Effect of permeation enhancers on the in vitro percutaneous absorption of pentazocine.

abstract：:A high performance liquid chromatography (HPLC) method was developed for the first time to quantify simultaneously the six major active ingredients in Acanthopanax senticosus (Rupr. et Maxim.) Harms, namely protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin. The analysis was pe...

journal_title：Biological & pharmaceutical bulletin

authors： Li Q,Jia Y,Xu L,Wang X,Shen Z,Liu Y,Bi K

更新日期：2006-03-01 00:00:00

abstract：:Compound C is a widely used chemical inhibitor that down-regulates AMP-activated protein kinase (AMPK) activity. However, it has been suggested that compound C exerts AMPK-independent effects in various cells. Here, we investigated whether compound C induces Sestrin2 (SESN2), an antioxidant enzyme induced by diverse s...

journal_title：Biological & pharmaceutical bulletin

authors： Seo K,Seo S,Ki SH,Shin SM

更新日期：2016-01-01 00:00:00

abstract：:The forced swimming test (FST) is suggested to produce abnormalities in the serotonergic and hypothalamic-pituitary-adrenal (HPA) axis systems. Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furoco...

journal_title：Biological & pharmaceutical bulletin

authors： Xu Q,Pan Y,Yi LT,Li YC,Mo SF,Jiang FX,Qiao CF,Xu HX,Lu XB,Kong LD,Kung HF

更新日期：2008-06-01 00:00:00

abstract：:Hinokitiol (beta-thujaplicin), beta-dolabrin and gamma-thujaplicin isolated from Thujopsis dolabrata SIEB. et ZUCC var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their minimu...

journal_title：Biological & pharmaceutical bulletin

authors： Inamori Y,Sakagami Y,Morita Y,Shibata M,Sugiura M,Kumeda Y,Okabe T,Tsujibo H,Ishida N

更新日期：2000-08-01 00:00:00

abstract：:The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2'-methyl ether (1), and three aromatic compounds, 4-O-methylsappanol (4), caesalpin...

journal_title：Biological & pharmaceutical bulletin

authors： Jeong GS,Lee DS,Kwon TO,Lee HS,An RB,Kim YC

更新日期：2009-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease with joint dysfunction following cartilage degradation. The level of lysophosphatidic acid (LPA) has been reported to be augmented in human synovial fluid from patients with RA. However, it remains to be elucidated whether LPA participates in cartilage destruction. ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuno K,Komiya M,Okuyama K,Imada K,Sato T

更新日期：2021-01-01 00:00:00

abstract：:The purpose of this review is to summarize the recent studies examining the expression of leukotrienes (LTs) and their receptors in nociceptive pathways, and their crucial roles in pathological pain conditions. LTs belong to a large family of lipid mediators, termed eicosanoids, which are derived from arachidonic acid...

journal_title：Biological & pharmaceutical bulletin

authors： Noguchi K,Okubo M

更新日期：2011-01-01 00:00:00

abstract：:Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M. de Tucumán, Argentina, from hemocultures, catheters and urine and identified as S. epidermidis, S. haemolyticus, S. ...

journal_title：Biological & pharmaceutical bulletin

authors： de Allori MC,Jure MA,Romero C,de Castillo ME

更新日期：2006-08-01 00:00:00

abstract：:Madecassoside (MA), one of the principle terpenoids in Centella asiatica, has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. The aim of this study is to investigate if MA also protected against myocardial ischemia-reperfusion injury in vivo. ...

journal_title：Biological & pharmaceutical bulletin

authors： Bian GX,Li GG,Yang Y,Liu RT,Ren JP,Wen LQ,Guo SM,Lu QJ

更新日期：2008-03-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs), i.e. human embryonic stem cells and human induced pluripotent stem cells, are able to self-renew and differentiate into multiple cell types. Because of these abilities, numerous attempts have been made to utilize hPSCs in regenerative medicine/cell therapy. hPSCs are, however, als...

journal_title：Biological & pharmaceutical bulletin

authors： Kuroda T,Yasuda S,Sato Y

更新日期：2013-01-01 00:00:00

abstract：:We investigated the gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5, and CYP3A7), UGT-dependent glucuronosyl transferase isoforms (UGT1A6 and UGT1A9), and ABC transporter (ABCB1) after exposure to 0.1, 0.5, and 2.5% dimethyl sulfoxide (DMSO). GAPDH mRNA levels...

