Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1.

abstract：:Treatment of Xenopus blastula with activin converts undifferentiated presumptive ectoderm (animal cap) into mesoderm and endoderm in a dose-dependent manner. At low concentrations, activin induces ventral mesoderm such as blood cells. Here we show that activin-treated aggregates of animal cap cells prepared from undif...

journal_title：Biological & pharmaceutical bulletin

authors： Nagamine K,Furue M,Fukui A,Matsuda A,Hori T,Asashima M

更新日期：2007-10-01 00:00:00

abstract：:As one of the adverse effects of oxaliplatin, a key agent in colon cancer chemotherapy, a taste disorder is a severe issue in a clinical situation because it decreases the quality of life of patients. However, there is little information on the mechanism underlying the oxaliplatin-induced taste disorder. Here, we exam...

journal_title：Biological & pharmaceutical bulletin

authors： Ohishi A,Nishida K,Yamanaka Y,Miyata A,Ikukawa A,Yabu M,Miyamoto K,Bansho S,Nagasawa K

更新日期：2016-01-01 00:00:00

abstract：:Two carboxylesterases with pI 6.0 and 6.2 derived from rat liver microsomes were purified. The two isozymes were remarkably different in substrate specificity, but they had equal enzymatic activity for alpha-naphthyl acetate and were inhibited equally by phenylmethylsulfonyl fluoride (PMSF) and bis-(4-nitrophenyl) pho...

journal_title：Biological & pharmaceutical bulletin

authors： Luan L,Sugiyama T,Takai S,Usami Y,Adachi T,Katagiri Y,Hirano K

更新日期：1997-01-01 00:00:00

abstract：:Hyphal growth of Candida albicans was observed at neutral condition, whereas the yeast growth was increased below pH 5. Eight out of 12 strains of C. albicans grow in hyphal form at pH 7, and hyphal formation was inhibited in all strains at pH 4. The addition of GMP, an alternative oxidase (AOX) activator, induced the...

journal_title：Biological & pharmaceutical bulletin

authors： Konno N,Ishii M,Nagai A,Watanabe T,Ogasawara A,Mikami T,Matsumoto T

更新日期：2006-05-01 00:00:00

abstract：:An efficient delivery system is required if antisense oligodeoxynucleotides (ODN) are to be utilized for gene therapy. We report herein on the development of a novel ODN delivery system, ODN-encapsulated nano particles (ODN-ENP) using an efficient and simple packaging method. The ODN-ENP consists of a condensed ODN pa...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada Y,Kogure K,Nakamura Y,Inoue K,Akita H,Nagatsugi F,Sasaki S,Suhara T,Harashima H

更新日期：2005-10-01 00:00:00

abstract：:We previously reported the isolation of a novel cerebroside (1-O-(beta-D-glucopyranosyl)-(2S,3R,4E,8Z)-2-N-palmityloc tadecasphinga-4,8-diene; LCC) from the fruits of Lycium chinense MILL. (Solanaceae) which protected primary cultured rat hepatocytes from the toxicity induced by carbon tetrachloride (CCl4). The presen...

journal_title：Biological & pharmaceutical bulletin

authors： Kim SY,Lee EJ,Kim HP,Kim YC,Moon A,Kim YC

更新日期：1999-08-01 00:00:00

abstract：:In a previous study we found that 50% ethanol extracts of immature fruits of Citrus unshiu (satsuma mandarin) have anti-allergic effects against the Type I, II and IV allergic reactions. However, many adverse interactions between citrus fruit, especially grapefruit juice, and drugs have been reported due to the inhibi...

journal_title：Biological & pharmaceutical bulletin

authors： Fujita T,Kawase A,Niwa T,Tomohiro N,Masuda M,Matsuda H,Iwaki M

更新日期：2008-05-01 00:00:00

abstract：:The protective effect of sodium-L-ascorbyl-2 phosphate (As-2P), a stable form of ascorbic acid (AsA), against photodamage induced by a single dose of UVB exposure (290-320 nm, Max 312 nm) was investigated using cultured mouse skin. When the cultured skin was treated with various As-2P concentrations, the cutaneous AsA...

journal_title：Biological & pharmaceutical bulletin

authors： Nayama S,Takehana M,Kanke M,Itoh S,Ogata E,Kobayashi S

更新日期：1999-12-01 00:00:00

abstract：:The roles of OmpC and OmpF in acidic resistance (AR) were examined. When ompC and ompF were deleted, AR was decreased. The decreased level of AR seen in the mutant that was deficient in ompC and ompF was elevated by the addition of glutamate, but not by the addition of arginine or lysine. The expression levels of adiA...

