Abstract:
:Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited more potent antibacterial activity than those of the topsentin class. Deoxytopsentin (1) and hamacanthin A (5) also exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus, with MIC values of less than 12.5 microg/ml. In the antifungal activity test, hamacanthins, especially hamacanthin A (5), showed potent inhibitory activity against medically important pathogenic fungi. In contrast, all of the topsentins (1-4) were inactive against fungal growth. These compounds (1-9) also exhibited moderate cytotoxicity against cancer cell lines at concentrations between 1.1 and >20 microg/ml.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Oh KB,Mar W,Kim S,Kim JY,Lee TH,Kim JG,Shin D,Sim CJ,Shin Jdoi
10.1248/bpb.29.570subject
Has Abstractpub_date
2006-03-01 00:00:00pages
570-3issue
3eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/29.570journal_volume
29pub_type
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