Bile acids in porcine fetal bile.

abstract：:The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 microM, and 19 of ...

journal_title：Biological & pharmaceutical bulletin

authors： Takahira M,Kusano A,Shibano M,Kusano G,Koizumi K,Suzuki R,Kim HS,Wataya Y

更新日期：1998-08-01 00:00:00

abstract：:Changes in carbonyl reductase (CR) activity towards seven substrates in adrenal glands of female rats were investigated during estrous cycle and the circadian patterns of adrenal CR activity towards seven substrates in male rats were examined. The localization of the enzyme protein in the adrenal gland was carried out...

journal_title：Biological & pharmaceutical bulletin

authors： Inazu N,Nagashima Y,Satoh T

更新日期：1995-05-01 00:00:00

abstract：:Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glyca...

journal_title：Biological & pharmaceutical bulletin

authors： Hotta Y,Fujino R,Kimura O,Endo T

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to determine the stimulatory effects of Maillard reaction, a non-enzymatic browning reaction on the expression of pro-inflammatory cytokines and phagocytic activity induced by whey protein concentrate (WPC). Glycated WPC (G-WPC) was prepared by a reaction between WPC and the lactose it contai...

journal_title：Biological & pharmaceutical bulletin

authors： Chun SH,Lee HA,Lee KB,Kim SH,Park KY,Lee KW

更新日期：2016-01-01 00:00:00

abstract：:The effect of fungichromin (FC) on the formation of Candida albicans biofilm was assessed using 2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction method, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results showed that FC revealed an inhibitor...

journal_title：Biological & pharmaceutical bulletin

authors： An D,Wang X,Li J,Jiang S,Ma X,Zhang H,Shi H,Sun H,Ye L,Li J

更新日期：2016-12-01 00:00:00

abstract：:Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine...

journal_title：Biological & pharmaceutical bulletin

authors： Ueda JY,Tezuka Y,Banskota AH,Tran QL,Tran QK,Saiki I,Kadota S

更新日期：2003-10-01 00:00:00

abstract：:We attempted to produce a model mouse with a liver injury resulting from an immunological mechanism in C57BL/6J mice, and the effect of hepatitis on the hepatic microsomal mixed-function oxidase system was studied. An experimental immunological liver injury model was caused by the intravenous injection of an anti-basi...

journal_title：Biological & pharmaceutical bulletin

authors： Ishikawa M,Takayanagi Y,Sasaki K

更新日期：1993-10-01 00:00:00

abstract：:The riboflavin sensitized oxidation of cysteine under an aerobic condition was investigated. The effects of various scavengers, such as superoxide dismutase, catalase, mannitol, sodium azide and potassium ferrocyanide (an electron donor), on the photooxidation were determined. A reaction mechanism involving the supero...

journal_title：Biological & pharmaceutical bulletin

authors： Sarkar B,Das U,Bhattacharyya S,Bose SK

更新日期：1997-08-01 00:00:00

abstract：:Direct detection of nitric oxide (NO) is essential for understanding the precise mechanism of its production from endothelial cells. Previously, we developed an NO detection system based on the chemiluminescence reaction between NO and luminol-H2O2. Here, we have applied this system to cultured endothelial cells for t...

journal_title：Biological & pharmaceutical bulletin

authors： Kurumatani H,Kikuchi K,Nagano T,Hirobe M,Yamazaki J,Nagao T

更新日期：1998-12-01 00:00:00

abstract：:Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic m...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang H,Sun X,Xie Y,Tian F,Hu H,Tan W

更新日期：2018-01-01 00:00:00

abstract：:P2X7 receptor (P2X7R), a purinergic receptor, is involved in pathophysiological events such as inflammation and cell death, and thus is an attractive target for therapeutic approaches. It is reported that divalent metal cations (DMCs) inhibit P2X7R activation and that there are species differences in their inhibitory ...

