Abstract:
:TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory neurons (OSNs). We carried out histochemical analyses of TRPV2 and insulin-like growth factor-I receptor (IGF-IR) using in situ hybridization and immunofluorescence in the adult olfactory system. In olfactory mucosa, intensive TRPV2 immunostaining was observed at the olfactory axon bundles but not at the soma. TRPV2-positive labeling was preferentially found in the olfactory nerve layer in the olfactory bulb (OB). Furthermore, we demonstrated that a positive signal for IGF-IR mRNA was detected in OSNs expressing TRPV2 mRNA. In embryonic stages, TRPV2 immunoreactivity was observed on axon bundles of developing OSNs in the nasal region starting from 12.5 d of gestation and through fetal development. Observations in this study suggest that TRPV2 coupled with IGF-IR localizes to growing olfactory axons in the OSNs.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Matsui H,Noguchi T,Takakusaki K,Kashiwayanagi Mdoi
10.1248/bpb.b14-00413subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1907-12issue
12eissn
0918-6158issn
1347-5215pii
DN/JST.JSTAGE/bpb/b14-00413journal_volume
37pub_type
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