for the treatment of allergic asthma and rhinitis, were investigated. The number of sneezes by actively sensitized mice after a topical antigen challenge was significantly reduced...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi M,Ikeda Y,Kido T,Yuzurihara M,Kase Y,Yamamoto M,Ishige A,Sasaki H

更新日期：2002-12-01 00:00:00

abstract：:Using a plaque reduction assay, treatment of human influenza A viruses with the fruit-juice concentrate of Japanese plum (Prunus mume SIEB. et ZUCC) showed strong in vitro anti-influenza activity against human influenza A viruses before viral adsorption, but not after viral adsorption, with 50% inhibitory concentratio...

journal_title：Biological & pharmaceutical bulletin

authors： Yingsakmongkon S,Miyamoto D,Sriwilaijaroen N,Fujita K,Matsumoto K,Jampangern W,Hiramatsu H,Guo CT,Sawada T,Takahashi T,Hidari K,Suzuki T,Ito M,Ito Y,Suzuki Y

更新日期：2008-03-01 00:00:00

abstract：:Although distigmine is known to sometimes cause severe adverse drug reactions (ADRs), such as cholinergic crisis, there are limited data on the risk factors for these ADRs. In this study, we defined a serum cholinesterase (sChE) cutoff level for early detection of ADRs to distigmine and sought to identify risk factors...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuboshi S,Nagai K,Okajima H

更新日期：2020-01-01 00:00:00

abstract：:The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topo...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada M,Hayashi K,Ikeda S,Tsutsui K,Tsutsui K,Ito T,Iinuma M,Nozaki H

更新日期：2006-07-01 00:00:00

abstract：:Propiverine hydrochloride, oxybutynin hydrochloride and terodiline hydrochloride have both anticholinergic and antispasmodic effects, and are used for the management of urinary frequency and incontinence. The average standard therapeutic doses of these drugs differ greatly. We retrospectively analyzed their pharmacolo...

journal_title：Biological & pharmaceutical bulletin

authors： Takayanagi R,Mizushima H,Ozeki T,Yokoyama H,Iga T,Yamada Y

更新日期：2007-07-01 00:00:00

abstract：:No strategies for curing Alzheimer's disease have been developed yet as we do not know the exact cause of the disease. The only therapy that is available for patients is symptomatic treatment. Since Alzheimer's disease is associated with downregulation of the cholinergic system in the brain, its stimulation is expecte...

journal_title：Biological & pharmaceutical bulletin

authors： Narahashi T,Moriguchi S,Zhao X,Marszalec W,Yeh JZ

更新日期：2004-11-01 00:00:00

abstract：:The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of as...

journal_title：Biological & pharmaceutical bulletin

authors： Lares-Asseff I,Juárez-Olguín H,Flores-Pérez J,Guillé-Pérez A,Vargas A

更新日期：2004-05-01 00:00:00

abstract：:The binding and internalization of fractionated [3H]heparin (FH) was kinetically analyzed in rat liver parenchymal cells to clarify its cellular uptake mechanism. The binding of FH to the cell surface was saturable with the dissociation constant (Kd) of 53.5 nM and a maximum binding capacity (Bmax) of 19.9 pmol/mg pro...

journal_title：Biological & pharmaceutical bulletin

authors： Urano K,Haba M,Yuasa H,Watanabe J

更新日期：1997-06-01 00:00:00

abstract：:The purpose of this study was to develop a method for the measurement of the cell kinetics of spleen lymphocytes using the ROSA 26 transgenic mouse ubiquitously expressing beta-galactosidase (beta-gal). Spleen lymphocytes were isolated from ROSA 26 mice and intravenously inoculated into C57BL/6 mice under normal condi...

journal_title：Biological & pharmaceutical bulletin

authors： Hosoya K,Takashima T,Matsuda K,Terasaki T

更新日期：2002-10-01 00:00:00

abstract：:Glycosaminoglycans (GAGs) play important roles in various biological processes such as cell adhesion and signal transduction, as well as promote anti-inflammatory activity. We previously revealed that glycol-split heparin (HP)-aliphatic amine conjugates form self-assembled nanoparticles and suppress the production of ...

journal_title：Biological & pharmaceutical bulletin

authors： Yanamoto S,Babazada H,Sakai S,Higuchi Y,Yamashita F,Hashida M

更新日期：2017-01-01 00:00:00

abstract：:The mechanical properties of cells are considered promising biomarkers for the early detection of cancer and the testing of drug efficacy against it. Nevertheless, generalized correlations between drug resistance and the nano-mechanical properties of cancer cells are yet to be defined due to the lack of necessary stud...

journal_title：Biological & pharmaceutical bulletin

authors： Seo YH,Jo YN,Oh YJ,Park S

更新日期：2015-01-01 00:00:00

abstract：:We examined the effects of ginseng total saponin (GTS) and several ginsenosides injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the antinociception induced by cold water swimming. The tail-flick response was used as an antinociceptive parameter. We found that i.t. injection of GTS time- and dose...

journal_title：Biological & pharmaceutical bulletin

authors： Choi SS,Lee JK,Suh HW

更新日期：2003-06-01 00:00:00