journal_title：Biological & pharmaceutical bulletin

authors： Fujiwara M,Ohbori K,Ohishi A,Nishida K,Uozumi Y,Nagasawa K

更新日期：2017-01-01 00:00:00

abstract：:The effects of Cu, Zn-superoxide disumutase (SOD) delivered by genetically modified skin fibroblasts on cold-induced skin edema were studied in rats. Cold-induced skin edema was induced on the dorsal skin following transplantation of ILSOD cells, genetically modified skin fibroblasts which release secretable SOD prote...

journal_title：Biological & pharmaceutical bulletin

authors： Nishiguchi K,Komada F,Tanigawara Y,Sakai Y,Iwakawa S,Okumura K

更新日期：1998-12-01 00:00:00

abstract：:We previously reported that kiwi fruit is rich in polyphenols and has immunostimulatory activity. Polyphenols are widely known for having anti-oxidant effects. We also revealed potential anti-oxidant effects of kiwi fruit in vivo by oral administration to mice. Here, we compared the anti-oxidant effects of kiwi fruit ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwasawa H,Morita E,Yui S,Yamazaki M

更新日期：2011-01-01 00:00:00

abstract：:We have previously reported the expression of CYP genes in human myeloblastic and lymphoid cell lines, and the induction of the CYP3A4 and GSTP1 genes by oxidative stress in the human erythroleukemia cell line, K562. To further elucidate the role of drug metabolizing enzymes in hematogenesis, we have characterized the...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai F,Shimizu M,Sakamoto T,Kobayashi T,Tamura H

更新日期：2007-10-01 00:00:00

abstract：:The present study was designed to evaluate skin permeation enhancement effect of essential oils from Ligusticum chuanxiong Hort (chuanxiong oil) in rabbits and to compare the in vivo absorption and in vitro permeation using flurbiprofen as a model drug. In vivo results demonstrated that chuanxiong oil showed a rapid a...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang LC,Hu JH,Li L,Gao LH,Zhu QG,Li Z,Wang ZZ,Su DF

更新日期：2006-06-01 00:00:00

abstract：:The aim of the present study was to determine the effect of sulfaphenazole (SP) on the pharmacokinetics of ampiroxicam (AM) which is metabolized by cytochrome P-450 (CYP) 2C9, since SP is a potent inhibitor of CYP 2C9, and so a dramatic pharmacokinetic drug interaction between both drugs is assumed after dosing. Singl...

journal_title：Biological & pharmaceutical bulletin

authors： Ogiso T,Iwaki M,Tanaka H,Kobayashi E,Tanino T,Sawada A,Uno S

更新日期：1999-02-01 00:00:00

abstract：:Periodontitis is initiated by accumulation of microbial plaque and activation of gingival inflammation through overexpression of matrix metalloproteinases (MMPs), leading to tissue destruction. Natural MMP inhibitors may be developed as therapeutic agents against periodontitis. In this study, panduratin A, a natural b...

journal_title：Biological & pharmaceutical bulletin

authors： Yanti,Oh HI,Anggakusuma,Hwang JK

更新日期：2009-01-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) is a central mediator of cellular responses to low oxygen and has recently become an important therapeutic target for solid tumor therapy. To identify small molecule inhibitors of the HIF-1 transcriptional activation, we have established a high through-put assay system using a stable...

journal_title：Biological & pharmaceutical bulletin

authors： Yamazaki Y,Hasebe Y,Egawa K,Nose K,Kunimoto S,Ikeda D

更新日期：2006-10-01 00:00:00

abstract：:The effects of alpha(1)-acid glycoprotein (AGP) on human erythrocyte membrane were examined in vitro. Bovine and dog AGP, in addition to human AGP or asialo human AGP were used, and the collected data were compared with that for human serum albumin (HSA). A new technique developed by Kikuchi was used to investigate er...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto K,Nishi K,Tokutomi Y,Irie T,Suenaga A,Otagiri M

更新日期：2003-01-01 00:00:00

abstract：:Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been ...

