Effect of the hot water extract of Artocarpus camansi leaves on 2,4,6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity in mice.


:Medicinal plants with reported anti-inflammatory activity could have the potential use as anti-allergens and inhibitors of allergic contact dermatitis reactions produced by allergens and chemicals. Some species from the genus Artocarpus were reported to have anti-inflammatory activity. In the Philippines one local source is Artocarpus camansi BLANCO (Moraceae), which is utilized as an ingredient of their cuisine, and decoction of leaves is used for diabetes and baths of people with rheumatism. The objective of this study was to evaluate the effect of the hot water extract of A. camansi leaves on contact hypersensitivity (CHS) in mice. Contact hypersensitivity was induced using 2,4,6-trinitrochlorobenzene (TNCB). The results showed that the A. camansi hot water extract exhibited significant activity against the swelling produced during 24 h and 48 h post-challenge. The same responses were observed from the mice that received the kamansi ethanol-precipitate (KEP) and kamansi ethanol precipitate water-soluble (KEPWS) fractions. Since the high molecular mass fraction showed the significant activity, we therefore speculate that the compound responsible might be a polysaccharide and/or glycoprotein. In conclusion, our results suggest that the hot water extract of A. camansi leaves might be an effective natural product to treat allergic contact dermatitis. However, further investigations are required to understand the mechanisms involved.


Biol Pharm Bull


Salonga RB,Hisaka S,Nose M




Has Abstract


2014-01-01 00:00:00














  • Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells.

    abstract::The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Lee MH,Kim JY,Ryu JH

    更新日期:2005-12-01 00:00:00

  • A redox-silent analogue of tocotrienol inhibits cobalt(II) chloride-induced VEGF expression via Yes signaling in mesothelioma cells.

    abstract::Vascular endothelial growth factor (VEGF) plays a crucial role in tumor angiogenesis and represents an attractive anticancer target. We have previously demonstrated that a redox-silent analogue of α-tocotrienol, 6-O-carboxypropyl-α-tocotrienol (T3E) exhibits potent anti-carcinogenic property in human malignant mesothe...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sato A,Virgona N,Ando A,Ota M,Yano T

    更新日期:2014-01-01 00:00:00

  • Synergistic Anticancer Effects of Formononetin and Temozolomide on Glioma C6 Cells.

    abstract::Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Zhang X,Ni Q,Wang Y,Fan H,Li Y

    更新日期:2018-08-01 00:00:00

  • Molecular and sugar-binding heterogeneity of C-type lectins from Osmerus (Spirinchus) lanceolatus eggs.

    abstract::Two C-type lectins (OLLafs and OLLafl) were isolated from Osmerus (Spirinchus) lanceolatus eggs using asialofetuin-Sepharose column. OLLafs and OLLafl were eluted with 0.2 M sucrose and 0.2 M lactose from the same column, respectively. OLLafl has been estimated to be a heterodimeric protein composed of H- and L-subuni...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sugawara S,Hosono M,Ogawa Y,Takayanagi M,Nitta K

    更新日期:2005-05-01 00:00:00

  • Prescription Optimization and Oral Bioavailability Study of Salvianolic Acid Extracts W/O/W Multiple Emulsion.

    abstract::The purpose of this study is to develop a new method of preparing salvianolic acid extracts (SAE) water-in-oil-in-water (W/O/W) multiple emulsion (ME). SAE injection is used in the treatment of brain infarct and promotion of blood circulation in China. However, the injection is not convenient, and the oral preparation...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Song Y,Gao H,Zhang S,Zhang Y,Jin X,Sun J

    更新日期:2017-12-01 00:00:00

  • Adrenergic beta1 receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients.

    abstract::In the process of lipolysis, adipocytes are stimulated by catecholamines through beta(1), beta(2), and beta(3) adrenergic receptors (ARs). So far, beta(2) and beta(3) AR polymorphisms have been reported related to obesity. However, the relation of beta(1)AR polymorphisms to obesity has not been evaluated. In the prese...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nonen S,Yamamoto I,Liu J,Maeda M,Motomura T,Igarashi T,Fujio Y,Azuma J

