Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress.

abstract：:We have found a new compound from thermophile extracts which inhibits antigen presentation on mouse macrophages. The substance inhibits the expression of the class II major histocompatibility molecule (Ia). It was extracted from Bacillus stearothermophilus UBT8038 and purified by silica gel column chromatography. The ...

journal_title：Biological & pharmaceutical bulletin

authors： Kohama Y,Itoh M,Tanaka K,Senba T,Itoh S,Mimura T

更新日期：1994-07-01 00:00:00

abstract：:Calcium channel blockers have become important tools in the treatment of cardiovascular disorders and other diseases. Hybridization of well established calcium antagonist subclasses was an attempt to optimize their pharmacological profile. The intension of this study was to investigate the electrophysiological propert...

journal_title：Biological & pharmaceutical bulletin

authors： Schade B,Erker T,Weber M,Studenik C

更新日期：2004-09-01 00:00:00

abstract：:Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Nakamura S,Yoshikawa M

更新日期：2014-01-01 00:00:00

abstract：:The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measure...

journal_title：Biological & pharmaceutical bulletin

authors： Teramachi H,Hatakeyama H,Matsushita R,Imai Y,Miyamoto K,Tsuji A

更新日期：2002-10-01 00:00:00

abstract：:The absorption of glycerol was examined using the closed loop of the rat small intestine in situ to clarify the transport mechanism. The absorption of glycerol, evaluated by its disappearance from the intestinal lumen, was saturable and reduced under the Na(+)-free conditions, suggesting the involvement of an Na(+)-de...

journal_title：Biological & pharmaceutical bulletin

authors： Kato T,Hayashi Y,Inoue K,Yuasa H

更新日期：2005-03-01 00:00:00

abstract：:To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin ...

journal_title：Biological & pharmaceutical bulletin

authors： Konoshima T,Takasaki M,Tatsumoto T,Kozuka M,Kasai R,Tanaka O,Nie RL,Tokuda H,Nishino H,Iwashima A

更新日期：1994-05-01 00:00:00

abstract：:Monoclonal antibodies are widely used for the treatment of various diseases, and because therapeutic monoclonal antibodies are stored in an aqueous solution or in a lyophilized state, the preparation of a stabilizing formulation that prevents their deterioration (degradation and aggregation) is crucial. Given the stru...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa T,Ito T,Endo R,Nakagawa K,Sawa E,Wakamatsu K

更新日期：2010-01-01 00:00:00

abstract：:Povidone-iodine (PVP-I), an antibacterial medicine, was infiltrated in sepiolite (SPL). The available iodine content in this new pharmaceutical product, a sepiolite preparation containing povidone-iodine (PVP-I-SPL), was retained at 98.9 and 98.3% during storage at 40 degrees C for 3 and 6 months, respectively. The ef...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Nagai K,Maruyama M,Inoue H,Katsuyama Y,Atobe O,Ogata H,Yamato S,Tachikawa E,Zenda H

更新日期：1999-01-01 00:00:00

abstract：:Agaricus blazei is a medicinal mushroom native to Brazil. It used to be a source of anti-tumor and immunmoactive compounds and considered a health food in many countries. However, its specific effect against mast cell-mediated anaphylactic reactions is still unknown. In the present study, we investigated the effect of...

journal_title：Biological & pharmaceutical bulletin

authors： Choi YH,Yan GH,Chai OH,Choi YH,Zhang X,Lim JM,Kim JH,Lee MS,Han EH,Kim HT,Song CH

更新日期：2006-07-01 00:00:00

abstract：:The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of as...

journal_title：Biological & pharmaceutical bulletin

authors： Lares-Asseff I,Juárez-Olguín H,Flores-Pérez J,Guillé-Pérez A,Vargas A

更新日期：2004-05-01 00:00:00

abstract：:Acetaminophen (APAP) is a widely used analgesic and antipyretic drug. Drug-induced liver injury from agents such as APAP is known to vary between individuals within a species. To avoid liver injury and ensure the proper use of pharmaceutical products, it is important to be able to predict such risks using genetic info...

