Abstract:
:Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine-derived (colon 26-L5 carcinoma, Lewis lung carcinoma, B16-BL6 melanoma) cell lines. The cardenolides selectively and strongly inhibited proliferation of the HT-1080 (IC(50) values, 0.054-1.6 microM) and A549 (IC(50), 0.016-0.65 microM) cell lines. The characteristic morphological changes and ladder-like DNA fragmentation in those cells treated with the cardenolides indicated the antiproliferative activity was due to the induction of apoptosis.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Ueda JY,Tezuka Y,Banskota AH,Tran QL,Tran QK,Saiki I,Kadota Sdoi
10.1248/bpb.26.1431subject
Has Abstractpub_date
2003-10-01 00:00:00pages
1431-5issue
10eissn
0918-6158issn
1347-5215journal_volume
26pub_type
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