In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid.

abstract：:We examined the protective ability of tea melanin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity in C57BL6J mice. Reduced tea melanin (RTM) and non-reduced tea melanin (NRTM) were incorporated to distinguish anti-oxidant activity from alternative pathways. The mice were given a single oral dose of...

journal_title：Biological & pharmaceutical bulletin

authors： Hung YC,Huang GS,Sava VM,Blagodarsky VA,Hong MY

更新日期：2006-11-01 00:00:00

abstract：:Using a surface plasmon resonance (SPR) system, we investigated the lipid membrane-binding properties of four analogues of the 18-residue linear amphipathic beta-sheet cationic antimicrobial peptide (KIGAKI)3-NH2, each of which contains a single isoleucine-to-tryptophan substitution. The results of the SPR study revea...

journal_title：Biological & pharmaceutical bulletin

authors： Kamimori H,Blazyk J,Aguilar MI

更新日期：2005-01-01 00:00:00

abstract：:The gastric mucus is an important factor in the gastric mucosal protection from acid, pepsin and various reagents (alcohol, aspirin, etc.). MUC5AC is the mucin secreted from surface mucous cells, and belongs to the gel-forming mucin. We examined the regulation of rat MUC5AC (rMUC5AC) mRNA by glucocorticoid in vivo and...

journal_title：Biological & pharmaceutical bulletin

authors： Tanaka T,Kobayashi T,Sunaga K,Tani S

更新日期：2001-06-01 00:00:00

abstract：:Many lines of evidences have shown that Panax ginseng exhibits beneficial effects on cardiovascular systems. We previously demonstrated that ginsenoside Rg(3) (Rg(3)), one of active ingredients of Panax ginseng, inhibits Ca(2+) channel currents in a stereospecific manner and affects the steady-state activation but not...

journal_title：Biological & pharmaceutical bulletin

authors： Choi SH,Lee JH,Pyo MK,Lee BH,Shin TJ,Hwang SH,Kim BR,Lee SM,Oh JW,Kim HC,Bae CS,Rhim H,Nah SY

更新日期：2009-07-01 00:00:00

abstract：:Dermatan sulfate-proteoglycans (DS-PGs) were extracted from rabbit, rat and bovine defatted livers by magnesium chloride extraction and DEAE-cellulose chromatography, and then submitted successively to Asahipak GS-520 gel filtration chromatography, Asahipak ES-502N anion exchange chromatography, and cellulose acetate ...

journal_title：Biological & pharmaceutical bulletin

authors： Koshiishi I,Motoki K,Qiu G,Imanari T

更新日期：1993-04-01 00:00:00

abstract：:Using a validated high-performance liquid chromatographic (HPLC) method, the pharmacokinetics of multi-constituents in Huangqin-Tang decoction were simultaneously studied both in the compound prescription and in each single herb decoction. At different intervals (0, 1, 2, 4, 8, 12, 24, 36, 48 h) after oral administrat...

journal_title：Biological & pharmaceutical bulletin

authors： Zuo F,Zhou ZM,Zhang Q,Mao D,Xiong YL,Wang YL,Yan MZ,Liu ML

更新日期：2003-07-01 00:00:00

abstract：:This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OFI methanol extract was calculated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulfo...

journal_title：Biological & pharmaceutical bulletin

authors： Okur ME,Ayla Ş,Karadağ AE,Çiçek Polat D,Demirci S,Seçkin İ

更新日期：2020-01-01 00:00:00

abstract：:Virus entry, assembly, and budding are important processes in the replication cycle of a virus. Viruses are dependent on host living cells for their replication. Viruses use the proliferative mechanism of host cells for replication of viral components. Lipid rafts, specific membrane microdomains play a critical role i...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki T,Suzuki Y

更新日期：2006-08-01 00:00:00

abstract：:Neuroprotective effects of estrogen and estrogen-like chemicals on neurodegenerative diseases, especially Parkinson's disease, have been well established. In the present study, we compared the effects of Bak Foong Pill (BFP), a well-known gynaecological tonic in China, and 17beta-estradiol, on dopamine transporter (DA...

