Studies on thermophile products. X. Further biological properties of isofatty acid-containing phosphatidylglycerol that enhances the induction of suppressor T cells.

abstract：:It has been well known that Vibrio cholerae inhabit in environmental water. As many patients infected with cholera toxin-producing V. cholerae O1 (toxigenic V. cholerae O1) emerge in Kolkata, India, it has been thought that toxigenic V. cholerae O1 is easily detected in environmental water in Kolkata. However, we coul...

journal_title：Biological & pharmaceutical bulletin

authors： Paul SS,Takahashi E,Chowdhury G,Miyoshi SI,Mizuno T,Mukhopadhyay AK,Dutta S,Okamoto K

更新日期：2020-08-01 00:00:00

abstract：:The hypoglycemic and hypolipidemic effect of docosahexaenoic acid (DHA; C22: 6omega-3) ethyl ester was examined in KK-Ay mice and neonatal streptozotocin-induced diabetic (NSZ) which are respectively obese and lean animal models of non-insulin-dependent diabetes mellitus (NIDDM), and in ddY normal mice. Single adminis...

journal_title：Biological & pharmaceutical bulletin

authors： Shimura T,Miura T,Usami M,Ishihara E,Tanigawa K,Ishida H,Seino Y

更新日期：1997-05-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists are clinically useful for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH), and their therapeutic effects are mediated through the blockade of prostatic alpha(1)-adrenoceptors. The present study was undertaken to predict the magnitude and duration of alph...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada S,Kato Y,Okura T,Kagawa Y,Kawabe K

更新日期：2007-07-01 00:00:00

abstract：:Pantethine and fursultiamine have been evaluated for their clinical usefulness in the treatment and prevention of uncomplicated postoperative adhesive intestinal obstruction. In recent years, the actions of drugs used to treat gastrointestinal diseases have been elucidated pharmacologically from the viewpoints of gast...

journal_title：Biological & pharmaceutical bulletin

authors： Suzuki Y,Itoh H,Abe T,Nishimura F,Sato Y,Takeyama M

更新日期：2011-01-01 00:00:00

abstract：:D-Aspartate (D-Asp), a free D-amino acid found in mammals, plays crucial roles in the neuroendocrine, endocrine, and central nervous systems. Recent studies have implicated D-Asp in the pathophysiology of infertility and N-methyl-D-Asp receptor-related diseases. D-Asp oxidase (DDO), a degradative enzyme that is stereo...

journal_title：Biological & pharmaceutical bulletin

authors： Katane M,Kawata T,Nakayama K,Saitoh Y,Kaneko Y,Matsuda S,Saitoh Y,Miyamoto T,Sekine M,Homma H

更新日期：2015-01-01 00:00:00

abstract：:In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1-->3)-beta-D-glucans, such as sonifilan (SPG) and SSG, did not induce cytokine production from macro...

journal_title：Biological & pharmaceutical bulletin

authors： Okazaki M,Adachi Y,Ohno N,Yadomae T

更新日期：1995-10-01 00:00:00

abstract：:Candida albicans is the most important human fungal pathogen. Amphotericin (AmB) is a gold standard of antifungal treatment for fungi, but the severe side effect of this drug restricts its clinical application. In this study, the interaction of AmB and baicalein (BE) was investigated against thirty clinical isolates o...

journal_title：Biological & pharmaceutical bulletin

authors： Fu Z,Lu H,Zhu Z,Yan L,Jiang Y,Cao Y

更新日期：2011-01-01 00:00:00

abstract：:Cephradine-containing ethylcellulose microparticles (MPC) were prepared by the solvent evaporation method. Chitosan-coated MPC (Chi-MPC) were prepared by doping MPC with viscous chitosan solution and subsequently drying. When fluorescein isothiocyanate (FITC)-labeled chitosan-coated ethylcellulose microparticles witho...

journal_title：Biological & pharmaceutical bulletin

authors： Takishima J,Onishi H,Machida Y

更新日期：2002-11-01 00:00:00

abstract：:In order to prepare fine granules of sparfloxacin (SPFX), a new quinolone anti-bacterial drug that shows masking of the bitter taste of SPFX and dissolutes at a rapid rate, various film-coated fine granules containing 20% SPFX and 0-52% low-substituted hydroxypropylcellulose(L-HPC) in the cores, were prepared by a spr...

journal_title：Biological & pharmaceutical bulletin

authors： Shirai Y,Sogo K,Yamamoto K,Kojima K,Fujioka H,Makita H,Nakamura Y

更新日期：1993-02-01 00:00:00

abstract：:Six polyphenolic acid esters were synthesized and their antioxidative properties were evaluated in three model systems [2,2'-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, 2,2'-azobis(2-amidinopropane)dihydrochloride (AAPH)-induced lipid peroxidation system, and the dye-bleaching assay of peroxynitrit...

