Pharmacological characteristics of Ryokan-kyomi-shinge-nin-to, an antiallergic Kampo medicine.

abstract：:This study aimed to investigate the mechanism by which the human lung cancer drug resistance-related gene BC006151 regulates chemosensitivity by down-regulating BC006151 expression via antisense gene transfer in H446/(C)DDP cells. A retroviral vector containing the antisense BC006151 sequence was constructed and trans...

journal_title：Biological & pharmaceutical bulletin

authors： Li S,Shi H,Ji F,Wang B,Feng Q,Feng X,Jia Z,Zhao Q,Qian G

更新日期：2010-01-01 00:00:00

abstract：:Apoptosis is the main form of β-cell death in diabetes. Ginseng has been used as an anti-diabetic herb for several thousand years in Asia with ginsenoside Rg1 and ginsenoside Rb1 as important active ingredients. In this study, we demonstrated ginsenoside Rg1 and Rb1 protect β-cells from high glucose/cytokine-induced p...

journal_title：Biological & pharmaceutical bulletin

authors： Chen F,Chen Y,Kang X,Zhou Z,Zhang Z,Liu D

更新日期：2012-01-01 00:00:00

abstract：:In most species, solar light is both a DNA-damaging agent and the key entraining stimulus for the endogenous circadian clock. The zebrafish is an attractive vertebrate system in which to study the influence of light on gene expression because the DNA repair proteins and circadian oscillators in this species are light-...

journal_title：Biological & pharmaceutical bulletin

authors： Osaki T,Uchida Y,Hirayama J,Nishina H

更新日期：2011-01-01 00:00:00

abstract：:The sialic acid binding lectin from bullfrog Rana catesbeiana oocyte (cSBL) is known to have anti-tumor activity. In order to investigate the relationship between the net charge of cSBL and its anti-tumor effect, cSBL was modified with a water-soluble carbodiimide (EDC) in the presence of three kinds of nucleophiles, ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwama M,Ogawa Y,Sasaki N,Nitta K,Takayanagi Y,Ohgi K,Tsuji T,Irie M

更新日期：2001-09-01 00:00:00

abstract：:The purpose of this study is to develop a new method of preparing salvianolic acid extracts (SAE) water-in-oil-in-water (W/O/W) multiple emulsion (ME). SAE injection is used in the treatment of brain infarct and promotion of blood circulation in China. However, the injection is not convenient, and the oral preparation...

journal_title：Biological & pharmaceutical bulletin

authors： Song Y,Gao H,Zhang S,Zhang Y,Jin X,Sun J

更新日期：2017-12-01 00:00:00

abstract：:This study was conducted to investigate the effects of the extracts of green romaine lettuce (GRE) on sleep enhancement. GRE contains 1071.7 and 199.2 µg/g of extracts of lactucin and lactucopicrin, respectively, known as sleep enhancement substances. When 100 mg/kg of GRE was administered orally, sleep latency and du...

journal_title：Biological & pharmaceutical bulletin

authors： Kim HW,Suh HJ,Choi HS,Hong KB,Jo K

更新日期：2019-01-01 00:00:00

abstract：:The prophylactic action of scymnol in a rat peripheral arterial occlusion model, involving injection of 5% lactic acid into the femoral artery, was investigated. Increases in serum lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) activities and in plasma leve...

journal_title：Biological & pharmaceutical bulletin

authors： Ishida H,Nakayasu H,Nukaya H,Tsuji K

更新日期：1999-08-01 00:00:00

abstract：:Coenzyme Q10 (Co-Q10) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q10...

journal_title：Biological & pharmaceutical bulletin

authors： Ewees MG,Messiha BA,Abo-Saif AA,Abd El-Latif HA

更新日期：2016-01-01 00:00:00

abstract：:Central nervous system (CNS) agents cause fractures among the elderly, but fracture risks of a wide range of CNS agent classes have not been analyzed in a study with the same population and definitions of variables. This study aimed to estimate the degree of fragility fracture risk of a wide range of CNS agent classes...

journal_title：Biological & pharmaceutical bulletin

authors： Ohara E,Bando Y,Yoshida T,Ohara M,Kirino Y,Iihara N

更新日期：2020-01-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) plays an important role in the development of glomerulonephritis. The study of experimental glomerulonephritis in rats was performed to examine the antinephritic effects of TJN-331, a new herbally-derived chemical compound. To clarify the action of TJN-331 ((E)-N-(3,4-dimet...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitte...

