Investigation of the safety of topical metronidazole from a pharmacokinetic perspective.

abstract：:Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glyca...

journal_title：Biological & pharmaceutical bulletin

authors： Hotta Y,Fujino R,Kimura O,Endo T

更新日期：2018-01-01 00:00:00

abstract：:A study of the biliary bile acid composition in porcine fetus compared with that of the adult pig is described. Biles, collected during gestation (weeks 4, 15 to 17 and at birth), aged six months and two years old, were analyzed by gas-liquid chromatography and capillary GC-MS. Bile acids were separated into different...

journal_title：Biological & pharmaceutical bulletin

authors： Kuramoto T,Miyamoto J,Konishi M,Hoshita T,Masul T,Une M

更新日期：2000-10-01 00:00:00

abstract：:A novel type of arylsulfate sulfotransferase (ASST) from a predominant human intestinal bacterium catalyzes the stoichiometric transfer of a sulfate group from phenolic sulfate esters to phenols. We clarified that polyphenols were better substrates of this enzyme than the corresponding glycosides. Additionally, a coum...

journal_title：Biological & pharmaceutical bulletin

authors： Konishi-Imamura L,Sato M,Dohi K,Kadota S,Namba T,Kobashi K

更新日期：1994-08-01 00:00:00

abstract：:We studied in vitro metabolites of 2,4,6,2',4',6'-hexachlorobiphenyl (HCB, IUPAC PCB No. 155) produced by liver microsomes of a phenobarbital (PB)-treated beagle dog. The major metabolites were 3-hydroxy-2,4,6,2',4',6'-HCB (M-1), 4-hydroxy-2,6,2',4',6'-pentachlorobiphenyl (PenCB, M-2) and 3,4-dihydroxy-2,6,2',4',6'-Pe...

journal_title：Biological & pharmaceutical bulletin

authors： Ariyoshi N,Yoshimura H,Oguri K

更新日期：1993-09-01 00:00:00

abstract：:Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bupleurum Kaoi in huma...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu YL,Kuo PL,Weng TC,Yen MH,Chiang LC,Lin CC

更新日期：2004-07-01 00:00:00

abstract：:Astragali Radix (AR), is a popular herbal medicine used to treat allergic diseases in Korea, Japan and China. Our study examined the effect of an AR ethanol extract on both in vitro and in vivo murine CD4 T cells' differentiation into Th1 and Th2 subsets. CD4 T cells from Balb/c mice were activated with anti-CD3/anti-...

journal_title：Biological & pharmaceutical bulletin

authors： Kang H,Ahn KS,Cho C,Bae HS

更新日期：2004-12-01 00:00:00

abstract：:A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd:spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as ...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi M,Takao K,Shiota Y,Sugita Y,Takahashi M,Nakae D,Samejima K

更新日期：2006-05-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) is strongly implicated as a key process in the onset of atherosclerosis. In this study, nine alkylated (C10-C5) flavonoids from Sophora flavescens were examined for their inhibitory effects on copper-induced LDL oxidation. Of the flavonoids tested, sophoraflavanone G (1), kur...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong TS,Ryu YB,Kim HY,Curtis-Long MJ,An S,Lee JH,Lee WS,Park KH

更新日期：2008-11-01 00:00:00

abstract：:Carboxamide-methylated light chain (G1L) from human serum IgG inhibited the secretion of tumor necrosis factor (TNF-alpha), one of the inflammatory cytokines, from adherent splenocytes and thioglycolate-induced peritoneal macrophages. The inhibition of TNF-alpha secretion by G1L was associated with disappearance of ty...

journal_title：Biological & pharmaceutical bulletin

authors： Mimura T,Takeuchi K,Hiramatsu K,Tsujikawa K,Kohama Y,Itoh S

更新日期：1995-10-01 00:00:00

abstract：:The effect of the hypothyroidism induced by thiamazole on toxic interactions between propranolol and disopyramide were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 ml/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubati...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Kanke M

更新日期：2005-10-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have the potential to be used in the cellular therapy of solid organs. However, tissue regeneration is limited by the death of transplanted cells. One of the main mechanisms of stem cell death in transplanted organs is through ischemia. In the present study, we sought to inves...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang W,Su X,Gao Y,Sun B,Yu Y,Wang X,Zhang F

