Examination of stability of anticonvulsants in a protease solution and assay of anticonvulsants in hairs.

abstract：:In the present study, we designed and synthesized a novel 1,5-diarylpyrazole derivative, 2-amino-N-(2-methyl-5-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl) acetamide hydrochloride (CC06), which was intended to act as a prodrug and would exert potent anti-inflammatory activity after being converte...

journal_title：Biological & pharmaceutical bulletin

authors： Yin LL,Li MH,Wang X,Zhang WY

更新日期：2009-06-01 00:00:00

abstract：:The characteristics of the binding of human lactoferrin (LF) to the cells of a human monocytic leukemia cell line, THP-1, were investigated. 125I-Labeled LF (125I-LF) bound to THP-1 cells, and the binding increased markedly as the cells matured into macrophages (THP-1 macrophages) by stimulation with phorbol 12-myrist...

journal_title：Biological & pharmaceutical bulletin

authors： Eda S,Kikugawa K,Beppu M

更新日期：1996-02-01 00:00:00

abstract：:Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K+ (KV) channel blockers on the resting tension in endothelium-...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiwara K,Ohya S,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2017-01-01 00:00:00

abstract：:Caesalpinia ferrea MART. (Leguminosae) called as Juca is one of the medicinal plants in Brazil used for diabetes. From the fruits of this plant, ellagic acid (EA) and 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid (TEA) have been recently isolated as aldose reductase (AR) inhibitors. In this study, we examined to pr...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda H,Kawanishi K,Moriyasu M

更新日期：2004-10-01 00:00:00

abstract：:Prunella vulgaris L., commonly known as "self-heal" or "heal-all," is a perennial herb with a long history of medicinal use. Phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H), and 4-coumarate:coenzyme-A (CoA) ligase (4CL) are important enzymes in the phenylpropanoid pathway and in the accumulation of ro...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YB,Shin Y,Tuan PA,Li X,Park Y,Park NI,Park SU

更新日期：2014-01-01 00:00:00

abstract：:Ointments of the skin depigmentation agent hydroquinone (HQ) have been prepared by extemporaneous nonsterile compounding in our hospital. The HQ ointments were highly effective in the treatment of various types of skin pigmentations; however, various problems have emerged including chromatic aberration of the ointment...

journal_title：Biological & pharmaceutical bulletin

authors： Matsubayashi T,Sakaeda T,Kita T,Kurimoto Y,Nakamura T,Nishiguchi K,Fujita T,Kamiyama F,Yamamoto A,Okumura K

更新日期：2003-09-01 00:00:00

abstract：:LAT1 (L-type amino acid transporter 1), one of the L-type amino acid transporters, transports the branched and aromatic amino acids. LAT1 requires the heavy chain of 4F2 antigen (4F2hc) for the functional expression as an amino acid transporter. The expression of this transporter is up-regulated in tumor cells and rap...

journal_title：Biological & pharmaceutical bulletin

authors： Asano S,Kameyama M,Oura A,Morisato A,Sakai H,Tabuchi Y,Chairoungdua A,Endou H,Kanai Y

更新日期：2007-03-01 00:00:00

abstract：:The number of spleen Mac-1-positive cells was markedly increased in methylcholanthrene-induced Meth-A fibrosarcoma (Meth-A)-implanted mice. When the sera of Meth-A-implanted mice were added to normal bone marrow cells, granulocyte and macrophage colony stimulating factor (GM-CSF)-dependent growth of bone marrow cells ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe T,Okada A,Mikami T,Matsumoto T,Suzuki M

更新日期：1995-12-01 00:00:00

abstract：:Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ is absorbed when a topical preparation is applied to cancerous tissue r...

journal_title：Biological & pharmaceutical bulletin

authors： Iida J,Kudo T,Shimada K,Yatsuno Y,Yamagishi S,Hasegawa S,Ike H,Sato T,Kagaya H,Ito K

更新日期：2013-01-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, and motility. This pathway is often upregulated in human cancers and as such represents an attractive target for mechanism-based approaches to cancer treatment. H...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno M,Tanimura S,Ozaki K

更新日期：2011-01-01 00:00:00

abstract：:Treatment of Xenopus blastula with activin converts undifferentiated presumptive ectoderm (animal cap) into mesoderm and endoderm in a dose-dependent manner. At low concentrations, activin induces ventral mesoderm such as blood cells. Here we show that activin-treated aggregates of animal cap cells prepared from undif...

