Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis.

Abstract:

:A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1beta,2alpha,3alpha,23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1-2 and 4-8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 microM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

journal_name

Biol Pharm Bull

authors

Thuong PT,Min BS,Jin W,Na M,Lee J,Seong R,Lee YM,Song K,Seong Y,Lee HK,Bae K,Kang SS

doi

10.1248/bpb.29.830

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

830-3

issue

4

eissn

0918-6158

issn

1347-5215

pii

JST.JSTAGE/bpb/29.830

journal_volume

29

pub_type

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