Determination of human linear IgE epitopes of Japanese cedar allergen Cry j 1.

abstract：:The permeability of murine leukemia L1210 cells toward non-permeant fluorescent Lucifer Yellow (LY) was evaluated by flow cytometry following vortex-stirring of cells with LY in the presence of high molecular weight polyacrylic acid (A-119). Permeabilization by this technique was greatly enhanced in growth phase cells...

journal_title：Biological & pharmaceutical bulletin

authors： Noda Y,Shimizu N,Kawazoe Y

更新日期：1996-12-01 00:00:00

abstract：:T cells play a principal role in cellular immunity and govern the regulatory mechanism in humoral immunity. Therefore, T cells play a key role as either effectors or regulators in the immune network. Mizoribine (MZR), an immunosuppressive agent, suppresses both humoral and cellular immunity by acting on both T cells a...

journal_title：Biological & pharmaceutical bulletin

authors： Kamada H,Inoue N,Takaoka Y,Nakagami K,Mori H,Nagai H

更新日期：1996-09-01 00:00:00

abstract：:Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi OSSIS was performed in order to obtain basic inform...

journal_title：Biological & pharmaceutical bulletin

authors： Ha JH,Lee MG,Chang SM,Lee JT

更新日期：2006-07-01 00:00:00

abstract：:The present study examined the anti-obesity effects of pine needle extract (PNE) in 3T3-L1 preadipocytes and in vivo studies. PNE treatment suppressed both glycerol-3-phosphate dehydrogenase activity and expression of peroxisome proliferator-activated receptor (PPAR) gamma in cultured 3T3-L1 adipocytes. To investigate...

journal_title：Biological & pharmaceutical bulletin

authors： Jeon JR,Kim JY

更新日期：2006-10-01 00:00:00

abstract：:Mouth washing after inhalation of corticosteroids is effective for prevention of local adverse effects such as hoarseness and oropharyngeal candidiasis. To establish an optimal procedure for such mouth washing, we investigated the removal rates of drug residues remaining on the oropharyngeal mucosa using various mouth...

journal_title：Biological & pharmaceutical bulletin

authors： Yokoyama H,Yamamura Y,Ozeki T,Iga T,Yamada Y

更新日期：2006-09-01 00:00:00

abstract：:In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis. Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solu...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Zhang K,Li Z,Zhao J,Zhang Y,Feng N

更新日期：2017-01-01 00:00:00

abstract：:A current anti-inflammatory agent often targets the prevention of inflammatory disorder development. The standardized Centella asiatica ECa 233 extract has been previously reported for anti-inflammatory effect. This study aimed to investigate its anti-inflammatory effect and mechanisms of ECa 233 in lipopolysaccharide...

journal_title：Biological & pharmaceutical bulletin

authors： Sukketsiri W,Tanasawet S,Moolsap F,Tantisira MH,Hutamekalin P,Tipmanee V

更新日期：2019-01-01 00:00:00

abstract：:To investigate chemopreventive effect of liposomal beta-sitosterol on tumor metastasis, we prepared liposomal beta-sitosterol composed of egg yolk phosphatidylcholine for oral delivery. Although orally administered beta-sitosterol (4 micromol as beta-sitosterol/mouse) was not absorbed into plasma, the amount of immune...

journal_title：Biological & pharmaceutical bulletin

authors： Imanaka H,Koide H,Shimizu K,Asai T,Kinouchi Shimizu N,Ishikado A,Makino T,Oku N

更新日期：2008-03-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the chemoresistant cancers. There is a pressing need to establish therapeutic approaches to prevent RCC proliferation and metastasis. The electrophilic 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is an endogenous anti-cancerous agent. Treatment with high concentrations of 15d-PGJ2 ...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto Y,Koma H,Yagami T

更新日期：2020-01-01 00:00:00

abstract：:Sixteen flavonoids including quercetin and kaempferol and their relatives were examined for their ability to promote DNA degradation induced by the bleomycin (BLM)-Fe complex. Three hydroxyl groups in the flavonoidal nucleus were proposed as a crucial structural requirement for effectively promoting DNA degradation: 1...

journal_title：Biological & pharmaceutical bulletin

authors： Sugihara N,Kaneko A,Furuno K

更新日期：2003-08-01 00:00:00

abstract：:The present study aimed to determine the occurrence of autophagy following ischemia/reperfusion (I/R) injury in the rat spinal cord and whether autophagy inhibition contributes to neural tissue damage and locomotor impairment. A spinal cord I/R model was induced via descending thoracic aorta occlusion for 10 min using...