journal_title：Biological & pharmaceutical bulletin

authors： Hsu LY,Lin CF,Hsu WC,Hsu WL,Chang TC

更新日期：2005-07-01 00:00:00

abstract：:The effect of Laennec, a hydrolyte of human placenta, on immune-mediated liver injury was investigated in vivo and in vitro in murine. Vena caudalis administration of concanavalin A (Con A) was employed to establish an in vivo liver-injury model, and in vitro hepatotoxicity was induced by 8 h interaction between Con A...

journal_title：Biological & pharmaceutical bulletin

authors： Wu J,Yang T,Wang C,Liu Q,Yao J,Sun H,Kaku T,Liu KX

更新日期：2008-11-01 00:00:00

abstract：:The human adenovirus type 5 (Ad5) early-region 1A (E1A) proteins have been shown to have strong tumor-suppressive activities in human tumor cells and to enhance the sensitivity of a variety of malignant tumors to apoptosis induced by ionizing radiation and chemotherapeutic agents. However, the inherent limitations of ...

journal_title：Biological & pharmaceutical bulletin

authors： Ma Y,Zhou X,Zhao Q,Li Y,Liu Y,Wang Z,Zhang Y

更新日期：2003-02-01 00:00:00

abstract：:Two subclones (K562-L and -H) were previously isolated from K562 human leukemic cells according to hemoglobin production: K562-L was expressed in less than 5% and K562-H in more than 90% of dianisidine positive cells. 12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophori...

journal_title：Biological & pharmaceutical bulletin

authors： Sasaki D,Kosunago S,Mikami T,Matsumoto T,Suzuki M

更新日期：1993-10-01 00:00:00

abstract：:Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic research regarding exosome analysis and applications in drug delivery. To increase exosome yield, we attempted to stimulate tumor cells via the addition of lipos...

journal_title：Biological & pharmaceutical bulletin

authors： Emam SE,Ando H,Abu Lila AS,Shimizu T,Ukawa M,Okuhira K,Ishima Y,Mahdy MA,Ghazy FS,Ishida T

更新日期：2018-01-01 00:00:00

abstract：:It has been well known that 3-O-methyldopa (3-OMD) is a metabolite of L-3,4-dihydroxyphenylalanine (L-DOPA) formed by catechol O-methyltransferase (COMT), and 3-OMD blood level often reaches higher than physiological level in Parkinson's disease (PD) patients receiving long term L-DOPA therapy. However, the physiologi...

journal_title：Biological & pharmaceutical bulletin

authors： Onzawa Y,Kimura Y,Uzuhashi K,Shirasuna M,Hirosawa T,Taogoshi T,Kihira K

更新日期：2012-01-01 00:00:00

abstract：:Lysosomal trapping was investigated in the retinal capillary endothelial cells that are responsible for the inner blood-retinal barrier (BRB) using LysoTracker(®) Red (LTR). Using confocal microscopy on TR-iBRB2 cells, an in vitro model of the inner BRB, the presence of lysosomal trapping in retinal capillary endothel...

journal_title：Biological & pharmaceutical bulletin

authors： Kubo Y,Seko N,Usui T,Akanuma S,Hosoya K

更新日期：2016-01-01 00:00:00

abstract：:The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sano K,Koushi E,Irie K,Higuchi S,Tsuchihashi R,Kinjo J,Egashira N,Oishi R,Uchida N,Nagai H,Nishimura R,Tanaka H,Morimoto S,Mishima K,Iwasaki K,Fujiwara M

更新日期：2009-12-01 00:00:00

abstract：:Proteasome inhibitors are a novel class of molecular-targeted anti-cancer drugs that suppress the degradation of malfolded proteins, trigger endoplasmic reticulum (ER) stress, and activate apoptosis signals. Glucose-regulated protein 78 (GRP78), a major ER chaperone, is one of the most important molecules for transduc...

journal_title：Biological & pharmaceutical bulletin

authors： Matsumura K,Sakai C,Kawakami S,Yamashita F,Hashida M

更新日期：2014-01-01 00:00:00

abstract：:The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the part of both academic and pharmaceutical laboratories to develop highly specific inhibitors. In this study, inhibitory activity of previously synthesized arylaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Altuntas TG,Olgen S,Nebioglu D,Akaho E

更新日期：2004-01-01 00:00:00

abstract：:The release of hepatic lipase (HTGL), which is responsible for the hydrolysis of lipoprotein triacylglyceride, produced by heparin from the isolated rat hepatocytes in primary culture has been examined. Tyrosine kinase (TK) inhibitors (ST-638 and biochanin A) inhibited the heparin-stimulated release of HTGL activity. ...

journal_title：Biological & pharmaceutical bulletin

authors： Tagashira H,Nakahigashi S,Kerakawati R,Motoyashiki T,Morita T

更新日期：2005-03-01 00:00:00

abstract：:A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1-...

