Abstract:
:Monocytes/macrophages are known to be involved in atherogenesis, and the adherence of monocytes to the endothelium is considered an earliest characteristic of atherogenesis. Therefore, we studied the mechanism by which Shosaikoto, a Kampo medicine, shows anti-atherosclerotic action, which has been already shown in hypercholesterolemic rabbits. Hypercholesterolemia in rabbits gradually reduced the monocyte number in peripheral blood, whereas Shosaikoto treatment suppressed this decrease in circulating monocytes. Furthermore, although monocytes from hypercholesterolemic rabbits increased in adherence to endothelial cells even without lipopolysaccharide (LPS) activation, Shosaikoto treatment reduced the enhanced adherence observed in monocytes from hypercholesterolemic rabbits. These data suggested that the anti-atherosclerotic action shown by Shosaikoto resulted partly from the suppression of the enhanced adherence characteristic of hypercholesterolemia.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Shen YR,Inoue M,Ogihara Ydoi
10.1248/bpb.19.149subject
Has Abstractpub_date
1996-01-01 00:00:00pages
149-52issue
1eissn
0918-6158issn
1347-5215journal_volume
19pub_type
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journal_title:Biological & pharmaceutical bulletin
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pub_type: 杂志文章
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journal_title:Biological & pharmaceutical bulletin
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2019-01-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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更新日期:2001-07-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Biological & pharmaceutical bulletin
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