Investigation of phagocyte-inducible factor in tumor-implanted mice.

Abstract:

:The number of spleen Mac-1-positive cells was markedly increased in methylcholanthrene-induced Meth-A fibrosarcoma (Meth-A)-implanted mice. When the sera of Meth-A-implanted mice were added to normal bone marrow cells, granulocyte and macrophage colony stimulating factor (GM-CSF)-dependent growth of bone marrow cells was significantly enhanced. Analysis of the Meth-A-implanted mice sera showed that the levels of serum transferrin were markedly elevated. When the sera of Meth-A-implanted mice were pretreated with anti-mouse transferrin antibody, the enhancement of GM-CSF-dependent cell growth was almost abolished. Cell growth was also stimulated by the addition of transferrin which also caused an increase in the number of Mac-1-positive cells. Analysis of the effect of transferrin on bone marrow cells showed that the response of the cells to GM-CSF was significantly increased by preincubation with transferrin.

journal_name

Biol Pharm Bull

authors

Watanabe T,Okada A,Mikami T,Matsumoto T,Suzuki M

doi

10.1248/bpb.18.1643

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1643-6

issue

12

eissn

0918-6158

issn

1347-5215

journal_volume

18

pub_type

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