Synthesis, anticonvulsant and antihypertensive activities of 8-substituted quinoline derivatives.

abstract：:The potential hair growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase...

journal_title：Biological & pharmaceutical bulletin

authors： Choi JS,Jeon MH,Moon WS,Moon JN,Cheon EJ,Kim JW,Jung SK,Ji YH,Son SW,Kim MR

更新日期：2014-01-01 00:00:00

abstract：:ICR/f mutation in rat, an inherited disorder, is characterized by the development of cataracts. In this study, we analyzed and compared the crystallins in normal and cataractous rat lenses using gel filtration and two-dimensional gel electrophoresis, and determined the transglutaminase activities and Ca2+ content in t...

journal_title：Biological & pharmaceutical bulletin

authors： Takeuchi N,Kamei A

更新日期：2000-03-01 00:00:00

abstract：:The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topo...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada M,Hayashi K,Ikeda S,Tsutsui K,Tsutsui K,Ito T,Iinuma M,Nozaki H

更新日期：2006-07-01 00:00:00

abstract：:Nitric oxide (NO) and the partial pressure of oxygen (pO(2)) in the liver were simultaneously quantified in rats with partial hepatic ischemia/reperfusion injury (PHIRI). Real-time NO/pO(2) monitoring and immunohistochemical analysis for superoxide dismutase and inducible nitric oxide synthase (iNOS) and endothelial N...

journal_title：Biological & pharmaceutical bulletin

authors： Hataji K,Watanabe T,Oowada S,Nagaya M,Kamibayashi M,Murakami E,Kawakami H,Ishiuchi A,Kumai T,Nakano H,Kobayashi S,Otsubo T

更新日期：2010-01-01 00:00:00

abstract：:A protocol for de novo regeneration and rapid micropropagation of Scrophularia yoshimurae (Scrophulariaceae) has been developed. Multiple shoot development was achieved by culturing the shoot-tip, leaf-base, stem-node and stem-internode explants on Murashige and Skoog (MS) medium supplemented with 4.44 microM N6-benzy...

journal_title：Biological & pharmaceutical bulletin

authors： Sagare AP,Kuo CL,Chueh FS,Tsay HS

更新日期：2001-11-01 00:00:00

abstract：:The protective effect of panduratin A, isolated from Kaempferia pandurata ROXB. (Zingiberaceae), against tert-butylhydroperoxide (t-BHP)-induced cytotoxicity was investigated in a human hepatoma cell line, HepG2. The tetrazolium dye colorimetric test (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) ...

journal_title：Biological & pharmaceutical bulletin

authors： Sohn JH,Han KL,Lee SH,Hwang JK

更新日期：2005-06-01 00:00:00

abstract：:Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been ...

journal_title：Biological & pharmaceutical bulletin

authors： O'Leary R,Rerek M,Wood EJ

更新日期：2004-02-01 00:00:00

abstract：:Sixteen flavonoids including flavonols, flavones, flavanonol and catechins, and five aromatic compounds were examined for their ability to scavenge superoxide radical (O2-*) generated enzymatically in a xanthin-xanthinoxidase system and non-enzymatically in a phenazine methosulfate-NADH system. Pyrogallol, gallic acid...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno K,Akasako T,Sugihara N

更新日期：2002-01-01 00:00:00

abstract：:We previously reported that the topical application of ascorbic acid 2-O-alpha-glucoside (AA-2G) suppressed the cutaneous inflammation by ultraviolet irradiation in human and guinea pigs (Miyai et al., Nishinihon J. Dermatol., 58, 439-443 (1996)). In this paper, the effect of AA-2G on the lethal damage induced by ultr...

journal_title：Biological & pharmaceutical bulletin

authors： Miyai E,Yanagida M,Akiyama J,Yamamoto I

更新日期：1997-06-01 00:00:00

abstract：:Syncytiotrophoblasts play an essential role in restriction of drug delivery through the blood-placenta barrier (BPB). Conditionally immortalized syncytiotrophoblast cell lines, TR-TBTs, were established at gestational day 18 from pregnant transgenic rats (Tg-rats) harboring the temperature-sensitive SV 40 (ts SV40) la...