更新日期：2009-08-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) plays an important role in the development of glomerulonephritis. The study of experimental glomerulonephritis in rats was performed to examine the antinephritic effects of TJN-331, a new herbally-derived chemical compound. To clarify the action of TJN-331 ((E)-N-(3,4-dimet...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:Polyethylenimine (PEI) is widely used for non-viral transfection in vitro and in vivo. Hepatectomy is an interesting and considerable factor modifying PEI-mediated gene expression. We investigated the gene expression in mice over time following partial hepatectomy after an intravenous injection of PEI/plasmid DNA (pDN...

journal_title：Biological & pharmaceutical bulletin

authors： Tada Y,Kitahara T,Yoshioka T,Nakamura T,Ichikawa N,Nakashima M,Nishida K,Nakamura J,Sasaki H

更新日期：2006-08-01 00:00:00

abstract：:The improvement of diabetic complications such as lipid lowering and anti-oxidative potential of Hydrangea Dulcis Folium (HDF) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into 3 groups after induction of streptozotocin (STZ)-diabetes: normal control; diabetic control; dia...

journal_title：Biological & pharmaceutical bulletin

authors： Kim HK,Kim MJ,Lyu ES,Shin DH

更新日期：2009-01-01 00:00:00

abstract：:Vonoprazan fumarate (vonoprazan) is a new kind of acid suppressant with potent acid inhibitory effects. Therefore, it has been administered to kidney transplant recipients for treatment or prophylaxis of steroid ulcers, refractory peptic ulcers, and gastroesophageal reflux disease. Because tacrolimus, which is a well-...

journal_title：Biological & pharmaceutical bulletin

authors： Mei T,Noguchi H,Suetsugu K,Hisadome Y,Kaku K,Okabe Y,Masuda S,Nakamura M

更新日期：2020-01-01 00:00:00

abstract：:The human adenovirus type 5 (Ad5) early-region 1A (E1A) proteins have been shown to have strong tumor-suppressive activities in human tumor cells and to enhance the sensitivity of a variety of malignant tumors to apoptosis induced by ionizing radiation and chemotherapeutic agents. However, the inherent limitations of ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma Y,Zhou X,Zhao Q,Li Y,Liu Y,Wang Z,Zhang Y

更新日期：2003-02-01 00:00:00

abstract：:Inhibition of Rho kinase (ROCK) ameliorates many cardiovascular dysfunctions. The aim of the current study is to investigate the anti-inflammatory effects of fasudil, a selective ROCK inhibitor, on high cholesterol diet-induced hypercholesterolemic rats and its possible mechanisms. In hypercholesterolemic rats, we fou...

journal_title：Biological & pharmaceutical bulletin

authors： Ma Z,Zhang J,Du R,Ji E,Chu L

更新日期：2011-01-01 00:00:00

abstract：:The induction of lymphangiogenesis is an important process to promote cancer growth and cancer metastasis via the lymphatic system. Identifying the compounds that can prevent lymphangiogenesis for cancer therapy is urgently required. Chrysin, 5,7-dihydroxyflavone, a natural flavone extracted from Thai propolis, was us...

journal_title：Biological & pharmaceutical bulletin

authors： Prangsaengtong O,Athikomkulchai S,Xu J,Koizumi K,Inujima A,Shibahara N,Shimada Y,Tadtong S,Awale S

更新日期：2016-01-01 00:00:00

abstract：:The present study investigated whether or not Sho-saiko-to (crude powder extract, TJ-9) can suppress nitric oxide (NO) generation by endotoxin-activated J774A.1 cells in order to study the preventive mechanism of Sho-saiko-to against endotoxemia. In this experiment, we estimated the NO2- in the murine macrophage cell ...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Furusawa S,Yokota K,Sasaki K,Takayanagi Y

更新日期：1995-04-01 00:00:00

abstract：:The purpose of this study was to determine the high-density lipoprotein (HDL)-associated alpha-tocopherol (alpha-tocopherol-HDL) transport and clarify the contribution of scavenger receptor class B, type I (SR-BI) to the uptake in the human retinal pigment epithelial cell line (ARPE-19 cells). [(3)H]alpha-Tocopherol-H...

journal_title：Biological & pharmaceutical bulletin

authors： Akanuma S,Yamamoto A,Okayasu S,Tachikawa M,Hosoya K

更新日期：2009-06-01 00:00:00

abstract：:In this study, we examined the usefulness of a tissue-clearing technique for the evaluation of the lung distribution of aerosolized drugs. An aerosol formulation of TexasRed dextran (70 kDa), a model compound of drug carrier for aerosolized drugs, was administered intrapulmonarily to mice using a MicroSprayer, and the...

