Nano-mechanical reinforcement in drug-resistant ovarian cancer cells.

abstract：:A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1-...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta Y,Lee JB,Hayashi K,Hayashi T

更新日期：2009-05-01 00:00:00

abstract：:The fat-specific protein 27 (Fsp27) gene belongs to the cell death-inducing DNA fragmentation factor 45-like effector family. Fsp27 is highly expressed in adipose tissue as well as the fatty liver of ob/ob mice. Fsp27 is directly regulated by the peroxisome proliferator-activated receptor γ (PPARγ) in livers of geneti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuo K,Matsusue K,Aibara D,Takiguchi S,Gonzalez FJ,Yamano S

更新日期：2017-01-01 00:00:00

abstract：:We performed experiments on the cis-inhibition and trans-stimulation effect on pirarubicin uptake in order to clarify the involvement of a carrier in the pirarubicin, daunorubicin and/or doxorubicin transport systems in rat polymorphonuclear leukocytes. The uptake of daunorubicin and doxorubicin was a saturable concen...

journal_title：Biological & pharmaceutical bulletin

authors： Nagasawa K,Nomiyama M,Ohnishi N,Yokoyama T,Iwakawa S,Okumura K

更新日期：1994-09-01 00:00:00

abstract：:The number of alkalotolerant intestinal bacteria was 1% of the total flora in humans and 0.8% of those in rats. The beta-glucosidase and beta-glucuronidase activity of these intestinal bacteria was induced by elevating the pH of the medium, but the growth was not changed. The enzyme activity in a medium of pH 7 was 5-...

journal_title：Biological & pharmaceutical bulletin

authors： Kim DH,Kang HJ,Park SH,Kobashi K

更新日期：1994-03-01 00:00:00

abstract：:Allergic rhinitis (AR) caused by house dust mite (HDM) and Japanese cedar pollen (JCP) represents a significant, expanding health problem in Japan. Allergic symptoms often have a severe impact on the QOL such as sleep disturbance and reduced school and work performance. In addition to the classical symptoms, AR is kno...

journal_title：Biological & pharmaceutical bulletin

authors： Ohashi-Doi K,Lund K,Mitobe Y,Okamiya K

更新日期：2020-01-01 00:00:00

abstract：:Apoptotic cells must be recognized early for phagocytosis to ensure that their toxic contents do not damage neighboring cells. In some cases this is achieved via CD43-capped membrane glycoproteins, the sialylpolylactosaminyl chains of which serve as ligands for phagocytosis by macrophages. However, because many additi...

journal_title：Biological & pharmaceutical bulletin

authors： Oguri E,Miki Y,Hirano K,Yamanaka M,Beppu M

更新日期：2012-01-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:The inhibitory effects of tetrandrine (an alkaloid isolated from the Chinese medicine Stephania tetrandrae S. Moore) were investigated in terms of the angiogenesis in an adjuvant-induced chronic inflammation model of mouse and tube formation of rat vascular endothelial cells (EC). Tetrandrine (7.5-30 mg/kg) reduced th...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi S,Inaba K,Kimura I,Kimura M

更新日期：1998-04-01 00:00:00

abstract：:The aim of this work is to investigate the therapeutic efficacy of VP-343 ((N-[4-[[(2S,3aR)-2-hydroxy-2,3,3a,4-tetrahydropyrrolo[1,2-a]qunoxalin-5(1H)-yl]phenyl]-4'-methyl[1,1'-biphenyl]-2-carboxamide), a selective vasopressin V2 receptor antagonist, using the experimental SIADH (syndrome of inappropriate secretion of...

journal_title：Biological & pharmaceutical bulletin

authors： Naito A,Hasegawa H,Kurasawa T,Ohtake Y,Matsukawa H,Ezure Y,Tsuriya Y,Koike K,Shigenobu K

更新日期：2000-11-01 00:00:00

abstract：:The effect of extracellular calcium on the intracellular calcium level of newborn rat skin basal cells was examined. The intracellular calcium level of basal cells was affected by the extracellular calcium concentration on culture of the cells on a collagen-coated filter, but not on a plate. The intracellular calcium ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohkura K,Hori H,Terada H

更新日期：1998-01-01 00:00:00

abstract：:Nafamostat mesilate, an ester drug with extensive hydrolysis in vivo, exhibits species difference in the relative contribution for its hydrolysis in blood and tissues. For the rat, the main hydrolysis site may be blood and human may be tissue (mainly by liver). The paper gave in vivo evidence that human tissue may giv...

