Low Viability of Cholera Toxin-Producing Vibrio cholerae O1 in the Artificial Low Ionic Strength Aquatic Solution.

abstract：:The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferat...

journal_title：Biological & pharmaceutical bulletin

authors： Maehama T

更新日期：2007-09-01 00:00:00

abstract：:The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the foll...

journal_title：Biological & pharmaceutical bulletin

authors： Guerra GC,de Menezes MS,de Araújo AA,de Araújo Júnior RF,de Medeiros CA

更新日期：2016-01-01 00:00:00

abstract：:The protective effect of sodium-L-ascorbyl-2 phosphate (As-2P), a stable form of ascorbic acid (AsA), against photodamage induced by a single dose of UVB exposure (290-320 nm, Max 312 nm) was investigated using cultured mouse skin. When the cultured skin was treated with various As-2P concentrations, the cutaneous AsA...

journal_title：Biological & pharmaceutical bulletin

authors： Nayama S,Takehana M,Kanke M,Itoh S,Ogata E,Kobayashi S

更新日期：1999-12-01 00:00:00

abstract：:When ginsenoside R(c) was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside R(c) to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidoba...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Choo MK,Park EK,Park SY,Shin HY,Kim DH

更新日期：2002-06-01 00:00:00

abstract：:We previously screened the anti-itching activities of 33 herbal medicines in substance P (SP)-induced itching model mice. One of the most potent antipruritogenic extracts, the methanol extract of fruits of Cnidium monnieri (Cnidii Fructus) was studied further. The chloroform-soluble fraction of the methanol extract ma...

journal_title：Biological & pharmaceutical bulletin

authors： Basnet P,Yasuda I,Kumagai N,Tohda C,Nojima H,Kuraishi Y,Komatsu K

更新日期：2001-09-01 00:00:00

abstract：:Recent reports have shown that dimethyl fumarate (DMF) prevents brain damage induced by intracerebral hemorrhage and this beneficial effect is mediated by the nuclear erythroid 2 p45-related factor-2-antioxidant response element (Nrf2-ARE) pathway. However, the downstream mechanism underlying the activation of the Nrf...

journal_title：Biological & pharmaceutical bulletin

authors： Kume T,Suenaga A,Izumi Y,Akaike A

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the influence of caffeine and theophylline on the development of dental caries in rats. Six Wistar dams (spf), mutans streptococci free, were obtained, each with six male pups. The dams were infected by Streptococcus sobrinus 6715 and divided into three groups which received d...

journal_title：Biological & pharmaceutical bulletin

authors： Ruenis AP,Rosalen PL,Volpato MC,Groppo FC

更新日期：2000-03-01 00:00:00

abstract：:Nitric oxide (NO) and the partial pressure of oxygen (pO(2)) in the liver were simultaneously quantified in rats with partial hepatic ischemia/reperfusion injury (PHIRI). Real-time NO/pO(2) monitoring and immunohistochemical analysis for superoxide dismutase and inducible nitric oxide synthase (iNOS) and endothelial N...

journal_title：Biological & pharmaceutical bulletin

authors： Hataji K,Watanabe T,Oowada S,Nagaya M,Kamibayashi M,Murakami E,Kawakami H,Ishiuchi A,Kumai T,Nakano H,Kobayashi S,Otsubo T

更新日期：2010-01-01 00:00:00

abstract：:Monoclonal antibodies are widely used for the treatment of various diseases, and because therapeutic monoclonal antibodies are stored in an aqueous solution or in a lyophilized state, the preparation of a stabilizing formulation that prevents their deterioration (degradation and aggregation) is crucial. Given the stru...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa T,Ito T,Endo R,Nakagawa K,Sawa E,Wakamatsu K

更新日期：2010-01-01 00:00:00

abstract：:The adsorption characteristics of eight adsorbents, cholestyramine, colestimide, aluminum silicate, sucralfate, aluminum hydroxide, calcium polystyrene sulfonate, carbon sphere and medicinal carbon, on the drugs such as methotrexate, antidepressants, mizoribine and ciprofloxacin hydrochloride were investigated in vitr...

journal_title：Biological & pharmaceutical bulletin

authors： Toyoguchi T,Ebihara M,Ojima F,Hosoya J,Nakagawa Y

更新日期：2005-05-01 00:00:00

abstract：:Postprandial hypertriglyceridemia, as well as postprandial hyperglycemia, are important factors contributing to the development of cardiovascular disease in patients with type 2 diabetes. Nateglinide is a recently approved antidiabetic that suppresses postprandial hyperglycemia by stimulating the early phase of insuli...