journal_title：Biological & pharmaceutical bulletin

authors： Togami K,Kitayama A,Daisho T,Wang R,Tada H,Chono S

更新日期：2018-01-01 00:00:00

abstract：:Uridine 5'-diphosphate-glucuronosyltransferase (UGT) catalyzes a major phase II reaction in a drug-metabolizing enzyme system. Although the UGT1A subfamily is expressed mainly in the liver, it is also expressed in the brain. The purpose of the present study was to elucidate the effect of β-naphthoflavone (BNF), one of...

journal_title：Biological & pharmaceutical bulletin

authors： Sakakibara Y,Katoh M,Kondo Y,Nadai M

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study is to investigate the effects of long-term Hypericum perforatum treatment on spatial learning and memory in rats. Hypericum preparation (HP) standardized to 0.3% hypericin content was administered orally for 9 weeks in doses of 4.3 and 13 microg/kg corresponding to therapeutic dosages in h...

journal_title：Biological & pharmaceutical bulletin

authors： Widy-Tyszkiewicz E,Piechal A,Joniec I,Blecharz-Klin K

更新日期：2002-10-01 00:00:00

abstract：:The skeletal renin–angiotensin system (RAS) is involved in the progression of osteoporosis and the active peptide within the RAS, angiotensin II (ANG II), has deleterious effects on bones. This study was performed to investigate whether suppression of the rate-limiting step of the RAS cascade by the renin inhibitor al...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang FY,Yang FJ,Yang JL,Wang L,Zhang Y

更新日期：2014-01-01 00:00:00

abstract：:D-Aspartate (D-Asp), a free D-amino acid found in mammals, plays crucial roles in the neuroendocrine, endocrine, and central nervous systems. Recent studies have implicated D-Asp in the pathophysiology of infertility and N-methyl-D-Asp receptor-related diseases. D-Asp oxidase (DDO), a degradative enzyme that is stereo...

journal_title：Biological & pharmaceutical bulletin

authors： Katane M,Kawata T,Nakayama K,Saitoh Y,Kaneko Y,Matsuda S,Saitoh Y,Miyamoto T,Sekine M,Homma H

更新日期：2015-01-01 00:00:00

abstract：:Puerarin (daidzein 8-C-glucoside) is an isoflavone C-glucoside contained in the roots of Pueraria lobata OHWI. We have previously isolated the human intestinal bacterium, strain PUE, which metabolizes puerarin to daidzein, though the enzyme which cleaves C-glycosidic bond has not been clarified. Here, we identified on...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura K,Zhu S,Komatsu K,Hattori M,Iwashima M

更新日期：2019-03-01 00:00:00

abstract：:To study the role of asarinin on collagen-induced arthritis (CIA) and its treatment mechanism on dendritic cells (DCs) and T cells. Before the onset of arthritis, asarinin were given orally to CIA mouse. Macroscopic scoring and micrometer caliper measurement were used to assess arthritis. The occurrence of cartilage d...

journal_title：Biological & pharmaceutical bulletin

authors： Dai Q,Wang M,Li Y,Li J

更新日期：2019-07-01 00:00:00

abstract：:Postprandial hypertriglyceridemia, as well as postprandial hyperglycemia, are important factors contributing to the development of cardiovascular disease in patients with type 2 diabetes. Nateglinide is a recently approved antidiabetic that suppresses postprandial hyperglycemia by stimulating the early phase of insuli...

journal_title：Biological & pharmaceutical bulletin

authors： Mine T,Miura K,Kitahara Y,Okano A,Kawamori R

更新日期：2002-11-01 00:00:00

abstract：:Plasma hyaluronan binding protein (PHBP) is produced only in liver and kidney in mouse. The induction of PHBP mRNA and the conversion of pro PHBP to the active hetero-dimer form were studied after CCl4, D-galactosamine, HgCl2 or turpentine administration and after partial hepatectomy. The results indicated that the ad...

journal_title：Biological & pharmaceutical bulletin

authors： Choi-Miura NH,Otsuyama K,Sano Y,Saito K,Takahashi K,Tomita M

更新日期：2001-08-01 00:00:00

abstract：:A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phos...

journal_title：Biological & pharmaceutical bulletin

authors： Tasduq SA,Mondhe DM,Gupta DK,Baleshwar M,Johri RK

更新日期：2005-07-01 00:00:00