Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing.

abstract：:Plasmodium falciparum thymidylate kinase (PfTMK) is a potential chemotherapeutic target as it can tolerate a range of substrates, which distinguishes it from other thymidylate kinases. An important step in drug development is to determine the interaction of ligands competing for their target sites in a proposed drug t...

journal_title：Biological & pharmaceutical bulletin

authors： Kandeel M,Kitade Y

更新日期：2011-01-01 00:00:00

abstract：:The pharmacological characteristics of Ryokan-kyomi-shinge-nin-to (RKS), a traditional oriental herbal (Kampo) medicine which has been used for the treatment of allergic asthma and rhinitis, were investigated. The number of sneezes by actively sensitized mice after a topical antigen challenge was significantly reduced...

journal_title：Biological & pharmaceutical bulletin

authors： Sakaguchi M,Ikeda Y,Kido T,Yuzurihara M,Kase Y,Yamamoto M,Ishige A,Sasaki H

更新日期：2002-12-01 00:00:00

abstract：:To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid X receptor (FXR...

journal_title：Biological & pharmaceutical bulletin

authors： Qu X,Zhang Y,Zhang S,Zhai J,Gao H,Tao L,Song Y

更新日期：2018-01-01 00:00:00

abstract：:This study was conducted to demonstrate the inhibitory effect of saucerneol G (SG), a new lignan, isolated from the aerial part of Saururus chinensis (Saururaceae) on lipopolysaccharide (LPS)-stimulated matrix metalloproteinase-9 (MMP)-9 inductions in RAW 264.7 cells. Aimed at evaluating the mechanism of action by whi...

journal_title：Biological & pharmaceutical bulletin

authors： Lu Y,Hong TG,Jin M,Yang JH,Suh SJ,Piao DG,Ko HK,Seo CS,Chang YC,Kim CH,Son JK,Chang HW

更新日期：2010-01-01 00:00:00

abstract：:Polysaccharides are involved in biological responses and can activate complement system, which plays an important role in primary host defense mechanisms. We investigated anticomplementary activities from spice plants and selected thyme (Thymus vulgaris L.) as a potent complementary activator. Acidic polysaccharide (T...

journal_title：Biological & pharmaceutical bulletin

authors： Chun H,Shin DH,Hong BS,Cho HY,Yang HC

更新日期：2001-08-01 00:00:00

abstract：:This study was designed to test the efficacy of eugenol, a compound obtained from the essential oil of cloves (Syzygium aromaticum) in collagen-induced arthritis (CIA), a well characterized murine model of rheumatoid arthritis. Macroscopic clinical evidence of CIA manifests first as periarticular erythema and edema in...

journal_title：Biological & pharmaceutical bulletin

authors： Grespan R,Paludo M,Lemos Hde P,Barbosa CP,Bersani-Amado CA,Dalalio MM,Cuman RK

更新日期：2012-01-01 00:00:00

abstract：:Hyphal growth of Candida albicans was observed at neutral condition, whereas the yeast growth was increased below pH 5. Eight out of 12 strains of C. albicans grow in hyphal form at pH 7, and hyphal formation was inhibited in all strains at pH 4. The addition of GMP, an alternative oxidase (AOX) activator, induced the...

journal_title：Biological & pharmaceutical bulletin

authors： Konno N,Ishii M,Nagai A,Watanabe T,Ogasawara A,Mikami T,Matsumoto T

更新日期：2006-05-01 00:00:00

abstract：:As an attempt to find bioactive medicinal herbs exerting anti-asthmatic activity, the effects of an ethanol extract from the parts of Saururus chinensis were evaluated in both in vitro and in vivo. The ethanol extract of S. chinensis (ESC) inhibited generation of the cyclooxygenase-2 (COX-2) dependent phases of prosta...

journal_title：Biological & pharmaceutical bulletin

authors： Lee E,Haa K,Yook JM,Jin MH,Seo CS,Son KH,Kim HP,Bae KH,Kang SS,Son JK,Chang HW

更新日期：2006-02-01 00:00:00

abstract：:Prunella vulgaris L., commonly known as "self-heal" or "heal-all," is a perennial herb with a long history of medicinal use. Phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H), and 4-coumarate:coenzyme-A (CoA) ligase (4CL) are important enzymes in the phenylpropanoid pathway and in the accumulation of ro...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YB,Shin Y,Tuan PA,Li X,Park Y,Park NI,Park SU

更新日期：2014-01-01 00:00:00

abstract：:The number of spleen Mac-1-positive cells was markedly increased in methylcholanthrene-induced Meth-A fibrosarcoma (Meth-A)-implanted mice. When the sera of Meth-A-implanted mice were added to normal bone marrow cells, granulocyte and macrophage colony stimulating factor (GM-CSF)-dependent growth of bone marrow cells ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe T,Okada A,Mikami T,Matsumoto T,Suzuki M

