Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR.

abstract：:Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited m...

journal_title：Biological & pharmaceutical bulletin

authors： Oh KB,Mar W,Kim S,Kim JY,Lee TH,Kim JG,Shin D,Sim CJ,Shin J

更新日期：2006-03-01 00:00:00

abstract：:A series of 8-substituted quinolines were synthesized and tested against seizures induced by maximal electro shock (MES), pentylenetetrazole (scMet) and antihypertensive activities. Neurologic deficit was evaluated by the rotarod test. Among the newly synthesized derivatives, several compounds with a 2-hydroxypropylox...

journal_title：Biological & pharmaceutical bulletin

authors： Muruganantham N,Sivakumar R,Anbalagan N,Gunasekaran V,Leonard JT

更新日期：2004-10-01 00:00:00

abstract：:Pairs of forward and reverse primers and TaqMan probes specific to each of 15 human sulfotransferases were prepared. The mRNA expression level of each target enzyme was analyzed in total RNA from single and pooled specimens of various human tissues (adrenal gland, bone marrow, brain, colon, heart, kidney, liver, lung,...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Naito S

更新日期：2007-04-01 00:00:00

abstract：:3',4'-Diisovalerylkhellactone diester (PJ-1) is a coumarin derivative purified from the medicinal herb Peucedanum japonicum Thunb. We examined its in vitro effects on various aspects of platelet reactivity. PJ-1 inhibited the aggregation and ATP release of rabbit platelets induced by PAF (platelet-activating factor) a...

journal_title：Biological & pharmaceutical bulletin

authors： Hsiao G,Ko FN,Jong TT,Teng CM

更新日期：1998-07-01 00:00:00

abstract：:Most of the fatigue in everyday life is a combination of physical and mental fatigue. Recently, an animal model of combined fatigue was designed by housing rats in a cage filled with water. We have previously hypothesized that mental fatigue is caused partly by neuronal brain damage through the activation of N-methyl-...

journal_title：Biological & pharmaceutical bulletin

authors： Morimoto Y,Zhang Q,Adachi K

更新日期：2012-01-01 00:00:00

abstract：:Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K+ (KV) channel blockers on the resting tension in endothelium-...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiwara K,Ohya S,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2017-01-01 00:00:00

abstract：:Purslane (Portulaca oleracea L.) is popular as a potherb in many areas of Europe, Asia, and the Mediterranean region and is widely distributed around the globe. It has a wide range of pharmacological effects, such as antibacterial, anti-aging, anti-inflammatory, and anti-oxidative properties. Although the extract of p...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JY,Oh HM,Kwak SC,Cheon YH,Lee MS,Rho MC,Oh J

更新日期：2015-01-01 00:00:00

abstract：:Nitrogen oxide, which is produced by activated macrophages, has been demonstrated to possess anti-tumor activity. We report herein the synergistic effect of sodium nitrite (NO2-) and/or sodium nitroprusside (SNP) on lysophospholipid (LysoPL)-mediated cytolysis. The incubation of 51Cr-labeled mouse melanoma (B16) cells...

journal_title：Biological & pharmaceutical bulletin

authors： Kanematsu M,Takagi K,Suketa Y

更新日期：1994-01-01 00:00:00

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:Novel methods for molecular authentication of Atractylodes-derived crude drugs (Jutsu) were established based on PCR-restriction fragment length polymorphism (RFLP) and direct sequencing of chloroplast trnK. Two regions inside the chloroplast trnK were selected as molecular markers for identification and discriminatio...

journal_title：Biological & pharmaceutical bulletin

authors： Mizukami H,Okabe Y,Kohda H,Hiraoka N

更新日期：2000-05-01 00:00:00

abstract：:Allergic rhinitis (AR) caused by house dust mite (HDM) and Japanese cedar pollen (JCP) represents a significant, expanding health problem in Japan. Allergic symptoms often have a severe impact on the QOL such as sleep disturbance and reduced school and work performance. In addition to the classical symptoms, AR is kno...