journal_title：Biological & pharmaceutical bulletin

authors： Sato-Masumoto N,Uchikura T,Sugiwaki H,Yoshimura M,Masada S,Atsumi T,Watanabe M,Tanaka N,Uchiyama N,Amakura Y,Hakamatsuka T

更新日期：2017-01-01 00:00:00

abstract：:Rats stressed by specific alternation of rhythm in temperature (SART) show various symptoms of disautonomia, increased pulse rates, continuous hypotension, and severe orthostatic hypotension (OH) when they are subjected to postural change. The OH symptoms are improved by muscarinic M2-receptor blockers. In the present...

journal_title：Biological & pharmaceutical bulletin

authors： Funakami Y,Hata T,Itoh E,Itano S

更新日期：2007-02-01 00:00:00

abstract：:Effects of epidermal growth factor (EGF) on the expression of alpha(2)-adrenergic responses were examined in primary cultures of adult rat hepatocytes. The alpha(2)-responses were assessed by the inhibition of the rate of forskolin-stimulated cAMP formation by the selective alpha(2)-adrenergic agonists, oxymetazoline ...

journal_title：Biological & pharmaceutical bulletin

authors： Ogihara M

更新日期：1996-04-01 00:00:00

abstract：:The emulsion prepared with β-cyclodextrin as an emulsifier (βCDE) is considered to be a Pickering emulsion. We examined the characteristics of βCDEs using captopril (CP) as a model drug, and studied the in vitro skin permeation of CP from βCDEs through hairless mouse skin. The stability of βCDE was increased with incr...

journal_title：Biological & pharmaceutical bulletin

authors： Taguchi H,Tanaka H,Hashizaki K,Saito Y,Fujii M

更新日期：2019-01-01 00:00:00

abstract：:Medicinal plants with reported anti-inflammatory activity could have the potential use as anti-allergens and inhibitors of allergic contact dermatitis reactions produced by allergens and chemicals. Some species from the genus Artocarpus were reported to have anti-inflammatory activity. In the Philippines one local sou...

journal_title：Biological & pharmaceutical bulletin

authors： Salonga RB,Hisaka S,Nose M

更新日期：2014-01-01 00:00:00

abstract：:Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antib...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui E,Takayama K,Sato E,Okamura N

更新日期：2011-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-α) plays an important role in the developing process of inflammatory bowel disease. Tight junction protein zonula occludens-1 (ZO-1), one of epithelial junctional proteins, maintains the permeability of intestinal barrier. The objective of this study was to investigate the mechanism of...

journal_title：Biological & pharmaceutical bulletin

authors： Wang L,Zhang R,Chen J,Wu Q,Kuang Z

更新日期：2017-04-01 00:00:00

abstract：:The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda T,Yokomizo K,Okawa M,Tsuchihashi R,Kinjo J,Nohara T,Uyeda M

更新日期：2005-09-01 00:00:00

abstract：:The hepatoprotecive effects of recombinant human epidermal growth factor (hEGF) on chemically and immunologically induced experimental liver injury models were examined. The hEGF clearly decreased serum transaminase levels in D-galactosamine (D-GalN) and D-GalN/lipopolysaccharide (LPS)-induced liver injury models unde...

journal_title：Biological & pharmaceutical bulletin

authors： Cho JY,Yeon JD,Kim JY,Yoo ES,Yu YH,Park MH

更新日期：2000-10-01 00:00:00

abstract：:A homology-based cloning strategy yielded Sdga, a cDNA clone presumably encoding alpha-subunit of heterotrimeric guanosine 5'-triphosphate-binding protein complex, from leaf tissues of Scoparia dulcis. Phylogenetic tree analysis of G-protein alpha-subunits from various biological sources suggested that, unlike in anim...

journal_title：Biological & pharmaceutical bulletin

authors： Shite M,Yamamura Y,Hayashi T,Kurosaki F

更新日期：2008-11-01 00:00:00

abstract：:This study was conducted to determine the beneficial effects of treating digestive disorders of (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol diacetate (TDEYA) detected in the plasma in hydrolyzed form: (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEY), following the oral administration of a decoction of Atractylodes r...