更新日期：1995-12-01 00:00:00

abstract：:Resveratrol, which is found in grapes, red wine, and berries, has many beneficial health effects, such as anti-cancer, neuro-protective, anti-inflammatory, and life-prolonging effects. However, the cellular mechanisms by which resveratrol acts are relatively unknown, especially in terms of possible regulation of recep...

journal_title：Biological & pharmaceutical bulletin

authors： Lee BH,Hwang SH,Choi SH,Shin TJ,Kang J,Lee SM,Nah SY

更新日期：2011-01-01 00:00:00

abstract：:Effects of selenium supplementation on atopic dermatitis (AD) were investigated by administering seleno-L-methionine (SeMet) using a mouse model of AD caused by repeated application of 2,4,6-trinitrochlorobenzene (TNCB). BALB/c mice were sensitized with TNCB to the abdomen on day -7; then, TNCB was applied repeatedly ...

journal_title：Biological & pharmaceutical bulletin

authors： Arakawa T,Sugiyama T,Matsuura H,Okuno T,Ogino H,Sakazaki F,Ueno H

更新日期：2018-01-01 00:00:00

abstract：:Two angiotensin-I-converting enzyme (ACE) inhibitory peptides were isolated from a tryptic hydrolysate of human serum albumin (HSA). The peptides were identified by sequencing and other analyses as Ala-Trp and the nonapeptide Ala-Phe-Lys-Ala-Trp-Ala-Val-Ala-Arg (human albutensin A), corresponding to f(213-214) and f(2...

journal_title：Biological & pharmaceutical bulletin

authors： Nakagomi K,Ebisu H,Sadakane Y,Fujii N,Akizawa T,Tanimura T

更新日期：2000-07-01 00:00:00

abstract：:The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of as...

journal_title：Biological & pharmaceutical bulletin

authors： Lares-Asseff I,Juárez-Olguín H,Flores-Pérez J,Guillé-Pérez A,Vargas A

更新日期：2004-05-01 00:00:00

abstract：:The present study was designed to examine whether the methanol extract of Sorbus commixta cortex (MSC) could prevent the development of atherosclerosis through regulating the vascular nitric oxide (NO) and endothelin-1 (ET-1) systems in atherogenic-diet rats. Our findings show that aortic NO production as well as endo...

journal_title：Biological & pharmaceutical bulletin

authors： Sohn EJ,Kang DG,Mun YJ,Woo WH,Lee HS

更新日期：2005-08-01 00:00:00

abstract：:A series of 8-substituted quinolines were synthesized and tested against seizures induced by maximal electro shock (MES), pentylenetetrazole (scMet) and antihypertensive activities. Neurologic deficit was evaluated by the rotarod test. Among the newly synthesized derivatives, several compounds with a 2-hydroxypropylox...

journal_title：Biological & pharmaceutical bulletin

authors： Muruganantham N,Sivakumar R,Anbalagan N,Gunasekaran V,Leonard JT

更新日期：2004-10-01 00:00:00

abstract：:It is well established that vesicular nucleotide transporter (VNUT) is responsible for vesicular storage of nucleotides such as ATP, and that VNUT-expressing cells can secrete nucleotides upon exocytosis, playing an important role in purinergic chemical transmission. In the present study, we show that VNUT is expresse...

journal_title：Biological & pharmaceutical bulletin

authors： Harada Y,Hiasa M

更新日期：2014-01-01 00:00:00

abstract：:The anti-inflammatory effects of 1,6-anhydro-3,4-dideoxy-2-furfuryl-beta-D-threo-3-enopyranose (MT2221) were investigated using animal models and compared with the effects of dexamethasone (DEX) and cyclosporin A (CYA). MT2221 inhibited carrageenan-induced acute inflammation and adjuvant arthritis in rats, as well as ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizukoshi S,Tsukamoto M,Tanaka H,Nakamura K,Kato F

更新日期：1994-08-01 00:00:00

abstract：:Novel delivery technology using cell-penetrating peptides (CPPs) have recently shown their potential and are emerging as promising candidates for an oral protein and peptide delivery systems. As with for the development of any absorption enhancer that is meant to function across an epithelial layer covering a surface ...

journal_title：Biological & pharmaceutical bulletin

authors： Nielsen EJ,Kamei N,Takeda-Morishita M

更新日期：2015-01-01 00:00:00

abstract：:Povidone-iodine (PVP-I), an antibacterial medicine, was infiltrated in sepiolite (SPL). The available iodine content in this new pharmaceutical product, a sepiolite preparation containing povidone-iodine (PVP-I-SPL), was retained at 98.9 and 98.3% during storage at 40 degrees C for 3 and 6 months, respectively. The ef...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta S,Nagai K,Maruyama M,Inoue H,Katsuyama Y,Atobe O,Ogata H,Yamato S,Tachikawa E,Zenda H

