Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity.

abstract：:Panaxydol, a polyacetylenic compound derived from Panax ginseng has been reported to suppress the growth of cancer cells. However, the molecular mechanisms underlying cell cycle arrest by this compound in non-small cell lung cancer (NSCLC) are unknown. Our study found that panaxydol treatment induced cell cycle arrest...

journal_title：Biological & pharmaceutical bulletin

authors： Lee JH,Leem DG,Chung KS,Kim KT,Choi SY,Lee KT

更新日期：2018-01-01 00:00:00

abstract：:Arsenicals are known to be toxic and carcinogenic in humans. Inorganic arsenicals are enzymatically methylated to monomethylarsonic acid (MMAsV) and dimethylarsinic acid (DMAsV), which are the major pentavalent methyl arsenic metabolites. Recent reports indicate that trivalent methyl arsenicals are produced through me...

journal_title：Biological & pharmaceutical bulletin

authors： Kojima C,Sakurai T,Waalkes MP,Himeno S

更新日期：2005-10-01 00:00:00

abstract：:A bacterium isolated as the contaminant of a batch of commercial benzalkonium chloride (BAC) solution (10% (w/v)) stored in a loosely capped bottle in the Department of Pharmacy Shinshu University Hospital was identified as Pseudomonas fluorescens belonging to biotype G of Stanier, et al. The strain was highly resista...

journal_title：Biological & pharmaceutical bulletin

authors： Nagai K,Ohta S,Zenda H,Matsumoto H,Makino M

更新日期：1996-06-01 00:00:00

abstract：:Infection of human cell with human immunodeficiency virus type-1 (HIV-1) was suppressed by cellular genetic factor(s) at reverse transcription step. Although same amount of virus adsorbed on both cells, small amount of HIV-1 (IIIB strain) infected HeLa (MAGI/CCR5) cell, while large amount of HIV-1 infected HOS (GHOST/...

journal_title：Biological & pharmaceutical bulletin

authors： Tempaku A

更新日期：2005-05-01 00:00:00

abstract：:We previously reported that kiwi fruit is rich in polyphenols and has immunostimulatory activity. Polyphenols are widely known for having anti-oxidant effects. We also revealed potential anti-oxidant effects of kiwi fruit in vivo by oral administration to mice. Here, we compared the anti-oxidant effects of kiwi fruit ...

journal_title：Biological & pharmaceutical bulletin

authors： Iwasawa H,Morita E,Yui S,Yamazaki M

更新日期：2011-01-01 00:00:00

abstract：:Immediate early genes (IEG) are rapidly but transiently induced directly by intracellular signaling cascades to alter patterns of gene expression. It has been proposed that histone modifications could be the key to the quick alteration of chromatin structure, as this spread occurs too rapidly to be the consequence of ...

journal_title：Biological & pharmaceutical bulletin

authors： Sng JC,Taniura H,Yoneda Y

更新日期：2004-05-01 00:00:00

abstract：:Coffee is a popular beverage worldwide with various nutritional benefits. Diterpene cafestol, one of the major components of coffee, contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects. In thi...

journal_title：Biological & pharmaceutical bulletin

authors： Shen T,Lee J,Lee E,Kim SH,Kim TW,Cho JY

更新日期：2010-01-01 00:00:00

abstract：:In this paper we investigated the vascular activity and possible mechanism of Orientin, from bamboo leaves (Phyllostachys nigra), in isolated thoracic aortic rings from New Zealand rabbit. Among the four compounds, studied, only Orientin relaxed phenylephrine-induced contractions with an IC50 value of 2.28 microM in t...

journal_title：Biological & pharmaceutical bulletin

authors： Fu XC,Wang MW,Li SP,Zhang Y,Wang HL

更新日期：2005-01-01 00:00:00

abstract：:The hypoglycemic and hypolipidemic effect of docosahexaenoic acid (DHA; C22: 6omega-3) ethyl ester was examined in KK-Ay mice and neonatal streptozotocin-induced diabetic (NSZ) which are respectively obese and lean animal models of non-insulin-dependent diabetes mellitus (NIDDM), and in ddY normal mice. Single adminis...

journal_title：Biological & pharmaceutical bulletin

authors： Shimura T,Miura T,Usami M,Ishihara E,Tanigawa K,Ishida H,Seino Y

更新日期：1997-05-01 00:00:00

abstract：:Qingkailing injection is a well-known composite formula of traditional Chinese medicine and is commonly used in clinical practice, which could offer immunomodulatory effect from our clinical experience on uveitis treatment by Qingkailing. We did the experiment in order to investigate the curative effect and mechanism ...

