Arachidonic acid-induced hind limb gangrene: a new experimental rat model of peripheral vascular disease.

abstract：:Monocytes/macrophages are known to be involved in atherogenesis, and the adherence of monocytes to the endothelium is considered an earliest characteristic of atherogenesis. Therefore, we studied the mechanism by which Shosaikoto, a Kampo medicine, shows anti-atherosclerotic action, which has been already shown in hyp...

journal_title：Biological & pharmaceutical bulletin

authors： Shen YR,Inoue M,Ogihara Y

更新日期：1996-01-01 00:00:00

abstract：:Transdermal nicotine patch (TNP) contains approximately 16.6 and 24.9 mg of nicotine per 20 and 30 cm2 (TNP-20 and TNP-30). The aims of the study are to investigate linearity of nicotine pharmacokinetics after single application of different strengths of TNP and to directly compare plasma nicotine concentrations with ...

journal_title：Biological & pharmaceutical bulletin

authors： Sobue S,Sekiguchi K,Kikkawa H,Akasaki M,Irie S

更新日期：2006-05-01 00:00:00

abstract：:A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solut...

journal_title：Biological & pharmaceutical bulletin

authors： Murata Y,Hirai D,Kofuji K,Miyamoto E,Kawashima S

更新日期：2004-03-01 00:00:00

abstract：:The effects of exercise on the metabolism of caffeine (CA) were studied 3h after administration of the drug to race horses which then underwent exercise sets (1000-m gallop). Analysis was made of pharmacokinetics of CA, changes in its plasma concentrations, its metabolites, i.e., theophylline (TP), theobromine (TB) an...

journal_title：Biological & pharmaceutical bulletin

authors： Aramaki S,Suzuki E,Ishidaka O,Momose A

更新日期：1995-11-01 00:00:00

abstract：:We examined the association of biological components in airborne particles, i.e., proteins and endotoxins, in outdoor air with asthma exacerbation in the Fukuoka metropolitan area, Fukuoka, Japan. Data on emergency department (ED) visits for asthma in children (age, 0-14 years) and adults (age, 15-64 years) were colle...

journal_title：Biological & pharmaceutical bulletin

authors： Ishida T,Khan MS,Kodama H,Uejima Y,Kawase Y,Matsumoto T,Yamamura Y,Sera N,Gotou T,Hirakawa M,Yano Y,Shima M,Yamagishi N,Wakabayashi K,Watanabe T

更新日期：2020-01-01 00:00:00

abstract：:Alkyl viologens showed cytotoxicity when incubated with cultured murine leukemia L1210 cells for 48 h, whereas they were not cytotoxic when briefly incubated for 10 min. Under the permeabilizing conditions achieved by vortex-stirring with a high molecular weight polyacrylic acid (A-119), appreciable cytotoxicity was s...

journal_title：Biological & pharmaceutical bulletin

authors： Shimizu N,Wu W,Kohara A,Kohda K,Suzuki T,Kawazoe Y

更新日期：1997-02-01 00:00:00

abstract：:We have developed a mass microscope in which a microscope is combined with high-resolution matrix assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). This technique is a powerful tool for investigating the spatial distribution of biomolecules without the need for any time-consuming extraction, ...

journal_title：Biological & pharmaceutical bulletin

authors： Saito Y,Waki M,Hameed S,Hayasaka T,Setou M

更新日期：2012-01-01 00:00:00

abstract：:In a previous report, we had demonstrated the antioxidant activity of the sialic acid N-acetylneuraminic acid (Neu5Ac, NANA). This activity can counteract the cytotoxicity of hydrogen peroxide (H2O2), and the antitoxicity is a result of a direct chemical reaction, whereby NANA reduces H2O2 in the culture media. The in...

journal_title：Biological & pharmaceutical bulletin

authors： Iijima R,Takahashi H,Ikegami S,Yamazaki M

更新日期：2007-03-01 00:00:00

abstract：:Plasma hyaluronan binding protein (PHBP) is produced only in liver and kidney in mouse. The induction of PHBP mRNA and the conversion of pro PHBP to the active hetero-dimer form were studied after CCl4, D-galactosamine, HgCl2 or turpentine administration and after partial hepatectomy. The results indicated that the ad...