journal_title：Biological & pharmaceutical bulletin

authors： Wei X,Zhou Z,Li L,Gu J,Wang C,Xu F,Dong Q,Zhou X

更新日期：2016-01-01 00:00:00

abstract：:We synthesized a new quaternary ammonium salt, N-alkyl-N-2-hydroxyethyl-N, N-dimethylammonium butyl phosphate (ABP) that does not precipitate in the presence of anionic surfactants by incorporating a paired butyl phosphate anion into cationic surfactants. ABP showed much greater bactericidal activities and antirusting...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Makino M,Nagai K,Zenda H

更新日期：1996-02-01 00:00:00

abstract：:Radiation induces an important inflammatory response in the irradiated organs, characterized by leukocyte infiltration and vascular changes. Since adhesion molecules play an important role in facilitating the immune response at the inflammation sites, interfering with the expression of these molecules may be an import...

journal_title：Biological & pharmaceutical bulletin

authors： Ma ZC,Hong Q,Wang YG,Tan HL,Xiao CR,Liang QD,Cai SH,Gao Y

更新日期：2010-01-01 00:00:00

abstract：:Digitalis has been used to treat congestive heart failure for more than 200 years, although the dual effects (proliferation and death) induced by digitalis on cell growth have been known for many years, the mechanisms by which digitalis causes the actions were not completely known. The aim of this work was to characte...

journal_title：Biological & pharmaceutical bulletin

authors： Qiu J,Gao HQ,Zhou RH,Liang Y,Zhang XH,Wang XP,You BA,Cheng M

更新日期：2007-02-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) has been found to have a membrane-stabilizing activity in studies using lysosomes. Using dimyristoyl L-alpha-phosphatidylcholine (DMPC) as a substrate, the effects of idebenone and related benzoquinones on phospholipid digestion by phospholipase A...

journal_title：Biological & pharmaceutical bulletin

authors： Amano T,Terao S,Imada I

更新日期：1995-05-01 00:00:00

abstract：:Extracellular nucleotides have multiple biological actions in processes such as proliferation, differentiation, chemotaxis, and cytokine secretion through P2X receptors on the cell surface. To determine the biological activity of adenosine triphosphate (ATP) and the expression of P2 nucleotide receptors in murine bone...

journal_title：Biological & pharmaceutical bulletin

authors： Yoon MJ,Lee HJ,Lee YS,Kim JH,Park JK,Chang WK,Shin HC,Kim DK

更新日期：2007-04-01 00:00:00

abstract：:Small interfering RNAs (siRNAs) are expected to offer a means of treating rheumatoid arthritis (RA) because they allow the specific silencing of genes related to RA pathogenesis. In our previous study, we reported that the siRNA targeted against RelA (anti-RelA siRNA), an important nuclear factor-kappaB (NF-κB) subdom...

journal_title：Biological & pharmaceutical bulletin

authors： Kanazawa T,Tamano K,Sogabe K,Endo T,Ibaraki H,Takashima Y,Seta Y

更新日期：2017-01-01 00:00:00

abstract：:Acetaminophen (APAP) is a widely used analgesic and antipyretic drug. Drug-induced liver injury from agents such as APAP is known to vary between individuals within a species. To avoid liver injury and ensure the proper use of pharmaceutical products, it is important to be able to predict such risks using genetic info...

journal_title：Biological & pharmaceutical bulletin

authors： Kanno S,Tomizawa A,Yomogida S

更新日期：2016-01-01 00:00:00

abstract：:Schizophyllan (SPG) is used to treat cervical cancer in combination with irradiation to enhance the immunological surveillance system. Dectin-1 is a cell surface receptor for 1,3-beta-glucan. In this study, we prepared two anti-Dectin-1 monoclonal antibodies, 4B2 and SC30 having a K(D) of 7.04 x 10(-8) M and 1.55 x 10...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda Y,Adachi Y,Ishii T,Tamura H,Aketagawa J,Tanaka S,Ohno N

更新日期：2007-08-01 00:00:00

abstract：:We attempted to produce a model mouse with a liver injury resulting from an immunological mechanism in C57BL/6J mice, and the effect of hepatitis on the hepatic microsomal mixed-function oxidase system was studied. An experimental immunological liver injury model was caused by the intravenous injection of an anti-basi...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa M,Takayanagi Y,Sasaki K

