Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I.

abstract：:Characteristics of transport of an oral aminocephalosporin, cefroxadine, in rabbit small intestinal brush border membrane vesicles were examined. Uptake rate of cefroxadine was saturable in the presence of an inward H+ gradient, and kinetic parameters were similar to those of cephradine. However, the uptake rate was a...

journal_title：Biological & pharmaceutical bulletin

authors： Kitagawa S,Sugaya Y

更新日期：1996-02-01 00:00:00

abstract：:Nafamostat mesilate, an ester drug with extensive hydrolysis in vivo, exhibits species difference in the relative contribution for its hydrolysis in blood and tissues. For the rat, the main hydrolysis site may be blood and human may be tissue (mainly by liver). The paper gave in vivo evidence that human tissue may giv...

journal_title：Biological & pharmaceutical bulletin

authors： Cao YG,Chen YC,Hao K,Zhang M,Liu XQ

更新日期：2008-11-01 00:00:00

abstract：:Continuous oral administration of the acidic polysaccharide (TAP) solution (0.5 g/l) and the TAP-H (degradation products of TAP) solution (1.5 g/l) instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model (KK-Ay) mice. TAP and TAP-H...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Kochi M,Usui S,Hirano K,Aizawa K,Inakuma T

更新日期：2001-12-01 00:00:00

abstract：:It has been well known that 3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) formed by catechol O-methyltransferase (COMT), and 3-OMD blood level often reaches higher than physiological level in Parkinson's disease (PD) patients receiving long term L-DOPA therapy. However, the physiologi...

journal_title：Biological & pharmaceutical bulletin

authors： Onzawa Y,Kimura Y,Uzuhashi K,Shirasuna M,Hirosawa T,Taogoshi T,Kihira K

更新日期：2012-01-01 00:00:00

abstract：:We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 microM. Time course study revealed that simultaneous co-treatment of...

journal_title：Biological & pharmaceutical bulletin

authors： Ishiwata S,Nakashita K,Ozawa Y,Niizeki M,Nozaki S,Tomioka Y,Mizugaki M

更新日期：1999-11-01 00:00:00

abstract：:The antitumour activity of the methanolic extract of Glinus lotoides (MGL) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean survival time of tumour bearing mice and peritoneal cell count in normal mice was observed with respect to the control group. Whe...

journal_title：Biological & pharmaceutical bulletin

authors： Kavimani S,Manisenthilkumar KT,Ilango R,Krishnamoorthy G

更新日期：1999-11-01 00:00:00

abstract：:Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) trigger...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CS,Won C,Yoo H,Yi EH,Cho Y,Maeng JW,Sung SH,Ye SK,Chung MH

更新日期：2009-11-01 00:00:00

abstract：:Although hypokalemia is an adverse effect of Yokukansan preparation, especially in geriatric patients, its association with age is unclear. We investigated whether age is a risk factor for hypokalemia. This single-center retrospective cohort study, conducted at Tokyo Women's Medical University, Medical Center East bet...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamaga R,Kei M,Hosohata K,Itoh T

更新日期：2020-01-01 00:00:00

abstract：:Arsenicals are known to be toxic and carcinogenic in humans. Inorganic arsenicals are enzymatically methylated to monomethylarsonic acid (MMAsV) and dimethylarsinic acid (DMAsV), which are the major pentavalent methyl arsenic metabolites. Recent reports indicate that trivalent methyl arsenicals are produced through me...

journal_title：Biological & pharmaceutical bulletin

authors： Kojima C,Sakurai T,Waalkes MP,Himeno S

更新日期：2005-10-01 00:00:00

abstract：:The effects of erythromycin, clarithromycin and rokitamycin on the metabolism of nifedipine were studied in vitro and in situ. Erythromycin, clarithromycin or rokitamycin added to nifedipine did not inhibit the formation of metabolite, M-1, of nifedipine, whereas pretreatment with erythromycin or clarithromycin signif...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuruta S,Nakamura K,Arimori K,Nakano M

更新日期：1997-04-01 00:00:00

abstract：:In this study, the effects of N-acyl taurates (NATs) on the intestinal absorption of curcumin (CUR), a water-insoluble and poorly absorbed compound, were examined in rats. Sodium methyl lauroyl taurate (LMT) and sodium methyl cocoyl taurate (CMT) were the most effective in increasing the solubility and intestinal abso...