journal_title：Biological & pharmaceutical bulletin

authors： Choi-Miura NH,Otsuyama K,Sano Y,Saito K,Takahashi K,Tomita M

更新日期：2001-08-01 00:00:00

abstract：:The number of spleen Mac-1-positive cells was markedly increased in methylcholanthrene-induced Meth-A fibrosarcoma (Meth-A)-implanted mice. When the sera of Meth-A-implanted mice were added to normal bone marrow cells, granulocyte and macrophage colony stimulating factor (GM-CSF)-dependent growth of bone marrow cells ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe T,Okada A,Mikami T,Matsumoto T,Suzuki M

更新日期：1995-12-01 00:00:00

abstract：:A current anti-inflammatory agent often targets the prevention of inflammatory disorder development. The standardized Centella asiatica ECa 233 extract has been previously reported for anti-inflammatory effect. This study aimed to investigate its anti-inflammatory effect and mechanisms of ECa 233 in lipopolysaccharide...

journal_title：Biological & pharmaceutical bulletin

authors： Sukketsiri W,Tanasawet S,Moolsap F,Tantisira MH,Hutamekalin P,Tipmanee V

更新日期：2019-01-01 00:00:00

abstract：:The inhibitory effects of various sulfated compounds on the activities of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-alpha-N-acetylneuramin...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka M,Shiraishi T,Furuhata K,Uda Y

更新日期：1998-11-01 00:00:00

abstract：:We investigated the selectivity of T-440 for the inhibition of phosphodiesterases (PDEs) in vitro and for bronchial anti-spasmogenic effects in vivo. Using a fast protein liquid chromatography system, five PDE isozymes, PDE 1, PDE 2, PDE 3, PDE 4 and PDE 5 were prepared from guinea pig and dog tissues. T-440 selective...

journal_title：Biological & pharmaceutical bulletin

authors： Yamagata S,Wada K,Sugaya T,Oka K,Kaminuma O,Kikkawa H,Ikezawa K

更新日期：1997-12-01 00:00:00

abstract：:Melanogenesis inhibitory and free radical scavenging activities of nine cyclic (1-9) and one acyclic diarylheptanoids (10), and two phenolic compounds, (+)-rhododendrol (11) and (+)-catechin (12), isolated from the ethyl acetate-soluble fraction of the MeOH extract of the bark of Acer nikoense MAXIM. (Aceraceae) were ...

journal_title：Biological & pharmaceutical bulletin

authors： Akazawa H,Akihisa T,Taguchi Y,Banno N,Yoneima R,Yasukawa K

更新日期：2006-09-01 00:00:00

abstract：:The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impair...

journal_title：Biological & pharmaceutical bulletin

authors： Kaur H,Jaggi AS,Singh N

更新日期：2010-01-01 00:00:00

abstract：:Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, do...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara Y,Kinashi Y,Takahara Y,Hichiya H,Okada K,Murata M,Shigeyama M,Hanioka N

更新日期：2014-01-01 00:00:00

abstract：:Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ is absorbed when a topical preparation is applied to cancerous tissue r...

journal_title：Biological & pharmaceutical bulletin

authors： Iida J,Kudo T,Shimada K,Yatsuno Y,Yamagishi S,Hasegawa S,Ike H,Sato T,Kagaya H,Ito K

更新日期：2013-01-01 00:00:00

abstract：:Meiosis activating sterol (MAS), the intermediate of cholesterol biosynthesis, is an important substance to stimulate oocytes maturation in FSH-induced signal transduction pathway. Lanosterol 14alpha-demethylase (CYP51) converts lanosterol to MAS. Although MAS is firstly isolated from bovine testis, the information ab...

journal_title：Biological & pharmaceutical bulletin

authors： Wang F,Shen Y,Song X,Xia G,Chen X,Zhou B,Lei L

更新日期：2006-03-01 00:00:00

abstract：:This study aimed to investigate the mechanism by which the human lung cancer drug resistance-related gene BC006151 regulates chemosensitivity by down-regulating BC006151 expression via antisense gene transfer in H446/(C)DDP cells. A retroviral vector containing the antisense BC006151 sequence was constructed and trans...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Shi H,Ji F,Wang B,Feng Q,Feng X,Jia Z,Zhao Q,Qian G

更新日期：2010-01-01 00:00:00

abstract：:When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Ba...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Bae EA,Han MJ,Park HJ,Choi JW

更新日期：2002-01-01 00:00:00

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:The emulsion prepared with β-cyclodextrin as an emulsifier (βCDE) is considered to be a Pickering emulsion. We examined the characteristics of βCDEs using captopril (CP) as a model drug, and studied the in vitro skin permeation of CP from βCDEs through hairless mouse skin. The stability of βCDE was increased with incr...

