当前位置： SCI文献检索 > BIOLOGICAL & PHARMACEUTICAL BULLETIN期刊下所有文献 > A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers.

A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers.

Abstract：

:We investigated the properties of honokiol, a natural rexinoid, as a regulator of retinoid X receptor (RXR) heterodimers with various partner nuclear receptors (NRs), in comparison with those of the synthetic rexinoid bexarotene. Honokiol alone was hardly capable of activating peroxisome proliferator-activated receptor (PPAR) γ/RXR, RXR/liver X receptor (LXR), and RXR/vitamin D receptor (VDR) heterodimers, whereas it effectively potentiated their activation by agonists for the partner NRs of the RXR heterodimers. These findings were further supported by increased mRNA and protein levels for the respective NR target genes. Bexarotene alone activated PPARγ/RXR and RXR/LXR heterodimers, but not RXR/VDR heterodimers, and facilitated the activation of all three RXR heterodimers by the respective PPARγ, LXR, and VDR agonists. When the potencies of honokiol and bexarotene were compared, honokiol was able to serve as a subsidiary agonist in the activation of RXR heterodimers in a similar manner to bexarotene. However, it seemed to potentiate the activation of PPARγ/RXR heterodimers by the PPARγ agonist rosiglitazone more efficiently than bexarotene, and was a less potent RXR agonist than bexarotene. In conclusion, we have demonstrated that honokiol is a rexinoid that possesses distinct properties from bexarotene, and mainly has subsidiary roles in the activation of RXR heterodimers by potentiating the activation of RXR heterodimers by agonists for the partner NRs.

journal_name

Biol Pharm Bull

journal_title

Biological & pharmaceutical bulletin

authors

Kotani H,Tanabe H,Mizukami H,Amagaya S,Inoue M

doi

10.1248/bpb.35.1

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1-9

issue

1

eissn

0918-6158

issn

1347-5215

pii

JST.JSTAGE/bpb/35.1

journal_volume

35

pub_type

杂志文章

相关文献

BIOLOGICAL & PHARMACEUTICAL BULLETIN文献大全
  • Development of a Diagnostic Screening Strategy for Niemann-Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of N-Palmitoyl-O-phosphocholine-serine and Sphingosylphosphorylcholine.

    abstract：:Early diagnosis of Niemann-Pick diseases (NPDs) is important for better prognosis of such diseases. N-Palmitoyl-O-phosphocholine-serine (PPCS) is a new NPD biomarker possessing high sensitivity, and with its combination with sphingosylphosphocholine (SPC) it may be possible to distinguish NPD-C from NPD-A/B. In this s...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.b20-00400

    authors： Iwahori A,Maekawa M,Narita A,Kato A,Sato T,Ogura J,Sato Y,Kikuchi M,Noguchi A,Higaki K,Okuyama T,Takahashi T,Eto Y,Mano N

    更新日期：2020-09-01 00:00:00

  • Antioxidative effect of sesamol and related compounds on lipid peroxidation.

    abstract：:The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe(2)+, on the lipid peroxidation of rat liver microsomes induced by CCl(4) or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe(2)+ were demonstrated. Consequently, sesamol and related compounds,...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.19.623

    authors： Uchida M,Nakajin S,Toyoshima S,Shinoda M

    更新日期：1996-04-01 00:00:00

  • Protective effects of sodium-L-ascorbyl-2 phosphate on the development of UVB-induced damage in cultured mouse skin.

    abstract：:The protective effect of sodium-L-ascorbyl-2 phosphate (As-2P), a stable form of ascorbic acid (AsA), against photodamage induced by a single dose of UVB exposure (290-320 nm, Max 312 nm) was investigated using cultured mouse skin. When the cultured skin was treated with various As-2P concentrations, the cutaneous AsA...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.22.1301

    authors： Nayama S,Takehana M,Kanke M,Itoh S,Ogata E,Kobayashi S

    更新日期：1999-12-01 00:00:00

  • Enhanced myopathy following administration of hypolipidemic agents under urethane anesthesia.