journal_title：Biological & pharmaceutical bulletin

authors： Kanno S,Tomizawa A,Yomogida S

更新日期：2016-01-01 00:00:00

abstract：:It has been well known that Vibrio cholerae inhabit in environmental water. As many patients infected with cholera toxin-producing V. cholerae O1 (toxigenic V. cholerae O1) emerge in Kolkata, India, it has been thought that toxigenic V. cholerae O1 is easily detected in environmental water in Kolkata. However, we coul...

journal_title：Biological & pharmaceutical bulletin

authors： Paul SS,Takahashi E,Chowdhury G,Miyoshi SI,Mizuno T,Mukhopadhyay AK,Dutta S,Okamoto K

更新日期：2020-08-01 00:00:00

abstract：:A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd:spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as ...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi M,Takao K,Shiota Y,Sugita Y,Takahashi M,Nakae D,Samejima K

更新日期：2006-05-01 00:00:00

abstract：:We investigated whether endogenous nitric oxide (NO) has a role as an inhibitory modulator of norepinephrine (NE)- and angiotensin II (Ang II)-induced renal effects in anesthetized dogs. Intrarenal arterial infusion of NE (100 ng/kg/min) or Ang II (10 ng/kg/min) decreased renal blood flow (RBF), glomerular filtration ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura Y,Egi Y,Maekawa H,Miura A,Murata S,Morimoto S

更新日期：1995-04-01 00:00:00

abstract：:Protein purification is a key technique for the identification of novel sensory nerve-specific proteins. A 35 kDa protein, the sensory neuronal specific protein, was isolated and purified from rabbit spinal ganglia and sensory fibers by homogenizing and deriving soluble extracts, followed by ion exchange chromatograph...

journal_title：Biological & pharmaceutical bulletin

authors： Ping XP,Wang JZ

更新日期：2000-05-01 00:00:00

abstract：:Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals, including humans. In the present study, we demonstrated the anti-inflammatory effects of MSM in lipopolysaccharide (LPS...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YH,Kim DH,Lim H,Baek DY,Shin HK,Kim JK

更新日期：2009-04-01 00:00:00

abstract：:A significant sex-related difference was observed for the pharmacokinetics of acetohexamide in Wistar-Imamichi (Wistar-IM) rats. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. Testectomy was found to decrease the plasma clearance (CLp) o...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Kaneko M,Mori Y,Otagiri M

更新日期：1999-04-01 00:00:00

abstract：:The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly...

journal_title：Biological & pharmaceutical bulletin

authors： Moriguchi T,Takashina K,Chu PJ,Saito H,Nishiyama N

更新日期：1994-12-01 00:00:00

abstract：:Ferulic acid (FA), a naturally occurring polyphenol abundant in vegetables and rice bran, is known to possess a potent antioxidant activity, thereby protecting cells from oxidative stress. In the present study, we show that in addition to its known anti-oxidant activity, ferulic acid exerts substantial inhibitory acti...

journal_title：Biological & pharmaceutical bulletin

authors： Bian Z,Furuya N,Zheng DM,Oliva Trejo JA,Tada N,Ezaki J,Ueno T

更新日期：2013-01-01 00:00:00

abstract：:The success of green tea as a cancer preventive is based on evidence that green tea contains tannins and antioxidants, does not show toxicity in humans and has long traditional use in Asia. In the light of this, herbal medicines are now also attracting attention as potential sources of cancer preventive agents. Using ...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe S,Suganuma M,Imayoshi Y,Taniguchi S,Yoshida T,Fujiki H

更新日期：2001-10-01 00:00:00

abstract：:The present study provides the first evidence that stilbene oxide and styrene oxide are reductively metabolized to the corresponding olefins in rats. When cis- or trans-stilbene oxide was given orally to rats, both cis- and trans-stilbene were isolated from the urine and feces. Styrene was also isolated from the urine...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura S,Shiraishi Y,Mita M,Sueki H,Maeda C,Tatsumi K

更新日期：2000-02-01 00:00:00

abstract：:Systems for delivering nucleic acids are now fundamental technologies for realizing personalized medicine. Among the various nucleic acid delivery systems that are currently available, lipid-nanoparticles (LNPs) that contain short interfering RNA (siRNA) have been extensively investigated for clinical applications. LN...

