Molecular cloning and characterization of genes involved in rosmarinic acid biosynthesis from Prunella vulgaris.

abstract：:The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda T,Yokomizo K,Okawa M,Tsuchihashi R,Kinjo J,Nohara T,Uyeda M

更新日期：2005-09-01 00:00:00

abstract：:This article has been retracted by the Editorial Committee of The Pharmaceutical Society of Japan because it contains scientific misconduct. Although the data published in this article were generated in part by the first author, the authors violated authorship and sponsorship protocol. ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Lee JH,Kim YJ

更新日期：2015-11-06 00:00:00

abstract：:Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

journal_title：Biological & pharmaceutical bulletin

authors： Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

更新日期：2018-11-01 00:00:00

abstract：:The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee MH,Kim JY,Ryu JH

更新日期：2005-12-01 00:00:00

abstract：:Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic research regarding exosome analysis and applications in drug delivery. To increase exosome yield, we attempted to stimulate tumor cells via the addition of lipos...

journal_title：Biological & pharmaceutical bulletin

authors： Emam SE,Ando H,Abu Lila AS,Shimizu T,Ukawa M,Okuhira K,Ishima Y,Mahdy MA,Ghazy FS,Ishida T

更新日期：2018-01-01 00:00:00

abstract：:Early diagnosis of Niemann-Pick diseases (NPDs) is important for better prognosis of such diseases. N-Palmitoyl-O-phosphocholine-serine (PPCS) is a new NPD biomarker possessing high sensitivity, and with its combination with sphingosylphosphocholine (SPC) it may be possible to distinguish NPD-C from NPD-A/B. In this s...

journal_title：Biological & pharmaceutical bulletin

authors： Iwahori A,Maekawa M,Narita A,Kato A,Sato T,Ogura J,Sato Y,Kikuchi M,Noguchi A,Higaki K,Okuyama T,Takahashi T,Eto Y,Mano N

更新日期：2020-09-01 00:00:00

abstract：:ICR/f mutation in rat, an inherited disorder, is characterized by the development of cataracts. In this study, we analyzed and compared the crystallins in normal and cataractous rat lenses using gel filtration and two-dimensional gel electrophoresis, and determined the transglutaminase activities and Ca2+ content in t...

journal_title：Biological & pharmaceutical bulletin

authors： Takeuchi N,Kamei A

更新日期：2000-03-01 00:00:00

abstract：:Two different forms of oxytocinase (L-cystine aminopeptidase, CAP; EC 3.4.11.3) were purified from the 9000 g and 105000 g precipitate fractions of human placenta homogenate by sequential chromatography on columns of hydroxyapatite, DE-32, nickel ion affinity, and Sephadex G-200. One species (CAP-I) purifed from the m...

journal_title：Biological & pharmaceutical bulletin

authors： Itoh C,Watanabe M,Nagamatsu A,Soeda S,Kawarabayashi T,Shimeno H

更新日期：1997-01-01 00:00:00

abstract：:Three antiinflammatory saponin components were isolated from the alkaline hydrolysate of a butanol-soluble portion of Kalopanax pictus bark extract through an in vivo activity-guided fractionation procedure. The hydrolysate showed inhibition of adjuvant induced arthritis in rats. After further fractionation, the ethyl...

journal_title：Biological & pharmaceutical bulletin

authors： Li DW,Hyun JE,Jeong CS,Kim YS,Lee EB

更新日期：2003-04-01 00:00:00

abstract：:The number of alkalotolerant intestinal bacteria was 1% of the total flora in humans and 0.8% of those in rats. The beta-glucosidase and beta-glucuronidase activity of these intestinal bacteria was induced by elevating the pH of the medium, but the growth was not changed. The enzyme activity in a medium of pH 7 was 5-...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Kang HJ,Park SH,Kobashi K

更新日期：1994-03-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Recent studies indicated that the members of the Rab GTPase family, Rab8...

journal_title：Biological & pharmaceutical bulletin

authors： Imai M,Kawakami F,Kubo M,Kanzaki M,Maruyama H,Kawashima R,Maekawa T,Kurosaki Y,Kojima F,Ichikawa T

更新日期：2020-01-01 00:00:00

abstract：:Thyroid hormone, thyroxine (T4) binding to glycosylated human serum albumin (G-HSA), and native human serum albumin (HSA) were studied as a function of pH using the fluorescence method. T4 binding affinity for G-HSA was remarkably reduced in an alkaline pH as compared with the native HSA. The thermodynamic parameters ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe N,Yoshida S

更新日期：1995-01-01 00:00:00

abstract：:The physiological correlation between casein kinase I (CK-I) and an isoform eta of protein kinase C (C-kinase eta) was investigated in vitro, since it has been reported that (i) cholesterol-3-sulfate (CH-3S) effectively activates C-kinase eta rather than the other isoforms (C-kinase epsilon and C-kinase delta) in vitr...

journal_title：Biological & pharmaceutical bulletin

authors： Okano M,Yokoyama T,Miyanaga T,Ohtsuki K

更新日期：2004-01-01 00:00:00

abstract：:A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was esta...

journal_title：Biological & pharmaceutical bulletin

authors： Thuong PT,Min BS,Jin W,Na M,Lee J,Seong R,Lee YM,Song K,Seong Y,Lee HK,Bae K,Kang SS