journal_title：Biological & pharmaceutical bulletin

authors： Bekhit A,Fukamachi T,Saito H,Kobayashi H

更新日期：2011-01-01 00:00:00

abstract：:Ras, a small G-protein, physiologically directs cell proliferation and cell cycle via regulation of mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling cascade. Dysregulation of Ras/MEK/ERK signaling has been reported to cause tumorigenesis and gliomas. Nobiletin, a citr...

journal_title：Biological & pharmaceutical bulletin

authors： Aoki K,Yokosuka A,Mimaki Y,Fukunaga K,Yamakuni T

更新日期：2013-01-01 00:00:00

abstract：:Cerebral ischemia causes the depletion of oxygen and nutrition from brain tissues, and when persistent, results in irreversible damage to the cell function and survival. The cellular response to ischemic conditions and its mechanisms have been investigated widely in in vivo and in vitro experimental models, yet no stu...

journal_title：Biological & pharmaceutical bulletin

authors： Ujita S,Mizunuma M,Matsuki N,Ikegaya Y

更新日期：2011-01-01 00:00:00

abstract：:Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antib...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui E,Takayama K,Sato E,Okamura N

更新日期：2011-01-01 00:00:00

abstract：:A study of the biliary bile acid composition in porcine fetus compared with that of the adult pig is described. Biles, collected during gestation (weeks 4, 15 to 17 and at birth), aged six months and two years old, were analyzed by gas-liquid chromatography and capillary GC-MS. Bile acids were separated into different...

journal_title：Biological & pharmaceutical bulletin

authors： Kuramoto T,Miyamoto J,Konishi M,Hoshita T,Masul T,Une M

更新日期：2000-10-01 00:00:00

abstract：:The in vitro skin permeability of 16 drugs with a wide range of lipophilicity (log P; -0.95-4.40) was evaluated by the use of an ethanol/water (60/40) binary vehicle with or without lauric acid as a permeation enhancer. The enhancing effect by the addition of lauric acid to the ethanol/water (60/40) binary vehicle cou...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CK,Uchida T,Kitagawa K,Yagi A,Kim NS,Goto S

更新日期：1994-10-01 00:00:00

abstract：:Studies were performed to characterize the opioid receptors in guinea pig brain using the radiolabeled opioid antagonists, [3H]naloxone and [3H]diprenorphine and the kappa-agonist [3H]U-69593. The binding of [3H]U-69593 to guinea pig cerebellar membranes was reduced by NaCl, guanyl-5'yl-imidodiphosphate (GppNHp) and N...

journal_title：Biological & pharmaceutical bulletin

authors： Ishige K,Makimura M,Ito Y,Murakoshi Y

更新日期：1993-09-01 00:00:00

abstract：:Tryptanthrin originally isolated from Isatis tinctoria L. has been characterized to have anti-inflammatory activities through the dual inhibition of cyclooxygenase-2 and 5-lipoxygenase mediated prostaglandin and leukotriene syntheses. To characterize phase I metabolite(s), tryptanthrin was incubated with rat liver mic...

journal_title：Biological & pharmaceutical bulletin

authors： Lee SK,Kim GH,Kim DH,Kim DH,Jahng Y,Jeong TC

更新日期：2007-10-01 00:00:00

abstract：:Pantethine and fursultiamine have been evaluated for their clinical usefulness in the treatment and prevention of uncomplicated postoperative adhesive intestinal obstruction. In recent years, the actions of drugs used to treat gastrointestinal diseases have been elucidated pharmacologically from the viewpoints of gast...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Itoh H,Abe T,Nishimura F,Sato Y,Takeyama M

更新日期：2011-01-01 00:00:00

abstract：:The free radical scavenging activities of Panax ginseng C.A. MEYER are known to increase by heat processing. Phenolic acids and Maillard reaction products (MRPs) have been suggested as active free radical scavenging components from our previous research, but heat processing-induced chemical and activity changes of gin...

journal_title：Biological & pharmaceutical bulletin

authors： Kang KS,Kim HY,Baek SH,Yoo HH,Park JH,Yokozawa T

更新日期：2007-04-01 00:00:00

abstract：:Onset of cancer and neurodegenerative disease occurs by abnormal cell growth and neuronal cell death, respectively, and the number of patients with both diseases has been increasing in parallel with an increase in mean lifetime, especially in developed countries. Although both diseases are sporadic, about 10% of the d...

journal_title：Biological & pharmaceutical bulletin

authors： Ariga H

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to investigate the absorption behavior of an ophthalmic drug injected in rabbit periocular tissues. After intracapsular, retrobulbar and palpebral conjunctival injections of 150 microl and 50 microl fluorescein isothiocyanate dextran (FITC-dextran, average molecular weight 11000), leakage...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki H,Kashiwagi S,Mukai T,Nishida K,Nakamura J,Nakashima M,Ichikawa M

