Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis.

abstract：:The present work aimed to investigate the vasorelaxant effect of isotirumalin, a dihydroflavonol isolated from Derris urucu (Leguminosae). The vasorelaxant effect of isotirumalin was investigated in the rat aorta, in the presence and in the absence of a functional endothelium. The production of nitric oxide (NO) induc...

journal_title：Biological & pharmaceutical bulletin

authors： Mendes LJ,Capettini LS,Lôbo LT,da Silva GA,Arruda MS,Lemos VS,Côrtes SF

更新日期：2011-01-01 00:00:00

abstract：:In Parkinson's disease, while dopamine (DA) replacement therapy, such as with L-DOPA (levodopa), improves the symptoms, it does not inhibit the degeneration of DA neurons in the substantia nigra. Numerous studies have suggested that both endogenous and environmental neurotoxins and oxidative stress may participate in ...

journal_title：Biological & pharmaceutical bulletin

authors： Kitamura Y,Kakimura J,Taniguchi T

更新日期：2002-03-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) play key roles in the early stage of atherosclerosis. Nitric oxide (NO) and ROS are responsible for regulation of the transcriptional pathways of nuclear Factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK), key regulators of c...

journal_title：Biological & pharmaceutical bulletin

authors： Han JM,Jin YY,Kim HY,Park KH,Lee WS,Jeong TS

更新日期：2010-01-01 00:00:00

abstract：:The present study describes the activity of Ca(2+)-ATPase in liver plasma membrane and cytosolic-free Ca2+ concentration ([Ca2+]i) in an individual vital cell in mouse liver 18 h after endotoxin administration. Ca(2+)-ATPase activity in liver plasma membrane in the poisoned mice was markedly decreased to 28% of that i...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi S,Tsutsumi E,Yokota K

更新日期：1993-08-01 00:00:00

abstract：:Small extracellular vesicles (sEVs), including exosomes as typical example, are cell-derived vesicles comprising lipid bilayer with a diameter approximately 100 nm. sEVs are endogenous delivery vehicles that deliver their contents such as nucleic acids and proteins to recipient cells. Because of their potential nature...

journal_title：Biological & pharmaceutical bulletin

authors： Takakura Y,Matsumoto A,Takahashi Y

更新日期：2020-01-01 00:00:00

abstract：:Human parvovirus B19 is a clinically important pathogen in both children and adults. In adults, it frequently causes acute and chronic arthritis, which may be related to persistent infection. The effect of the capsid of human parvovirus B19 on monocytes, which are thought to be responsible for the first line of defens...

journal_title：Biological & pharmaceutical bulletin

authors： Fujita T,Ikejima H,Yamagata N,Kudo Y,Hoshi K

更新日期：2007-11-01 00:00:00

abstract：:To investigate the protective effect of ginsenoside Re (Re) against cerebral ischemia-reperfusion injury, adult male Wistar rats weighing 250-300 g were subjected to either sham surgery or middle cerebral artery occlusion (MCAO) for 2 h of brain ischemia and 2 h reperfusion. A fluorescence polarization assay was carri...

journal_title：Biological & pharmaceutical bulletin

authors： Zhou XM,Cao YL,Dou DQ

更新日期：2006-12-01 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs) are produced primarily by CYPs from arachidonic acid (AA) and then further metabolized to the corresponding dihydroxyeicosatrienoic acids (DHETs). EETs play important roles in physiological processes such as regulating vasodilation and inflammation. Thus, the drug inhibition of CYP-med...

journal_title：Biological & pharmaceutical bulletin

authors： Mukai Y,Toda T,Takeuchi S,Senda A,Yamashita M,Eliasson E,Rane A,Inotsume N

更新日期：2015-01-01 00:00:00

abstract：:CCAAT/enhancer-binding protein delta (C/EBPdelta) transcription factor is rapidly induced at an early stage of acute phase response. We previously reported that this induction was mainly mediated by acute phase response factor/signal transducers and activators of transcription 3 (APRF/STAT3). Furthermore, the high exp...

journal_title：Biological & pharmaceutical bulletin

authors： Tanabe A,Kumahara C,Osada S,Nishihara T,Imagawa M

更新日期：2000-12-01 00:00:00

abstract：:Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitte...

journal_title：Biological & pharmaceutical bulletin

authors： Sato-Masumoto N,Uchikura T,Sugiwaki H,Yoshimura M,Masada S,Atsumi T,Watanabe M,Tanaka N,Uchiyama N,Amakura Y,Hakamatsuka T

