Abstract:
:The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2'-methyl ether (1), and three aromatic compounds, 4-O-methylsappanol (4), caesalpine J (5), pluchoic acid (6). At concentrations of 20-40 microM, compound 2 showed significant cytoprotective effects against glutamate-induced oxidative stress through the induction of heme oxygenase (HO)-1 in HT22-immortalized hippocampal cells. Compound 3 also showed moderate neuroprotective effect at 40 microM, but compounds 1, 4-6 did not show any protective effects against glutamate-induced cytotoxicity in HT22 cells.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Jeong GS,Lee DS,Kwon TO,Lee HS,An RB,Kim YCdoi
10.1248/bpb.32.945subject
Has Abstractpub_date
2009-05-01 00:00:00pages
945-9issue
5eissn
0918-6158issn
1347-5215pii
JST.JSTAGE/bpb/32.945journal_volume
32pub_type
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journal_title:Biological & pharmaceutical bulletin
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