    更新日期:2008-02-01 00:00:00

  • Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract.

    abstract::The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Moriguchi T,Takashina K,Chu PJ,Saito H,Nishiyama N

    更新日期:1994-12-01 00:00:00

  • Up-Regulation of the Voltage-Gated KV2.1 K+ Channel in the Renal Arterial Myocytes of Dahl Salt-Sensitive Hypertensive Rats.

    abstract::Salt-sensitive hypertension induces renal injury via decreased blood flow in the renal artery (RA), and ion channel dysfunction in RA myocytes (RAMs) may be involved in the higher renal vascular resistance. We examined the effects of several voltage-gated K+ (KV) channel blockers on the resting tension in endothelium-...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ogiwara K,Ohya S,Suzuki Y,Yamamura H,Imaizumi Y

    更新日期:2017-01-01 00:00:00

  • Decline in plasma membrane Ca(2+)-ATPase activity and increase in cytosolic-free Ca2+ concentration of endotoxin-injected mice livers.

    abstract::The present study describes the activity of Ca(2+)-ATPase in liver plasma membrane and cytosolic-free Ca2+ concentration ([Ca2+]i) in an individual vital cell in mouse liver 18 h after endotoxin administration. Ca(2+)-ATPase activity in liver plasma membrane in the poisoned mice was markedly decreased to 28% of that i...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sakaguchi S,Tsutsumi E,Yokota K

    更新日期:1993-08-01 00:00:00

  • Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats.

    abstract::Schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has been shown to enhance mitochondrial antioxidant status in liver, heart and brain tissues in rodents. Whether or not long-term Sch B treatment can protect against oxidative stress-induced cerebral damage remai...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Chen N,Chiu PY,Ko KM

    更新日期:2008-07-01 00:00:00

  • Effects of surfactants and protease inhibitors on nasal absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats.

    abstract::The effects of various surfactants and protease inhibitors on the nasal absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) were examined in rats. No effects of bile salts and acids such as sodium glycocholate or taurocholic acid, amphoteric surfactants such as lauryldimethyl betaine, or an...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Machida M,Sano K,Arakawa M,Hayashi M,Awazu S

    更新日期:1994-10-01 00:00:00

  • Detoxification of paraquat poisoning: effects of alkylsulfates and alkylsulfonates on paraquat poisoning in mice and rats.

    abstract::The study revealed that high molecular polyvinyl sulfate (PVP) or sulfonate (PVS), and low molecular alkyldisulfonates (NaO3S(CH2)nSO3Na, n = 2--5: EDS, TDS, BDS and PDS) can alleviate acute toxicity of the herbicide, paraquat dichloride (PQ) in mice. Their activity as antidotes and the mode of the action varied depen...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tsuchiya T,Yoshida T,Imaeda A,Kiho T,Ukai S

    更新日期:1995-04-01 00:00:00

  • Transport mechanism of anthracycline derivatives in human leukemia cell lines: uptake and efflux of daunorubicin and doxorubicin in HL60 and its resistant cells and comparison with those of pirarubicin.

    abstract::We examined the transport mechanisms of daunorubicin (DNR) and doxorubicin (ADR) in HL60 and HL60/THP cells which were the non-P-glycoprotein-mediated resistant clone of the parent HL60 cells and showed a low degree of resistance, and compared them with those of pirarubicin (THP). In both lines, it appeared that the u...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Nagasawa K,Natazuka T,Nomiyama M,Ohnishi N,Yokoyama T

    更新日期:1996-01-01 00:00:00

  • Studies on kochiae fructus. III. Antinociceptive and antiinflammatory effects of 70% ethanol extract and its component, momordin Ic from dried fruits of Kochia scoparia L.