    abstract：:The enhanced effect of urethane anesthesia on the serum creatine kinase (CPK) level following administration of hypolipidemic agents was examined to develop a convenient experimental screening method for drug-induced myopathy. After oral administration of a hypolipidemic agent to rats, 25% urethane solution was infuse...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.20.104

    authors： Nakai A,Nishikata M,Uchida T,Ichikawa M,Matsuyama K

    更新日期：1997-01-01 00:00:00

  • Occurrence of a novel L-2,4-diaminobutyrate decarboxylase activity in some species of Enterobacteriaceae, and purification and characterization of the enzymes of Enterobacter aerogenes and Serratia marcescens.

    abstract：:L-2,4-Diaminobutyrate decarboxylase (DABA DC) is a novel enzyme yielding 1,3-diaminopropane (DAP) from DABA, which has previously been purified from strains of the genera Vibrio and Acinetobacter. In this study, we also detected DABA DC activity in the species of Enterobacteriaceae: E. aerogenes, E. cloacae, E. agglom...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.19.1298

    authors： Yamamoto S,Mutoh N,Ikai H,Nagasaka M

    更新日期：1996-10-01 00:00:00

  • DY-9760e, a calmodulin antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.

    abstract：:DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate), a calmodulin antagonist, provides protection against Ca(2+) overload-associated cytotoxicity and brain injury after cerebral ischemia in rats. In this study, we assessed the e...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.28.629

    authors： Sugimura M,Takamori H,Fukushi H,Kitano Y,Kanazawa Y,Shirasaki Y

    更新日期：2005-04-01 00:00:00

  • Prostacyclin (PGI) receptor binding and cyclic AMP synthesis activities of PGI1 analogues, SM-10906 and its methyl ester, SM-10902, in mastocytoma P-815 cells.

    abstract：:The prostacyclin I1 (PGI1) analogue, SM-10906 and its methyl ester, SM-10902, have been compared with the PGI2 analogue, iloprost, with respect to binding to the PGI2 receptor, stimulation of adenylate cyclase activity and inhibition of thrombin-induced Ca2+ mobilization in mastocytoma P-815 cells. SM-10906 displaced ...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.17.74

    authors： Oka M,Negishi M,Yamamoto T,Satoh K,Hirohashi T,Ichikawa A

    更新日期：1994-01-01 00:00:00

  • Identification of in vitro metabolites of 2,4,6,2',4',6'-hexachlorobiphenyl from phenobarbital-treated dog liver microsomes.

    abstract：:We studied in vitro metabolites of 2,4,6,2',4',6'-hexachlorobiphenyl (HCB, IUPAC PCB No. 155) produced by liver microsomes of a phenobarbital (PB)-treated beagle dog. The major metabolites were 3-hydroxy-2,4,6,2',4',6'-HCB (M-1), 4-hydroxy-2,6,2',4',6'-pentachlorobiphenyl (PenCB, M-2) and 3,4-dihydroxy-2,6,2',4',6'-Pe...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.16.852

    authors： Ariyoshi N,Yoshimura H,Oguri K

    更新日期：1993-09-01 00:00:00

  • Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells.

    abstract：:The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.28.2253

    authors： Lee MH,Kim JY,Ryu JH

    更新日期：2005-12-01 00:00:00

  • The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages.

    abstract：:Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals, including humans. In the present study, we demonstrated the anti-inflammatory effects of MSM in lipopolysaccharide (LPS...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.32.651

    authors： Kim YH,Kim DH,Lim H,Baek DY,Shin HK,Kim JK

    更新日期：2009-04-01 00:00:00

  • Investigation of the safety of topical metronidazole from a pharmacokinetic perspective.

    abstract：:Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ is absorbed when a topical preparation is applied to cancerous tissue r...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.b12-00687

    authors： Iida J,Kudo T,Shimada K,Yatsuno Y,Yamagishi S,Hasegawa S,Ike H,Sato T,Kagaya H,Ito K

    更新日期：2013-01-01 00:00:00

  • Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.

    abstract：:The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 microM, and 19 of ...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.21.823

    authors： Takahira M,Kusano A,Shibano M,Kusano G,Koizumi K,Suzuki R,Kim HS,Wataya Y

    更新日期：1998-08-01 00:00:00

  • Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by tryptanthrin.