journal_title：Biological & pharmaceutical bulletin

authors： Liu B,Xie JX,Rowlands DK,Gou YL,Leung CC,Chung YW,Chan HC

更新日期：2004-08-01 00:00:00

abstract：:Acute toxicity (24 h) and general behavior in mice of a lignan from Justicia hyssopifolia, a beta-D-glucoside (elenoside), was studied, and the cytotoxic activity was performed. Elenoside (arylnaphthalene lignan) in mice showed a moderate toxicity order (305 mg/kg) and central depressive properties at doses of 25, 50,...

journal_title：Biological & pharmaceutical bulletin

authors： Navarro E,Alonso SJ,Alonso PJ,Trujillo J,Jorge E,Perez C

更新日期：2001-03-01 00:00:00

abstract：:Effects of certain antiallergic drugs on experimental conjunctivitis were studied with guinea pigs. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting histamine- and antigen-induced conjunctivitis in guinea pigs. By contrast, amlexanox was only effective in inhibiting antigen-induced conjunctiv...

journal_title：Biological & pharmaceutical bulletin

authors： Kamei C,Izushi K,Nakamura S

更新日期：1995-11-01 00:00:00

abstract：:The cardiac toxicity of amitriptyline and the effect of the light schedule on it were studied in chick embryos. Fertilized eggs of White Leghorns were incubated under dark conditions and investigated, on two occasions, in the light phase and in the dark phase. Amitriptyline was injected into the air sac of fertilized ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Sugiyama T,Kanke M

更新日期：2004-02-01 00:00:00

abstract：:Liposomes were prepared from hydrogenated lecithin (H-PC) by sonication (S) or injection (I) of H-PC dissolved in ethanol containing dl-tocopherol acetate (VEA). The effects of liposomes on the dermal absorption of VEA were studied. The particle diameter of S-liposomes was smaller than that of I-liposomes. The penetra...

journal_title：Biological & pharmaceutical bulletin

authors： Natsuki R,Morita Y,Osawa S,Takeda Y

更新日期：1996-05-01 00:00:00

abstract：:Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited m...

journal_title：Biological & pharmaceutical bulletin

authors： Oh KB,Mar W,Kim S,Kim JY,Lee TH,Kim JG,Shin D,Sim CJ,Shin J

更新日期：2006-03-01 00:00:00

abstract：:We investigated a method for the simultaneous screening, identification, and quantitative determination of salicylic acid, acetaminophen, theophylline, barbiturates, and bromvalerylurea, drugs that frequently cause acute poisoning in Japan and therefore require rapid analysis for effective treatment in the clinical se...

journal_title：Biological & pharmaceutical bulletin

authors： Hori Y,Fujisawa M,Shimada K,Hirose Y,Yoshioka T

更新日期：2006-01-01 00:00:00

abstract：:The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like,...

journal_title：Biological & pharmaceutical bulletin

authors： Lee BM,Kim HS,Jeohn GH

更新日期：2000-07-01 00:00:00

abstract：:Biotin-binding human immunoglobulin G (B-IgG) was quantitatively measured using an F(ab')2anti-human IgG-coated multi-well microplate for the first time. B-IgG was caught by F(ab')2anti-human IgG and was detected by the following detecting reagents: Peroxidase-labeled streptavidin, avidin and peroxidase-biotin, or avi...

journal_title：Biological & pharmaceutical bulletin

authors： Muratsugu M,Muramoto E,Fukui T

更新日期：2003-11-01 00:00:00

abstract：:The liposome, a closed phospholipid bilayered vesicular system, has received considerable attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of liposomes to encapsulate both hydrophilic and hydrophobic drugs, coupled with their biocompatibility and biodegradability, make lipos...

journal_title：Biological & pharmaceutical bulletin

authors： Abu Lila AS,Ishida T

更新日期：2017-01-01 00:00:00

abstract：:DJ-927, currently undergoing Phase I clinical trial, is a new orally effective taxane with potent antitumor effects. The absorption, tissue distribution, and excretion of DJ-927 were investigated in mice, dogs, and monkeys after a single oral administration. After oral administration of [14C]DJ-927, radioactivity was ...

journal_title：Biological & pharmaceutical bulletin

authors： Ono C,Takao A,Atsumi R

更新日期：2004-03-01 00:00:00

abstract：:Shikonin, a major ingredient in the Chinese traditional herb Lithospermum erythrorhixon, exhibits multiple biological functions including antimicrobial, anti-inflammatory, and antitumor effects. In this study, we delineated the molecular mechanisms of shikonin in the apoptosis of 143B osteosarcoma cells. Shikonin redu...

