Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis.


:A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1beta,2alpha,3alpha,23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1-2 and 4-8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 microM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.


Biol Pharm Bull


Thuong PT,Min BS,Jin W,Na M,Lee J,Seong R,Lee YM,Song K,Seong Y,Lee HK,Bae K,Kang SS




Has Abstract


2006-04-01 00:00:00














  • Suppression of inflammatory reactions by terpinen-4-ol, a main constituent of tea tree oil, in a murine model of oral candidiasis and its suppressive activity to cytokine production of macrophages in vitro.

    abstract::The onset of oral candidiasis is accompanied by inflammatory symptoms such as pain in the tongue, edema or tissue damage and lowers the quality of life (QOL) of the patient. In a murine oral candidiasis model, the effects were studied of terpinen-4-ol (T-4-ol), one of the main constituents of tea tree oil, Melaleuca a...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ninomiya K,Hayama K,Ishijima SA,Maruyama N,Irie H,Kurihara J,Abe S

    更新日期:2013-01-01 00:00:00

  • Binding characteristics of human lactoferrin to the human monocytic leukemia cell line THP-1 differentiated into macrophages.

    abstract::The characteristics of the binding of human lactoferrin (LF) to the cells of a human monocytic leukemia cell line, THP-1, were investigated. 125I-Labeled LF (125I-LF) bound to THP-1 cells, and the binding increased markedly as the cells matured into macrophages (THP-1 macrophages) by stimulation with phorbol 12-myrist...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Eda S,Kikugawa K,Beppu M

    更新日期:1996-02-01 00:00:00

  • Differentiation inducing effects of 2-chloro-3-amino-1,4-naphthoquinone on human leukemia HL-60.

    abstract::There are some highly cytotoxic anticancer compounds inducing differentiation of cancer cells to normal cells at below highly cytotoxic concentration. Naphthoquinone derivatives having cytotoxic effects on cancer cell were tested to learn whether they have differentiation inducing activity in human leukemia HL-60 cell...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Bae KA,Choung SY

    更新日期:1996-06-01 00:00:00

  • Prophylactic effects of ajoene on cerebral injury in stroke-prone spontaneously hypertensive rats (SHRSP).

    abstract::As part of a basic study on the prevention of cerebral injury, ajoene (0.5 mg/d) and oil-macerated garlic extract (OMGE, containing 0.5 mg ajoene/d) were administrated to stroke-prone spontaneously hypertensive rats (SHRSP) among 8 weeks from 9 weeks of age. In the control group, 3 of 10 rats died (30%), whereas all S...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yamada N,Hattori A,Nishikawa T,Fukuda H,Fujino T

    更新日期:2006-04-01 00:00:00

  • Tissue-specific mRNA expression profiles of human carbohydrate sulfotransferase and tyrosylprotein sulfotransferase.

    abstract::Pairs of forward and reverse primers and TaqMan probes specific to each of 15 human sulfotransferases were prepared. The mRNA expression level of each target enzyme was analyzed in total RNA from single and pooled specimens of various human tissues (adrenal gland, bone marrow, brain, colon, heart, kidney, liver, lung,...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nishimura M,Naito S

    更新日期:2007-04-01 00:00:00

  • Aconitine, a main component of aconite, increases spontaneous acetylcholine release from the frontal cerebral cortex of freely moving rats.

    abstract::We investigated whether peripherally administered aconitine increases spontaneous acetylcholine (ACh) release from the frontal cerebral cortex in freely moving rats using in vivo microdialysis, as it relates to aconitine-induced bradycardia estimated by a tail-artery cuff technique in unilateral anterior hypothalamus ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kimura I,Takada M,Nojima H,Kimura M

    更新日期:1996-11-01 00:00:00

  • Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages.

    abstract::Glycosaminoglycans (GAGs) play important roles in various biological processes such as cell adhesion and signal transduction, as well as promote anti-inflammatory activity. We previously revealed that glycol-split heparin (HP)-aliphatic amine conjugates form self-assembled nanoparticles and suppress the production of ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yanamoto S,Babazada H,Sakai S,Higuchi Y,Yamashita F,Hashida M