journal_title：Biological & pharmaceutical bulletin

authors： Cao YG,Chen YC,Hao K,Zhang M,Liu XQ

更新日期：2008-11-01 00:00:00

abstract：:Prophylactic oral administration of a novel immunomodulator (immunosuppressant), FTY720 (1 mg/kg, three times a week), completely prevented the development of experimental autoimmune myasthenia gravis (EAMG) in C57BL/6 mice. EAMG has been used as an animal model for human myasthenia gravis, and was established by immu...

journal_title：Biological & pharmaceutical bulletin

authors： Kohno T,Tsuji T,Hirayama K,Iwatsuki R,Hirose M,Watabe K,Yoshikawa H,Kohno T,Matsumoto A,Fujita T,Hayashi M

更新日期：2005-04-01 00:00:00

abstract：:Sixteen flavonoids including quercetin and kaempferol and their relatives were examined for their ability to promote DNA degradation induced by the bleomycin (BLM)-Fe complex. Three hydroxyl groups in the flavonoidal nucleus were proposed as a crucial structural requirement for effectively promoting DNA degradation: 1...

journal_title：Biological & pharmaceutical bulletin

authors： Sugihara N,Kaneko A,Furuno K

更新日期：2003-08-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been employed to create a Parkinson's disease-like model in both rodents and primates based primarily on its ability to create a striatal dopamine deficit due to the loss of dopaminergic neurons in the substantia nigra compacta. The present study w...

journal_title：Biological & pharmaceutical bulletin

authors： Geng X,Song L,Pu X,Tu P

更新日期：2004-06-01 00:00:00

abstract：:The tissue distribution and disposition of carnitine, which plays an important role in the transport of long-chain fatty acids across the mitochondrial inner membrane for beta-oxidation, are well controlled by carnitine transporter organic cation/carnitine transporter 2 (OCTN2). Since little information is available o...

journal_title：Biological & pharmaceutical bulletin

authors： Maeda T,Wakasawa T,Funabashi M,Fukushi A,Fujita M,Motojima K,Tamai I

更新日期：2008-06-01 00:00:00

abstract：:Acetohexamide (AH) is reduced to its alcohol metabolite by carbonyl reductase. We have previously shown that carbonyl reductase present in the liver microsomes of rats is a male-specific and androgen-dependent enzyme. In the present study, the role of microsomal carbonyl reductase in the pharmacokinetics of AH was exa...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Shimada H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical effects and security of YiSuiShengXueGranule (YSSXG) on treating 156 patients with beta-thalassemia major. METHODS:YSSXG was given orally to 156 patients with beta-thalassemia in GuangXi Autonomous Region (the high incidence area of beta-thalassemia in China) for 3 months as one t...

journal_title：Biological & pharmaceutical bulletin

authors： Fang S,Wu Z,Zhang X,Liu Y,Wang W,Chai L,Cai H,Yi J,Wang L,Chen Y,Lv X,Huang Y,Wang R,Chen P

更新日期：2007-11-01 00:00:00

abstract：:The present study was designed to investigate the modulatory effects of rottlerin on ischemia reperfusion induced myocardial injury. Isolated rat hearts were exposed to 30 min of global ischemia followed by 120 min of reperfusion using Langendorff apparatus. Myocardial injury was assessed in the terms of infarct size,...

journal_title：Biological & pharmaceutical bulletin

authors： Kaur K,Singh M,Singh N,Jaggi AS

更新日期：2008-09-01 00:00:00

abstract：:Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) trigger...

journal_title：Biological & pharmaceutical bulletin

authors： Lee CS,Won C,Yoo H,Yi EH,Cho Y,Maeng JW,Sung SH,Ye SK,Chung MH

更新日期：2009-11-01 00:00:00

abstract：:Most of the fatigue in everyday life is a combination of physical and mental fatigue. Recently, an animal model of combined fatigue was designed by housing rats in a cage filled with water. We have previously hypothesized that mental fatigue is caused partly by neuronal brain damage through the activation of N-methyl-...

journal_title：Biological & pharmaceutical bulletin

authors： Morimoto Y,Zhang Q,Adachi K

更新日期：2012-01-01 00:00:00

abstract：:Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin apioside), and eight antib...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui E,Takayama K,Sato E,Okamura N

