Electrophysiological and pharmacological properties of the pulmonary vein myocardium.

abstract：:The purpose of this study is to develop a new method of preparing salvianolic acid extracts (SAE) water-in-oil-in-water (W/O/W) multiple emulsion (ME). SAE injection is used in the treatment of brain infarct and promotion of blood circulation in China. However, the injection is not convenient, and the oral preparation...

journal_title：Biological & pharmaceutical bulletin

authors： Song Y,Gao H,Zhang S,Zhang Y,Jin X,Sun J

更新日期：2017-12-01 00:00:00

abstract：:In vivo reducing capacity and cytosolic glutathione peroxidase (GSH-Px) activity in liver homogenate were evaluated in 6 weeks old Se-deficient and normal rats. GSH-Px was significantly lower in Se-deficient rats than in normal rats. In vivo reducing capacity in head and liver parts, estimated from in vivo signal deca...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto K,Endo K,Utsumi H

更新日期：2000-05-01 00:00:00

abstract：:A traditional Chinese herbal medicine, Qizhu Tang (QZT) was studied for its in vitro antioxidant activity and the effect on cerebral oxidative damage after forebrain ischemia followed by reperfusion in rats. The QZT decoction was shown to have strong hydroxyl radical (*OH) scavenging activity (approx. 0.1 mM as Trolox...

journal_title：Biological & pharmaceutical bulletin

authors： Xuejiang W,Ichikawa H,Konishi T

更新日期：2001-05-01 00:00:00

abstract：:Acute biliary pancreatitis (ABP) with a high mortality rate is an incurable digestive system disease induced by abnormal bile acid regurgitation due to the biliary obstruction. Dehydrocholic acid (DA) alleviates the severity of cholestatic hepatitis related to biliary inflammation, suggesting DA is potential to develo...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Xin G,Li S,Wei Z,Ming Y,Yuan J,Wen E,Xing Z,Yu K,Li Y,Zhang J,Zhang B,Niu H,Huang W

更新日期：2020-01-01 00:00:00

abstract：:The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topo...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada M,Hayashi K,Ikeda S,Tsutsui K,Tsutsui K,Ito T,Iinuma M,Nozaki H

更新日期：2006-07-01 00:00:00

abstract：:Cannabinoids are the active ingredients in marijuana, which is among the most widely used addictive drugs despite the well-documented harmfulness related to its abuse. The mechanism underlying cannabinoid addiction remains unclear, which is attributed partially to the difficulty in behavioral testing of high-dose cann...

journal_title：Biological & pharmaceutical bulletin

authors： Liu T,Zheng Q,Qian Z,Wang H,Liu Z,Ren W,Zhang X,Han J

更新日期：2016-05-01 00:00:00

abstract：:A rapid and highly sensitive LC-MS-MS method for simultaneous determination of 25-hydroxyvitamin D2 125(OH)D21 and 25-hydroxyvitamin D3 125(OH)D3] in human plasma has been developed using derivatization with a Cookson-type reagent, 4-12-(6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydroquinoxalyl)ethyll-1,2,4-triazoline-3,5-di...

journal_title：Biological & pharmaceutical bulletin

authors： Higashi T,Awada D,Shimada K

更新日期：2001-07-01 00:00:00

abstract：:Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi OSSIS was performed in order to obtain basic inform...

journal_title：Biological & pharmaceutical bulletin

authors： Ha JH,Lee MG,Chang SM,Lee JT

更新日期：2006-07-01 00:00:00

abstract：:Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associat...

journal_title：Biological & pharmaceutical bulletin

authors： Yanagihara S,Taniguchi Y,Hosono M,Yoshioka E,Ishikawa R,Shimada Y,Kadoya T,Kutsukake K

更新日期：2010-01-01 00:00:00

abstract：:This study investigated the effects of compounds isolated from 70% ethanol (EtOH) extraction of Smilax china L. (SCE), a plant belonging to the family Smilacaceae on nicotine-induced endothelial dysfunction (ED) in human umbilical vein endothelial cells. We isolated 10 compounds from ethyl acetate (EtOAc) fraction of ...