journal_title：Biological & pharmaceutical bulletin

authors： Ohashi-Doi K,Lund K,Mitobe Y,Okamiya K

更新日期：2020-01-01 00:00:00

abstract：:Using the par to rep region of the 24653 bp plasmid pN315, which is present in Staphylococcus aureus strain N315, we constructed three vectors that can be shuttled between Escherichia coli and S. aureus and maintained stably in S. aureus. Due to plasmid incompatibility, the resident plasmid in S. aureus cells can be r...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo M,Kurokawa K,Lee BL,Sekimizu K

更新日期：2010-01-01 00:00:00

abstract：:Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) trigger...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CS,Won C,Yoo H,Yi EH,Cho Y,Maeng JW,Sung SH,Ye SK,Chung MH

更新日期：2009-11-01 00:00:00

abstract：:We investigated acute cytotoxic effects and Hg accumulation after exposure to methylmercury (MeHg) or Hg(2+) in the presence or absence of serum in cultured astrocytes prepared from the cerebral hemisphere or cerebellum of newborn rats. Dose-related changes in viable cell numbers after exposure to mercuric compounds w...

journal_title：Biological & pharmaceutical bulletin

authors： Adachi T,Kunimoto M

更新日期：2005-12-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Recent studies indicated that the members of the Rab GTPase family, Rab8...

journal_title：Biological & pharmaceutical bulletin

authors： Imai M,Kawakami F,Kubo M,Kanzaki M,Maruyama H,Kawashima R,Maekawa T,Kurosaki Y,Kojima F,Ichikawa T

更新日期：2020-01-01 00:00:00

abstract：:Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been ...

journal_title：Biological & pharmaceutical bulletin

authors： O'Leary R,Rerek M,Wood EJ

更新日期：2004-02-01 00:00:00

abstract：:Diosgenyl saponins are the most abundant steroid saponins, and exert a large variety of biological functions. In a previous report, we showed that dioscin was able to induce cytotoxicity and apoptosis in human myeloblast leukemia HL-60 cells. This study further investigated the action mechanisms underlying this effect...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MJ,Wang Z,Ju Y,Zhou JB,Wang Y,Wong RN

更新日期：2004-07-01 00:00:00

abstract：:Albumin extracted from serum by a simple technique using trichloroacetic acid and ethanol has been applied to a fructosamine assay using nitroblue tetrazolium. A fructosamine assay using extracted albumin sample was carried out without interference from low molecular weight substances with reducing activities and othe...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkawara E,Nohara Y,Kanno Y,Suzuki H,Matsumoto G,Kinoshita T,Watanabe M

更新日期：2002-09-01 00:00:00

abstract：:We determined the effects of psychotropic drugs on the cytochrome P450 2D (CYP2D)-mediated 21-hydroxylation of progesterone (PROG) and allopregnanolone (ALLO) with the goal of clarifying whether neurosteroid levels are affected by psychotropic drugs in the brain. PROG or ALLO was incubated with rat CYP2D4 or human CYP...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa T,Okada K,Hiroi T,Imaoka S,Narimatsu S,Funae Y

更新日期：2008-03-01 00:00:00

abstract：:The discovery that angiogenesis is a key condition for the growth of a tumor beyond a millimeter or two, brings about a new approach in the treatment of tumors using drugs able to inhibit the formation of new blood vessels. Also, it has been realized that antiangiogenic drugs can be useful in the treatment of other pa...

journal_title：Biological & pharmaceutical bulletin

authors： González RP,Leyva A,Moraes MO

更新日期：2001-10-01 00:00:00

abstract：:The inhibitory effects of five angiotensin-converting enzyme (ACE) inhibitors on the uptake of an aminocephalosporin antibiotic, cefroxadine, by rabbit small intestinal brush-border membrane vesicles were examined in the presence of an inward H+ gradient. Dixon plot analysis showed that all these ACE inhibitors inhibi...

