Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of the blood-placenta barrier.

abstract：:Consuming food at uncommon times during the day might be associated with obesity in experimental animals and humans. We previously reported that mice become obese and their metabolism becomes disrupted when they consume food during the daytime (sleep phase feeding; SPF), but not during the nighttime (active phase feed...

journal_title：Biological & pharmaceutical bulletin

authors： Oishi K,Okauchi H

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this research is improvement of therapeutic treatment for periodontitis by using lipophilic and/or hydrophilic zinc materials. The sample suspension injections were prepared from zinc octanate (C8Zn), zinc stearate (C18Zn), zinc sulfate hepta-hydrate (ZnSO4) and tricalcium phosphate (ZnTCP) containing 6...

journal_title：Biological & pharmaceutical bulletin

authors： Tokudome Y,Otsuka M

更新日期：2012-01-01 00:00:00

abstract：:Uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) plays important roles in the glucuronidation of various drugs and endogenous substances. Minipigs have been used as experimental animals in pharmacological and toxicological studies, because many of their physiological characteristics are similar to those ...

journal_title：Biological & pharmaceutical bulletin

authors： Miyake Y,Mayumi K,Jinno H,Tanaka-Kagawa T,Narimatsu S,Hanioka N

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present study was to determine the effect of sulfaphenazole (SP) on the pharmacokinetics of ampiroxicam (AM) which is metabolized by cytochrome P-450 (CYP) 2C9, since SP is a potent inhibitor of CYP 2C9, and so a dramatic pharmacokinetic drug interaction between both drugs is assumed after dosing. Singl...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiso T,Iwaki M,Tanaka H,Kobayashi E,Tanino T,Sawada A,Uno S

更新日期：1999-02-01 00:00:00

abstract：:Nitro reduction is a critical step in the mutagenic activation of nitroarene. Nitroarene and quinone are known to be reduced by common enzymes, and thus, naphthoquinone (NQ) was studied for its effects on the mutagenicity of nitroarene in the Ames test using Salmonella typhimurium TA98 without S9. The mutagenicity of ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohmori K,Kishi M,Nakaoka T,Miyata N

更新日期：1999-01-01 00:00:00

abstract：:The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species ha...

journal_title：Biological & pharmaceutical bulletin

authors： Namekata I,Tsuneoka Y,Tanaka H

更新日期：2013-01-01 00:00:00

abstract：:(1-->3)-beta-D-Glucans exhibit a variety of biological and immunopharmacological activities, and the degree of these activities depends on the nature of the individual glucans e.q. molecular weight, degree of branching and conformation. Based on the generally accepted evidence that the conformation of Sonifilan (SPG) ...

journal_title：Biological & pharmaceutical bulletin

authors： Miura NN,Ohno N,Adachi Y,Aketagawa J,Tamura H,Tanaka S,Yadomae T

更新日期：1995-01-01 00:00:00

abstract：:A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was esta...

journal_title：Biological & pharmaceutical bulletin

authors： Thuong PT,Min BS,Jin W,Na M,Lee J,Seong R,Lee YM,Song K,Seong Y,Lee HK,Bae K,Kang SS

更新日期：2006-04-01 00:00:00

abstract：:Cry j 1 is one of the major allergens in Japanese cedar pollen. We attempt high throughput analysis and comprehensive identification of the linear IgE epitopes of Cry j 1. A series of overlapping synthetic Cry j 1 peptides chemically spotted on cellulose membrane was probed with sera from patients in Japan and United ...

journal_title：Biological & pharmaceutical bulletin

authors： Takagi K,Teshima R,Sawada J

更新日期：2005-08-01 00:00:00

abstract：:Lutein is a carotenoid and it has antioxidant effects. Lutein may have a protective effect on ischemia reperfusion (I/R) injury induced by free radical species. However, little is known about the protective effect of lutein on I/R injury in vivo. The present study was undertaken to clarify the protective effects of lu...

journal_title：Biological & pharmaceutical bulletin

authors： Ogura W,Itagaki S,Kurokawa T,Noda T,Hirano T,Mizuno S,Iseki K

更新日期：2006-08-01 00:00:00

abstract：:Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

journal_title：Biological & pharmaceutical bulletin

authors： Ariga H

更新日期：2015-01-01 00:00:00

abstract：:The role of leukotriene B4 (LTB4) in leukocyte infiltration in zymosan-induced rat pleurisy was investigated by studying the effects of 5-lipoxygenase inhibitors, T-0757 and AA-861, and a cyclooxygenase inhibitor, indomethacin, on leukocyte infiltration and LTB4 levels in the inflammatory exudate of rat pleurisy induc...

