Antiproliferative activity of cardenolides isolated from Streptocaulon juventas.

Abstract:

:Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine-derived (colon 26-L5 carcinoma, Lewis lung carcinoma, B16-BL6 melanoma) cell lines. The cardenolides selectively and strongly inhibited proliferation of the HT-1080 (IC(50) values, 0.054-1.6 microM) and A549 (IC(50), 0.016-0.65 microM) cell lines. The characteristic morphological changes and ladder-like DNA fragmentation in those cells treated with the cardenolides indicated the antiproliferative activity was due to the induction of apoptosis.

journal_name

Biol Pharm Bull

authors

Ueda JY,Tezuka Y,Banskota AH,Tran QL,Tran QK,Saiki I,Kadota S

doi

10.1248/bpb.26.1431

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1431-5

issue

10

eissn

0918-6158

issn

1347-5215

journal_volume

26

pub_type

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