journal_title：Biological & pharmaceutical bulletin

authors： Nagamine K,Furue M,Fukui A,Matsuda A,Hori T,Asashima M

更新日期：2007-10-01 00:00:00

abstract：:To elucidate drug interaction between human immunodeficiency virus (HIV) protease inhibitors (PIs), the effect of indinavir (IDV) on the intestinal exsorption of other HIV PIs, amprenavir (APV), saquinavir (SQV) and nelfinavir (NFV) was investigated in rats using an in situ single perfusion method. IDV in the intestin...

journal_title：Biological & pharmaceutical bulletin

authors： Gao W,Kageyama M,Inoue Y,Tadano J,Fukumoto K,Fukushima K,Yamasaki D,Nishimura A,Yoshikawa Y,Shibata N,Takada K

更新日期：2003-02-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is primarily expressed in central and peripheral terminals of non-myelinated primary afferent neurons. We previously showed that AS1928370, a novel TRPV1 antagonist that can prevent ligand-induced activation but not proton-induced activation, ameliorates neuropathic pai...

journal_title：Biological & pharmaceutical bulletin

authors： Watabiki T,Kiso T,Tsukamoto M,Aoki T,Matsuoka N

更新日期：2011-01-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO and prostaglandins by both enzymes are also believed to be involved in the pathogenesis of certain human cancers. Crude extracts of Selaginella tamariscina are used as an ori...

journal_title：Biological & pharmaceutical bulletin

authors： Woo ER,Pokharel YR,Yang JW,Lee SY,Kang KW

更新日期：2006-05-01 00:00:00

abstract：:It has been suggested that imbalances in gut microbiota are related to diseases associated with metabolism, the central nervous system, etc. Therefore, analysis of short-chain fatty acids (SCFAs) produced by gut microbiota is very important as an indicator of causation, demonstrating the effects on the host due to cha...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue H,Takayama K,Takahara C,Tabuchi N,Okamura N,Narahara N,Kojima E,Date Y,Tsuruta Y

更新日期：2019-01-01 00:00:00

abstract：:This study was performed to examine the effects of the antifibrotic agents TJN-331 and tranilast on mesangial expansion in a rat model of anti-Thy1 nephritis. We first investigated the effects of TJN-331 and tranilast on mesangial expansion induced by anti-Thy1 serum in rats, and determined the counts of glomerular ce...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Kase Y,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:Two conjugates of marine polysaccharide (MPS) and bovine serum albumin (BSA) were prepared using two methods, periodate oxidation and reductive amination, with the intent of enhancing its immunogenicity. Sera samples from Balb/c mice immunized with the products named MPS-BSAp and MPS-BSAr respectively were evaluated b...

journal_title：Biological & pharmaceutical bulletin

authors： Gan L,Xin X,Geng M,Ding J

更新日期：2004-10-01 00:00:00

abstract：:The therapeutic value of an antirheumatic alkaloid, sinomenine (SIN), was investigated in the acute experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). SIN is a bioactive alkaloid derived from the Chinese medicinal plant, Sinomenium acutum REHDER & E. H. WILSON (Family Menispermaceae). Ch...

journal_title：Biological & pharmaceutical bulletin

authors： Zeng Y,Gu B,Ji X,Ding X,Song C,Wu F

更新日期：2007-08-01 00:00:00

abstract：:The present study was to study the hepatoprotective effects of phloridzin (PHL) on hepatic fibrosis induced by carbon tetrachloride (CCl₄) in rats, on the basis of this investigation, the possible mechanism of PHL was elucidated. Male Sprague Dawley (SD) rats were randomly divided into six groups: control, model, PHL-...

journal_title：Biological & pharmaceutical bulletin

authors： Deng G,Wang J,Zhang Q,He H,Wu F,Feng T,Zhou J,Zou K,Hattori M

更新日期：2012-01-01 00:00:00

abstract：:The number of alkalotolerant intestinal bacteria was 1% of the total flora in humans and 0.8% of those in rats. The beta-glucosidase and beta-glucuronidase activity of these intestinal bacteria was induced by elevating the pH of the medium, but the growth was not changed. The enzyme activity in a medium of pH 7 was 5-...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Kang HJ,Park SH,Kobashi K

更新日期：1994-03-01 00:00:00

abstract：:Hepatic organic anion transporters OATP1B1 and OATP1B3 are expressed at the sinusoidal membrane of hepatocytes and contribute to the hepatic uptake of a wide variety of clinically used drugs. To identify the antibiotics that interact with the human organic anion transporters OATP1B1 and OATP1B3, we applied a screening...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi H,Takeuchi T,Okada M,Kobayashi M,Unno M,Abe T,Goto J,Hishinuma T,Shimada M,Mano N