    abstract：:In addition to regulation of normal cell functions, hepatocyte growth factor (HGF) has also been shown to be involved in malignant cell transformation and in growth, invasion and metastasis in cancer cells. Inhibitors of HGF production have a potential for interfering with malignant cell transformation and progression...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.28.260

    authors： Motoki T,Takami Y,Yagi Y,Tai A,Yamamoto I,Gohda E

    更新日期：2005-02-01 00:00:00

  • Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages.

    abstract：:Although macrophage phagocytoses modified low-density lipoprotein (LDL), excessive accumulation of modified LDL induces macrophage foam cell formation, which is a feature of atherosclerotic plaque. Thus, the identification of scavenger receptor for modified LDL will provide better understanding of an atherosclerotic e...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.b15-00260

    authors： Miki Y,Tachibana Y,Ohminato Y,Fujiwara Y

    更新日期：2015-01-01 00:00:00

  • Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress.

    abstract：:The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of ...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.32.2065

    authors： Sano K,Koushi E,Irie K,Higuchi S,Tsuchihashi R,Kinjo J,Egashira N,Oishi R,Uchida N,Nagai H,Nishimura R,Tanaka H,Morimoto S,Mishima K,Iwasaki K,Fujiwara M

    更新日期：2009-12-01 00:00:00

  • Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.

    abstract：:Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary fibrosis is a common complication in these interstitial lung diseases, and PF always has a poor prognosis and short survival. To date, there ...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.b15-00358

    authors： Hao Y,Liu Y

    更新日期：2016-01-01 00:00:00

  • Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish.

    abstract：:In most species, solar light is both a DNA-damaging agent and the key entraining stimulus for the endogenous circadian clock. The zebrafish is an attractive vertebrate system in which to study the influence of light on gene expression because the DNA repair proteins and circadian oscillators in this species are light-...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.34.1343

    authors： Osaki T,Uchida Y,Hirayama J,Nishina H

    更新日期：2011-01-01 00:00:00

  • Inhibition of prostaglandin E2 and leukotriene C4 in mouse peritoneal macrophages and thromboxane B2 production in human platelets by flavonoids from Stachys chrysantha and Stachys candida.

    abstract：:Seven flavonoids of Stachys chrysantha and Stachys candida have been isolated. The structures of the compounds were elucidated by spectroscopic methods, particularly highfield NMR spectroscopy. The effects of the methanol extracts of these two endemic Greek Stachys sp. and their main flavonoids were examined on arachi...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.23.47

    authors： Skaltsa H,Bermejo P,Lazari D,Silvan AM,Skaltsounis AL,Sanz A,Abad MJ

    更新日期：2000-01-01 00:00:00

  • Soluble guanylyl cyclase inhibitor prevents Sema3F-induced collapse of axonal and dendritic growth cones of dentate granule cells.

    abstract：:Controlling axon and dendrite elongation is critical in developing precise neural circuits. Using isolated cultures of dentate granule neurons, we succeeded in simultaneously monitoring the behaviors of axonal and dendritic outgrowth. Our previous study shows that cAMP contributes differentially to Sema3F-induced resp...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.29.796

    authors： Yamada RX,Matsuki N,Ikegaya Y

    更新日期：2006-04-01 00:00:00

  • Properties of an alginate gel bead containing a chitosan-drug salt.

    abstract：:A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solut...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.27.440

    authors： Murata Y,Hirai D,Kofuji K,Miyamoto E,Kawashima S

    更新日期：2004-03-01 00:00:00

  • Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.

    abstract：:Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of echinacoside on kainic acid-induced seizures in rats. The rats w...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.b18-00407

    authors： Lu CW,Hsieh HL,Lin TY,Hsieh TY,Huang SK,Wang SJ

    更新日期：2018-11-01 00:00:00

  • Potentiation of cytotoxic activity in naïve and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies.

    abstract：:When hot-water extracts of mushroom Agaricus brazei MURRILL fruiting bodies (Agaricus extracts) were administered orally into Meth A-bearing mice, tumor growth was significantly inhibited compared with controls given water orally. Treatment with Agaricus extracts for five successive days significantly increased natura...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.27.404

    authors： Takimoto H,Wakita D,Kawaguchi K,Kumazawa Y

    更新日期：2004-03-01 00:00:00

  • Isosteviol Sodium Inhibits Astrogliosis after Cerebral Ischemia/Reperfusion Injury in Rats.