journal_title：Biological & pharmaceutical bulletin

authors： Kikuchi M,Tsuzurahara K,Naito K

更新日期：1995-09-01 00:00:00

abstract：:Ceramide kinase (CerK) and ceramide-1-phosphate (C1P) are involved in various cellular functions, while regulation of the enzyme activity has not been well elucidated. We herein investigated the effects of several glycerophospholipids on human recombinant CerK activity with CaCl2 and MgCl2 by measuring the formation o...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuzaki W,Takahashi H,Nakamura H,Murayama T

更新日期：2016-01-01 00:00:00

abstract：:We performed experiments on the cis-inhibition and trans-stimulation effect on pirarubicin uptake in order to clarify the involvement of a carrier in the pirarubicin, daunorubicin and/or doxorubicin transport systems in rat polymorphonuclear leukocytes. The uptake of daunorubicin and doxorubicin was a saturable concen...

journal_title：Biological & pharmaceutical bulletin

authors： Nagasawa K,Nomiyama M,Ohnishi N,Yokoyama T,Iwakawa S,Okumura K

更新日期：1994-09-01 00:00:00

abstract：:We investigated the possible protective effects of benidipine (Coniel), a calcium antagonist, on mechanical dysfunction, metabolic damage and changes in vascular reactivity during ischemia and reperfusion in the Langendorff-perfused rat heart. The responses of perfusion pressure to U-46619, a vasoconstrictor, and acet...

journal_title：Biological & pharmaceutical bulletin

authors： Yao K,Karasawa A

更新日期：1994-04-01 00:00:00

abstract：:The permeability of insulin across Xenopus pulmonary membrane and the effects of various absorption enhancers on insulin permeability were examined using an in vitro Ussing chamber technique. Absorption enhancers used in this study were sodium caprate (NaCap), sodium glycocholate (NaGC), sodium salicylate (NaSal) and ...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto A,Tanaka H,Okumura S,Shinsako K,Ito M,Yamashita M,Okada N,Fujita T,Muranishi S

更新日期：2001-04-01 00:00:00

abstract：:We developed a novel fluorometric assay method for the measurement of glycosyltransferase activities using mono- and di-saccharides aminated and tagged with 7-hydroxycoumarin-3-carboxylic acid (coumarin) as substrates, N-acetylglucosamine (GlcNAc)-coumarin for beta1,4-galactosyltransferase from bovine milk and Gal bet...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Masuda D,Matsuzawa Y,Satoh T,Matsumoto K

更新日期：1999-04-01 00:00:00

abstract：:A simple and efficient method for the separation of phosphatidylinositol 4-phosphate (PI 4-P) from phosphatidylinositol (PI) and phosphatidylserine (PS) is described. A mixture of PI, PI 4-P and PS was injected onto a Sep-Pak C18 cartridge. PI and PS were flushed through the cartridge with solvent 1 [methanol-chlorofo...

journal_title：Biological & pharmaceutical bulletin

authors： Morisaki N,Masaoka M,Shirai R,Hashimoto Y

更新日期：2000-09-01 00:00:00

abstract：:The present study was designed to investigate the modulatory effects of rottlerin on ischemia reperfusion induced myocardial injury. Isolated rat hearts were exposed to 30 min of global ischemia followed by 120 min of reperfusion using Langendorff apparatus. Myocardial injury was assessed in the terms of infarct size,...

journal_title：Biological & pharmaceutical bulletin

authors： Kaur K,Singh M,Singh N,Jaggi AS

更新日期：2008-09-01 00:00:00

abstract：:Plasma hyaluronan binding protein (PHBP) is produced only in liver and kidney in mouse. The induction of PHBP mRNA and the conversion of pro PHBP to the active hetero-dimer form were studied after CCl4, D-galactosamine, HgCl2 or turpentine administration and after partial hepatectomy. The results indicated that the ad...