journal_title：Biological & pharmaceutical bulletin

authors： Kitagawa S,Takeda J,Sato S

更新日期：1999-07-01 00:00:00

abstract：:Acute pancreatitis (AP) is one kind of acute surgical abdominal disease in the world. It causes intestinal damage with subsequent bacterial migration, endotoxemia and secondary pancreatic infections. In this investigation, we determined that edaravone (EDA) reduces pancreatic and intestinal injury after AP in mice. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Wang B,Lin W

更新日期：2020-01-01 00:00:00

abstract：:Lectin-like receptors natural killer group 2D (NKG2D) and CD94 on natural killer (NK) cells bind to α2,3-NeuAc-containing N-glycans and heparin/heparan sulfate (HS). Using recombinant glutathione S-transferase-fused extracellular lectin-like domains of NKG2D (rGST-NKG2Dlec) and CD94 (rGST-CD94lec), we evaluated their ...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Suzuki C,Imaizumi Y,Xin X,Azuma Y,Matsumoto K

更新日期：2011-01-01 00:00:00

abstract：:A homology-based cloning strategy yielded Sdga, a cDNA clone presumably encoding alpha-subunit of heterotrimeric guanosine 5'-triphosphate-binding protein complex, from leaf tissues of Scoparia dulcis. Phylogenetic tree analysis of G-protein alpha-subunits from various biological sources suggested that, unlike in anim...

journal_title：Biological & pharmaceutical bulletin

authors： Shite M,Yamamura Y,Hayashi T,Kurosaki F

更新日期：2008-11-01 00:00:00

abstract：:Schwann cell injury is observed in diabetic neuropathy. It is speculated that glycolaldehyde (GA), a precursor of advanced glycation end products (AGEs), contributes to the pathogenesis and development of diabetic neuropathy. Here, we demonstrated for the first time that GA at near-physiological concentration decrease...

journal_title：Biological & pharmaceutical bulletin

authors： Sato K,Tatsunami R,Yama K,Tampo Y

更新日期：2013-01-01 00:00:00

abstract：:The oligopeptide transporter PEPT1 (SLC15A1) is responsible for absorption of peptidic nutrients in the small intestine. Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transp...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuoka K,Tamai I,Morohashi Y,Kubo Y,Saitoh R,Tsuji A,Kato Y

更新日期：2009-08-01 00:00:00

abstract：:To improve bioavailability of pueraria flavones (PF), a self-microemulsifying drug delivery system (SMEDDS) dropping pills composed of PF, Crodamol GTCC, Maisine 35-1, Cremophor RH 40, 1,2-propylene glycol and polyethylene glycol 6000 (PEG6000) was developed. Particle size, zeta potential, morphology and in vitro drug...

journal_title：Biological & pharmaceutical bulletin

authors： Guan Q,Zhang G,Sun S,Fan H,Sun C,Zhang S

更新日期：2016-05-01 00:00:00

abstract：:Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administrat...

journal_title：Biological & pharmaceutical bulletin

authors： Zuo F,Zhou ZM,Zhang Q,Mao D,Xiong YL,Wang YL,Yan MZ,Liu ML

更新日期：2003-07-01 00:00:00

abstract：:Darexaban maleate is a novel oral direct factor Xa inhibitor. Darexaban glucuronide (YM-222714) was the major component in plasma after oral administration of darexaban to humans and is the pharmacologically active metabolite. Additionally, YM-222714 N-oxides were detected as minor metabolites in human plasma and urin...

journal_title：Biological & pharmaceutical bulletin

authors： Shiraga T,Yajima K,Teragaki T,Suzuki K,Hashimoto T,Iwatsubo T,Miyashita A,Usui T

更新日期：2012-01-01 00:00:00

abstract：:For analyzing the concentrations of drugs in hairs, a new method of digestion of hairs with Biopurase, a protease obtained from Bacillus subtilis, was examined. The concentrations of drugs in hairs were then determined in order to examine the usefulness of the protease for the digestion of hairs. The stability of five...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii J,Higashi A,Nakano M

更新日期：1996-12-01 00:00:00