Biochemical characterization of a Pseudomonas fluorescens strain isolated from a benzalkonium chloride solution.

abstract：:Nanoparticles are used in many fields and in everyday products. Silver nanoparticles are the most frequently used nanoparticles; for example, in food-related products, owing to their antibacterial activity. However, it has been pointed out that they might have unexpected biological effects, and evaluation of their eff...

journal_title：Biological & pharmaceutical bulletin

authors： Maki A,Lin Y,Aoyama M,Sato K,Gao JQ,Tsujino H,Nagano K,Higashisaka K,Tsutsumi Y

更新日期：2020-01-01 00:00:00

abstract：:Nitrogen oxide, which is produced by activated macrophages, has been demonstrated to possess anti-tumor activity. We report herein the synergistic effect of sodium nitrite (NO2-) and/or sodium nitroprusside (SNP) on lysophospholipid (LysoPL)-mediated cytolysis. The incubation of 51Cr-labeled mouse melanoma (B16) cells...

journal_title：Biological & pharmaceutical bulletin

authors： Kanematsu M,Takagi K,Suketa Y

更新日期：1994-01-01 00:00:00

abstract：:The effect of the Dynorphin A analog, E2078, on the physicochemical properties of lipid membranes was investigated. E2078 induces the leakage of calcein, especially out of negatively-charged vesicles. The peptide binds to dipalmitoylphosphatidylglycerol sonicated vesicles according to the Lamgmuir isotherm, with a bin...

journal_title：Biological & pharmaceutical bulletin

authors： Asai Y,Watanabe S

更新日期：1999-05-01 00:00:00

abstract：:The effect of carboxamidemethylated Fc fragment (CM-Fc) from human immunoglobulin G (IgG) on type II collagen (C II)-induced arthritis (CIA) in DBA/1J mice was studied. CM-Fc suppressed the development of CIA while Fc fragment did not. CM-Fc inhibited the increase in serum anti-C II IgG. CM-Fc suppressed C II-induced ...

journal_title：Biological & pharmaceutical bulletin

authors： Mimura T,Itoh M,Gohgi H,Suzuki N,Takeuchi K,Tsujikawa K,Kohama Y

更新日期：1994-05-01 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson's disease. LRRK2 is a large protein with multiple functional domains, including a guanosine 5'-triphosphate (GTP)-binding domain and a protein kinase domain. Recent studies indicated that the members of the Rab GTPase family, Rab8...

journal_title：Biological & pharmaceutical bulletin

authors： Imai M,Kawakami F,Kubo M,Kanzaki M,Maruyama H,Kawashima R,Maekawa T,Kurosaki Y,Kojima F,Ichikawa T

更新日期：2020-01-01 00:00:00

abstract：:R(-)-Apomorphine is a dopamine agonist used for rescue management of motor function impairment associated with levodopa therapy in Parkinson's disease patients. The aim of this study was to examine the role of proton-coupled organic cation antiporter in uptake of R(-)-apomorphine and its S-enantiomer in human brain, u...

journal_title：Biological & pharmaceutical bulletin

authors： Okura T,Higuchi K,Kitamura A,Deguchi Y

更新日期：2014-01-01 00:00:00

abstract：:We investigated the effects of restraint and footshock stress and norepinephrine treatment on gastric emptying. The gastric emptying was significantly inhibited by restraint stress. beta(3)-adrenergic antagonist canceled the inhibition of gastric emptying caused by restraint stress, while beta(1)-, beta(2)-, alpha(1)-...

journal_title：Biological & pharmaceutical bulletin

authors： Tsukada F,Nagura Y,Abe S,Sato N,Ohkubo Y

更新日期：2003-03-01 00:00:00

abstract：:Nafamostat mesilate, an ester drug with extensive hydrolysis in vivo, exhibits species difference in the relative contribution for its hydrolysis in blood and tissues. For the rat, the main hydrolysis site may be blood and human may be tissue (mainly by liver). The paper gave in vivo evidence that human tissue may giv...

journal_title：Biological & pharmaceutical bulletin

authors： Cao YG,Chen YC,Hao K,Zhang M,Liu XQ

更新日期：2008-11-01 00:00:00

abstract：:We reported previously that N-linked glycoproteins were accumulated in the cytosol of the normal aging rat brain, and that one protein had been identified as cathepsin D (Mech. Ageing Dev., 127, 771-778 (2006)). In this study, to elucidate the mechanism of cathepsin D accumulation in the cytosol, we examined the effec...

journal_title：Biological & pharmaceutical bulletin

authors： Miura Y,Sakurai Y,Hayakawa M,Shimada Y,Zempel H,Sato Y,Hisanaga S,Endo T