    abstract：:Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic m...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.b17-00921

    authors： Zhang H,Sun X,Xie Y,Tian F,Hu H,Tan W

    更新日期：2018-01-01 00:00:00

  • Identification of the crude drug atractylodes rhizome (Byaku-jutsu) and atractylodes lancea rhizome (So-jutsu) using chloroplast TrnK sequence as a molecular marker.

    abstract：:Novel methods for molecular authentication of Atractylodes-derived crude drugs (Jutsu) were established based on PCR-restriction fragment length polymorphism (RFLP) and direct sequencing of chloroplast trnK. Two regions inside the chloroplast trnK were selected as molecular markers for identification and discriminatio...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.23.589

    authors： Mizukami H,Okabe Y,Kohda H,Hiraoka N

    更新日期：2000-05-01 00:00:00

  • Effect of a nutritive-tonic drink on scopolamine-induced memory impairment in mice.

    abstract：:The effects of a liquid nutritive and tonic drug (NTD) selected from a modification of the "Kai-xin-shou-yu-shen-qi-wan" prescription, on scopolamine-induced amnesia in mice were investigated using the passive avoidance and water-maze tasks. A popular NTD in Japan that contains 17 crude (natural) drug extracts togethe...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.28.1886

    authors： Sakata Y,Chida R,Ishige K,Edagawa Y,Tadano T,Ito Y

    更新日期：2005-10-01 00:00:00

  • Activity of artificial mutant variants of human growth hormone changes in charged residues around 62-67.

    abstract：:Our previous work has shown that the amino acid residues around 62-67 located in the connecting loop between helix I and II of human growth hormone (hGH) are important in eliciting the differentiation of preadipose 3T3-F442A cells to adipocytes. In this study, we evaluated the role of the charged residues around 62-67...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.18.797

    authors： Uchida E,Shimokawa S,Takasu H,Ikehara M,Uesugi S,Tomita K,Tanaka A,Morikawa M,Nishikawa S,Hayakawa T

    更新日期：1995-06-01 00:00:00

  • Effects of 3,6-dimethylpyrazine-2-thiol on reproductive and accessory reproductive organs in male rats.

    abstract：:The weights of prostate and seminal vesicle were decreased by treatment with 3,6-dimethylpyrazine-2-thiol(3,6-DMP-SH) but the weights of testes and the plasma testosterone levels were not changed. The recovery of the weight of prostate and seminal vesicles of testosterone-treated orchidectomized rats were inhibited by...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.19.360

    authors： Yamada K,Komatsu H,Ohta A

    更新日期：1996-03-01 00:00:00

  • Mechanism of decreased susceptibility for Gram-negative bacteria and synergistic effect with ampicillin of indole-3-carbinol.

    abstract：:Indole-3-carbinol (I3C) is a natural compound found in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. In a previous study, I3C exhibited broad spectrum antibacterial activities. Particularly, it showed a more potent antibact...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.31.1798

    authors： Sung WS,Lee DG

    更新日期：2008-09-01 00:00:00

  • Aconitine induces bradycardia through a transmission pathway including the anterior hypothalamus in conscious mice.

    abstract：:Aconitine administered intraperitoneally (i.p.) produces bradycardia mainly by a central muscarinic action. The involvement of hypothalamic regions in the occurrence of aconitine-induced bradycardia was investigated in hypothalamus-lesioned mice. The lesions were made by passing a direct current (1.5 mA, 13 s) through...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.20.856

    authors： Kimura I,Takada M,Nojima H

    更新日期：1997-08-01 00:00:00

  • Pharmacognostical studies of cistanchis herba (III) phylogenetic relationship of the cistanche plants based on plastid rps2 gene and rpl16-rpl14 intergenic spacer sequences.

    abstract：:The phylogenetic relationship of Cistanche deserticola, C. salsa and C. tubulosa was analyzed by comparing the nucleotide sequences of the plastid rps2 gene and the intergenic spacer region between rpl16 and rpl14. By comparison of sequence data, the Cistanche samples were distinguishable from each other. The results ...

    journal_title：Biological & pharmaceutical bulletin

    pub_type： 杂志文章

    doi：10.1248/bpb.25.218

    authors： Tomari N,Ishizuka Y,Moriya A,Kojima S,Deyama T,Mizukami H,Tu P

    更新日期：2002-02-01 00:00:00