journal_title：Biological & pharmaceutical bulletin

authors： Sakurai T,Sugawara H,Saito K,Kano Y

更新日期：1994-10-01 00:00:00

abstract：:Monocytes/macrophages are known to be involved in atherogenesis, and the adherence of monocytes to the endothelium is considered an earliest characteristic of atherogenesis. Therefore, we studied the mechanism by which Shosaikoto, a Kampo medicine, shows anti-atherosclerotic action, which has been already shown in hyp...

journal_title：Biological & pharmaceutical bulletin

authors： Shen YR,Inoue M,Ogihara Y

更新日期：1996-01-01 00:00:00

abstract：:The effect of pulsed output ultrasound (1 MHz) with on/off ratios of 1:2, 1:4 and 1:9 on transdermal absorption of indomethacin from an ointment was studied in rats. Ultrasound energy was supplied for between 10 and 19 min at a range of intensities (1.0-2.5 W.cm-2), energy levels commonly used for therapeutic purposes...

journal_title：Biological & pharmaceutical bulletin

authors： Asano J,Suisha F,Takada M,Kawasaki N,Miyazaki S

更新日期：1997-03-01 00:00:00

abstract：:A novel constituent, shamimicin, 1"', 1"'-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran along with lupeol, which possesses potent hypotensive activity, has been isolated from Bombax ceiba stem bark. BCBMM--one of the most active hypotensive fractions has revealed its advers...

journal_title：Biological & pharmaceutical bulletin

authors： Saleem R,Ahmad SI,Ahmed M,Faizi Z,Zikr-ur-Rehman S,Ali M,Faizi S

更新日期：2003-01-01 00:00:00

abstract：:A fungus of Pestalotiopsis species produced an extracellular, water-soluble polysaccharide (PS-N). PS-N exhibited significant hypoglycemic activity in streptozotocin-induced diabetic mice following intraperitoneal administration and had an effect on oral glucose tolerance in normal mice following oral administration. ...

journal_title：Biological & pharmaceutical bulletin

authors： Kiho T,Itahashi S,Sakushima M,Matsunaga T,Usui S,Ukai S,Mori H,Sakamoto H,Ishiguro Y

更新日期：1997-02-01 00:00:00

abstract：:The pharmacokinetics of ketotifen fumarate (KF) was examined after administration in rabbits through four different routes (intravenous, intranasal, oral and rectal). The time-course of the plasma concentration of KF after intravenous administration (1 mg/kg dose) fitted a two-compartment open model. KF was rapidly ab...

journal_title：Biological & pharmaceutical bulletin

authors： Yagi N,Taniuchi Y,Hamada K,Sudo J,Sekikawa H

更新日期：2002-12-01 00:00:00

abstract：:The inhibitory effects of a potent nitric oxide (NO) synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), on 2-deoxy-D-glucose (2-DG)-induced hyperglycemia were investigated in rats. L-NAME significantly inhibited 2-DG-induced hyperglycemia, although N(G)-nitro-D-arginine methyl ester (D-NAME) did not affe...

journal_title：Biological & pharmaceutical bulletin

authors： Sugimoto Y,Yamada J,Yoshikawa T,Horisaka K

更新日期：1997-12-01 00:00:00

abstract：:The bioavailability of morphine after rectal administration using three types of suppositories containing morphine hydrochloride (10 mg) in different added forms was evaluated in rabbits. Three types of suppositories were constructed with a base material (Witepsol H-15): a conventional suppository containing morphine ...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto Y,Watanabe Y,Yamamoto I,Matsumoto M

更新日期：1993-02-01 00:00:00

abstract：:T cells play a principal role in cellular immunity and govern the regulatory mechanism in humoral immunity. Therefore, T cells play a key role as either effectors or regulators in the immune network. Mizoribine (MZR), an immunosuppressive agent, suppresses both humoral and cellular immunity by acting on both T cells a...

journal_title：Biological & pharmaceutical bulletin

authors： Kamada H,Inoue N,Takaoka Y,Nakagami K,Mori H,Nagai H

更新日期：1996-09-01 00:00:00

abstract：:To improve bioavailability of pueraria flavones (PF), a self-microemulsifying drug delivery system (SMEDDS) dropping pills composed of PF, Crodamol GTCC, Maisine 35-1, Cremophor RH 40, 1,2-propylene glycol and polyethylene glycol 6000 (PEG6000) was developed. Particle size, zeta potential, morphology and in vitro drug...

journal_title：Biological & pharmaceutical bulletin

authors： Guan Q,Zhang G,Sun S,Fan H,Sun C,Zhang S

更新日期：2016-05-01 00:00:00