journal_title：Biological & pharmaceutical bulletin

authors： O'Leary R,Rerek M,Wood EJ

更新日期：2004-02-01 00:00:00

abstract：:Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bupleurum Kaoi in huma...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu YL,Kuo PL,Weng TC,Yen MH,Chiang LC,Lin CC

更新日期：2004-07-01 00:00:00

abstract：:To elucidate insecticidal activity of spider toxins, metal ions in venoms and in the bodies were determined by thin layer chromatography, spark source mass spectrometry, ion chromatography, inductively coupled plasma emission spectrometry and atomic absorption spectrometry. Two kinds of spiders were used, Nephila clav...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Narai N,Shinkai A,Tokuda T,Saito K,Shioya M,Tokoro N,Kono Y

更新日期：1994-04-01 00:00:00

abstract：:This study examined the osteoblast-like MC3T3-E1 cell responses to poly(DL-lactide) (PDLLA) and poly(L-lactide) (PLLA) with different weight average molecular weight (M.W.). Colony formation of MC3T3-E1 cells on the PLLA with M.W. 270000 or 1370000 was slightly lower than that on glass. The protein, DNA and hydroxypro...

journal_title：Biological & pharmaceutical bulletin

authors： Ikarashi Y,Tsuchiya T,Kaniwa M,Nakamura A

更新日期：2000-12-01 00:00:00

abstract：:We have previously reported that restraint stress inhibits small intestinal motility in rats, and that the adrenergic beta3-antagonist SR59230A administration recovered the inhibition. In the present study, we compared the effects of restraint stress and norepinephrine on small intestinal motility using alpha- and bet...

journal_title：Biological & pharmaceutical bulletin

authors： Tsukada F,Sawamura K,Kohno H,Ohkubo Y

更新日期：2002-01-01 00:00:00

abstract：:Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) trigger...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CS,Won C,Yoo H,Yi EH,Cho Y,Maeng JW,Sung SH,Ye SK,Chung MH

更新日期：2009-11-01 00:00:00

abstract：:The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species ha...

journal_title：Biological & pharmaceutical bulletin

authors： Namekata I,Tsuneoka Y,Tanaka H

更新日期：2013-01-01 00:00:00

abstract：:The present paper proposes a new approach for fitting the plasma effect-site equilibrium rate constant (Ke0) of propofol to satisfy the condition that the effect-site concentration (Ce) is equal at the time of loss of consciousness (LOC) and recovery of consciousness (ROC). Forty patients receiving intravenous anesthe...

journal_title：Biological & pharmaceutical bulletin

authors： Wu Q,Sun B,Wang S,Zhao L,Qi F

更新日期：2013-01-01 00:00:00

abstract：:Several Pt(IV) and Pt(II) complexes containing 1R,2R-cyclohexanediamine (1R,2R-dach) as a carrier ligand were synthesized. The cytotoxicities and the uptake of the platinum complexes by leukemia L1210 cells were compared in order to study the correlation between their structures and cytotoxicities. [Pt(II)Cl2(1R,2R-da...

journal_title：Biological & pharmaceutical bulletin

authors： Yamashita T,Hirose J,Noji M,Saito R,Tomida H,Kidani Y

更新日期：1993-10-01 00:00:00

abstract：:We previously isolated berberine from aqueous extracts of tsu-kan-gan, a Kampo formula used for the treatment of osteoporosis. Berberine caused an inhibitory effect on parathyroid hormone (PTH)-stimulated bone resorption in neonatal mouse bone. In this report we describe the inhibitory effect of berberine on the forma...

journal_title：Biological & pharmaceutical bulletin

authors： Li H,Miyahara T,Tezuka Y,Namba T,Suzuki T,Dowaki R,Watanabe M,Nemoto N,Tonami S,Seto H,Kadota S

更新日期：1999-04-01 00:00:00

abstract：:The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of as...

journal_title：Biological & pharmaceutical bulletin

authors： Lares-Asseff I,Juárez-Olguín H,Flores-Pérez J,Guillé-Pérez A,Vargas A

更新日期：2004-05-01 00:00:00