    更新日期:2017-01-01 00:00:00

  • Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity.

    abstract::When ginsenoside R(c) was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside R(c) to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidoba...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Bae EA,Choo MK,Park EK,Park SY,Shin HY,Kim DH

    更新日期:2002-06-01 00:00:00

  • Suberoylanilide Hydroxamic Acid Can Re-sensitize a Cisplatin-Resistant Human Bladder Cancer.

    abstract::Cisplatin chemotherapy is the standard treatment for metastatic urothelial carcinoma. Although there are second-line chemotherapeutic agents approved by the U.S. Food and Drug Administration (FDA) such as those targeting programmed death-ligand 1 (PD-L1), more effective pharmacotherapy is required for cisplatin-resist...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ryu H,Jin H,Ho JN,Bae J,Lee E,Lee SE,Lee S

    更新日期:2019-01-01 00:00:00

  • Down-regulation of the large-conductance Ca(2+)-activated K+ channel, K(Ca)1.1 in the prostatic stromal cells of benign prostate hyperplasia.

    abstract::Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel encoded by K(Ca)1.1 plays an important role in the control of smooth muscle tone by modulating membrane potential and intracellular Ca(2+) mobilization. BK(Ca) channel is functionally expressed in prostatic smooth muscle cells, and is activated by α(1)-adrenocep...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Niwa S,Ohya S,Kojima Y,Sasaki S,Yamamura H,Sakuragi M,Kohri K,Imaizumi Y

    更新日期:2012-01-01 00:00:00

  • Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities.

    abstract::In a previous study we found that 50% ethanol extracts of immature fruits of Citrus unshiu (satsuma mandarin) have anti-allergic effects against the Type I, II and IV allergic reactions. However, many adverse interactions between citrus fruit, especially grapefruit juice, and drugs have been reported due to the inhibi...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Fujita T,Kawase A,Niwa T,Tomohiro N,Masuda M,Matsuda H,Iwaki M

    更新日期:2008-05-01 00:00:00

  • Evaluation of Proteinuria Using Urine Protein : Creatine Ratio in Treatment with Molecular Targeted Agents for Advanced Renal Cell Carcinoma.

    abstract::The usefulness of the urine protein : creatine ratio (UPCR) in management of molecular targeted therapy and immunotherapy has not been studied, although urine protein dipstick testing (uPr) is widely used in the clinical setting. The aim of this study was to investigate the usefulness of UPCR as compared to uPr in pat...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nakamura K,Tanaka T,Masumori N,Miyamoto A,Hirano T

    更新日期:2020-01-01 00:00:00

  • Determination of reduced nicotinamide adenine dinucleotide phosphate concentration using high-performance liquid chromatography with fluorescence detection: ratio of the reduced form as a biomarker of oxidative stress.

    abstract::Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the principal source of reducing power in numerous processes of physiological importance. We examined the influence of oxidative stress on the relative amounts of NADPH in human red blood cells (RBCs). To determine the homeostasis of the NADPH existing in ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ogasawara Y,Funakoshi M,Ishii K

    更新日期:2009-11-01 00:00:00

  • Liposomes as immunomodulator--inhibitory effect of liposomes on NO production from macrophages.

    abstract::Liposomes have been artificially made into membranous vesicles composed essentially of naturally occurring phospholipids and have been found to serve as a carrier of drugs and an immunological adjuvant. After being intravenously injected, they are quickly removed from the blood circulation and trapped by Kupffer cells...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Aramaki Y

    更新日期:2000-11-01 00:00:00

  • Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade.

    abstract::Cancer is one of the leading causes of death in the world. The triterpenoid compound asiatic acid derived from the tropical medicinal plant Centella asiatica displays cytotoxic activity on fibroblast cells and several other kinds of cells. The present work studies asiatic acid-mediated growth inhibition of cancer cell...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tang XL,Yang XY,Jung HJ,Kim SY,Jung SY,Choi DY,Park WC,Park H

