Abstract:
:The present study provides the first evidence that stilbene oxide and styrene oxide are reductively metabolized to the corresponding olefins in rats. When cis- or trans-stilbene oxide was given orally to rats, both cis- and trans-stilbene were isolated from the urine and feces. Styrene was also isolated from the urine and feces of rats given styrene oxide. These metabolites were identified unequivocally by UV and mass spectral comparison with authentic samples, and on the basis of their TLC and HPLC behavior. However, these olefins were not detected in the urine or feces of antibiotics-treated rats dosed with cis- or trans-stilbene oxide. Cecal contents of the untreated rats exhibited olefin oxide reductase activities toward cis- and trans-stilbene oxides under anaerobic conditions. The results suggest that intestinal bacteria play an important role in the reduction of olefin oxides to the corresponding olefins in the animal body.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Kitamura S,Shiraishi Y,Mita M,Sueki H,Maeda C,Tatsumi Kdoi
10.1248/bpb.23.265subject
Has Abstractpub_date
2000-02-01 00:00:00pages
265-8issue
2eissn
0918-6158issn
1347-5215journal_volume
23pub_type
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