更新日期：2011-01-01 00:00:00

abstract：:This study examined the osteoblast-like MC3T3-E1 cell responses to poly(DL-lactide) (PDLLA) and poly(L-lactide) (PLLA) with different weight average molecular weight (M.W.). Colony formation of MC3T3-E1 cells on the PLLA with M.W. 270000 or 1370000 was slightly lower than that on glass. The protein, DNA and hydroxypro...

journal_title：Biological & pharmaceutical bulletin

authors： Ikarashi Y,Tsuchiya T,Kaniwa M,Nakamura A

更新日期：2000-12-01 00:00:00

abstract：:The usefulness of the urine protein : creatine ratio (UPCR) in management of molecular targeted therapy and immunotherapy has not been studied, although urine protein dipstick testing (uPr) is widely used in the clinical setting. The aim of this study was to investigate the usefulness of UPCR as compared to uPr in pat...

journal_title：Biological & pharmaceutical bulletin

authors： Nakamura K,Tanaka T,Masumori N,Miyamoto A,Hirano T

更新日期：2020-01-01 00:00:00

abstract：:The inhibitory effects of some flavonoids on the infectivity of rotavirus, which predominantly causes sporadic diarrhea in infants and young children, were investigated. Among tested flavonoids, diosmin and hesperidin had the most potent inhibitory activity on rotavirus infection. The fifty percent inhibitory concentr...

journal_title：Biological & pharmaceutical bulletin

authors： Bae EA,Han MJ,Lee M,Kim DH

更新日期：2000-09-01 00:00:00

abstract：:Five rabbit aldo-keto reductases (AKRs) that participate in the reduction of drug ketones and endogenous ketosteroids have recently been cloned and characterized. Among them, AKR1C30 and AKR1C31 show the highest amino acid sequence identity of 91%, but markedly differ in their substrate specificity and inhibitor sensi...

journal_title：Biological & pharmaceutical bulletin

authors： Endo S,Arai Y,Matsunaga T,Ikari A,El-Kabbani O,Hara A,Kitade Y

更新日期：2014-01-01 00:00:00

abstract：:The complete molecule or the ligand-binding domain-containing region of each of the three subtypes of human retinoic acid receptors (hRAR alpha, hRAR beta and hRAR gamma) was expressed in Escherichia coli. The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude...

journal_title：Biological & pharmaceutical bulletin

authors： Fukasawa H,Iijima T,Kagechika H,Hashimoto Y,Shudo K

更新日期：1993-04-01 00:00:00

abstract：:Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. However, its function in cognition has yet been investigated. In the present stu...

journal_title：Biological & pharmaceutical bulletin

authors： Liao Y,Bae HJ,Zhang J,Kwon Y,Koo B,Jung IH,Kim HM,Park JH,Lew JH,Ryu JH

更新日期：2019-01-01 00:00:00

abstract：:Cationic lipid-mediated transfer of DNA is promising in gene therapy. However, one disadvantage with this approach is the induction of an inflammatory response, which may decrease transgene expression. Recently, we found that plasmid DNA containing N6-methyladenine (N6-MeA), a bacterium-specific modified base, induced...

journal_title：Biological & pharmaceutical bulletin

authors： Ochiai H,Harashima H,Kamiya H

更新日期：2005-10-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) plays an important role in the development of glomerulonephritis. The study of experimental glomerulonephritis in rats was performed to examine the antinephritic effects of TJN-331, a new herbally-derived chemical compound. To clarify the action of TJN-331 ((E)-N-(3,4-dimet...

journal_title：Biological & pharmaceutical bulletin

authors： Saegusa Y,Sadakane C,Koseki J,Hasegawa Y,Shindo S,Maruyama H,Takeda S,Takeda H,Hattori T

更新日期：2010-01-01 00:00:00

abstract：:Mume fruit, the Japanese apricot (Prunus mume SIEB. et ZUCC.), is popular in Japan and is mostly consumed in the pickled form called umeboshi. This fruit is known to have anti-microbial properties, but the principal constituents responsible for the antimicrobial properties have not yet been elucidated. We investigated...

journal_title：Biological & pharmaceutical bulletin

authors： Mitani T,Ota K,Inaba N,Kishida K,Koyama HA

更新日期：2018-01-01 00:00:00