更新日期：2017-01-01 00:00:00

abstract：:The inducibility of chromosomal aberration was studied using five mammalian topoisomerase inhibitors in Chinese hamster lung fibroblastic cells (CHL) in two protocols involving 6 and 24 h treatment, with respect to the mechanism of chromosomal aberration. In the 6 h treatment plus 18 h recovery culture (6 h treatment)...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki H,Nakane S

更新日期：1994-02-01 00:00:00

abstract：:A protocol for de novo regeneration and rapid micropropagation of Scrophularia yoshimurae (Scrophulariaceae) has been developed. Multiple shoot development was achieved by culturing the shoot-tip, leaf-base, stem-node and stem-internode explants on Murashige and Skoog (MS) medium supplemented with 4.44 microM N6-benzy...

journal_title：Biological & pharmaceutical bulletin

authors： Sagare AP,Kuo CL,Chueh FS,Tsay HS

更新日期：2001-11-01 00:00:00

abstract：:Chronic fatigue (CF) is a common reason for consulting a physician due to affecting quality of life, but only a few effective treatments are available. The aim of this study was to examine the effectiveness of subcutaneous injection of the human placental extract (HPE) on medically indescribable cases of CF and safety...

journal_title：Biological & pharmaceutical bulletin

authors： Park SB,Kim KN,Sung E,Lee SY,Shin HC

更新日期：2016-05-01 00:00:00

abstract：:Some P450 enzymes are expressed not only in the liver but also in the small intestine, and these enzymes play an important role in first-pass drug metabolism in the small intestine. Cytochrome P450 (CYP)2C19 has been confirmed to exist in the small intestine of white people, but not yet in Japanese. We investigated th...

journal_title：Biological & pharmaceutical bulletin

authors： Hayashi M,Matsumoto N,Takenoshita-Nakaya S,Takeba Y,Watanabe M,Kumai T,Takagi M,Tanaka M,Otsubo T,Kobayashi S

更新日期：2011-01-01 00:00:00

abstract：:The effects of gamma-oryzanol, a drug mainly used for the treatment of hyperlipidaemia, on several cytochrome P450 (CYP) specific reactions in human liver microsomes were investigated to predict drug interactions with gamma-oryzanol in vivo from in vitro data. The following eight CYP catalytic reactions were used in t...

journal_title：Biological & pharmaceutical bulletin

authors： Umehara K,Shimokawa Y,Miyamoto G

更新日期：2004-07-01 00:00:00

abstract：:An accumulating body of evidence indicates that inflammation plays a crucial role in the pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is an intracellular multiprotein complex that regulates caspase-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Takahashi M

更新日期：2019-01-01 00:00:00

abstract：:The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sano K,Koushi E,Irie K,Higuchi S,Tsuchihashi R,Kinjo J,Egashira N,Oishi R,Uchida N,Nagai H,Nishimura R,Tanaka H,Morimoto S,Mishima K,Iwasaki K,Fujiwara M

更新日期：2009-12-01 00:00:00

abstract：:A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 microm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5-200 ng...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura M,Fukawa K,Sugiyama T,Katagiri Y

更新日期：2004-06-01 00:00:00

abstract：:Changes in carbonyl reductase (CR) activity towards seven substrates in adrenal glands of female rats were investigated during estrous cycle and the circadian patterns of adrenal CR activity towards seven substrates in male rats were examined. The localization of the enzyme protein in the adrenal gland was carried out...

journal_title：Biological & pharmaceutical bulletin

authors： Inazu N,Nagashima Y,Satoh T

更新日期：1995-05-01 00:00:00

abstract：:Stevens-Johnson syndrome (SJS) was diagnosed in a 39-year-old woman, treated with ampicillin (4000-8000 mg daily), phenytoin (250 mg daily), and furosemide (20-40 mg daily) for 25, 21, and 20 d, respectively, before the appearance of the eruption. The lymphocyte stimulation test with the MTT [3-(4,5-dimethyl thiazol-2...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshimura T,Hamaguchi E,Usami E,Nakashima K,Kawaguchi M,Suzuki N,Okamoto Y,Nakao T,Yamazaki F

更新日期：2004-06-01 00:00:00

abstract：:The hydrodynamic method by rapid intravenous injection of a large volume of plasmid DNA is known to be an efficient and liver-specific method of in vivo gene delivery and achieves high levels of foreign gene expression, particularly in hepatocytes. Low transgene activities have also been observed in other organs such ...