journal_title：Biological & pharmaceutical bulletin

authors： Shirane D,Tanaka H,Nakai Y,Yoshioka H,Akita H

更新日期：2018-01-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been employed to create a Parkinson's disease-like model in both rodents and primates based primarily on its ability to create a striatal dopamine deficit due to the loss of dopaminergic neurons in the substantia nigra compacta. The present study w...

journal_title：Biological & pharmaceutical bulletin

authors： Geng X,Song L,Pu X,Tu P

更新日期：2004-06-01 00:00:00

abstract：:Two acidic polysaccharides, called ginsenan S-IA and ginsenan S-IIA, were isolated from the root of Panax ginseng C. A. Meyer. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.6 x 10(4) and 1.0 x 10(5), respectively. Ginsenan S-IA is composed of L-arabi...

journal_title：Biological & pharmaceutical bulletin

authors： Tomoda M,Hirabayashi K,Shimizu N,Gonda R,Ohara N,Takada K

更新日期：1993-11-01 00:00:00

abstract：:Preparation of the fatty alcohol propylene glycol (FAPG) ointment base plays an important role in controlling the physicochemical properties of ointments. These essay investigates the effects of preparative conditions such as cooling rate and stirring rate on the percutaneous absorption of norfloxacin from FAPG ointme...

journal_title：Biological & pharmaceutical bulletin

authors： Lin HH,Hsu LR,Wu PC,Tsai YH

更新日期：1995-11-01 00:00:00

abstract：:In 3,4-methylenedioxyamphetamine (MDA)-treated rat brain and urine, 3-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (3Me6,7MDTIQ) was detected as a new metabolite. The content of 3Me6,7MDTIQ in (R)-MDA-treated rat was significantly higher than that in (S)-MDA-treated brain and urine. This result suggests th...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagawa H,Makino Y,Yoshida Y,Ohta S,Hirobe M

更新日期：1993-06-01 00:00:00

abstract：:When hot-water extracts of mushroom Agaricus brazei MURRILL fruiting bodies (Agaricus extracts) were administered orally into Meth A-bearing mice, tumor growth was significantly inhibited compared with controls given water orally. Treatment with Agaricus extracts for five successive days significantly increased natura...

journal_title：Biological & pharmaceutical bulletin

authors： Takimoto H,Wakita D,Kawaguchi K,Kumazawa Y

更新日期：2004-03-01 00:00:00

abstract：:Hydroxyoctadecadienoic acids (HODEs) are generated by oxidation of linoleic acid in vivo and thought to mediate various pathophysiological responses. In this study, we examined the effects of HODEs on EL4 mouse lymphoma cell growth and found that 9-(E,Z)-HODE inhibited EL4 cell growth in a dose-dependent manner, where...

journal_title：Biological & pharmaceutical bulletin

authors： Kodaka A,Hayakawa Y,AlSayegh RJ,Yasuhara T,Tomoda H,Oku T,Dan S,Tsuiji M,Tsuji T

更新日期：2019-01-01 00:00:00

abstract：:A possible evaluation technique was devised for examing timely cholesterol synthetic activity in the rat liver. The principle of the technique is to measure the incorporation rate of 14C atoms into a few target metabolites excreted in bile with time after an intraportal injection of [1,2-14C] acetate to the conscious ...

journal_title：Biological & pharmaceutical bulletin

authors： Okuyama M,Tsunogai M,Watanabe N,Asakura Y,Shigematsu A

更新日期：1995-11-01 00:00:00

abstract：:We investigated the genotypic status of thiopurine methyltransferase (TPMT) polymorphism to evaluate the possible risk of the toxicity of azathioprine (AZA) in 68 patients with systemic lupus erythematosus (SLE). The allele frequency of TPMT mutation in the SLE group (2.9%) was higher than that in 174 Japanese healthy...

journal_title：Biological & pharmaceutical bulletin

authors： Okada Y,Nakamura K,Kodama T,Ueki K,Tsukada Y,Maezawa A,Tsukamoto N,Nojima Y,Ishizaki T,Horiuchi R,Yamamoto K

更新日期：2005-11-01 00:00:00