journal_title：Biological & pharmaceutical bulletin

authors： Kitano T,Iizasa H,Hwang IW,Hirose Y,Morita T,Maeda T,Nakashima E

更新日期：2004-06-01 00:00:00

abstract：:Cerebral ischemia causes the depletion of oxygen and nutrition from brain tissues, and when persistent, results in irreversible damage to the cell function and survival. The cellular response to ischemic conditions and its mechanisms have been investigated widely in in vivo and in vitro experimental models, yet no stu...

journal_title：Biological & pharmaceutical bulletin

authors： Ujita S,Mizunuma M,Matsuki N,Ikegaya Y

更新日期：2011-01-01 00:00:00

abstract：:Five rabbit aldo-keto reductases (AKRs) that participate in the reduction of drug ketones and endogenous ketosteroids have recently been cloned and characterized. Among them, AKR1C30 and AKR1C31 show the highest amino acid sequence identity of 91%, but markedly differ in their substrate specificity and inhibitor sensi...

journal_title：Biological & pharmaceutical bulletin

authors： Endo S,Arai Y,Matsunaga T,Ikari A,El-Kabbani O,Hara A,Kitade Y

更新日期：2014-01-01 00:00:00

abstract：:Protein purification is a key technique for the identification of novel sensory nerve-specific proteins. A 35 kDa protein, the sensory neuronal specific protein, was isolated and purified from rabbit spinal ganglia and sensory fibers by homogenizing and deriving soluble extracts, followed by ion exchange chromatograph...

journal_title：Biological & pharmaceutical bulletin

authors： Ping XP,Wang JZ

更新日期：2000-05-01 00:00:00

abstract：:The hepatoprotecive effects of recombinant human epidermal growth factor (hEGF) on chemically and immunologically induced experimental liver injury models were examined. The hEGF clearly decreased serum transaminase levels in D-galactosamine (D-GalN) and D-GalN/lipopolysaccharide (LPS)-induced liver injury models unde...

journal_title：Biological & pharmaceutical bulletin

authors： Cho JY,Yeon JD,Kim JY,Yoo ES,Yu YH,Park MH

更新日期：2000-10-01 00:00:00

abstract：:There exist limitations in the detection of exogenous oligosaccharides due to their polydisperse and diversiform nature, and particularly the interference of endogenous glycosaminoglycans (GAGs). Herein, a surface plasmon resonance (SPR) assay for detecting acidic oligosaccharide sugar chain (AOSC), an anti-Alzheimer'...

journal_title：Biological & pharmaceutical bulletin

authors： Guo X,Xin X,Gan L,Nie Q,Geng M

更新日期：2006-01-01 00:00:00

abstract：:Madecassoside (MA), one of the principle terpenoids in Centella asiatica, has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. The aim of this study is to investigate if MA also protected against myocardial ischemia-reperfusion injury in vivo. ...

journal_title：Biological & pharmaceutical bulletin

authors： Bian GX,Li GG,Yang Y,Liu RT,Ren JP,Wen LQ,Guo SM,Lu QJ

更新日期：2008-03-01 00:00:00

abstract：:Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitte...

journal_title：Biological & pharmaceutical bulletin

authors： Sato-Masumoto N,Uchikura T,Sugiwaki H,Yoshimura M,Masada S,Atsumi T,Watanabe M,Tanaka N,Uchiyama N,Amakura Y,Hakamatsuka T

更新日期：2017-01-01 00:00:00

abstract：:The physiological correlation between casein kinase I (CK-I) and an isoform eta of protein kinase C (C-kinase eta) was investigated in vitro, since it has been reported that (i) cholesterol-3-sulfate (CH-3S) effectively activates C-kinase eta rather than the other isoforms (C-kinase epsilon and C-kinase delta) in vitr...

journal_title：Biological & pharmaceutical bulletin

authors： Okano M,Yokoyama T,Miyanaga T,Ohtsuki K

更新日期：2004-01-01 00:00:00

abstract：:To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL, grape seed oil, and other excipients. The HUMC showed plastic flow behavior due to a gel structure with a cream base. ...

journal_title：Biological & pharmaceutical bulletin

authors： Lee SG,Kim SR,Cho HI,Kang MH,Yeom DW,Lee SH,Lee S,Choi YW

更新日期：2014-01-01 00:00:00

abstract：:Methylripariochromene A (MRC) was isolated from the leaves of Orthosiphon aristatus (Lamiaceae) and subjected to the examination of several pharmacological actions related to antihypertensive activity. The following four findings were revealed from the present study: 1) MRC caused a continuous decrease in systolic blo...

