In vitro response of immunoregulatory cytokine expression in human monocytic cells to human parvovirus B19 capsid.

abstract：:Effects of supplemented docosahexaenoic acid (DHA), given as diacylglycerol (DG) rich in DHA (DHA-DG), triacylglycerol (TG) rich in DHA (DHA-TG) or fish oil concentrate (DHA-70), on the serum concentration of TG and its bioavailability in the rats with diet-induced hyperlipidemia were studied. Hypertriglyceridemia was...

journal_title：Biological & pharmaceutical bulletin

authors： Tamai T,Murota I,Maruyama K,Baba T,Toyama T,Watanabe N,Kudo N,Kawashima Y

更新日期：2007-12-01 00:00:00

abstract：:Defining a quantitative and reliable relationship between in vitro drug release and in vivo absorption is highly desired for rational development, optimization, and evaluation of controlled-release dosage forms and manufacturing process. During the development of once daily extended-release (ER) tablet of glipizide, a...

journal_title：Biological & pharmaceutical bulletin

authors： Ghosh A,Bhaumik UK,Bose A,Mandal U,Gowda V,Chatterjee B,Chakrabarty US,Pal TK

更新日期：2008-10-01 00:00:00

abstract：:Schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has been shown to enhance mitochondrial antioxidant status in liver, heart and brain tissues in rodents. Whether or not long-term Sch B treatment can protect against oxidative stress-induced cerebral damage remai...

journal_title：Biological & pharmaceutical bulletin

authors： Chen N,Chiu PY,Ko KM

更新日期：2008-07-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the chemoresistant cancers. There is a pressing need to establish therapeutic approaches to prevent RCC proliferation and metastasis. The electrophilic 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is an endogenous anti-cancerous agent. Treatment with high concentrations of 15d-PGJ2 ...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto Y,Koma H,Yagami T

更新日期：2020-01-01 00:00:00

abstract：:In addition to regulation of normal cell functions, hepatocyte growth factor (HGF) has also been shown to be involved in malignant cell transformation and in growth, invasion and metastasis in cancer cells. Inhibitors of HGF production have a potential for interfering with malignant cell transformation and progression...

journal_title：Biological & pharmaceutical bulletin

authors： Motoki T,Takami Y,Yagi Y,Tai A,Yamamoto I,Gohda E

更新日期：2005-02-01 00:00:00

abstract：:The present paper proposes a new approach for fitting the plasma effect-site equilibrium rate constant (Ke0) of propofol to satisfy the condition that the effect-site concentration (Ce) is equal at the time of loss of consciousness (LOC) and recovery of consciousness (ROC). Forty patients receiving intravenous anesthe...

journal_title：Biological & pharmaceutical bulletin

authors： Wu Q,Sun B,Wang S,Zhao L,Qi F

更新日期：2013-01-01 00:00:00

abstract：:The pharmacokinetics of ketotifen fumarate (KF) was examined after administration in rabbits through four different routes (intravenous, intranasal, oral and rectal). The time-course of the plasma concentration of KF after intravenous administration (1 mg/kg dose) fitted a two-compartment open model. KF was rapidly ab...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Taniuchi Y,Hamada K,Sudo J,Sekikawa H

更新日期：2002-12-01 00:00:00

abstract：:To investigate chemopreventive effect of liposomal beta-sitosterol on tumor metastasis, we prepared liposomal beta-sitosterol composed of egg yolk phosphatidylcholine for oral delivery. Although orally administered beta-sitosterol (4 micromol as beta-sitosterol/mouse) was not absorbed into plasma, the amount of immune...

journal_title：Biological & pharmaceutical bulletin

authors： Imanaka H,Koide H,Shimizu K,Asai T,Kinouchi Shimizu N,Ishikado A,Makino T,Oku N

更新日期：2008-03-01 00:00:00

abstract：:The effect of 4-(4-chlorobenzyl)pyridine (4-CBP) on rat hepatic microsomal cytochrome P450 (P450) and its molecular species (CYP2B1, 2E1, 3A2, 2C11, and 2C12), and on drug-metabolizing enzyme activities were examined in vivo and in vitro. Treatment of rats with 4-CBP resulted in the induction of P450 and drug-metaboli...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi Y,Ohshiro N,Sasaki T,Tokuyama S,Tobe T,Yoshida T,Yamamoto T