journal_title：Biological & pharmaceutical bulletin

authors： Mine T,Miura K,Kitahara Y,Okano A,Kawamori R

更新日期：2002-11-01 00:00:00

abstract：:Behavioral and psychological symptoms of dementia (BPSD) are commonly seen in patients with Alzheimer's disease (AD) and other forms of senile dementia. BPSD have a serious impact on the quality of life of dementia patients, as well as on that of their caregivers. However, effective drug therapy for BPSD has not been ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida N,Egashira N,Iwasaki K,Ishibashi A,Tashiro R,Nogami A,Manome N,Abe M,Takasaki K,Mishima K,Takata J,Oishi R,Nishimura R,Fujiwara M

更新日期：2009-03-01 00:00:00

abstract：:Microvessels are composed of endothelial cells that cover the luminal surface and pericytes that wrap around and along endothelial cells. In the present study, we investigated the regulation of fibrinolysis in cultured human brain microvascular pericytes and endothelial cells after exposure to thrombin. It was found t...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto C,Sugato M,Fujiwara Y,Kaji T

更新日期：2005-02-01 00:00:00

abstract：:A previous study showed that macelignan extracted from Myristica fragrans has anti-inflammatory properties using hippocampal neuronal and primary microglial cells. Subsequently, a study using animals with chronic lipopolysaccharide (LPS) infusion into the brain showed that oral treatments of macelignan reduced the hip...

journal_title：Biological & pharmaceutical bulletin

authors： Ma J,Hwang YK,Cho WH,Han SH,Hwang JK,Han JS

更新日期：2009-06-01 00:00:00

abstract：:In vitro studies were conducted to identify human drug-metabolizing enzymes involved in the metabolism of SNI-2011 ((+/-)-cis-2-methylspiro [1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline hydrochloride hydrate). When 14C-SNI-2011 was incubated with human liver microsomes, SNI-2011 trans-s...

journal_title：Biological & pharmaceutical bulletin

authors： Washio T,Arisawa H,Kohsaka K,Yasuda H

更新日期：2001-11-01 00:00:00

abstract：:Pentosidine, a fluorescent cross-linking compound, accumulates in extracellular matrix, especially in the collagen, and is formed by the nonenzymatic process of advanced Maillard reaction. We developed a method of determination of pentosidine and tried to examine its level in urine and serum of elder patients. The met...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara K,Nakamura K,Kanai M,Nagayama Y,Takahashi S,Saito N,Nagata M

更新日期：1998-10-01 00:00:00

abstract：:Selective inhibitors of phosphodiesterases (PDEs) have been suggested to have anti-inflammatory effects on bronchial asthma through the inhibition of chemotaxis, adhesion, degranulation, the respiratory burst, and survival prolongation of eosinophils. However, the mechanisms by which these agents inhibit eosinophil su...

journal_title：Biological & pharmaceutical bulletin

authors： Wang W,Masu K,Tamura G,Suzuki K,Ohwada K,Okuyama K,Shirato K,Takayanagi M,Ohno I

更新日期：2005-03-01 00:00:00

abstract：:Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most ...

journal_title：Biological & pharmaceutical bulletin

authors： dos Santos MD,Almeida MC,Lopes NP,de Souza GE

更新日期：2006-11-01 00:00:00

abstract：:Collagen-induced arthritis (CIA) is an experimental model of rheumatoid arthritis (RA) used for studying the clinical, immunological and genetic factors of the disease. Many studies of genetic susceptibility to CIA have been performed, usually with two strains of mice, DBA/1 and B10.RIII, since they are highly suscept...

journal_title：Biological & pharmaceutical bulletin

authors： Hida S,Nagi-Miura N,Adachi Y,Ohno N

更新日期：2006-06-01 00:00:00

abstract：:The total alkaloid fractions of the methanolic extracts of the leaves, ripe fruits, roots, seeds and stem of Solanum pseudocapsicum were subjected to in-vitro cytotoxicity, short-term toxicity and long-term survival studies. All the five fractions exhibited potent activity. The total alkaloid fraction of leaves was fo...

journal_title：Biological & pharmaceutical bulletin

authors： Vijayan P,Vijayaraj P,Setty PH,Hariharpura RC,Godavarthi A,Badami S,Arumugam DS,Bhojraj S

更新日期：2004-04-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs), i.e. human embryonic stem cells and human induced pluripotent stem cells, are able to self-renew and differentiate into multiple cell types. Because of these abilities, numerous attempts have been made to utilize hPSCs in regenerative medicine/cell therapy. hPSCs are, however, als...