更新日期：1993-10-01 00:00:00

abstract：:An alkaloid piperine isolated from the Piper Nigrum was found to inhibit lipid droplet accumulation in mouse macrophages, and especially inhibited cholesteryl ester (CE) synthesis (IC50: 25 microM). The metabolism of cholesterol from lysosome to lipid droplet was inhibited with a similar IC50 (18 microM), indicating t...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuda D,Ohte S,Ohshiro T,Jiang W,Rudel L,Hong B,Si S,Tomoda H

更新日期：2008-06-01 00:00:00

abstract：:Metallothioneins (MTs) occur throughout the animal kingdom and they are induced in vivo by metals, hormones, cytotoxic agents, and some kind of stress. It is well known that various stresses such as starvation and immobilization can induce MT synthesis in animal tissues, but the influence of dietary restriction is unk...

journal_title：Biological & pharmaceutical bulletin

authors： Shinogi M,Sakaridani M,Yokoyama I

更新日期：1999-02-01 00:00:00

abstract：:Chitooligosaccharides, the oligomers made up of beta-1,4-linked D-glucosamine, are obtained by partial hydrolysis of chitosan, a deacetylation product of chitin. The antioxidant activity of various chitooligosaccharides was tested in vitro with aminoguanidine, pyridoxamine, and Trolox as reference compounds. Hydroxyla...

journal_title：Biological & pharmaceutical bulletin

authors： Chen AS,Taguchi T,Sakai K,Kikuchi K,Wang MW,Miwa I

更新日期：2003-09-01 00:00:00

abstract：:The mature form of rat adrenodoxin (Ad) was purified from a heterologous direct expression system in Escherichia coli with a yield of 56 mg/l culture. The purified Ad showed a A414/A280 ratio of 0.91 and the sequence of 10 amino terminal residues was identical with that of authentic rat Ad. By Time of Flight/Mass spec...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara Y,Aramaki H

更新日期：1998-10-01 00:00:00

abstract：:We showed previously that transdifferentiation of skin epidermis to mucous epithelium can be induced by treatment with 20 µM retinol for 1 d followed by culture for 4 d without retinol in chick embryonic tarsometatarsal skin. In mouse epidermal cells, 3 µM retinoic acid (an active metabolite of retinol) inhibits epide...

journal_title：Biological & pharmaceutical bulletin

authors： Obinata A,Akimoto Y

更新日期：2011-01-01 00:00:00

abstract：:Our previous study using apoptosis analysis suggested that Ca(2+) release through inositol 1,4,5-trisphosphate (IP3) receptors and the subsequent Ca(2+) influx through store-operated channels (SOCs) constitute a triggering signal for H2O2-induced β-cell apoptosis. In the present study, we further examined the obligato...

journal_title：Biological & pharmaceutical bulletin

authors： Sato T,Kaneko YK,Sawatani T,Noguchi A,Ishikawa T

更新日期：2015-01-01 00:00:00

abstract：:The in vitro skin permeability of 16 drugs with a wide range of lipophilicity (log P; -0.95-4.40) was evaluated by the use of an ethanol/water (60/40) binary vehicle with or without lauric acid as a permeation enhancer. The enhancing effect by the addition of lauric acid to the ethanol/water (60/40) binary vehicle cou...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CK,Uchida T,Kitagawa K,Yagi A,Kim NS,Goto S

更新日期：1994-10-01 00:00:00

abstract：:The effect of fungichromin (FC) on the formation of Candida albicans biofilm was assessed using 2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction method, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results showed that FC revealed an inhibitor...

journal_title：Biological & pharmaceutical bulletin

authors： An D,Wang X,Li J,Jiang S,Ma X,Zhang H,Shi H,Sun H,Ye L,Li J

更新日期：2016-12-01 00:00:00

abstract：:It is widely accepted that selective serotonin reuptake inhibitors (SSRIs) require 2 to 4 weeks of administration before improvements in emotional symptoms of depression are seen. We evaluated whether early monitoring of Hamilton Rating Scale for Depression (HAMD) scores in patients treated with the SSRI fluvoxamine c...

journal_title：Biological & pharmaceutical bulletin

authors： Katoh Y,Uchida S,Kawai M,Takei N,Mori N,Kawakami J,Kagawa Y,Yamada S,Namiki N,Hashimoto H

更新日期：2010-01-01 00:00:00