更新日期：1999-01-01 00:00:00

abstract：:Mume fruit, the Japanese apricot (Prunus mume SIEB. et ZUCC.), is popular in Japan and is mostly consumed in the pickled form called umeboshi. This fruit is known to have anti-microbial properties, but the principal constituents responsible for the antimicrobial properties have not yet been elucidated. We investigated...

journal_title：Biological & pharmaceutical bulletin

authors： Mitani T,Ota K,Inaba N,Kishida K,Koyama HA

更新日期：2018-01-01 00:00:00

abstract：:An increase in the number of glucocorticoid-induced tumor necrosis factor receptor-family related gene/protein (GITR)+CD25- (or fork-head box protein 3: Foxp3-) CD4+ T cells, after treating a mouse model of arthritis with fingolimod (FTY720), and a pathogenic antigen may play a key role in the establishment of immune ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshida Y,Mikami N,Nakanishi Y,Saimoto M,Nagaike A,Shimono H,Nakano S,Tsuji T,Kohno T

更新日期：2021-01-26 00:00:00

abstract：:Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured. Val...

journal_title：Biological & pharmaceutical bulletin

authors： Kubo K,Nanba H

更新日期：1997-07-01 00:00:00

abstract：:The roles of OmpC and OmpF in acidic resistance (AR) were examined. When ompC and ompF were deleted, AR was decreased. The decreased level of AR seen in the mutant that was deficient in ompC and ompF was elevated by the addition of glutamate, but not by the addition of arginine or lysine. The expression levels of adiA...

journal_title：Biological & pharmaceutical bulletin

authors： Bekhit A,Fukamachi T,Saito H,Kobayashi H

更新日期：2011-01-01 00:00:00

abstract：:The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female ...

journal_title：Biological & pharmaceutical bulletin

authors： Wang XK,Zhao Y,Liu T,Yi Y,Li CY,Wang HJ,Wang CH,Wang ZT,Ye ZG,Liang AH

更新日期：2015-01-01 00:00:00

abstract：:Recently we showed significance of biosurfactants in the field of non-viral vectors for gene transfection. There, a biosurfactant, mannosylerythritol lipid A (MEL-A), especially increased the efficiency of gene transfection mediated with cationic liposomes. However, the molecular mechanism has not been well-understood...

journal_title：Biological & pharmaceutical bulletin

authors： Ueno Y,Hirashima N,Inoh Y,Furuno T,Nakanishi M

更新日期：2007-01-01 00:00:00

abstract：:Over-expression of P-glycoprotein (P-gp) in lymphocytes is implicated in the failure of immunosuppressant therapy. We investigated P-gp function in peripheral-blood CD3+, CD4+, and CD8+ cells of 14 healthy subjects and 12 patients with systemic lupus erythematosus (SLE). P-gp function was estimated by the transporter ...

journal_title：Biological & pharmaceutical bulletin

authors： Henmi K,Yoshida M,Yoshikawa N,Hirano T

更新日期：2008-05-01 00:00:00

abstract：:We examined the biological activities present in Streptomyces strains preserved at the National Institute of Technology and Evaluation Biological Resource Center, and found a metabolite of Streptomyces roseolilacinus NBRC 12815 that showed a potent anti-tyrosinase activity. The compounds with anti-tyrosinase activity ...

journal_title：Biological & pharmaceutical bulletin

authors： Nakashima T,Anzai K,Kuwahara N,Komaki H,Miyadoh S,Harayama S,Tianero MD,Tanaka J,Kanamoto A,Ando K

更新日期：2009-05-01 00:00:00

abstract：:Cytochrome P450 monooxygenases (P450s) catalyze a wide variety of monooxygenation reactions in primary and secondary metabolism in plants. The share of P450 genes in each plant genome is estimated to be up to 1%. This implies that the diversification of P450 has made a significant contribution to the ability to acquir...

journal_title：Biological & pharmaceutical bulletin

authors： Mizutani M

更新日期：2012-01-01 00:00:00

abstract：:We have developed a mass microscope in which a microscope is combined with high-resolution matrix assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). This technique is a powerful tool for investigating the spatial distribution of biomolecules without the need for any time-consuming extraction, ...

journal_title：Biological & pharmaceutical bulletin

authors： Saito Y,Waki M,Hameed S,Hayasaka T,Setou M

更新日期：2012-01-01 00:00:00