journal_title：Biological & pharmaceutical bulletin

authors： Li X,Kawamura A,Sato Y,Morishita M,Kusamori K,Katsumi H,Sakane T,Yamamoto A

更新日期：2017-01-01 00:00:00

abstract：:The involvement of the peripheral serotonin2A (5-HT2A) receptor in alpha-methyl-5-HT-induced hyperglycemia was examined in rats. The 5-HT2A receptor antagonist, ketanserin, significantly inhibited alpha-methyl-5-HT-elicited hyperglycemia. Taken together with a previous report that 5-HT-induced hyperglycemia was preven...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimoto Y,Yamada J,Yoshikawa T,Horisaka K

更新日期：1996-10-01 00:00:00

abstract：:Methylripariochromene A (MRC) was isolated from the leaves of Orthosiphon aristatus (Lamiaceae) and subjected to the examination of several pharmacological actions related to antihypertensive activity. The following four findings were revealed from the present study: 1) MRC caused a continuous decrease in systolic blo...

journal_title：Biological & pharmaceutical bulletin

authors： Matsubara T,Bohgaki T,Watarai M,Suzuki H,Ohashi K,Shibuya H

更新日期：1999-10-01 00:00:00

abstract：:Berberine has a wide range of biochemical and pharmacologic effects, including antitumor activity, but the mechanisms involved in berberine-induced apoptosis remain unclear. The purpose of the present study was to investigate the changes in oxidative stress and endoplasmic reticulum (ER)-related molecules, which are c...

journal_title：Biological & pharmaceutical bulletin

authors： Eom KS,Kim HJ,So HS,Park R,Kim TY

更新日期：2010-01-01 00:00:00

abstract：:Tyrosinase is a key enzyme in the synthesis of melanin and is widely distributed in animals, plants, and microorganisms. As excessive melanin production causes not only hyperpigmenting effects on human skin but also melanosis in various foods, an inhibitor of tyrosinase has become of interest lately from a practical p...

journal_title：Biological & pharmaceutical bulletin

authors： Tsuchiya T,Yamada K,Minoura K,Miyamoto K,Usami Y,Kobayashi T,Hamada-Sato N,Imada C,Tsujibo H

更新日期：2008-08-01 00:00:00

abstract：:Although distigmine is known to sometimes cause severe adverse drug reactions (ADRs), such as cholinergic crisis, there are limited data on the risk factors for these ADRs. In this study, we defined a serum cholinesterase (sChE) cutoff level for early detection of ADRs to distigmine and sought to identify risk factors...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuboshi S,Nagai K,Okajima H

更新日期：2020-01-01 00:00:00

abstract：:Effects of nebracetam, a novel nootorpic agent, on the synaptosomal uptake of neurotransmitter monoamines of the brain regions were examined. Striatal and hippocampal synaptosomes were isolated by the Percoll gradient method, and the striatal dopamine uptake and hippocampal serotonin uptake were measured in the presen...

journal_title：Biological & pharmaceutical bulletin

authors： Takeo S,Hayashi H,Tadokoro M,Takagi K,Miyake K,Takagi N,Oshikawa S

更新日期：1997-04-01 00:00:00

abstract：:The present study was undertaken to clarify the effect of group I metabotropic glutamate receptor (mGluR) antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) on pentetrazol-induced kindled seizures. The mechanism of the anticonvulsant effect of AIDA was also studied. Mice were anesthetized with pentobarbital; t...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe Y,Kaida Y,Takechi K,Kamei C

更新日期：2010-01-01 00:00:00

abstract：:The utility of gastrointestinal physiology regulated-dogs (regulated-dogs) was evaluated in a bioavailability study. The gastrointestinal physiology of beagle dogs was regulated with a combined-treatment of intramuscular pentagastrin and intravenous atropine sulfate. Theophylline has been regarded as a drug that is ab...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara K,Kawata M,Mizuta H,Shibata M

更新日期：1994-07-01 00:00:00

abstract：:A lipid fraction obtained by activity-guided fractionation from the hexane extract of Sideritis javalambrensis was evaluated for anti-inflammatory activity. This fraction significantly inhibited paw oedema induced by carrageenan as well as ear oedema induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in mice after ...