journal_title：Biological & pharmaceutical bulletin

authors： Tian Q,Bi H,Cui Y,Guo D,Xie X,Su W,Wang X

更新日期：2012-01-01 00:00:00

abstract：:Hepatic organic anion transporters OATP1B1 and OATP1B3 are expressed at the sinusoidal membrane of hepatocytes and contribute to the hepatic uptake of a wide variety of clinically used drugs. To identify the antibiotics that interact with the human organic anion transporters OATP1B1 and OATP1B3, we applied a screening...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi H,Takeuchi T,Okada M,Kobayashi M,Unno M,Abe T,Goto J,Hishinuma T,Shimada M,Mano N

更新日期：2011-01-01 00:00:00

abstract：:6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone) has been found to have a membrane-stabilizing activity in studies using lysosomes. Using dimyristoyl L-alpha-phosphatidylcholine (DMPC) as a substrate, the effects of idebenone and related benzoquinones on phospholipid digestion by phospholipase A...

journal_title：Biological & pharmaceutical bulletin

authors： Amano T,Terao S,Imada I

更新日期：1995-05-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the chemoresistant cancers. There is a pressing need to establish therapeutic approaches to prevent RCC proliferation and metastasis. The electrophilic 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is an endogenous anti-cancerous agent. Treatment with high concentrations of 15d-PGJ2 ...

journal_title：Biological & pharmaceutical bulletin

authors： Yamamoto Y,Koma H,Yagami T

更新日期：2020-01-01 00:00:00

abstract：:We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased....

journal_title：Biological & pharmaceutical bulletin

authors： Matsumoto T,Watanabe S,Iguchi M,Ando M,Oda M,Nagata M,Yamada K,Taguchi K,Kobayashi T

更新日期：2016-01-01 00:00:00

abstract：:To elucidate insecticidal activity of spider toxins, metal ions in venoms and in the bodies were determined by thin layer chromatography, spark source mass spectrometry, ion chromatography, inductively coupled plasma emission spectrometry and atomic absorption spectrometry. Two kinds of spiders were used, Nephila clav...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Narai N,Shinkai A,Tokuda T,Saito K,Shioya M,Tokoro N,Kono Y

更新日期：1994-04-01 00:00:00

abstract：:The mature form of rat adrenodoxin (Ad) was purified from a heterologous direct expression system in Escherichia coli with a yield of 56 mg/l culture. The purified Ad showed a A414/A280 ratio of 0.91 and the sequence of 10 amino terminal residues was identical with that of authentic rat Ad. By Time of Flight/Mass spec...

journal_title：Biological & pharmaceutical bulletin

authors： Sagara Y,Aramaki H

更新日期：1998-10-01 00:00:00

abstract：:Darexaban maleate is a novel oral direct factor Xa inhibitor. Darexaban glucuronide (YM-222714) was the major component in plasma after oral administration of darexaban to humans and is the pharmacologically active metabolite. Additionally, YM-222714 N-oxides were detected as minor metabolites in human plasma and urin...

journal_title：Biological & pharmaceutical bulletin

authors： Shiraga T,Yajima K,Teragaki T,Suzuki K,Hashimoto T,Iwatsubo T,Miyashita A,Usui T

更新日期：2012-01-01 00:00:00

abstract：:The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the part of both academic and pharmaceutical laboratories to develop highly specific inhibitors. In this study, inhibitory activity of previously synthesized arylaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Altuntas TG,Olgen S,Nebioglu D,Akaho E

更新日期：2004-01-01 00:00:00

abstract：:3',4'-Diisovalerylkhellactone diester (PJ-1) is a coumarin derivative purified from the medicinal herb Peucedanum japonicum Thunb. We examined its in vitro effects on various aspects of platelet reactivity. PJ-1 inhibited the aggregation and ATP release of rabbit platelets induced by PAF (platelet-activating factor) a...

journal_title：Biological & pharmaceutical bulletin

authors： Hsiao G,Ko FN,Jong TT,Teng CM

更新日期：1998-07-01 00:00:00

abstract：:The complete molecule or the ligand-binding domain-containing region of each of the three subtypes of human retinoic acid receptors (hRAR alpha, hRAR beta and hRAR gamma) was expressed in Escherichia coli. The expressed recombinant RARs (rRARs: rRAR alpha/E, rRAR beta/E and rRAR gamma) showed nearly the same magnitude...