更新日期：2001-05-01 00:00:00

abstract：:R(-)-Apomorphine is a dopamine agonist used for rescue management of motor function impairment associated with levodopa therapy in Parkinson's disease patients. The aim of this study was to examine the role of proton-coupled organic cation antiporter in uptake of R(-)-apomorphine and its S-enantiomer in human brain, u...

journal_title：Biological & pharmaceutical bulletin

authors： Okura T,Higuchi K,Kitamura A,Deguchi Y

更新日期：2014-01-01 00:00:00

abstract：:Feast/famine regulatory proteins (FFRPs) comprise a single group of transcription factors systematically distributed throughout archaea and eubacteria. In the eubacterial domain in Escherichia coli, autotrophic pathways are activated and heterotrophic pathways are repressed by an FFRP, the leucine-responsive regulator...

journal_title：Biological & pharmaceutical bulletin

authors： Kawashima T,Aramaki H,Oyamada T,Makino K,Yamada M,Okamura H,Yokoyama K,Ishijima SA,Suzuki M

更新日期：2008-02-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:Sixteen flavonoids including quercetin and kaempferol and their relatives were examined for their ability to promote DNA degradation induced by the bleomycin (BLM)-Fe complex. Three hydroxyl groups in the flavonoidal nucleus were proposed as a crucial structural requirement for effectively promoting DNA degradation: 1...

journal_title：Biological & pharmaceutical bulletin

authors： Sugihara N,Kaneko A,Furuno K

更新日期：2003-08-01 00:00:00

abstract：:Candida albicans is the most important human fungal pathogen. Amphotericin (AmB) is a gold standard of antifungal treatment for fungi, but the severe side effect of this drug restricts its clinical application. In this study, the interaction of AmB and baicalein (BE) was investigated against thirty clinical isolates o...

journal_title：Biological & pharmaceutical bulletin

authors： Fu Z,Lu H,Zhu Z,Yan L,Jiang Y,Cao Y

更新日期：2011-01-01 00:00:00

abstract：:Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

journal_title：Biological & pharmaceutical bulletin

authors： de Allori MC,Jure MA,Romero C,de Castillo ME

更新日期：2006-08-01 00:00:00

abstract：:Pantethine and fursultiamine have been evaluated for their clinical usefulness in the treatment and prevention of uncomplicated postoperative adhesive intestinal obstruction. In recent years, the actions of drugs used to treat gastrointestinal diseases have been elucidated pharmacologically from the viewpoints of gast...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Itoh H,Abe T,Nishimura F,Sato Y,Takeyama M

更新日期：2011-01-01 00:00:00

abstract：:Accumulation of β-amyloid peptide (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). Previous studies have demonstrated the neuroprotective role of osthole against oxygen and glucose deprivation in cortical neurons. However, the effects of osthole on Aβ-induced neurotoxicity in ...

journal_title：Biological & pharmaceutical bulletin

authors： Hu Y,Wen Q,Liang W,Kang T,Ren L,Zhang N,Zhao D,Sun D,Yang J

更新日期：2013-01-01 00:00:00

abstract：:Cancer is one of the leading causes of death in the world. The triterpenoid compound asiatic acid derived from the tropical medicinal plant Centella asiatica displays cytotoxic activity on fibroblast cells and several other kinds of cells. The present work studies asiatic acid-mediated growth inhibition of cancer cell...

journal_title：Biological & pharmaceutical bulletin

authors： Tang XL,Yang XY,Jung HJ,Kim SY,Jung SY,Choi DY,Park WC,Park H

更新日期：2009-08-01 00:00:00

abstract：:The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 m...

journal_title：Biological & pharmaceutical bulletin

authors： Mantena SK,Mutalik S,Srinivasa H,Subramanian GS,Prabhakar KR,Reddy KR,Srinivasan KK,Unnikrishnan MK

更新日期：2005-03-01 00:00:00

abstract：:ICR/f mutation in rat, an inherited disorder, is characterized by the development of cataracts. In this study, we analyzed and compared the crystallins in normal and cataractous rat lenses using gel filtration and two-dimensional gel electrophoresis, and determined the transglutaminase activities and Ca2+ content in t...

journal_title：Biological & pharmaceutical bulletin

authors： Takeuchi N,Kamei A

更新日期：2000-03-01 00:00:00

abstract：:RS-7897 is a novel antianginal nitrate containing an L-2-oxothiazolidine-4-carboxylic acid (OTCA) and unlike other organic nitrates does not induce nitrate tolerance. OTCA is known to be converted to L-cysteine (L-Cys) by rat 5-oxo-prolinase (5-OPase) and was detected in the plasma of RS-7897-treated dogs. Nitrate tol...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe T,Abe K,Ishikawa H,Iijima Y