journal_title：Biological & pharmaceutical bulletin

authors： Godo A,de Heras BL,Vivas JM,Villar A

更新日期：2000-10-01 00:00:00

abstract：:Protective effects of quinic acids from Aster scaber on tetrahydropapaveroline (THP)-induced cell toxicity were evaluated in rat C6 glioma cells. Among 4 quinic acid derivatives tested, (-) 4,5-dicaffeoyl quinic acid (QA3) exhibited the highest protective effect against THP-induced cell toxicity. C6 cells treated with...

journal_title：Biological & pharmaceutical bulletin

authors： Soh Y,Kim JA,Sohn NW,Lee KR,Kim SY

更新日期：2003-06-01 00:00:00

abstract：:A homogeneous fluorescence polarization immunoassay (FPIA) was developed to measure levels of progesterone in urine using a TDx analyzer in photocheck mode (Abbott Labs). Two tracers of ethylenediamine fluorescein thiocarbamyl (EDF) were employed; one was synthesized from 11 alpha-hydroxyhemisuccinate progesterone (Pr...

journal_title：Biological & pharmaceutical bulletin

authors： Choi MJ,Choi J,Yoon DY,Park J,Eremin SA

更新日期：1997-04-01 00:00:00

abstract：:Although macrophage phagocytoses modified low-density lipoprotein (LDL), excessive accumulation of modified LDL induces macrophage foam cell formation, which is a feature of atherosclerotic plaque. Thus, the identification of scavenger receptor for modified LDL will provide better understanding of an atherosclerotic e...

journal_title：Biological & pharmaceutical bulletin

authors： Miki Y,Tachibana Y,Ohminato Y,Fujiwara Y

更新日期：2015-01-01 00:00:00

abstract：:In this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, Leishmania major, Leishmania tropica and Leishmania infantum (Pakistani isolate). Curcumin has shown an average IC5...

journal_title：Biological & pharmaceutical bulletin

authors： Saleheen D,Ali SA,Ashfaq K,Siddiqui AA,Agha A,Yasinzai MM

更新日期：2002-03-01 00:00:00

abstract：:In vivo redox reactions of nitroxyl contrast agents in bile and blood under an oxidative atmosphere were investigated using normal healthy Wistar rats. Differences in intracellular and extracellular volumes in redox environments are discussed. Pharmacokinetic profiles of two nitroxyl contrast agents, 3-carbamoyl-2,2,5...

journal_title：Biological & pharmaceutical bulletin

authors： Okajo A,Ui I,Manda S,Nakanishi I,Matsumoto K,Anzai K,Endo K

更新日期：2009-04-01 00:00:00

abstract：:To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flave...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi-Miyamoto T,Kawasuji T,Kuraishi Y,Suzuki H

更新日期：2003-05-01 00:00:00

abstract：:The therapeutic value of an antirheumatic alkaloid, sinomenine (SIN), was investigated in the acute experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). SIN is a bioactive alkaloid derived from the Chinese medicinal plant, Sinomenium acutum REHDER & E. H. WILSON (Family Menispermaceae). Ch...

journal_title：Biological & pharmaceutical bulletin

authors： Zeng Y,Gu B,Ji X,Ding X,Song C,Wu F

更新日期：2007-08-01 00:00:00

abstract：:This article has been retracted by the Editorial Committee of The Pharmaceutical Society of Japan because it contains scientific misconduct. Although the data published in this article were generated in part by the first author, the authors violated authorship and sponsorship protocol. ...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JH,Lee JH,Kim YJ

更新日期：2015-11-06 00:00:00

abstract：:Behavioral and psychological symptoms of dementia (BPSD) are commonly seen in patients with Alzheimer's disease (AD) and other forms of senile dementia. BPSD have a serious impact on the quality of life of dementia patients, as well as on that of their caregivers. However, effective drug therapy for BPSD has not been ...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida N,Egashira N,Iwasaki K,Ishibashi A,Tashiro R,Nogami A,Manome N,Abe M,Takasaki K,Mishima K,Takata J,Oishi R,Nishimura R,Fujiwara M

更新日期：2009-03-01 00:00:00

abstract：:We examined the effects of ginseng total saponin (GTS) and several ginsenosides injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the antinociception induced by cold water swimming. The tail-flick response was used as an antinociceptive parameter. We found that i.t. injection of GTS time- and dose...

journal_title：Biological & pharmaceutical bulletin

authors： Choi SS,Lee JK,Suh HW

更新日期：2003-06-01 00:00:00