    abstract::The 70% ethanol extract (KS-ext) from Kochiae Fructus (dried fruits of Kochia scoparia L.) was screened for its activity on nociceptive and inflammatory responses in experimental animals. Although KS-ext at an oral administration of 500 mg/kg had an antinociceptive effect on writhing responses induced by acetic acid, ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Matsuda H,Dai Y,Ido Y,Ko S,Yoshikawa M,Kubo M

    更新日期:1997-10-01 00:00:00

  • Mutations Leu427, Asn428, and Leu431 residues within transmembrane domain-I-segment 6 attenuate ginsenoside-mediated L-type Ca(2+) channel current inhibitions.

    abstract::Many lines of evidences have shown that Panax ginseng exhibits beneficial effects on cardiovascular systems. We previously demonstrated that ginsenoside Rg(3) (Rg(3)), one of active ingredients of Panax ginseng, inhibits Ca(2+) channel currents in a stereospecific manner and affects the steady-state activation but not...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Choi SH,Lee JH,Pyo MK,Lee BH,Shin TJ,Hwang SH,Kim BR,Lee SM,Oh JW,Kim HC,Bae CS,Rhim H,Nah SY

    更新日期:2009-07-01 00:00:00

  • Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells.

    abstract::Reactive oxygen species (ROS) are produced in various cells and affect many biological processes. We previously reported that 2-methyl-1,4-naphtoquinone (menadione) inhibited Ca(2+) influx from the extracellular medium and exocytosis evoked by antigen stimulation in the mast cell line, RBL-2H3. Mast cells release vari...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kawamura F,Nakanishi M,Hirashima N

    更新日期:2010-01-01 00:00:00

  • In vitro inhibitory effect of some flavonoids on rotavirus infectivity.

    abstract::The inhibitory effects of some flavonoids on the infectivity of rotavirus, which predominantly causes sporadic diarrhea in infants and young children, were investigated. Among tested flavonoids, diosmin and hesperidin had the most potent inhibitory activity on rotavirus infection. The fifty percent inhibitory concentr...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Bae EA,Han MJ,Lee M,Kim DH

    更新日期:2000-09-01 00:00:00

  • Hair analysis for drugs of abuse. XI. Disposition of benzphetamine and its metabolites into hair and comparison of benzphetamine use and methamphetamine use by hair analysis.

    abstract::In order to study the disposition of benzphetamine (BZP) and its metabolites, desmethyl benzphetamine (norBZP), p-hydroxy desmethyl benzphetamine (OHnorBZP), methamphetamine (MA) and amphetamine (AP), from plasma to hair in rats, an analytical method for identifying these drugs in plasma, urine and hair was developed ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kikura R,Nakahara Y

    更新日期:1995-12-01 00:00:00

  • A sensitive ELISA for the characterization of two forms of circulating intercellular adhesion molecule-1 in human plasma.

    abstract::Nine murine monoclonal antibodies (MAbs) raised against recombinant soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated by means of ELISAs, and their neutralizing activity was investigated in two bioassays employing Raji cells activated with phorbol myristate acetate. Three of the MAbs inhibited autoagg...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Inuzuka H,Seita T,Okamoto K,Iida K,Ogawa Y,Iwasa S

    更新日期:1995-08-01 00:00:00

  • Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway.

    abstract::Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Lv QQ,Wu WJ,Guo XL,Liu RL,Yang YP,Zhou DS,Zhang JX,Liu JY

    更新日期:2014-01-01 00:00:00

  • Antimicrobial resistance and production of biofilms in clinical isolates of coagulase-negative Staphylococcus strains.

    abstract::Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: de Allori MC,Jure MA,Romero C,de Castillo ME

    更新日期:2006-08-01 00:00:00

  • Possible mechanism of rottlerin induced modulation of ischemia reperfusion injury in isolated rat hearts.

