The antiproliferative activity of saponin-enriched fraction from Bupleurum Kaoi is through Fas-dependent apoptotic pathway in human non-small cell lung cancer A549 cells.

abstract：:Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β(2)-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaire...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshihara S,Fukuda H,Abe T,Arisaka O

更新日期：2010-01-01 00:00:00

abstract：:Transdermal nicotine patch (TNP) contains approximately 16.6 and 24.9 mg of nicotine per 20 and 30 cm2 (TNP-20 and TNP-30). The aims of the study are to investigate linearity of nicotine pharmacokinetics after single application of different strengths of TNP and to directly compare plasma nicotine concentrations with ...

journal_title：Biological & pharmaceutical bulletin

authors： Sobue S,Sekiguchi K,Kikkawa H,Akasaki M,Irie S

更新日期：2006-05-01 00:00:00

abstract：:We investigated the gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7), UGT-dependent glucuronosyl transferase isoforms (UGT1A6 and UGT1A9), and ABC transporter (ABCB1) after exposure to 0.1, 0.5, and 2.5% dimethyl sulfoxide (DMSO). GAPDH mRNA levels...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Ueda N,Naito S

更新日期：2003-07-01 00:00:00

abstract：:To determine the mechanism involved, the incorporation rate (ICR) of drugs into hair was compared to melanin affinity, lipophilicity and membrane permeability. The following 20 drugs were tested; amphetamine, methamphetamine, p-hydroxyamphetamine, p-hydroxymethamphetamine, cocaine, benzoylecgonine, ecgonine methyl est...

journal_title：Biological & pharmaceutical bulletin

authors： Nakahara Y,Takahashi K,Kikura R

更新日期：1995-09-01 00:00:00

abstract：:We investigated the efficacy of clonazepam as an antiemetic in cisplatin-based chemotherapy for lung cancer. Seven patients experienced cisplatin-induced vomiting despite antiemetic therapy including 5-hydroxytryptamine(3) (5-HT(3)) antagonist and dexamethasone. Therefore, the antiemetic therapy including clonazepam, ...

journal_title：Biological & pharmaceutical bulletin

authors： Hayashi M,Takao Y,Hata C,Teramachi H,Tsuchiya T

更新日期：2010-01-01 00:00:00

abstract：:Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The anti-proliferative effect of formononetin on human glioma cells had been confirmed. To improve therapeutic effects of TMZ...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang X,Ni Q,Wang Y,Fan H,Li Y

更新日期：2018-08-01 00:00:00

abstract：:The effects of exogenously applied gibberellic acid (GA(3)) or brassinolide (BL) on the H(+)-pumps and aquaporin in the vacuolar membrane of rice seedling leaf sheath were investigated. Antibodies against mung bean H(+)-PPase, the B subunit of V-ATPase, and radish tonoplast intrinsic protein (TIP) cross-reacted with t...

journal_title：Biological & pharmaceutical bulletin

authors： Yang S,Maeshima M,Tanaka Y,Komatsu S

更新日期：2003-01-01 00:00:00

abstract：:A deconvolution method for estimating the first-pass metabolism of orally administered drugs is proposed. This analysis can be carried out without assuming any pharmacokinetic models. The applicability of the deconvolution method was evaluated by application to the plasma concentration-time courses of aspirin and its ...

journal_title：Biological & pharmaceutical bulletin

authors： Yamashita F,Bando H,Takakura Y,Hashida M

更新日期：1995-12-01 00:00:00

abstract：:We reported previously that monkey embryonic stem cells (ESCs) were differentiated into hepatocytes by formation of embryoid bodies (EBs). However, this EB formation method is not always efficient for assays using a large number of samples simultaneously. A dispersion culture system, one of the differentiation methods...

journal_title：Biological & pharmaceutical bulletin

authors： Maruyama J,Matsunaga T,Yamaori S,Sakamoto S,Kamada N,Nakamura K,Kikuchi S,Ohmori S

更新日期：2013-01-01 00:00:00

abstract：:We determined the effects of psychotropic drugs on the cytochrome P450 2D (CYP2D)-mediated 21-hydroxylation of progesterone (PROG) and allopregnanolone (ALLO) with the goal of clarifying whether neurosteroid levels are affected by psychotropic drugs in the brain. PROG or ALLO was incubated with rat CYP2D4 or human CYP...

journal_title：Biological & pharmaceutical bulletin

authors： Niwa T,Okada K,Hiroi T,Imaoka S,Narimatsu S,Funae Y

更新日期：2008-03-01 00:00:00

abstract：:To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then e...