更新日期：2011-01-01 00:00:00

abstract：:We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated recepto...

journal_title：Biological & pharmaceutical bulletin

authors： Kotani H,Tanabe H,Mizukami H,Amagaya S,Inoue M

更新日期：2012-01-01 00:00:00

abstract：:The antitumor activity of fucoidan from Fucus vesiculosus was investigated in human colon carcinoma cells. The crude fucoidan, a polysaccharide composed predominantly of sulfated fucose, markedly inhibited the growth of HCT-15 cells (human colon carcinoma cells). After HCT-15 cells were treated with fucoidan, several ...

journal_title：Biological & pharmaceutical bulletin

authors： Hyun JH,Kim SC,Kang JI,Kim MK,Boo HJ,Kwon JM,Koh YS,Hyun JW,Park DB,Yoo ES,Kang HK

更新日期：2009-10-01 00:00:00

abstract：:RNA interference (RNAi) is a technology that specifically inhibits gene expression and is carried out by small 21-27-nucleotide double-stranded small interfering RNA (siRNA) or short hairpin RNA (shRNA). RNAi has become a very promising technology for genetic research, however problems remain with the delivery of siRN...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaguchi Y,Danjo K,Okuda T,Okamoto H

更新日期：2009-02-01 00:00:00

abstract：:The object of this study was to investigate the binding affinity of a newly synthesized 5-HT2 antagonist, (N-[2-[4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidino]ethyl]-1-formyl-4-piperidinecarboxamide monohydrochloride monohydrate) (AT-1015), in the rabbit platelet membrane using [3H]-ketanserin by radioligand bin...

journal_title：Biological & pharmaceutical bulletin

authors： Rashid M,Watanabe M,Nakazawa M,Nagatomo T

更新日期：2001-10-01 00:00:00

abstract：:Only a few biosynthetic pathways in fungal cells have been used as antifungal targets. Therefore, the number of antifungals has been limited, and a cross-drug resistance among them has emerged in the therapy of mycoses. Under such circumstances, the identification of an antifungal with a new mode of action is highly d...

journal_title：Biological & pharmaceutical bulletin

authors： Aoki Y,Kamiyama T,Fujii T,Yamamoto M,Ohwada J,Arisawa M

更新日期：1995-09-01 00:00:00

abstract：:NDRG2, a new member of the N-Myc downstream-regulated gene (NDRG) family, is a focus for study at present. Up to now, its expression and function in carcinoma remain to be elucidated. In this study, using a colorectal cancer tissue array and a series of 213 colorectal cancer samples, the relationship between Ndrg2 and...

journal_title：Biological & pharmaceutical bulletin

authors： Shi H,Jin H,Chu D,Wang W,Zhang J,Chen C,Xu C,Fan D,Yao L

更新日期：2009-06-01 00:00:00

abstract：:(1-->3)-beta-D-Glucans exhibit a variety of biological and immunopharmacological activities, and the degree of these activities depends on the nature of the individual glucans e.q. molecular weight, degree of branching and conformation. Based on the generally accepted evidence that the conformation of Sonifilan (SPG) ...

journal_title：Biological & pharmaceutical bulletin

authors： Miura NN,Ohno N,Adachi Y,Aketagawa J,Tamura H,Tanaka S,Yadomae T

更新日期：1995-01-01 00:00:00

abstract：:The mature form of rat adrenodoxin (Ad) was purified from a heterologous direct expression system in Escherichia coli with a yield of 56 mg/l culture. The purified Ad showed a A414/A280 ratio of 0.91 and the sequence of 10 amino terminal residues was identical with that of authentic rat Ad. By Time of Flight/Mass spec...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara Y,Aramaki H

更新日期：1998-10-01 00:00:00

abstract：:Extracellular nucleotides have multiple biological actions in processes such as proliferation, differentiation, chemotaxis, and cytokine secretion through P2X receptors on the cell surface. To determine the biological activity of adenosine triphosphate (ATP) and the expression of P2 nucleotide receptors in murine bone...

journal_title：Biological & pharmaceutical bulletin

authors： Yoon MJ,Lee HJ,Lee YS,Kim JH,Park JK,Chang WK,Shin HC,Kim DK

更新日期：2007-04-01 00:00:00