Abstract:
:The roles of OmpC and OmpF in acidic resistance (AR) were examined. When ompC and ompF were deleted, AR was decreased. The decreased level of AR seen in the mutant that was deficient in ompC and ompF was elevated by the addition of glutamate, but not by the addition of arginine or lysine. The expression levels of adiA and cadB were diminished by the deletion of ompC and ompF, and the conversion of arginine to agmatine and lysine to cadaverine by intact cells were reduced in the mutant. The expression of gadA/gadB was not affected by the deletion of ompC and ompF. These results suggest that the transport of arginine, lysine, and their decarboxylated products through OmpC and/or OmpF is essential for the survival of Escherichia coli cells under extremely acidic conditions.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Bekhit A,Fukamachi T,Saito H,Kobayashi Hdoi
10.1248/bpb.34.330subject
Has Abstractpub_date
2011-01-01 00:00:00pages
330-4issue
3eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/34.330journal_volume
34pub_type
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