    abstract::The present study was designed to investigate the modulatory effects of rottlerin on ischemia reperfusion induced myocardial injury. Isolated rat hearts were exposed to 30 min of global ischemia followed by 120 min of reperfusion using Langendorff apparatus. Myocardial injury was assessed in the terms of infarct size,...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kaur K,Singh M,Singh N,Jaggi AS

    更新日期:2008-09-01 00:00:00

  • Tissue-Clearing Techniques Enable Three-Dimensional Visualization of Aerosolized Model Compound and Lung Structure at the Alveolar Scale.

    abstract::In this study, we examined the usefulness of a tissue-clearing technique for the evaluation of the lung distribution of aerosolized drugs. An aerosol formulation of TexasRed dextran (70 kDa), a model compound of drug carrier for aerosolized drugs, was administered intrapulmonarily to mice using a MicroSprayer, and the...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Togami K,Kitayama A,Daisho T,Wang R,Tada H,Chono S

    更新日期:2018-01-01 00:00:00

  • Method for screening and quantitative determination of serum levels of salicylic Acid, acetaminophen, theophylline, phenobarbital, bromvalerylurea, pentobarbital, and amobarbital using liquid chromatography/electrospray mass spectrometry.

    abstract::We investigated a method for the simultaneous screening, identification, and quantitative determination of salicylic acid, acetaminophen, theophylline, barbiturates, and bromvalerylurea, drugs that frequently cause acute poisoning in Japan and therefore require rapid analysis for effective treatment in the clinical se...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Hori Y,Fujisawa M,Shimada K,Hirose Y,Yoshioka T

    更新日期:2006-01-01 00:00:00

  • Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse.

    abstract::It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the present study, we investi...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ito T,Nakanishi Y,Yamaji N,Murakami S,Schaffer SW

    更新日期:2018-01-01 00:00:00

  • Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis.

    abstract::A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was esta...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Thuong PT,Min BS,Jin W,Na M,Lee J,Seong R,Lee YM,Song K,Seong Y,Lee HK,Bae K,Kang SS

    更新日期:2006-04-01 00:00:00

  • Effects of tea from Turnera ulmifolia L. on mouse gastric mucosa support the Turneraceae as a new source of antiulcerogenic drugs.

    abstract::Turnera ulmifolia is a plant belonging to the family Turneraceae, popularly known in Brazil as chanana. This species is distributed from Guyana to southern Brazil where it is considered a weed. The plant occurs in tropical rain forest, fields, and gardens. Chanana tea is used in Brazilian folk medicine for the treatme...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Gracioso Jde S,Vilegas W,Hiruma-Lima CA,Souza Brito AR

    更新日期:2002-04-01 00:00:00

  • Effect of gamma-oryzanol on cytochrome P450 activities in human liver microsomes.

    abstract::The effects of gamma-oryzanol, a drug mainly used for the treatment of hyperlipidaemia, on several cytochrome P450 (CYP) specific reactions in human liver microsomes were investigated to predict drug interactions with gamma-oryzanol in vivo from in vitro data. The following eight CYP catalytic reactions were used in t...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Umehara K,Shimokawa Y,Miyamoto G

    更新日期:2004-07-01 00:00:00

  • The entering of indium-111 and iron-59 into the hepatocytes from partially hepatectomized rats differ from that of gallium-67.

    abstract::We recently suggested that the transferrin (Tf)-gallium-67 (67Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free 67Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (111In) and iron-59 (59Fe) with ...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sato R,Abe S,Yamada Y,Toyama D,Ohtake Y,Sato N,Ohkubo Y

    更新日期:2004-08-01 00:00:00

  • Search for new type of PPARγ agonist-like anti-diabetic compounds from medicinal plants.

    abstract::Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal...

    journal_title:Biological & pharmaceutical bulletin

    pub_type: 杂志文章,评审


    authors: Matsuda H,Nakamura S,Yoshikawa M

    更新日期:2014-01-01 00:00:00