journal_title：Biological & pharmaceutical bulletin

authors： Lincha VR,Zhao BT,Woo MH,Yang IJ,Shin HM

更新日期：2016-01-01 00:00:00

abstract：:We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 microM. Time course study revealed that simultaneous co-treatment of...

journal_title：Biological & pharmaceutical bulletin

authors： Ishiwata S,Nakashita K,Ozawa Y,Niizeki M,Nozaki S,Tomioka Y,Mizugaki M

更新日期：1999-11-01 00:00:00

abstract：:High-resolution deep tissue imaging is possible with two-photon excitation microscopy. With the combined application of two-photon imaging and perfusion with a polar fluorescent tracer, we have established a method to detect exocytic events inside secretory tissues. This method displays the spatiotemporal distribution...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi N

更新日期：2015-01-01 00:00:00

abstract：:The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda T,Yokomizo K,Okawa M,Tsuchihashi R,Kinjo J,Nohara T,Uyeda M

更新日期：2005-09-01 00:00:00

abstract：:Polysaccharides are involved in biological responses and can activate complement system, which plays an important role in primary host defense mechanisms. We investigated anticomplementary activities from spice plants and selected thyme (Thymus vulgaris L.) as a potent complementary activator. Acidic polysaccharide (T...

journal_title：Biological & pharmaceutical bulletin

authors： Chun H,Shin DH,Hong BS,Cho HY,Yang HC

更新日期：2001-08-01 00:00:00

abstract：:Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

journal_title：Biological & pharmaceutical bulletin

authors： Ariga H

更新日期：2015-01-01 00:00:00

abstract：:DNA rich in non-methylated CG motifs (CpGs) enhances induction of immune responses against co-administered antigen encoding genes. CpGs are therefore among the promising adjuvants known to date. However, naked plasmid DNA, even which contains CpG motifs, are taken up by antigen presenting cells via the endocytosis pat...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshikawa T,Imazu S,Gao JQ,Hayashi K,Tsuda Y,Okada N,Tsutsumi Y,Akashi M,Mayumi T,Nakagawa S

更新日期：2006-01-01 00:00:00

abstract：:The absorption and distribution of ulinastatin following intra-articular administration of [125I]ulinastatin to rabbits were determined and kinetic analysis using a multi-compartment model was performed. At 4 h after administration, the content of radioactivity in the synovial fluid, which was comparable to that of th...

journal_title：Biological & pharmaceutical bulletin

authors： Ohzawa N,Takahashi Y,Ogihara T,Nakai Y,Ishiguro J

更新日期：1997-07-01 00:00:00

abstract：:HL-60 cells differentiate into granulocyte-like cells by all-trans retinoic acid (ATRA) treatment, and the cellular proliferation is markedly reduced during the differentiation. To elucidate the molecular mechanisms of the growth arrest during the cellular differentiation, we examined the regulated expression of the t...

journal_title：Biological & pharmaceutical bulletin

authors： Horie N,Komada Y,Ueta Y,Suzuki T,Nozawa R,Takeishi K

更新日期：2001-12-01 00:00:00

abstract：:The degradation of 125I-endothelin-1 (125I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of E...

journal_title：Biological & pharmaceutical bulletin

authors： Edano T,Arai K,Koshi T,Torii T,Ohshima T,Hirata M,Ohkuchi M,Okabe T

更新日期：1994-03-01 00:00:00

abstract：:Effects of nebracetam, a novel nootorpic agent, on the synaptosomal uptake of neurotransmitter monoamines of the brain regions were examined. Striatal and hippocampal synaptosomes were isolated by the Percoll gradient method, and the striatal dopamine uptake and hippocampal serotonin uptake were measured in the presen...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Hayashi H,Tadokoro M,Takagi K,Miyake K,Takagi N,Oshikawa S

更新日期：1997-04-01 00:00:00

abstract：:The variable region of heavy chain [V(H)] of human rheumatoid factor (hRF) IgM was connected with the variable region of light chain [V(L)] with the peptide-linker (GGGSGGGSGGGS) by genetic engineering method and the single-chain Fv (scFv) was expressed in E. coli. On design, scFv and scFv (tag) were planned; the latt...

