Effect of the hot water extract of Artocarpus camansi leaves on 2,4,6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity in mice.


:Medicinal plants with reported anti-inflammatory activity could have the potential use as anti-allergens and inhibitors of allergic contact dermatitis reactions produced by allergens and chemicals. Some species from the genus Artocarpus were reported to have anti-inflammatory activity. In the Philippines one local source is Artocarpus camansi BLANCO (Moraceae), which is utilized as an ingredient of their cuisine, and decoction of leaves is used for diabetes and baths of people with rheumatism. The objective of this study was to evaluate the effect of the hot water extract of A. camansi leaves on contact hypersensitivity (CHS) in mice. Contact hypersensitivity was induced using 2,4,6-trinitrochlorobenzene (TNCB). The results showed that the A. camansi hot water extract exhibited significant activity against the swelling produced during 24 h and 48 h post-challenge. The same responses were observed from the mice that received the kamansi ethanol-precipitate (KEP) and kamansi ethanol precipitate water-soluble (KEPWS) fractions. Since the high molecular mass fraction showed the significant activity, we therefore speculate that the compound responsible might be a polysaccharide and/or glycoprotein. In conclusion, our results suggest that the hot water extract of A. camansi leaves might be an effective natural product to treat allergic contact dermatitis. However, further investigations are required to understand the mechanisms involved.


Biol Pharm Bull


Salonga RB,Hisaka S,Nose M




Has Abstract


2014-01-01 00:00:00














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    abstract::We previously isolated berberine from aqueous extracts of tsu-kan-gan, a Kampo formula used for the treatment of osteoporosis. Berberine caused an inhibitory effect on parathyroid hormone (PTH)-stimulated bone resorption in neonatal mouse bone. In this report we describe the inhibitory effect of berberine on the forma...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Li H,Miyahara T,Tezuka Y,Namba T,Suzuki T,Dowaki R,Watanabe M,Nemoto N,Tonami S,Seto H,Kadota S

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  • Absorption, distribution, and excretion of DJ-927, a novel orally effective taxane, in mice, dogs, and monkeys.

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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ono C,Takao A,Atsumi R

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    authors: Tomoda M,Hirabayashi K,Shimizu N,Gonda R,Ohara N,Takada K

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  • Metabolic Profiling of the Hippocampus of Rats Experiencing Nicotine-Withdrawal Symptoms.

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    更新日期:2009-04-01 00:00:00

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    pub_type: 杂志文章


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  • Intradermal concentration of hydroquinone after application of hydroquinone ointments is higher than its cytotoxic concentration.

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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.

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    journal_title:Biological & pharmaceutical bulletin

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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kanazawa H,Fujimoto S,Ohara A

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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sakaeda T,Takahashi K,Nishihara Y,Hirano K

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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kondo T,Inoue M,Mizukami H,Ogihara Y

    更新日期:1995-05-01 00:00:00

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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nakamura T,Kawano K,Shiraishi K,Yokoyama M,Maitani Y

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    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tasduq SA,Mondhe DM,Gupta DK,Baleshwar M,Johri RK

    更新日期:2005-07-01 00:00:00