journal_title：Biological & pharmaceutical bulletin

authors： Taguchi H,Tanaka H,Hashizaki K,Saito Y,Fujii M

更新日期：2019-01-01 00:00:00

abstract：:Darexaban maleate is a novel oral direct factor Xa inhibitor. Darexaban glucuronide (YM-222714) was the major component in plasma after oral administration of darexaban to humans and is the pharmacologically active metabolite. Additionally, YM-222714 N-oxides were detected as minor metabolites in human plasma and urin...

journal_title：Biological & pharmaceutical bulletin

authors： Shiraga T,Yajima K,Teragaki T,Suzuki K,Hashimoto T,Iwatsubo T,Miyashita A,Usui T

更新日期：2012-01-01 00:00:00

abstract：:Cisplatin chemotherapy is the standard treatment for metastatic urothelial carcinoma. Although there are second-line chemotherapeutic agents approved by the U.S. Food and Drug Administration (FDA) such as those targeting programmed death-ligand 1 (PD-L1), more effective pharmacotherapy is required for cisplatin-resist...

journal_title：Biological & pharmaceutical bulletin

authors： Ryu H,Jin H,Ho JN,Bae J,Lee E,Lee SE,Lee S

更新日期：2019-01-01 00:00:00

abstract：:The photodynamic therapy (PDT) depends on the presence of molecular oxygen. Thus, the efficiency of PDT is limited in anoxic regions of tumor tissue and vascular shutdown. It is reported the use of hyperbaric oxygen (HBO) may enhance the efficiency of PDT. However, there are rarely studies about utilizing HBO plus PDT...

journal_title：Biological & pharmaceutical bulletin

authors： Mei LH,Yang G,Fang F

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical effects and security of YiSuiShengXueGranule (YSSXG) on treating 156 patients with beta-thalassemia major. METHODS:YSSXG was given orally to 156 patients with beta-thalassemia in GuangXi Autonomous Region (the high incidence area of beta-thalassemia in China) for 3 months as one t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang S,Wu Z,Zhang X,Liu Y,Wang W,Chai L,Cai H,Yi J,Wang L,Chen Y,Lv X,Huang Y,Wang R,Chen P

更新日期：2007-11-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have the potential to be used in the cellular therapy of solid organs. However, tissue regeneration is limited by the death of transplanted cells. One of the main mechanisms of stem cell death in transplanted organs is through ischemia. In the present study, we sought to inves...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang W,Su X,Gao Y,Sun B,Yu Y,Wang X,Zhang F

更新日期：2009-08-01 00:00:00

abstract：:Ointments of the skin depigmentation agent hydroquinone (HQ) have been prepared by extemporaneous nonsterile compounding in our hospital. The HQ ointments were highly effective in the treatment of various types of skin pigmentations; however, various problems have emerged including chromatic aberration of the ointment...

journal_title：Biological & pharmaceutical bulletin

authors： Matsubayashi T,Sakaeda T,Kita T,Kurimoto Y,Nakamura T,Nishiguchi K,Fujita T,Kamiyama F,Yamamoto A,Okumura K

更新日期：2003-09-01 00:00:00

abstract：:Cationic lipid-mediated transfer of DNA is promising in gene therapy. However, one disadvantage with this approach is the induction of an inflammatory response, which may decrease transgene expression. Recently, we found that plasmid DNA containing N6-methyladenine (N6-MeA), a bacterium-specific modified base, induced...

journal_title：Biological & pharmaceutical bulletin

authors： Ochiai H,Harashima H,Kamiya H

更新日期：2005-10-01 00:00:00

abstract：:Using a plaque reduction assay, treatment of human influenza A viruses with the fruit-juice concentrate of Japanese plum (Prunus mume SIEB. et ZUCC) showed strong in vitro anti-influenza activity against human influenza A viruses before viral adsorption, but not after viral adsorption, with 50% inhibitory concentratio...

journal_title：Biological & pharmaceutical bulletin

authors： Yingsakmongkon S,Miyamoto D,Sriwilaijaroen N,Fujita K,Matsumoto K,Jampangern W,Hiramatsu H,Guo CT,Sawada T,Takahashi T,Hidari K,Suzuki T,Ito M,Ito Y,Suzuki Y

更新日期：2008-03-01 00:00:00