journal_title：Biological & pharmaceutical bulletin

authors： Nishimura M,Ueda N,Naito S

更新日期：2003-07-01 00:00:00

abstract：:Hepatoprotective activity guided chemical analyses led to the isolation of two dicaffeoyl quinic acid derivatives, methyl 3,4-di-O-caffeoyl quinate (1) and 3,4-di-O-caffeoyl quinic acid (2) from water extract of propolis, and their structures were determined by the use of 2D NMR. These compounds were stronger antihepa...

journal_title：Biological & pharmaceutical bulletin

authors： Basnet P,Matsushige K,Hase K,Kadota S,Namba T

更新日期：1996-04-01 00:00:00

abstract：:The pharmacological profiles of antigen-induced immediate airway response (IAR) in rats are not fully understood. In this study, we established an ovalbumin (OVA)-induced IAR model using noninvasive measurement in rats, and evaluated the effects of commonly used and effective antiasthmatic drugs, i.e. ketotifen (antih...

journal_title：Biological & pharmaceutical bulletin

authors： Miyagawa N,Iwasaki H,Kato T,Tanaka M,Shibata T,Wakitani K

更新日期：2008-12-01 00:00:00

abstract：:Sauchinone, a biologically active lignan found in Saururus chinensis (Saururaceae), exerts various biological activities against jaundice, inflammatory disease, hepatic steatosis, and oxidative injury. Despite its diverse applications, there exists some information about sauchinone's pharmacokinetics but its tissue di...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YJ,Han SY,Seo JS,Chin YW,Choi YH

更新日期：2015-01-01 00:00:00

abstract：:The effect of insulin administration on bone formation was investigated in the femoral diaphysis of rats with skeletal unloading. When the femoral-diaphyseal tissues from normal rats were cultured in the presence of insulin (10(-9) and 10(-8) M) for 48 h, the hormone produced a significant increase of alkaline phospha...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi M,Kishi S,Hoshi T

更新日期：1993-11-01 00:00:00

abstract：:Microsomal enzyme inducers are known to influence the expression of many transporter proteins and mRNA. In this study, we examined the effects of microsomal enzyme inducers on the mRNA expression of Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Associated Protein 2 (MRP2) in BALB/c mice. mRNA expres...

journal_title：Biological & pharmaceutical bulletin

authors： Han Y,Sugiyama Y

更新日期：2006-05-01 00:00:00

abstract：:The oral cavity contains almost half of the commensal bacterial population present in the human body. An increase in the number of these microorganisms may result in systemic diseases such as infective endocarditis and aspiration pneumonia as well as oral infections. It is essential to control the total numbers of the...

journal_title：Biological & pharmaceutical bulletin

authors： Tamura M,Saito H,Kikuchi K,Ishigami T,Toyama Y,Takami M,Ochiai K

更新日期：2011-01-01 00:00:00

abstract：:Nicotine, an addictive substance, is absorbed from the lungs following inhalation of tobacco smoke, and distributed to various tissues such as liver, brain, and retina. Recent in vivo and in vitro studies suggest the involvement of a carrier-mediated transport process in nicotine transport in the lung, liver, and inne...

journal_title：Biological & pharmaceutical bulletin

authors： Tega Y,Yamazaki Y,Akanuma SI,Kubo Y,Hosoya KI

更新日期：2018-01-01 00:00:00

abstract：:Inhibition of Rho kinase (ROCK) ameliorates many cardiovascular dysfunctions. The aim of the current study is to investigate the anti-inflammatory effects of fasudil, a selective ROCK inhibitor, on high cholesterol diet-induced hypercholesterolemic rats and its possible mechanisms. In hypercholesterolemic rats, we fou...

journal_title：Biological & pharmaceutical bulletin

authors： Ma Z,Zhang J,Du R,Ji E,Chu L

更新日期：2011-01-01 00:00:00

abstract：:This study investigated both morphologically and biochemically whether parsley (Petroselinum crispum), which is used as a folk remedy to decrease blood glucose, has any antidiabetic effect on pancreatic B cells of rats. Parsley extract was given to male diabetic rats. In the diabetic group given parsley extract, it wa...