journal_title：Biological & pharmaceutical bulletin

authors： Kuroda T,Yasuda S,Sato Y

更新日期：2013-01-01 00:00:00

abstract：:In order to treat a hyperammonemic patient with adult-onset type-II citrullinemia (CTLN2), sodium phenylacetate powder was prepared from chemical reagent grade phenylacetic acid in Gunma University Hospital. After purification by recrystalization, phenylacetic acid was neutralized with sodium carbonate and dried at 70...

journal_title：Biological & pharmaceutical bulletin

authors： Honda S,Yamamoto K,Sekizuka M,Oshima Y,Nagai K,Hashimoto G,Kaneko H,Tomomasa T,Konno Y,Horiuchi R

更新日期：2002-09-01 00:00:00

abstract：:The current study reports several post-translational modifications of alphaB-crystallin in normal human lenses. The isoforms of post-translational modified alphaB-crystallin were isolated from the normal human lenses of >70-age group by ion exchange chromatography and sodium dodecyl sulfate-polyacrylamide gel electrop...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei A,Hamaguchi T,Matsuura N,Iwase H,Masuda K

更新日期：2000-02-01 00:00:00

abstract：:In this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, Leishmania major, Leishmania tropica and Leishmania infantum (Pakistani isolate). Curcumin has shown an average IC5...

journal_title：Biological & pharmaceutical bulletin

authors： Saleheen D,Ali SA,Ashfaq K,Siddiqui AA,Agha A,Yasinzai MM

更新日期：2002-03-01 00:00:00

abstract：:The tissue distribution and disposition of carnitine, which plays an important role in the transport of long-chain fatty acids across the mitochondrial inner membrane for beta-oxidation, are well controlled by carnitine transporter organic cation/carnitine transporter 2 (OCTN2). Since little information is available o...

journal_title：Biological & pharmaceutical bulletin

authors： Maeda T,Wakasawa T,Funabashi M,Fukushi A,Fujita M,Motojima K,Tamai I

更新日期：2008-06-01 00:00:00

abstract：:As one of the adverse effects of oxaliplatin, a key agent in colon cancer chemotherapy, a taste disorder is a severe issue in a clinical situation because it decreases the quality of life of patients. However, there is little information on the mechanism underlying the oxaliplatin-induced taste disorder. Here, we exam...

journal_title：Biological & pharmaceutical bulletin

authors： Ohishi A,Nishida K,Yamanaka Y,Miyata A,Ikukawa A,Yabu M,Miyamoto K,Bansho S,Nagasawa K

更新日期：2016-01-01 00:00:00

abstract：:We examined whether adherence of enterohemorrhagic Escherichia coli (EHEC) O157:H7 to intestinal epithelial cells contributed to the induction of secretory immunoglobulin A (IgA) antibody production in mice. Wild-type EHEC O157:H7 and its mutants deficient in the espA, sepL, tir and eae genes, encoding adherent factor...

journal_title：Biological & pharmaceutical bulletin

authors： Nagano K,Taguchi K,Tokoro S,Tatsuno I,Mori H

更新日期：2014-01-01 00:00:00

abstract：:The physiological correlation between casein kinase I (CK-I) and an isoform eta of protein kinase C (C-kinase eta) was investigated in vitro, since it has been reported that (i) cholesterol-3-sulfate (CH-3S) effectively activates C-kinase eta rather than the other isoforms (C-kinase epsilon and C-kinase delta) in vitr...

journal_title：Biological & pharmaceutical bulletin

authors： Okano M,Yokoyama T,Miyanaga T,Ohtsuki K

更新日期：2004-01-01 00:00:00

abstract：:The in vivo metabolism of 1-nitropyrene, an important environmental pollutant, was examined in fish, focusing on nitroreduction followed by acylation. When goldfish were bathed in a solution of 1-nitropyrene or its reduction product, 1-aminopyrene, one or two metabolites were isolated from the solution, respectively. ...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura S,Tatsumi K

更新日期：1996-11-01 00:00:00

abstract：:The recent emergence of multidrug-resistant pathogens and/or pharmacokinetics-pharmacodynamics considerations may result in off-label use of a certain class of antibacterials, including tigecycline. This study was performed to clarify the safety profile of tigecycline in the user-derived manner and to compare it with ...

journal_title：Biological & pharmaceutical bulletin

authors： Kadoyama K,Sakaeda T,Tamon A,Okuno Y

更新日期：2012-01-01 00:00:00