Reductive metabolism of stilbene oxide and styrene oxide to the olefins in rats.

Abstract:

:The present study provides the first evidence that stilbene oxide and styrene oxide are reductively metabolized to the corresponding olefins in rats. When cis- or trans-stilbene oxide was given orally to rats, both cis- and trans-stilbene were isolated from the urine and feces. Styrene was also isolated from the urine and feces of rats given styrene oxide. These metabolites were identified unequivocally by UV and mass spectral comparison with authentic samples, and on the basis of their TLC and HPLC behavior. However, these olefins were not detected in the urine or feces of antibiotics-treated rats dosed with cis- or trans-stilbene oxide. Cecal contents of the untreated rats exhibited olefin oxide reductase activities toward cis- and trans-stilbene oxides under anaerobic conditions. The results suggest that intestinal bacteria play an important role in the reduction of olefin oxides to the corresponding olefins in the animal body.

journal_name

Biol Pharm Bull

authors

Kitamura S,Shiraishi Y,Mita M,Sueki H,Maeda C,Tatsumi K

doi

10.1248/bpb.23.265

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

265-8

issue

2

eissn

0918-6158

issn

1347-5215

journal_volume

23

pub_type

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