journal_title：Biological & pharmaceutical bulletin

authors： Yanardağ R,Bolkent S,Tabakoğlu-Oğuz A,Ozsoy-Saçan O

更新日期：2003-08-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:The release kinetics of dihydroetorphine (DHE) from pressure-sensitive adhesive (PSA) tape with an ethylene-vinyl acetate co-polymer (EVA) membrane as a diffusion-controlling membrane and its protective effect from an unpredictable increase in skin permeation of DHE caused by stratum corneum damage were investigated. ...

journal_title：Biological & pharmaceutical bulletin

authors： Ohmori S,Sugiyama Y,Morimoto Y

更新日期：2001-01-01 00:00:00

abstract：:The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 a...

journal_title：Biological & pharmaceutical bulletin

authors： Ikeda T,Yokomizo K,Okawa M,Tsuchihashi R,Kinjo J,Nohara T,Uyeda M

更新日期：2005-09-01 00:00:00

abstract：:We studied in vitro metabolites of 2,4,6,2',4',6'-hexachlorobiphenyl (HCB, IUPAC PCB No. 155) produced by liver microsomes of a phenobarbital (PB)-treated beagle dog. The major metabolites were 3-hydroxy-2,4,6,2',4',6'-HCB (M-1), 4-hydroxy-2,6,2',4',6'-pentachlorobiphenyl (PenCB, M-2) and 3,4-dihydroxy-2,6,2',4',6'-Pe...

journal_title：Biological & pharmaceutical bulletin

authors： Ariyoshi N,Yoshimura H,Oguri K

更新日期：1993-09-01 00:00:00

abstract：:In vitro studies were conducted to identify human drug-metabolizing enzymes involved in the metabolism of SNI-2011 ((+/-)-cis-2-methylspiro [1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline hydrochloride hydrate). When 14C-SNI-2011 was incubated with human liver microsomes, SNI-2011 trans-s...

journal_title：Biological & pharmaceutical bulletin

authors： Washio T,Arisawa H,Kohsaka K,Yasuda H

更新日期：2001-11-01 00:00:00

abstract：:Although hypokalemia is an adverse effect of Yokukansan preparation, especially in geriatric patients, its association with age is unclear. We investigated whether age is a risk factor for hypokalemia. This single-center retrospective cohort study, conducted at Tokyo Women's Medical University, Medical Center East bet...

journal_title：Biological & pharmaceutical bulletin

authors： Hirai T,Yamaga R,Kei M,Hosohata K,Itoh T

更新日期：2020-01-01 00:00:00

abstract：:Cerebral ischemia causes the depletion of oxygen and nutrition from brain tissues, and when persistent, results in irreversible damage to the cell function and survival. The cellular response to ischemic conditions and its mechanisms have been investigated widely in in vivo and in vitro experimental models, yet no stu...

journal_title：Biological & pharmaceutical bulletin

authors： Ujita S,Mizunuma M,Matsuki N,Ikegaya Y

更新日期：2011-01-01 00:00:00

abstract：:The effects of conjugated linoleic acid (CLA) against anaphylaxis and allergic pruritus were investigated using a in vivo assay. Inhibitory effects of CLA were observed on the immediate (type 1) hypersensitivity reaction, with CLA significantly suppressing the decrease in blood pressure (BP) and blood flow (BF) induce...

journal_title：Biological & pharmaceutical bulletin

authors： Ishiguro K,Oku H,Suitani A,Yamamoto Y

更新日期：2002-12-01 00:00:00

abstract：:Our previous work has shown that the amino acid residues around 62-67 located in the connecting loop between helix I and II of human growth hormone (hGH) are important in eliciting the differentiation of preadipose 3T3-F442A cells to adipocytes. In this study, we evaluated the role of the charged residues around 62-67...

journal_title：Biological & pharmaceutical bulletin

authors： Uchida E,Shimokawa S,Takasu H,Ikehara M,Uesugi S,Tomita K,Tanaka A,Morikawa M,Nishikawa S,Hayakawa T

更新日期：1995-06-01 00:00:00

abstract：:We developed a novel fluorometric assay method for the measurement of glycosyltransferase activities using mono- and di-saccharides aminated and tagged with 7-hydroxycoumarin-3-carboxylic acid (coumarin) as substrates, N-acetylglucosamine (GlcNAc)-coumarin for beta1,4-galactosyltransferase from bovine milk and Gal bet...

journal_title：Biological & pharmaceutical bulletin

authors： Higai K,Masuda D,Matsuzawa Y,Satoh T,Matsumoto K

更新日期：1999-04-01 00:00:00