更新日期：2004-03-01 00:00:00

abstract：:We have previously reported that restraint stress inhibits small intestinal motility in rats, and that the adrenergic beta3-antagonist SR59230A administration recovered the inhibition. In the present study, we compared the effects of restraint stress and norepinephrine on small intestinal motility using alpha- and bet...

journal_title：Biological & pharmaceutical bulletin

authors： Tsukada F,Sawamura K,Kohno H,Ohkubo Y

更新日期：2002-01-01 00:00:00

abstract：:Voltage-gated calcium channels (VGCCs) are classified into high-voltage-activated (HVA) channels and low-voltage-activated channels consisting of Cav3.1-3.3, known as T ("transient")-type VGCC. There is evidence that certain types of HVA channels are involved in neurogenic inflammation and inflammatory pain, in agreem...

journal_title：Biological & pharmaceutical bulletin

authors： Sekiguchi F,Tsubota M,Kawabata A

更新日期：2018-01-01 00:00:00

abstract：:Hydroxyoctadecadienoic acids (HODEs) are generated by oxidation of linoleic acid in vivo and thought to mediate various pathophysiological responses. In this study, we examined the effects of HODEs on EL4 mouse lymphoma cell growth and found that 9-(E,Z)-HODE inhibited EL4 cell growth in a dose-dependent manner, where...

journal_title：Biological & pharmaceutical bulletin

authors： Kodaka A,Hayakawa Y,AlSayegh RJ,Yasuhara T,Tomoda H,Oku T,Dan S,Tsuiji M,Tsuji T

更新日期：2019-01-01 00:00:00

abstract：:We investigated the effect of components in grapefruit juice (GFJ) on the transport of vinblastine, a substrate of P-glycoprotein (P-gp), across Caco-2 cells. The apical to basolateral flux of [3H]vinblastine was increased in the presence of GFJ extracts. The steady-state uptake of [3H]vinblastine from the apical side...

journal_title：Biological & pharmaceutical bulletin

authors： Takanaga H,Ohnishi A,Matsuo H,Sawada Y

更新日期：1998-10-01 00:00:00

abstract：:Calreticulin (CRT) and calnexin (CNX), homologous major chaperones in the endoplasmic reticulum (ER), are known to translocate to the cell surface in response to chemotherapeutic agents, such as mitoxantrone (MIT), and cellular stresses, including apoptosis. Cell surface CRT (ecto-CRT) is relevant to the phagocytic up...

journal_title：Biological & pharmaceutical bulletin

authors： Azuma Y,Suzuki K,Higai K,Matsumoto K,Tada S

更新日期：2020-10-01 00:00:00

abstract：:Oyaksungisan, the herbal prescription composed of eleven herbs, has been widely used in treatment of cerebral infarct in Oriental Medicine. However, the mechanisms by which the herbal formula affects on the production of pro- and anti-inflammatory cytokines in cerebral infarction patients remain unknown yet. The secre...

journal_title：Biological & pharmaceutical bulletin

authors： Kim Y,So HS,Kim JK,Park C,Lee JH,Woo WH,Cho KH,Moon BS,Park R

更新日期：2007-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the effect of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) on oxidative stress in plasma and pancreas of streptozotocin (STZ) induced diabetic rats. Oral administration of each of the seed extr...

journal_title：Biological & pharmaceutical bulletin

authors： Sathishsekar D,Subramanian S

更新日期：2005-06-01 00:00:00

abstract：:Diosgenyl saponins are the most abundant steroid saponins, and exert a large variety of biological functions. In a previous report, we showed that dioscin was able to induce cytotoxicity and apoptosis in human myeloblast leukemia HL-60 cells. This study further investigated the action mechanisms underlying this effect...

journal_title：Biological & pharmaceutical bulletin

authors： Liu MJ,Wang Z,Ju Y,Zhou JB,Wang Y,Wong RN

更新日期：2004-07-01 00:00:00

abstract：:Manganese (Mn) plays an important role in the etiology of several neurobehavioral disorders, but there is a lack of data regarding its specific effects on neurotransduction, especially dopaminergic neurotransduction. We investigated the relationship between motor deficits and alterations in the expression of tyrosine ...

journal_title：Biological & pharmaceutical bulletin

authors： Nam J,Kim K

更新日期：2008-10-01 00:00:00