    更新日期:2009-08-01 00:00:00

  • Relationship between lipophilicity and skin permeability of various drugs from an ethanol/water/lauric acid system.

    abstract::The in vitro skin permeability of 16 drugs with a wide range of lipophilicity (log P; -0.95-4.40) was evaluated by the use of an ethanol/water (60/40) binary vehicle with or without lauric acid as a permeation enhancer. The enhancing effect by the addition of lauric acid to the ethanol/water (60/40) binary vehicle cou...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Lee CK,Uchida T,Kitagawa K,Yagi A,Kim NS,Goto S

    更新日期:1994-10-01 00:00:00

  • Suppressive activity of lycoricidinol (narciclasine) against cytotoxicity of neutrophil-derived calprotectin, and its suppressive effect on rat adjuvant arthritis model.

    abstract::Calprotectin is a calcium- and zinc-binding protein complex that is abundant in cytosol of neutrophils. The concentration of calprotectin in extracellular fluids is greatly increased under various inflammatory conditions in vivo. We recently demonstrated that calprotectin inhibited cell growth and induced apoptosis of...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Mikami M,Kitahara M,Kitano M,Ariki Y,Mimaki Y,Sashida Y,Yamazaki M,Yui S

    更新日期:1999-07-01 00:00:00

  • Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA.

    abstract::Systems for delivering nucleic acids are now fundamental technologies for realizing personalized medicine. Among the various nucleic acid delivery systems that are currently available, lipid-nanoparticles (LNPs) that contain short interfering RNA (siRNA) have been extensively investigated for clinical applications. LN...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Shirane D,Tanaka H,Nakai Y,Yoshioka H,Akita H

    更新日期:2018-01-01 00:00:00

  • Leukotrienes in nociceptive pathway and neuropathic/inflammatory pain.

    abstract::The purpose of this review is to summarize the recent studies examining the expression of leukotrienes (LTs) and their receptors in nociceptive pathways, and their crucial roles in pathological pain conditions. LTs belong to a large family of lipid mediators, termed eicosanoids, which are derived from arachidonic acid...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Noguchi K,Okubo M

    更新日期:2011-01-01 00:00:00

  • Characterization of an expanded IL-10-producing-suppressive T cell population associated with immune tolerance.

    abstract::An increase in the number of glucocorticoid-induced tumor necrosis factor receptor-family related gene/protein (GITR)+CD25- (or fork-head box protein 3: Foxp3-) CD4+ T cells, after treating a mouse model of arthritis with fingolimod (FTY720), and a pathogenic antigen may play a key role in the establishment of immune ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yoshida Y,Mikami N,Nakanishi Y,Saimoto M,Nagaike A,Shimono H,Nakano S,Tsuji T,Kohno T

    更新日期:2021-01-26 00:00:00

  • Anticytotoxin Effects of Amentoflavone to Pneumolysin.

    abstract::Pneumolysin (PLY) is a devastating bacterial protein toxin of Streptococcus pneumoniae that punctures the cytomembrane, leading to pathological reactions, such as cell disruption and inflammation. Drugs capable of closely impacting the toxin are considered advantageous in the treatment of bacterial infections. Amentof...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Zhao X,Liu B,Liu S,Wang L,Wang J

    更新日期:2017-01-01 00:00:00

  • A Novel Bongkrekic Acid Analog-Mediated Modulation of the Size of Lipid Droplets: Evidence for the Appearance of Smaller Adipocytes.

    abstract::Thiazolidinediones (TZDs) are known as peroxisome proliferator-activated receptor γ (PPARγ) activators, and are used in the treatment of diabetes. Although the usefulness of TZDs has been demonstrated, some of their side effects are becoming an obstacle to their clinical applicability; edema is known to be evoked by t...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Okazaki H,Takeda S,Ishii H,Takemoto Y,Fujita S,Suyama M,Matsumoto K,Shindo M,Aramaki H

    更新日期:2017-01-01 00:00:00

  • Effect of a nutritive-tonic drink on scopolamine-induced memory impairment in mice.