journal_title：Biological & pharmaceutical bulletin

authors： Choi-Miura NH,Otsuyama K,Sano Y,Saito K,Takahashi K,Tomita M

更新日期：2001-08-01 00:00:00

abstract：:Transdermal nicotine patch (TNP) contains approximately 16.6 and 24.9 mg of nicotine per 20 and 30 cm2 (TNP-20 and TNP-30). The aims of the study are to investigate linearity of nicotine pharmacokinetics after single application of different strengths of TNP and to directly compare plasma nicotine concentrations with ...

journal_title：Biological & pharmaceutical bulletin

authors： Sobue S,Sekiguchi K,Kikkawa H,Akasaki M,Irie S

更新日期：2006-05-01 00:00:00

abstract：:The effects of 70% methanol extract (EA-ext) from Evodiae Fructus (EA) consisting of dried fruits of Evodia rutaecarpa var. bodinieri (Rutaceae) on nociceptive responses were investigated. Oral administration of 50 or 200 mg/kg EA-ext had the same antinociceptive effect on writhing responses as induced by acetic acid....

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda H,Wu JX,Tanaka T,Iinuma M,Kubo M

更新日期：1997-03-01 00:00:00

abstract：:Novel methods for molecular authentication of Atractylodes-derived crude drugs (Jutsu) were established based on PCR-restriction fragment length polymorphism (RFLP) and direct sequencing of chloroplast trnK. Two regions inside the chloroplast trnK were selected as molecular markers for identification and discriminatio...

journal_title：Biological & pharmaceutical bulletin

authors： Mizukami H,Okabe Y,Kohda H,Hiraoka N

更新日期：2000-05-01 00:00:00

abstract：:The uptake mechanism of aristolochic acid I (AAI) was investigated using Caco-2 cells cultured on dishes and permeable membranes. The uptake of AAI from the apical membrane of Caco-2 cells cultured on a dish was rapid, and a decrease in the pH of the incubation medium significantly increased uptake. Incubation at low ...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura O,Haraguchi K,Ohta C,Koga N,Kato Y,Endo T

更新日期：2014-01-01 00:00:00

abstract：:The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the part of both academic and pharmaceutical laboratories to develop highly specific inhibitors. In this study, inhibitory activity of previously synthesized arylaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Altuntas TG,Olgen S,Nebioglu D,Akaho E

更新日期：2004-01-01 00:00:00

abstract：:Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Ni Q,Wang Y,Fan H,Li Y

更新日期：2018-08-01 00:00:00

abstract：:Hinokitiol (beta-thujaplicin), beta-dolabrin and gamma-thujaplicin isolated from Thujopsis dolabrata SIEB. et ZUCC var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their minimu...

journal_title：Biological & pharmaceutical bulletin

authors： Inamori Y,Sakagami Y,Morita Y,Shibata M,Sugiura M,Kumeda Y,Okabe T,Tsujibo H,Ishida N

更新日期：2000-08-01 00:00:00

abstract：:In this study, the quantitative analysis of saikosaponins from Radix Bupleuri in China was performed by high performance liquid chromatography. Saikosaponin-a and -d were converted completely into saikosaponin-b1 and -b2 by mild acid treatment. Distinctive measuring of these converted diene-saponins provided a rapid a...

journal_title：Biological & pharmaceutical bulletin

authors： Li XQ,Gao QT,Chen XH,Bi KS

更新日期：2005-09-01 00:00:00

abstract：:We used three human urological cancer cell lines, PC-3, LNCaP and SKRC-1, to investigate the effects of the extract from Serenoa repens (Palmae) on tumor cell invasion. The invasion activity of these cell lines was determined in vitro using a Transwell cell-culture chamber. The invasion activity of PC-3 cells into Mat...

journal_title：Biological & pharmaceutical bulletin

authors： Ishii K,Usui S,Sugimura Y,Yamamoto H,Yoshikawa K,Hiran K

更新日期：2001-02-01 00:00:00

abstract：:Lectin-like receptors natural killer group 2D (NKG2D) and CD94 on natural killer (NK) cells bind to α2,3-NeuAc-containing N-glycans and heparin/heparan sulfate (HS). Using recombinant glutathione S-transferase-fused extracellular lectin-like domains of NKG2D (rGST-NKG2Dlec) and CD94 (rGST-CD94lec), we evaluated their ...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Suzuki C,Imaizumi Y,Xin X,Azuma Y,Matsumoto K

更新日期：2011-01-01 00:00:00