journal_title：Biological & pharmaceutical bulletin

authors： Hashimoto Y,Ikenaga T,Tanigawa K,Ueda T,Ezak I,Imoto T

更新日期：2000-08-01 00:00:00

abstract：:The success of arsenic trioxide (ATO) in treatment of acute promyelocytic leukemia (APL) attracts a great deal of attention to researchers to explore its activity of anti-leukemia. However, ATO has unavailable effect on chronic myeloid leukemia (CML), especially multidrug resistant (MDR)-CML, unless using high concent...

journal_title：Biological & pharmaceutical bulletin

authors： Wang X,Zhang X,Xu Z,Wang Z,Yue X,Li H

更新日期：2013-01-01 00:00:00

abstract：:We previously reported that, in Jurkat human T cells, the topoisomerase II inhibitor etoposide enhances sialidase activity and reduces cell surface sialic acid levels at an early stage of apoptosis and that the decreases in sialic acid are suppressed by the sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic ac...

journal_title：Biological & pharmaceutical bulletin

authors： Azuma Y,Sato H,Higai K,Matsumoto K

更新日期：2007-09-01 00:00:00

abstract：:Telekin, a eudesmane-type sesquiterpene lactone compound isolated from Chinese folk medicine Carpesium divaricatum, has been reported to strongly inhibit the proliferation of cancer cells. In this study, the involvement of a mitochondria-mediated pathway in the pro-apoptotic action of telekin was investigated in human...

journal_title：Biological & pharmaceutical bulletin

authors： Zheng B,Wu L,Ma L,Liu S,Li L,Xie W,Li X

更新日期：2013-01-01 00:00:00

abstract：:Since grape extract (GE) contains oligomeric proanthocyanidins and numerous polyphenols, dietary GE supplements may exert protective effects against various diseases. The present study investigated the pharmacological effects of GE derived from Chardonnay in vitro and in vivo. GE (100 µg/mL) completely inhibited tumor...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkita M,Hayashi H,Ito K,Shigematsu N,Tanaka R,Tsutsui H,Matsumura Y

更新日期：2019-01-01 00:00:00

abstract：:We examined the effects of ginseng total saponin (GTS) and several ginsenosides injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the antinociception induced by cold water swimming. The tail-flick response was used as an antinociceptive parameter. We found that i.t. injection of GTS time- and dose...

journal_title：Biological & pharmaceutical bulletin

authors： Choi SS,Lee JK,Suh HW

更新日期：2003-06-01 00:00:00

abstract：:Spontaneous transfer of protein from either influenza virus-infected or uninfected cells to dimyristoylphosphatidylcholine (DMPC) liposomes was examined. The amount of transferred protein of liposomes incubated with influenza virus-infected cells (I-lipo) was more than that of liposomes incubated with uninfected cells...

journal_title：Biological & pharmaceutical bulletin

authors： Kogure K,Itoh M,Hayashi K,Ueno M

更新日期：1995-08-01 00:00:00

abstract：:A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd:spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as ...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi M,Takao K,Shiota Y,Sugita Y,Takahashi M,Nakae D,Samejima K

更新日期：2006-05-01 00:00:00

abstract：:The present study was to study the hepatoprotective effects of phloridzin (PHL) on hepatic fibrosis induced by carbon tetrachloride (CCl₄) in rats, on the basis of this investigation, the possible mechanism of PHL was elucidated. Male Sprague Dawley (SD) rats were randomly divided into six groups: control, model, PHL-...

journal_title：Biological & pharmaceutical bulletin

authors： Deng G,Wang J,Zhang Q,He H,Wu F,Feng T,Zhou J,Zou K,Hattori M

更新日期：2012-01-01 00:00:00

abstract：:Recently, Banhabackchulchunmatang (HMC05) has been implicated as a preventive and/or therapeutic candidate for cardiovascular diseases due to its inhibition of atherosclerosis lesions and its reduction of neointima formation. Knowledge of the mechanism of HMC05 in smooth muscle cells (SMC) is limited. However, SMC may...

journal_title：Biological & pharmaceutical bulletin

authors： Gum SI,Shin HM,Cho MK

更新日期：2014-01-01 00:00:00