Abstract:
:Cancer is one of the leading causes of death in the world. The triterpenoid compound asiatic acid derived from the tropical medicinal plant Centella asiatica displays cytotoxic activity on fibroblast cells and several other kinds of cells. The present work studies asiatic acid-mediated growth inhibition of cancer cells and the underlying mechanism. Asiatic acid markedly inhibited cancer cell proliferation. Apoptosis of SW480 human colon cancer cells was induced by asiatic acid as shown by flow cytometry, DNA fragmentation and nuclear chromatin condensation experiments. Through increasing mitochondrial membrane permeability and cytochrome c release from mitochondria into cytosol, asiatic acid induced caspase-9 activity, which further activated caspase-3 and poly(ADP-ribose) polymerase cleavage resulting in irreversible apoptotic death in the tumor cells. Taken together, these results suggest that mitochondrial death apoptosis cascade plays very important roles in asiatic acid-induced cancer apoptosis.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Tang XL,Yang XY,Jung HJ,Kim SY,Jung SY,Choi DY,Park WC,Park Hdoi
10.1248/bpb.32.1399subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1399-405issue
8eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/32.1399journal_volume
32pub_type
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