journal_title：Biological & pharmaceutical bulletin

authors： Hattori Y,Koga K,Izumisawa T,Yamasaki M,Narishima R,Yoshida S,Fukui T,Maitani Y

更新日期：2009-04-01 00:00:00

abstract：:The purpose of this research is improvement of therapeutic treatment for periodontitis by using lipophilic and/or hydrophilic zinc materials. The sample suspension injections were prepared from zinc octanate (C8Zn), zinc stearate (C18Zn), zinc sulfate hepta-hydrate (ZnSO4) and tricalcium phosphate (ZnTCP) containing 6...

journal_title：Biological & pharmaceutical bulletin

authors： Tokudome Y,Otsuka M

更新日期：2012-01-01 00:00:00

abstract：:Penicillin binding proteins (PBPs) are penicillin-sensitive DD-peptidases catalyzing the terminal stages of bacterial cell wall assembly. We identified a Dictyostelium discoideum gene that encodes a protein of 522 amino acids showing similarity to Escherichia coli PBP4. The D. discoideum protein conserves three consen...

journal_title：Biological & pharmaceutical bulletin

authors： Yasukawa H,Kuroita T,Tamura K,Yamaguchi K

更新日期：2003-07-01 00:00:00

abstract：:The aim of this study was to determine the stimulatory effects of Maillard reaction, a non-enzymatic browning reaction on the expression of pro-inflammatory cytokines and phagocytic activity induced by whey protein concentrate (WPC). Glycated WPC (G-WPC) was prepared by a reaction between WPC and the lactose it contai...

journal_title：Biological & pharmaceutical bulletin

authors： Chun SH,Lee HA,Lee KB,Kim SH,Park KY,Lee KW

更新日期：2016-01-01 00:00:00

abstract：:The objectives of the present study were to assess pharmacokinetics, pharmacodynamics, tolerability and safety of intravenous administration of bivalirudin, a direct thrombin inhibitor, in healthy Chinese subjects. 48 subjects were equally divided into 4 groups (0.5 mg/kg, 0.75 mg/kg, 1.05 mg/kg intravenous bolus, and...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang D,Wang Z,Zhao X,Lu W,Gu J,Cui Y

更新日期：2011-01-01 00:00:00

abstract：:Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is the principal source of reducing power in numerous processes of physiological importance. We examined the influence of oxidative stress on the relative amounts of NADPH in human red blood cells (RBCs). To determine the homeostasis of the NADPH existing in ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogasawara Y,Funakoshi M,Ishii K

更新日期：2009-11-01 00:00:00

abstract：:Proteasome inhibitors are a novel class of molecular-targeted anti-cancer drugs that suppress the degradation of malfolded proteins, trigger endoplasmic reticulum (ER) stress, and activate apoptosis signals. Glucose-regulated protein 78 (GRP78), a major ER chaperone, is one of the most important molecules for transduc...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura K,Sakai C,Kawakami S,Yamashita F,Hashida M

更新日期：2014-01-01 00:00:00

abstract：:While the use of in vitro-transcribed mRNA (IVT-mRNA) in therapeutics is a rapidly expanding area, the transfection of the exogenous IVT-mRNA is accompanied by a risk of immune activation. This immunological defense mechanism suppresses cellular translation process and can reduce transfection efficiency to a considera...

journal_title：Biological & pharmaceutical bulletin

authors： Ohto T,Konishi M,Tanaka H,Onomoto K,Yoneyama M,Nakai Y,Tange K,Yoshioka H,Akita H

更新日期：2019-01-01 00:00:00

abstract：:A series of anthracene derivatives have been synthesized, and their potential individual cytotoxicity was evaluated using Jurkat T cells and peripheral blood mononuclear cells (PBMCs) in vitro. These compounds, except for 2l, showed less cytotoxicity in PBMCs than mitoxantrone. We also analyzed the antiproliferative a...

journal_title：Biological & pharmaceutical bulletin

authors： Chen RF,Chou CL,Wang MR,Chen CF,Liao JF,Ho LK,Tao CW,Huang HS

更新日期：2004-06-01 00:00:00

abstract：:A rat model of early sepsis induced by lipopolysaccharide (LPS) combined with interleukin-2 (IL-2) was developed. The primary aim was to assess the pharmacokinetics of gentamicin and sepsis-induced pathophysiological changes. Moreover, the effects on the glomerular filtration rate and tubular function were studied in ...

journal_title：Biological & pharmaceutical bulletin

authors： Studena S,Martinkova J,Slizova D,Krs O,Senkerik M,Springer D,Chládek J

更新日期：2012-01-01 00:00:00