    abstract::The effects of a liquid nutritive and tonic drug (NTD) selected from a modification of the "Kai-xin-shou-yu-shen-qi-wan" prescription, on scopolamine-induced amnesia in mice were investigated using the passive avoidance and water-maze tasks. A popular NTD in Japan that contains 17 crude (natural) drug extracts togethe...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sakata Y,Chida R,Ishige K,Edagawa Y,Tadano T,Ito Y

    更新日期:2005-10-01 00:00:00

  • L-type amino acid transporter-1 expressed in human astrocytomas, U343MGa.

    abstract::LAT1 (L-type amino acid transporter 1), one of the L-type amino acid transporters, transports the branched and aromatic amino acids. LAT1 requires the heavy chain of 4F2 antigen (4F2hc) for the functional expression as an amino acid transporter. The expression of this transporter is up-regulated in tumor cells and rap...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Asano S,Kameyama M,Oura A,Morisato A,Sakai H,Tabuchi Y,Chairoungdua A,Endou H,Kanai Y

    更新日期:2007-03-01 00:00:00

  • Decline in plasma membrane Ca(2+)-ATPase activity and increase in cytosolic-free Ca2+ concentration of endotoxin-injected mice livers.

    abstract::The present study describes the activity of Ca(2+)-ATPase in liver plasma membrane and cytosolic-free Ca2+ concentration ([Ca2+]i) in an individual vital cell in mouse liver 18 h after endotoxin administration. Ca(2+)-ATPase activity in liver plasma membrane in the poisoned mice was markedly decreased to 28% of that i...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sakaguchi S,Tsutsumi E,Yokota K

    更新日期:1993-08-01 00:00:00

  • Effect of Shosaikoto (Kampo medicine) on the adherence of monocytes in hypercholesterolemic rabbit.

    abstract::Monocytes/macrophages are known to be involved in atherogenesis, and the adherence of monocytes to the endothelium is considered an earliest characteristic of atherogenesis. Therefore, we studied the mechanism by which Shosaikoto, a Kampo medicine, shows anti-atherosclerotic action, which has been already shown in hyp...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Shen YR,Inoue M,Ogihara Y

    更新日期:1996-01-01 00:00:00

  • Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse.

    abstract::We examined the effects of ginseng total saponin (GTS) and several ginsenosides injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the antinociception induced by cold water swimming. The tail-flick response was used as an antinociceptive parameter. We found that i.t. injection of GTS time- and dose...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Choi SS,Lee JK,Suh HW

    更新日期:2003-06-01 00:00:00

  • Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction.

    abstract::Berberine has a wide range of biochemical and pharmacologic effects, including antitumor activity, but the mechanisms involved in berberine-induced apoptosis remain unclear. The purpose of the present study was to investigate the changes in oxidative stress and endoplasmic reticulum (ER)-related molecules, which are c...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Eom KS,Kim HJ,So HS,Park R,Kim TY

    更新日期:2010-01-01 00:00:00

  • Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain.

    abstract::Uridine 5'-diphosphate-glucuronosyltransferase (UGT) catalyzes a major phase II reaction in a drug-metabolizing enzyme system. Although the UGT1A subfamily is expressed mainly in the liver, it is also expressed in the brain. The purpose of the present study was to elucidate the effect of β-naphthoflavone (BNF), one of...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sakakibara Y,Katoh M,Kondo Y,Nadai M

    更新日期:2016-01-01 00:00:00

  • Difference between yeast and bovine mitochondrial ADP/ATP carriers in terms of conformational properties of the first matrix loop as deduced by use of copper-o-phenanthroline.

    abstract::The mitochondrial ADP/ATP carrier (AAC) has 6 transmembrane regions and 3 matrix loops. Our previous mutational study on the Cys residue in the LM1s of chimeric bovine type 1 AAC (yN-bAAC1), in which the N-terminal 11 amino acids of bovine type 1 AAC are substituted with the corresponding 26 amino acids of yeast type ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kihira Y,Ueno M,Terada H

    更新日期:2007-05-01 00:00:00