journal_title：Biological & pharmaceutical bulletin

authors： Matsubara T,Bohgaki T,Watarai M,Suzuki H,Ohashi K,Shibuya H

更新日期：1999-10-01 00:00:00

abstract：:The skeletal renin–angiotensin system (RAS) is involved in the progression of osteoporosis and the active peptide within the RAS, angiotensin II (ANG II), has deleterious effects on bones. This study was performed to investigate whether suppression of the rate-limiting step of the RAS cascade by the renin inhibitor al...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang FY,Yang FJ,Yang JL,Wang L,Zhang Y

更新日期：2014-01-01 00:00:00

abstract：:Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of diastereoisomers after incubation of paeoniflorin with Lactobacillus brevis in the presence of various thiols. The anticonvulsant activity of the adducts was investigated in mice using the maximal subcutaneous pentylenetetrazol seizure test and sodiu...

journal_title：Biological & pharmaceutical bulletin

authors： Abdel-Hafez AA,Meselhy MR,Nakamura N,Hattori M,Watanabe H,Murakami Y,El-Gendy MA,Mahfouz NM,Mohamed TA

更新日期：1999-05-01 00:00:00

abstract：:Methylmercury (MeHg) is a causative agent of Minamata disease and an environmental pollutant that comprises a large portion of organically occurring mercury. Many aspects of the biological defense mechanisms against MeHg toxicity remain unclear. Recently, nuclear factor-E2-related factor 2 (Nrf2), heat shock factor pr...

journal_title：Biological & pharmaceutical bulletin

authors： Hwang GW

更新日期：2012-01-01 00:00:00

abstract：:Changes in carbonyl reductase (CR) activity towards seven substrates in adrenal glands of female rats were investigated during estrous cycle and the circadian patterns of adrenal CR activity towards seven substrates in male rats were examined. The localization of the enzyme protein in the adrenal gland was carried out...

journal_title：Biological & pharmaceutical bulletin

authors： Inazu N,Nagashima Y,Satoh T

更新日期：1995-05-01 00:00:00

abstract：:Pantethine and fursultiamine have been evaluated for their clinical usefulness in the treatment and prevention of uncomplicated postoperative adhesive intestinal obstruction. In recent years, the actions of drugs used to treat gastrointestinal diseases have been elucidated pharmacologically from the viewpoints of gast...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Itoh H,Abe T,Nishimura F,Sato Y,Takeyama M

更新日期：2011-01-01 00:00:00

abstract：:We investigated the genotypic status of thiopurine methyltransferase (TPMT) polymorphism to evaluate the possible risk of the toxicity of azathioprine (AZA) in 68 patients with systemic lupus erythematosus (SLE). The allele frequency of TPMT mutation in the SLE group (2.9%) was higher than that in 174 Japanese healthy...

journal_title：Biological & pharmaceutical bulletin

authors： Okada Y,Nakamura K,Kodama T,Ueki K,Tsukada Y,Maezawa A,Tsukamoto N,Nojima Y,Ishizaki T,Horiuchi R,Yamamoto K

更新日期：2005-11-01 00:00:00

abstract：:We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased....

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto T,Watanabe S,Iguchi M,Ando M,Oda M,Nagata M,Yamada K,Taguchi K,Kobayashi T

更新日期：2016-01-01 00:00:00

abstract：:Glycosylation is a highly sophisticated post-translational modification of proteins that occurs in the endoplasmic reticulum (ER) and the Golgi apparatus. The vital biological functions served by protein glycosylation can be separated into two types. The first is the role of glycosylation in the extracellular environm...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto K

更新日期：2009-05-01 00:00:00

abstract：:The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 m...

journal_title：Biological & pharmaceutical bulletin

authors： Mantena SK,Mutalik S,Srinivasa H,Subramanian GS,Prabhakar KR,Reddy KR,Srinivasan KK,Unnikrishnan MK

更新日期：2005-03-01 00:00:00

abstract：:The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sano K,Koushi E,Irie K,Higuchi S,Tsuchihashi R,Kinjo J,Egashira N,Oishi R,Uchida N,Nagai H,Nishimura R,Tanaka H,Morimoto S,Mishima K,Iwasaki K,Fujiwara M

更新日期：2009-12-01 00:00:00