更新日期：2010-01-01 00:00:00

abstract：:Acute toxicity (24 h) and general behavior in mice of a lignan from Justicia hyssopifolia, a beta-D-glucoside (elenoside), was studied, and the cytotoxic activity was performed. Elenoside (arylnaphthalene lignan) in mice showed a moderate toxicity order (305 mg/kg) and central depressive properties at doses of 25, 50,...

journal_title：Biological & pharmaceutical bulletin

authors： Navarro E,Alonso SJ,Alonso PJ,Trujillo J,Jorge E,Perez C

更新日期：2001-03-01 00:00:00

abstract：:Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K+ (KV) channel blockers on the resting tension in endothelium-...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiwara K,Ohya S,Suzuki Y,Yamamura H,Imaizumi Y

更新日期：2017-01-01 00:00:00

abstract：:The lactose transport system of Citrobacter freundii was characterized. Both the lactose transport system and beta-galactosidase were induced with either lactose or isopropyl-beta-D-thiogalactopyranoside (IPTG), the latter being the better inducer. The Km values for methyl-beta-D-thiogalactopyranoside (TMG) transport ...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki N,Tsuda M,Wilson TH,Tsuchiya T

更新日期：1994-06-01 00:00:00

abstract：:Mucus on the nasal mucosa is translocated to the pharynx by ciliary beating, which is an important nonspecific defense mechanism called mucociliary clearance (MC). MC is one of the important factors determining the rate and extent of drug absorption after nasal application. The purpose of this study is to evaluate MC ...

journal_title：Biological & pharmaceutical bulletin

authors： Inoue D,Furubayashi T,Ogawara K,Kimura T,Higaki K,Katsumi H,Sakane T,Yamamoto A,Higashi Y

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the influence of caffeine and theophylline on the development of dental caries in rats. Six Wistar dams (spf), mutans streptococci free, were obtained, each with six male pups. The dams were infected by Streptococcus sobrinus 6715 and divided into three groups which received d...

journal_title：Biological & pharmaceutical bulletin

authors： Ruenis AP,Rosalen PL,Volpato MC,Groppo FC

更新日期：2000-03-01 00:00:00

abstract：:The characteristics of the binding of human lactoferrin (LF) to the cells of a human monocytic leukemia cell line, THP-1, were investigated. 125I-Labeled LF (125I-LF) bound to THP-1 cells, and the binding increased markedly as the cells matured into macrophages (THP-1 macrophages) by stimulation with phorbol 12-myrist...

journal_title：Biological & pharmaceutical bulletin

authors： Eda S,Kikugawa K,Beppu M

更新日期：1996-02-01 00:00:00

abstract：:The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang JY,Leu YL,Hwang TL,Cheng HC

更新日期：2004-11-01 00:00:00

abstract：:The prophylactic action of scymnol in a rat peripheral arterial occlusion model, involving injection of 5% lactic acid into the femoral artery, was investigated. Increases in serum lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) activities and in plasma leve...

journal_title：Biological & pharmaceutical bulletin

authors： Ishida H,Nakayasu H,Nukaya H,Tsuji K

更新日期：1999-08-01 00:00:00

abstract：:In order to clarify the arrhythmogenic effects of nonsedating antihistamines, we examined the effects of astemizole, a nonsedating antihistamine, on ventricular activation and RT intervals in a canine myocardial infarction model. Myocardial infarction was produced by two-stage ligation of the left anterior descending ...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimoto M,Hashimoto H,Ohmura T,Ikeda Y,Watanabe S,Ohashi K,Umemura K,Nakashima M

更新日期：1997-09-01 00:00:00

abstract：:The immunoreactivity (specific binding) of three Gly(A1)-sulfobenzoxadiazole-labeled insulins which have different spacer groups, Gly(A1)-[3-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin , Gly(A1)-[2-(4-sulfobenzoxadiazol-7-ylthio)acetyl]-insulin, Gly(A1)-[3-carboxy-2(or 3)-(4-sulfobenzoxadiazol-7-ylthio)propanoyl...

journal_title：Biological & pharmaceutical bulletin

authors： Nanami M,Zaitsu K,Ohkura Y

更新日期：1993-05-01 00:00:00

abstract：:To study the role of asarinin on collagen-induced arthritis (CIA) and its treatment mechanism on dendritic cells (DCs) and T cells. Before the onset of arthritis, asarinin were given orally to CIA mouse. Macroscopic scoring and micrometer caliper measurement were used to assess arthritis. The occurrence of cartilage d...

journal_title：Biological & pharmaceutical bulletin

authors： Dai Q,Wang M,Li Y,Li J

更新日期：2019-07-01 00:00:00

abstract：:Aromatase is a cytochrome P-450 enzyme complex that catalyzes the conversion of androst-4-ene-3,17-dione (AD) to estrone through three sequential oxygenations of the 19-methyl group. To gain insight into the ability of AD isomers, 4-en-6-one 1a, 5-en-4-one 2a, and 5-en-7-one 3a, competitive inhibitors of aromatase wit...