journal_title：Biological & pharmaceutical bulletin

authors： Fukasawa H,Iijima T,Kagechika H,Hashimoto Y,Shudo K

更新日期：1993-04-01 00:00:00

abstract：:The free radical scavenging activities of Panax ginseng C.A. MEYER are known to increase by heat processing. Phenolic acids and Maillard reaction products (MRPs) have been suggested as active free radical scavenging components from our previous research, but heat processing-induced chemical and activity changes of gin...

journal_title：Biological & pharmaceutical bulletin

authors： Kang KS,Kim HY,Baek SH,Yoo HH,Park JH,Yokozawa T

更新日期：2007-04-01 00:00:00

abstract：:Mume fruit, the Japanese apricot (Prunus mume SIEB. et ZUCC.), is popular in Japan and is mostly consumed in the pickled form called umeboshi. This fruit is known to have anti-microbial properties, but the principal constituents responsible for the antimicrobial properties have not yet been elucidated. We investigated...

journal_title：Biological & pharmaceutical bulletin

authors： Mitani T,Ota K,Inaba N,Kishida K,Koyama HA

更新日期：2018-01-01 00:00:00

abstract：:Plant phenolic compounds isolated from a 70% aqueous acetone extract of the leaves of Malus doumeri A. CHEV. var. formosana (KAWAK. & KOIDZ.) S. S. YING, a type of Taiwanese indigenous plant, were evaluated for potential application in the field of skin care. A phytochemical investigation of the active fractions resul...

journal_title：Biological & pharmaceutical bulletin

authors： Leu SJ,Lin YP,Lin RD,Wen CL,Cheng KT,Hsu FL,Lee MH

更新日期：2006-04-01 00:00:00

abstract：:We previously reported that, in Jurkat human T cells, the topoisomerase II inhibitor etoposide enhances sialidase activity and reduces cell surface sialic acid levels at an early stage of apoptosis and that the decreases in sialic acid are suppressed by the sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic ac...

journal_title：Biological & pharmaceutical bulletin

authors： Azuma Y,Sato H,Higai K,Matsumoto K

更新日期：2007-09-01 00:00:00

abstract：:Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals, including humans. In the present study, we demonstrated the anti-inflammatory effects of MSM in lipopolysaccharide (LPS...

journal_title：Biological & pharmaceutical bulletin

authors： Kim YH,Kim DH,Lim H,Baek DY,Shin HK,Kim JK

更新日期：2009-04-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:In an acute treatment experiment, metformin (150, 300 mg/kg, per os (p.o.)) markedly reduced the consumption of a high-fat diet (HFD) (45 kcal% fat-containing diet) for 2 h after the HFD was given to the fasted male C57BL/6J (B6) mice. In addition, metformin at a higher dose increased plasma active glucagon-like pepti...

journal_title：Biological & pharmaceutical bulletin

authors： Matsui Y,Hirasawa Y,Sugiura T,Toyoshi T,Kyuki K,Ito M

更新日期：2010-01-01 00:00:00

abstract：:Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. However, its function in cognition has yet been investigated. In the present stu...

journal_title：Biological & pharmaceutical bulletin

authors： Liao Y,Bae HJ,Zhang J,Kwon Y,Koo B,Jung IH,Kim HM,Park JH,Lew JH,Ryu JH

更新日期：2019-01-01 00:00:00

abstract：:Joint hypermobility syndrome (JHS) (also termed hypermobility type Ehlers-Danlos syndrome, hEDS) is a heritable connective tissue disorder that is characterized by generalized joint hypermobility, chronic pain, fatigue, and minor skin changes. Initially, it was reported that there is a small subset of patients with JH...

journal_title：Biological & pharmaceutical bulletin

authors： Yamada K,Watanabe A,Takeshita H,Fujita A,Miyake N,Matsumoto N,Matsumoto KI

更新日期：2019-01-01 00:00:00

abstract：:There are some highly cytotoxic anticancer compounds inducing differentiation of cancer cells to normal cells at below highly cytotoxic concentration. Naphthoquinone derivatives having cytotoxic effects on cancer cell were tested to learn whether they have differentiation inducing activity in human leukemia HL-60 cell...

journal_title：Biological & pharmaceutical bulletin

authors： Bae KA,Choung SY

更新日期：1996-06-01 00:00:00