journal_title：Biological & pharmaceutical bulletin

authors： Piao MG,Yang CW,Li DX,Kim JO,Jang KY,Yoo BK,Kim JA,Woo JS,Lyoo WS,Han SS,Lee YB,Kim DD,Yong CS,Choi HG

更新日期：2008-06-01 00:00:00

abstract：:The effect of 4-(4-chlorobenzyl)pyridine (4-CBP) on rat hepatic microsomal cytochrome P450 (P450) and its molecular species (CYP2B1, 2E1, 3A2, 2C11, and 2C12), and on drug-metabolizing enzyme activities were examined in vivo and in vitro. Treatment of rats with 4-CBP resulted in the induction of P450 and drug-metaboli...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi Y,Ohshiro N,Sasaki T,Tokuyama S,Tobe T,Yoshida T,Yamamoto T

更新日期：2001-05-01 00:00:00

abstract：:Daikenchuto (DKT) has been widely used for the treatment of postsurgical ileus in Japan. However, its effect on postsurgical adhesion formation has been obscure. In this study, the effect of DKT on postsurgical adhesion formation induced by cecum cauterization or cecum abrasion in mice was investigated. First, the exp...

journal_title：Biological & pharmaceutical bulletin

authors： Wu S,Uyama N,Itou RA,Hatano E,Tsutsui H,Fujimoto J

更新日期：2019-01-01 00:00:00

abstract：:The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe(2)+, on the lipid peroxidation of rat liver microsomes induced by CCl(4) or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe(2)+ were demonstrated. Consequently, sesamol and related compounds,...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida M,Nakajin S,Toyoshima S,Shinoda M

更新日期：1996-04-01 00:00:00

abstract：:The genetic similarities of four species of Glycyrrhiza plants were determined by DNA analyses of random amplified polymorphic DNA (RAPD) and restriction fragment length polymorphism (RFLP). The phylogenic trees were constructed from the genetic similarities estimated from RAPD and RFLP profiles. These results indicat...

journal_title：Biological & pharmaceutical bulletin

authors： Yamazaki M,Sato A,Shimomura K,Saito K,Murakoshi I

更新日期：1994-11-01 00:00:00

abstract：:Vonoprazan fumarate (vonoprazan) is a new kind of acid suppressant with potent acid inhibitory effects. Therefore, it has been administered to kidney transplant recipients for treatment or prophylaxis of steroid ulcers, refractory peptic ulcers, and gastroesophageal reflux disease. Because tacrolimus, which is a well-...

journal_title：Biological & pharmaceutical bulletin

authors： Mei T,Noguchi H,Suetsugu K,Hisadome Y,Kaku K,Okabe Y,Masuda S,Nakamura M

更新日期：2020-01-01 00:00:00

abstract：:Lysosomal trapping was investigated in the retinal capillary endothelial cells that are responsible for the inner blood-retinal barrier (BRB) using LysoTracker(®) Red (LTR). Using confocal microscopy on TR-iBRB2 cells, an in vitro model of the inner BRB, the presence of lysosomal trapping in retinal capillary endothel...

journal_title：Biological & pharmaceutical bulletin

authors： Kubo Y,Seko N,Usui T,Akanuma S,Hosoya K

更新日期：2016-01-01 00:00:00

abstract：:HL-60 cells differentiate into granulocyte-like cells by all-trans retinoic acid (ATRA) treatment, and the cellular proliferation is markedly reduced during the differentiation. To elucidate the molecular mechanisms of the growth arrest during the cellular differentiation, we examined the regulated expression of the t...

journal_title：Biological & pharmaceutical bulletin

authors： Horie N,Komada Y,Ueta Y,Suzuki T,Nozawa R,Takeishi K

更新日期：2001-12-01 00:00:00

abstract：:Stevens-Johnson syndrome (SJS) was diagnosed in a 39-year-old woman, treated with ampicillin (4000-8000 mg daily), phenytoin (250 mg daily), and furosemide (20-40 mg daily) for 25, 21, and 20 d, respectively, before the appearance of the eruption. The lymphocyte stimulation test with the MTT [3-(4,5-dimethyl thiazol-2...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshimura T,Hamaguchi E,Usami E,Nakashima K,Kawaguchi M,Suzuki N,Okamoto Y,Nakao T,Yamazaki F

更新日期：2004-06-01 00:00:00

abstract：:Plant phenolic compounds isolated from a 70% aqueous acetone extract of the leaves of Malus doumeri A. CHEV. var. formosana (KAWAK. & KOIDZ.) S. S. YING, a type of Taiwanese indigenous plant, were evaluated for potential application in the field of skin care. A phytochemical investigation of the active fractions resul...