journal_title：Biological & pharmaceutical bulletin

authors： Ohta Y,Lee JB,Hayashi K,Hayashi T

更新日期：2009-05-01 00:00:00

abstract：:The absorption of glycerol was examined using the closed loop of the rat small intestine in situ to clarify the transport mechanism. The absorption of glycerol, evaluated by its disappearance from the intestinal lumen, was saturable and reduced under the Na(+)-free conditions, suggesting the involvement of an Na(+)-de...

journal_title：Biological & pharmaceutical bulletin

authors： Kato T,Hayashi Y,Inoue K,Yuasa H

更新日期：2005-03-01 00:00:00

abstract：:To develop a piroxicam-loaded gelatin microcapsule with enhanced bioavailability, a gelatin microcapsule encapsulated ethanol and piroxicam has been formulated by using gelatin as a water-soluble polymer shell. The aqueous solubility and bioavailability of piroxicam in piroxicam-loaded microcapsule in rats were then e...

journal_title：Biological & pharmaceutical bulletin

authors： Piao MG,Yang CW,Li DX,Kim JO,Jang KY,Yoo BK,Kim JA,Woo JS,Lyoo WS,Han SS,Lee YB,Kim DD,Yong CS,Choi HG

更新日期：2008-06-01 00:00:00

abstract：:Aconitine administered intraperitoneally (i.p.) produces bradycardia mainly by a central muscarinic action. The involvement of hypothalamic regions in the occurrence of aconitine-induced bradycardia was investigated in hypothalamus-lesioned mice. The lesions were made by passing a direct current (1.5 mA, 13 s) through...

journal_title：Biological & pharmaceutical bulletin

authors： Kimura I,Takada M,Nojima H

更新日期：1997-08-01 00:00:00

abstract：:The onset of oral candidiasis is accompanied by inflammatory symptoms such as pain in the tongue, edema or tissue damage and lowers the quality of life (QOL) of the patient. In a murine oral candidiasis model, the effects were studied of terpinen-4-ol (T-4-ol), one of the main constituents of tea tree oil, Melaleuca a...

journal_title：Biological & pharmaceutical bulletin

authors： Ninomiya K,Hayama K,Ishijima SA,Maruyama N,Irie H,Kurihara J,Abe S

更新日期：2013-01-01 00:00:00

abstract：:Studies were performed to characterize the opioid receptors in guinea pig brain using the radiolabeled opioid antagonists, [3H]naloxone and [3H]diprenorphine and the kappa-agonist [3H]U-69593. The binding of [3H]U-69593 to guinea pig cerebellar membranes was reduced by NaCl, guanyl-5'yl-imidodiphosphate (GppNHp) and N...

journal_title：Biological & pharmaceutical bulletin

authors： Ishige K,Makimura M,Ito Y,Murakoshi Y

更新日期：1993-09-01 00:00:00

abstract：:We compared effects of the antiarrhythmic drug bepridil on the electrophysiological parameters in the isolated pulmonary vein preparation from guinea pigs with those in the left atrium. Three pairs of bipolar electrodes were attached to the left atrium, pulmonary vein and junctional region of left atrium and pulmonary...

journal_title：Biological & pharmaceutical bulletin

authors： Takahara A,Takeda K,Hagiwara M,Tanaka H

更新日期：2013-01-01 00:00:00

abstract：:In the present study, we evaluated the effect of the novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526) on the intragastric acidity of cynomolgus monkeys. The study was performed in a crossover manner with five male animals. CS-526...

journal_title：Biological & pharmaceutical bulletin

authors： Ito K,Kinoshita K,Yamamura N,Tomizawa A,Inaba F,Morikawa-Inomata Y,Tabata K,Shibakawa N

更新日期：2009-12-01 00:00:00

abstract：:Two C-type lectins (OLLafs and OLLafl) were isolated from Osmerus (Spirinchus) lanceolatus eggs using asialofetuin-Sepharose column. OLLafs and OLLafl were eluted with 0.2 M sucrose and 0.2 M lactose from the same column, respectively. OLLafl has been estimated to be a heterodimeric protein composed of H- and L-subuni...

journal_title：Biological & pharmaceutical bulletin

authors： Sugawara S,Hosono M,Ogawa Y,Takayanagi M,Nitta K

更新日期：2005-05-01 00:00:00

abstract：:A current anti-inflammatory agent often targets the prevention of inflammatory disorder development. The standardized Centella asiatica ECa 233 extract has been previously reported for anti-inflammatory effect. This study aimed to investigate its anti-inflammatory effect and mechanisms of ECa 233 in lipopolysaccharide...

journal_title：Biological & pharmaceutical bulletin

authors： Sukketsiri W,Tanasawet S,Moolsap F,Tantisira MH,Hutamekalin P,Tipmanee V

更新日期：2019-01-01 00:00:00