journal_title：Biological & pharmaceutical bulletin

authors： Chang IC,Huang YJ,Chiang TI,Yeh CW,Hsu LS

更新日期：2010-01-01 00:00:00

abstract：:A series of 8-substituted quinolines were synthesized and tested against seizures induced by maximal electro shock (MES), pentylenetetrazole (scMet) and antihypertensive activities. Neurologic deficit was evaluated by the rotarod test. Among the newly synthesized derivatives, several compounds with a 2-hydroxypropylox...

journal_title：Biological & pharmaceutical bulletin

authors： Muruganantham N,Sivakumar R,Anbalagan N,Gunasekaran V,Leonard JT

更新日期：2004-10-01 00:00:00

abstract：:To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flave...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi-Miyamoto T,Kawasuji T,Kuraishi Y,Suzuki H

更新日期：2003-05-01 00:00:00

abstract：:Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ is absorbed when a topical preparation is applied to cancerous tissue r...

journal_title：Biological & pharmaceutical bulletin

authors： Iida J,Kudo T,Shimada K,Yatsuno Y,Yamagishi S,Hasegawa S,Ike H,Sato T,Kagaya H,Ito K

更新日期：2013-01-01 00:00:00

abstract：:Tetramethylpyrazine is the active ingredient of a Chinese herbal medicine. In this study, tetramethylpyrazine was tested for its activities in irradiated bone marrow stromal QXMSC1 cells. The proliferation of QXMSC1 cells was measured by MTS assay kit and flow cytometry. To identify proteins involved in the processes ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma ZC,Tan HL,Xiao CR,Wang YG,Wang SQ,Gao Y

更新日期：2007-02-01 00:00:00

abstract：:The permeability of murine leukemia L1210 cells toward non-permeant fluorescent Lucifer Yellow (LY) was evaluated by flow cytometry following vortex-stirring of cells with LY in the presence of high molecular weight polyacrylic acid (A-119). Permeabilization by this technique was greatly enhanced in growth phase cells...

journal_title：Biological & pharmaceutical bulletin

authors： Noda Y,Shimizu N,Kawazoe Y

更新日期：1996-12-01 00:00:00

abstract：:The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topo...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada M,Hayashi K,Ikeda S,Tsutsui K,Tsutsui K,Ito T,Iinuma M,Nozaki H

更新日期：2006-07-01 00:00:00

abstract：:The effects of nefiracetam on the cerebral adenylyl cyclase (AC) activity of animals with microsphere embolism-induced memory dysfunction were examined. Sustained cerebral ischemia in the right cerebral hemisphere was induced by an injection of microspheres into the right internal carotid artery of rats. To examine le...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Miyake-Takagi K,Kikuchi K,Ando T,Ichikawa T,Omino K,Kajihara H,Takagi N,Tanonaka K

更新日期：2003-03-01 00:00:00

abstract：:As a study to assess the potential application of milk fat-globule membrane (MFGM), which is of natural origin and expected to be a safer alternative to synthetic emulsifiers, to pharmaceutical dosage forms, the oral absorption of alpha-linolenic acid was evaluated by the analysis of gastrointestinal disposition after...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Sekiya M,Ozeki S,Watanabe J

更新日期：1994-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the influence of caffeine and theophylline on the development of dental caries in rats. Six Wistar dams (spf), mutans streptococci free, were obtained, each with six male pups. The dams were infected by Streptococcus sobrinus 6715 and divided into three groups which received d...

journal_title：Biological & pharmaceutical bulletin

authors： Ruenis AP,Rosalen PL,Volpato MC,Groppo FC

更新日期：2000-03-01 00:00:00

abstract：:Hairy roots of interspecific hybrid ginseng (Panax ginseng x P. quinquefolium), induced by Agrobacterium rhizogenes ATCC 15834, grew well in B5 liquid media supplemented with 2.5 microM auxins (3-indole butyric acid (IBA), 1-naphtaleneacetic acid (NAA) and 3-indoleacetic acid (IAA)). The hairy roots cultured in B5 liq...

journal_title：Biological & pharmaceutical bulletin

authors： Washida D,Shimomura K,Takido M,Kitanaka S

更新日期：2004-05-01 00:00:00