Abstract:
:A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solution, while releasing CMP and taking up bile acid. The amount of bile acid taken up into the Alg-CS increased incrementally according to the degree of deacetylation of CS. Furthermore, the molecular weight of CS also affected the properties of the Alg-CS. An approximately linear relationship was observed between CMP release and bile acid uptake of Alg-CS.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Murata Y,Hirai D,Kofuji K,Miyamoto E,Kawashima Sdoi
10.1248/bpb.27.440subject
Has Abstractpub_date
2004-03-01 00:00:00pages
440-2issue
3eissn
0918-6158issn
1347-5215journal_volume
27pub_type
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