更新日期：1999-09-01 00:00:00

abstract：:Granisetron (GRN) is widely used for patients with various cancers who suffer from chemotherapy-induced vomiting and nausea. The, pharmacokinetics of GRN has not been fully evaluated in such patients, however, and its dosage regimen is still controversial. In this study, we determined GRN levels in serum and urine fro...

journal_title：Biological & pharmaceutical bulletin

authors： Wada I,Takeda T,Sato M,Saitoh H,Nakabayashi T,Mino K,Honma T,Takada M,Hirano K

更新日期：2001-04-01 00:00:00

abstract：:Deoxynybomycin was identified as an inducer of p21the/WAF1 gene following screening using a reporter, p21/luciferase. The present study examined its anti-proliferative effect on human tumor cell lines. Deoxynybomycin selectively inhibited growth of human osteoblastic sarcoma Saos-2, gastric cancer TMK-1, and monocytic...

journal_title：Biological & pharmaceutical bulletin

authors： Egawa K,Yamori T,Nosaka C,Kunimoto S,Takeuchi T,Nos K

更新日期：2000-09-01 00:00:00

abstract：:This study investigated both morphologically and biochemically whether parsley (Petroselinum crispum), which is used as a folk remedy to decrease blood glucose, has any antidiabetic effect on pancreatic B cells of rats. Parsley extract was given to male diabetic rats. In the diabetic group given parsley extract, it wa...

journal_title：Biological & pharmaceutical bulletin

authors： Yanardağ R,Bolkent S,Tabakoğlu-Oğuz A,Ozsoy-Saçan O

更新日期：2003-08-01 00:00:00

abstract：:Permeation enhancement of ketoprofen (KP) from supersaturated systems and the effects of antinucleant polymers on both stability and permeation of supersaturated KP were investigated using silicone membrane as a skin model. The supersaturation was prepared by the cosolvent technique with water and propylene glycol (PG...

journal_title：Biological & pharmaceutical bulletin

authors： Kumprakob U,Kawakami J,Adachi I

更新日期：2005-09-01 00:00:00

abstract：:To enhance tumor magnetic resonance imaging (MRI) signals via the selective accumulation of contrast agents, we prepared folate-modified gadolinium-lipid-based nanoparticles as MRI contrast agents. Folate-modified nanoparticles were comprised of polyethylene glycol (PEG)-lipid, gadolinium diethylenetriamine pentaaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura T,Kawano K,Shiraishi K,Yokoyama M,Maitani Y

更新日期：2014-01-01 00:00:00

abstract：:Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of diastereoisomers after incubation of paeoniflorin with Lactobacillus brevis in the presence of various thiols. The anticonvulsant activity of the adducts was investigated in mice using the maximal subcutaneous pentylenetetrazol seizure test and sodiu...

journal_title：Biological & pharmaceutical bulletin

authors： Abdel-Hafez AA,Meselhy MR,Nakamura N,Hattori M,Watanabe H,Murakami Y,El-Gendy MA,Mahfouz NM,Mohamed TA

更新日期：1999-05-01 00:00:00

abstract：:The effects of exogenously applied gibberellic acid (GA(3)) or brassinolide (BL) on the H(+)-pumps and aquaporin in the vacuolar membrane of rice seedling leaf sheath were investigated. Antibodies against mung bean H(+)-PPase, the B subunit of V-ATPase, and radish tonoplast intrinsic protein (TIP) cross-reacted with t...

journal_title：Biological & pharmaceutical bulletin

authors： Yang S,Maeshima M,Tanaka Y,Komatsu S

更新日期：2003-01-01 00:00:00

abstract：:Plasma hyaluronan-binding protein (PHBP), a serine protease that can activate coagulation factor VII and prourokinase, circulates in a single-chain form (pro-PHBP) and autoproteolytically converts to an active two-chain form with the aid of an effector such as spermidine and heparin. It has been postulated that PHBP p...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto E,Nishimura N,Okada K,Sekido C,Yamamichi S,Hasumi K

更新日期：2011-01-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, and motility. This pathway is often upregulated in human cancers and as such represents an attractive target for mechanism-based approaches to cancer treatment. H...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno M,Tanimura S,Ozaki K

更新日期：2011-01-01 00:00:00

abstract：:RNA interference (RNAi) is a technology that specifically inhibits gene expression and is carried out by small 21-27-nucleotide double-stranded small interfering RNA (siRNA) or short hairpin RNA (shRNA). RNAi has become a very promising technology for genetic research, however problems remain with the delivery of siRN...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaguchi Y,Danjo K,Okuda T,Okamoto H

更新日期：2009-02-01 00:00:00