journal_title：Biological & pharmaceutical bulletin

authors： Leu SJ,Lin YP,Lin RD,Wen CL,Cheng KT,Hsu FL,Lee MH

更新日期：2006-04-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are known as peroxisome proliferator-activated receptor γ (PPARγ) activators, and are used in the treatment of diabetes. Although the usefulness of TZDs has been demonstrated, some of their side effects are becoming an obstacle to their clinical applicability; edema is known to be evoked by t...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki H,Takeda S,Ishii H,Takemoto Y,Fujita S,Suyama M,Matsumoto K,Shindo M,Aramaki H

更新日期：2017-01-01 00:00:00

abstract：:Hepatic organic anion transporters OATP1B1 and OATP1B3 are expressed at the sinusoidal membrane of hepatocytes and contribute to the hepatic uptake of a wide variety of clinically used drugs. To identify the antibiotics that interact with the human organic anion transporters OATP1B1 and OATP1B3, we applied a screening...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi H,Takeuchi T,Okada M,Kobayashi M,Unno M,Abe T,Goto J,Hishinuma T,Shimada M,Mano N

更新日期：2011-01-01 00:00:00

abstract：:We used three human urological cancer cell lines, PC-3, LNCaP and SKRC-1, to investigate the effects of the extract from Serenoa repens (Palmae) on tumor cell invasion. The invasion activity of these cell lines was determined in vitro using a Transwell cell-culture chamber. The invasion activity of PC-3 cells into Mat...

journal_title：Biological & pharmaceutical bulletin

authors： Ishii K,Usui S,Sugimura Y,Yamamoto H,Yoshikawa K,Hiran K

更新日期：2001-02-01 00:00:00

abstract：:The liposome, a closed phospholipid bilayered vesicular system, has received considerable attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of liposomes to encapsulate both hydrophilic and hydrophobic drugs, coupled with their biocompatibility and biodegradability, make lipos...

journal_title：Biological & pharmaceutical bulletin

authors： Abu Lila AS,Ishida T

更新日期：2017-01-01 00:00:00

abstract：:The MeOH and water extracts of the Netherlands propolis were tested for their inhibitory activity toward nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage-like J774.1 cells. Both of the extract possessed significant NO inhibitory activity with IC(50) values of 23.8 and 51.5 microg/ml...

journal_title：Biological & pharmaceutical bulletin

authors： Nagaoka T,Banskota AH,Tezuka Y,Midorikawa K,Matsushige K,Kadota S

更新日期：2003-04-01 00:00:00

abstract：:Astilbin, a dihydroflavonol rhamnoside isolated from the leaves of Engelhardtia chrysolepis, enhanced the vanadate-stimulated release of lipoprotein lipase (LPL) activity from rat isolated fat pads. N-[2-(Methyl-amino)ethyl]-5-isoquinolinesulfonamide (H-8), a potent inhibitor of cAMP-dependent protein kinase (PKA), ma...

journal_title：Biological & pharmaceutical bulletin

authors： Motoyashiki T,Miyake M,Morita T,Mizutani K,Masuda H,Ueki H

更新日期：1998-05-01 00:00:00

abstract：:Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scaven...

journal_title：Biological & pharmaceutical bulletin

authors： Takeda O,Takechi S,Katoh T,Yamaguchi T

更新日期：2005-07-01 00:00:00

abstract：:It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the present study, we investi...

journal_title：Biological & pharmaceutical bulletin

authors： Ito T,Nakanishi Y,Yamaji N,Murakami S,Schaffer SW

更新日期：2018-01-01 00:00:00

abstract：:Sixteen flavonoids including quercetin and kaempferol and their relatives were examined for their ability to promote DNA degradation induced by the bleomycin (BLM)-Fe complex. Three hydroxyl groups in the flavonoidal nucleus were proposed as a crucial structural requirement for effectively promoting DNA degradation: 1...

journal_title：Biological & pharmaceutical bulletin

authors： Sugihara N,Kaneko A,Furuno K

更新日期：2003-08-01 00:00:00

abstract：:The present paper proposes a new approach for fitting the plasma effect-site equilibrium rate constant (Ke0) of propofol to satisfy the condition that the effect-site concentration (Ce) is equal at the time of loss of consciousness (LOC) and recovery of consciousness (ROC). Forty patients receiving intravenous anesthe...

journal_title：Biological & pharmaceutical bulletin

authors： Wu Q,Sun B,Wang S,Zhao L,Qi F

更新日期：2013-01-01 00:00:00