journal_title：Biological & pharmaceutical bulletin

authors： Numazawa M,Yamada K,Nagaoka M

更新日期：2001-04-01 00:00:00

abstract：:Stevens-Johnson syndrome (SJS) was diagnosed in a 39-year-old woman, treated with ampicillin (4000-8000 mg daily), phenytoin (250 mg daily), and furosemide (20-40 mg daily) for 25, 21, and 20 d, respectively, before the appearance of the eruption. The lymphocyte stimulation test with the MTT [3-(4,5-dimethyl thiazol-2...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshimura T,Hamaguchi E,Usami E,Nakashima K,Kawaguchi M,Suzuki N,Okamoto Y,Nakao T,Yamazaki F

更新日期：2004-06-01 00:00:00

abstract：:It has been well known that 3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) formed by catechol O-methyltransferase (COMT), and 3-OMD blood level often reaches higher than physiological level in Parkinson's disease (PD) patients receiving long term L-DOPA therapy. However, the physiologi...

journal_title：Biological & pharmaceutical bulletin

authors： Onzawa Y,Kimura Y,Uzuhashi K,Shirasuna M,Hirosawa T,Taogoshi T,Kihira K

更新日期：2012-01-01 00:00:00

abstract：:Monocytes/macrophages are known to be involved in atherogenesis, and the adherence of monocytes to the endothelium is considered an earliest characteristic of atherogenesis. Therefore, we studied the mechanism by which Shosaikoto, a Kampo medicine, shows anti-atherosclerotic action, which has been already shown in hyp...

journal_title：Biological & pharmaceutical bulletin

authors： Shen YR,Inoue M,Ogihara Y

更新日期：1996-01-01 00:00:00

abstract：:T cells play a principal role in cellular immunity and govern the regulatory mechanism in humoral immunity. Therefore, T cells play a key role as either effectors or regulators in the immune network. Mizoribine (MZR), an immunosuppressive agent, suppresses both humoral and cellular immunity by acting on both T cells a...

journal_title：Biological & pharmaceutical bulletin

authors： Kamada H,Inoue N,Takaoka Y,Nakagami K,Mori H,Nagai H

更新日期：1996-09-01 00:00:00

abstract：:To predict the actions of T-3762, a newly developed fluoroquinolone antimicrobial agent, as well as ciprofloxacin (CPFX) and ofloxacin (OFLX), on injection sites when dosed parenterally, their ability to increase cutaneous vascular permeability in dogs and to release histamine from rat peritoneal mast cells was examin...

journal_title：Biological & pharmaceutical bulletin

authors： Furuhata K,Fukuda Y,Soumi K,Arai H,Watanabe Y,Narita H

更新日期：1998-05-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative CCR4 antagonists, RS-1154 and RS-1269. Here, we investigate the pharmacological profiles of a novel pyrimidine-derivative CCR4 antagonist, 2-{4-[2-(diethylamino)et...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagami Y,Kawase Y,Yonekubo K,Nosaka E,Etori M,Takahashi S,Takagi N,Fukuda T,Kuribayashi T,Nara F,Yamashita M

更新日期：2010-01-01 00:00:00

abstract：:The tissue distribution and disposition of carnitine, which plays an important role in the transport of long-chain fatty acids across the mitochondrial inner membrane for beta-oxidation, are well controlled by carnitine transporter organic cation/carnitine transporter 2 (OCTN2). Since little information is available o...

journal_title：Biological & pharmaceutical bulletin

authors： Maeda T,Wakasawa T,Funabashi M,Fukushi A,Fujita M,Motojima K,Tamai I

更新日期：2008-06-01 00:00:00

abstract：:Medicinal plants with reported anti-inflammatory activity could have the potential use as anti-allergens and inhibitors of allergic contact dermatitis reactions produced by allergens and chemicals. Some species from the genus Artocarpus were reported to have anti-inflammatory activity. In the Philippines one local sou...

journal_title：Biological & pharmaceutical bulletin

authors： Salonga RB,Hisaka S,Nose M

更新日期：2014-01-01 00:00:00

abstract：:The hydrodynamic method by rapid intravenous injection of a large volume of plasmid DNA is known to be an efficient and liver-specific method of in vivo gene delivery and achieves high levels of foreign gene expression, particularly in hepatocytes. Low transgene activities have also been observed in other organs such ...

journal_title：Biological & pharmaceutical bulletin

authors： Hattori Y,Koga K,Izumisawa T,Yamasaki M,Narishima R,Yoshida S,Fukui T,Maitani Y

更新日期：2009-04-01 00:00:00