Simultaneous determination of protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin in Acanthopanax senticosus Harms by HPLC-DAD.

abstract：:Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associat...

journal_title：Biological & pharmaceutical bulletin

authors： Yanagihara S,Taniguchi Y,Hosono M,Yoshioka E,Ishikawa R,Shimada Y,Kadoya T,Kutsukake K

更新日期：2010-01-01 00:00:00

abstract：:The effect of aging on the intestinal transport of hydrophilic drugs (and probe compounds) was investigated in the rat small intestine. Passive transport was suggested to be unchanged with aging from 8 (young) to 54 (old) and further to 101 (very old) weeks old, as shown for D-xylose and urea in single-pass intestinal...

journal_title：Biological & pharmaceutical bulletin

authors： Yuasa H,Soga N,Kimura Y,Watanabe J

更新日期：1997-11-01 00:00:00

abstract：:Nine murine monoclonal antibodies (MAbs) raised against recombinant soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated by means of ELISAs, and their neutralizing activity was investigated in two bioassays employing Raji cells activated with phorbol myristate acetate. Three of the MAbs inhibited autoagg...

journal_title：Biological & pharmaceutical bulletin

authors： Inuzuka H,Seita T,Okamoto K,Iida K,Ogawa Y,Iwasa S

更新日期：1995-08-01 00:00:00

abstract：:The present study was aimed at kinetically characterizing the carrier-mediated transport systems for D-glucose and taurocholate in the rat colon, compared with their respective counterparts in the small intestine. The transport of these compounds was evaluated by measuring the initial uptake into everted intestinal ti...

journal_title：Biological & pharmaceutical bulletin

authors： Tomei S,Torimoto M,Hayashi Y,Inoue K,Yuasa H,Watanabe J

更新日期：2003-06-01 00:00:00

abstract：:The radioprotective effects of propolis and polyphenolic compounds from propolis on the radiation-induced mortality of mice exposed to 9 Gy of gamma-irradiation were studied. Intraperitoneal (i.p.) treatment of mice at doses of 100 mg kg(-1) body weight of propolis (water or ethanolic extract; WSDP or EEP) or its poly...

journal_title：Biological & pharmaceutical bulletin

authors： Orsolić N,Benković V,Horvat-Knezević A,Kopjar N,Kosalec I,Bakmaz M,Mihaljević Z,Bendelja K,Basić I

更新日期：2007-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease with joint dysfunction following cartilage degradation. The level of lysophosphatidic acid (LPA) has been reported to be augmented in human synovial fluid from patients with RA. However, it remains to be elucidated whether LPA participates in cartilage destruction. ...

journal_title：Biological & pharmaceutical bulletin

authors： Mizuno K,Komiya M,Okuyama K,Imada K,Sato T

更新日期：2021-01-01 00:00:00

abstract：:A homology-based cloning strategy yielded Sdga, a cDNA clone presumably encoding alpha-subunit of heterotrimeric guanosine 5'-triphosphate-binding protein complex, from leaf tissues of Scoparia dulcis. Phylogenetic tree analysis of G-protein alpha-subunits from various biological sources suggested that, unlike in anim...

journal_title：Biological & pharmaceutical bulletin

authors： Shite M,Yamamura Y,Hayashi T,Kurosaki F

更新日期：2008-11-01 00:00:00

abstract：:The present paper proposes a new approach for fitting the plasma effect-site equilibrium rate constant (Ke0) of propofol to satisfy the condition that the effect-site concentration (Ce) is equal at the time of loss of consciousness (LOC) and recovery of consciousness (ROC). Forty patients receiving intravenous anesthe...

journal_title：Biological & pharmaceutical bulletin

authors： Wu Q,Sun B,Wang S,Zhao L,Qi F

更新日期：2013-01-01 00:00:00

abstract：:In the investigation of chemical constituents in antiosteoporotic active fraction, 90% ethanol fraction of water extract of the rhizomes of Dioscorea spongiosa, twenty-two glycosides were isolated and their structures were elucidated. In order to know the role of each compound played in the fraction and to find the ex...

journal_title：Biological & pharmaceutical bulletin

authors： Yin J,Han N,Liu Z,Song S,Kadota S

更新日期：2010-01-01 00:00:00

abstract：:We recently isolated a novel lignan, 4-hydroxykobusin from Geranium thunbergii (Liu et al., Arch. Pharm. Res., 29, 1109-1113, 2006). Here, we studied its effect on the expression of inducible nitric oxide synthase (iNOS) gene in RAW264.7 cells. 4-Hydroxykobusin inhibited nitric oxide (NO) production in a concentration...

journal_title：Biological & pharmaceutical bulletin

authors： Pokharel YR,Liu QH,Oh JW,Woo ER,Kang KW

更新日期：2007-06-01 00:00:00

abstract：:The effects of hop extracts (Humulus lupulus L.) on histamine release from rat peritoneal mast cells and human basophilic KU812 cells were studied. Hop water extract (HWE) and XAD-4 50% methanol fraction of HWE (MFH) inhibited histamine release from rat mast cells induced by compound 48/80 at concentrations of 100 and...

journal_title：Biological & pharmaceutical bulletin

authors： Takubo M,Inoue T,Jiang S,Tsumuro T,Ueda Y,Yatsuzuka R,Segawa S,Watari J,Kamei C

更新日期：2006-04-01 00:00:00

abstract：:The estimation of metallothionein (MT) levels in a biological sample is required to study the physiological role or the induction of MT, which is a multifunctional protein. MT contains 61 amino acids with 20 homologous cysteines. The high selectivity, sensitivity and stability of N-[4-(dimethylamino-2-benzofuranyl)phe...

journal_title：Biological & pharmaceutical bulletin

authors： Shinogi M,Nishinaga K,Yokoyama I

更新日期：1996-07-01 00:00:00

abstract：:