更新日期：2006-04-01 00:00:00

abstract：:The therapeutic value of an antirheumatic alkaloid, sinomenine (SIN), was investigated in the acute experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). SIN is a bioactive alkaloid derived from the Chinese medicinal plant, Sinomenium acutum REHDER & E. H. WILSON (Family Menispermaceae). Ch...

journal_title：Biological & pharmaceutical bulletin

authors： Zeng Y,Gu B,Ji X,Ding X,Song C,Wu F

更新日期：2007-08-01 00:00:00

abstract：:Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) trigger...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CS,Won C,Yoo H,Yi EH,Cho Y,Maeng JW,Sung SH,Ye SK,Chung MH

更新日期：2009-11-01 00:00:00

abstract：:Apocynum venetum LINN. is an important Chinese crude drug, and its sibling species A. pictum SCHRENK is a confusable herb which is similar to it. The purpose of this study is to develop DNA molecular markers to distinguish A. venetum from A. pictum through the combinative technologies of bulked segregate analysis (BSA...

journal_title：Biological & pharmaceutical bulletin

authors： Lu C,Zhang W,Peng X,Gu G,Chen M,Tang Z

更新日期：2010-01-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:Lymphocyte homing is mediated by a specific interaction between the lymphocyte homing receptor L-selectin and its sulfated glycoprotein ligands, which are expressed on high endothelial venules (HEV) in the lymph nodes. To examine the significance of the sulfation of L-selectin ligands, our group has generated gene-tar...

journal_title：Biological & pharmaceutical bulletin

authors： Kawashima H

更新日期：2006-12-01 00:00:00

abstract：:A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1-...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta Y,Lee JB,Hayashi K,Hayashi T

更新日期：2009-05-01 00:00:00

abstract：:Changes in carbonyl reductase (CR) activity towards seven substrates in adrenal glands of female rats were investigated during estrous cycle and the circadian patterns of adrenal CR activity towards seven substrates in male rats were examined. The localization of the enzyme protein in the adrenal gland was carried out...

journal_title：Biological & pharmaceutical bulletin

authors： Inazu N,Nagashima Y,Satoh T

更新日期：1995-05-01 00:00:00

abstract：:The effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized (ovx) rats fed a calcium-deficient diet were investigated. Daidzin and genistin were orally administered to ovx rats for 4 weeks. The femurs of these rats showed significantly lower density, strength (breaking forces), ash weigh...

journal_title：Biological & pharmaceutical bulletin

authors： Ishida H,Uesugi T,Hirai K,Toda T,Nukaya H,Yokotsuka K,Tsuji K

更新日期：1998-01-01 00:00:00

abstract：:Collagen-induced arthritis (CIA) is an experimental model of rheumatoid arthritis (RA) used for studying the clinical, immunological and genetic factors of the disease. Many studies of genetic susceptibility to CIA have been performed, usually with two strains of mice, DBA/1 and B10.RIII, since they are highly suscept...

journal_title：Biological & pharmaceutical bulletin

authors： Hida S,Nagi-Miura N,Adachi Y,Ohno N

更新日期：2006-06-01 00:00:00

abstract：:When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Ba...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Bae EA,Han MJ,Park HJ,Choi JW

更新日期：2002-01-01 00:00:00

abstract：:Preparation of the fatty alcohol propylene glycol (FAPG) ointment base plays an important role in controlling the physicochemical properties of ointments. These essay investigates the effects of preparative conditions such as cooling rate and stirring rate on the percutaneous absorption of norfloxacin from FAPG ointme...

journal_title：Biological & pharmaceutical bulletin

authors： Lin HH,Hsu LR,Wu PC,Tsai YH

更新日期：1995-11-01 00:00:00

abstract：:The present study investigated whether or not Sho-saiko-to (crude powder extract, TJ-9) can suppress nitric oxide (NO) generation by endotoxin-activated J774A.1 cells in order to study the preventive mechanism of Sho-saiko-to against endotoxemia. In this experiment, we estimated the NO2- in the murine macrophage cell ...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Furusawa S,Yokota K,Sasaki K,Takayanagi Y

更新日期：1995-04-01 00:00:00

abstract：:In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1-->3)-beta-D-glucans, such as sonifilan (SPG) and SSG, did not induce cytokine production from macro...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki M,Adachi Y,Ohno N,Yadomae T

更新日期：1995-10-01 00:00:00

abstract：:Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on...

journal_title：Biological & pharmaceutical bulletin

authors： Park E,Chun HS

更新日期：2017-08-01 00:00:00

abstract：:Skeletal muscle is a major site for glucose metabolism and its injury by cytokines can induce insulin resistance leading to type 2 diabetes. It has been suggested that quercetin may act as an anti-diabetic agent, however, the effects of quercetin on insulin resistance in skeletal muscle remain unknown. We aimed to inv...

journal_title：Biological & pharmaceutical bulletin

authors： Dai X,Ding Y,Zhang Z,Cai X,Bao L,Li Y

更新日期：2013-01-01 00:00:00

abstract：:As part of a basic study on the prevention of cerebral injury, ajoene (0.5 mg/d) and oil-macerated garlic extract (OMGE, containing 0.5 mg ajoene/d) were administrated to stroke-prone spontaneously hypertensive rats (SHRSP) among 8 weeks from 9 weeks of age. In the control group, 3 of 10 rats died (30%), whereas all S...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada N,Hattori A,Nishikawa T,Fukuda H,Fujino T

更新日期：2006-04-01 00:00:00