Abstract:
:Recently we showed significance of biosurfactants in the field of non-viral vectors for gene transfection. There, a biosurfactant, mannosylerythritol lipid A (MEL-A), especially increased the efficiency of gene transfection mediated with cationic liposomes. However, the molecular mechanism has not been well-understood yet. Here, through the examination of the ability of cationic liposomes containing an MEL (MEL-A, MEL-B or MEL-C) for important transfectional processes of the DNA capsulation and the membrane fusion with anionic liposomes, we found that MEL-A-containing liposomes increased both processes, but that MEL-B and MEL-C-containing liposomes just increased either of them. The results indicated that these kinds of the physicochemical properties in MEL-A-containing liposomes are able to increase the efficiency of liposome-mediated gene transfection.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Ueno Y,Hirashima N,Inoh Y,Furuno T,Nakanishi Mdoi
10.1248/bpb.30.169subject
Has Abstractpub_date
2007-01-01 00:00:00pages
169-72issue
1eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/30.169journal_volume
30pub_type
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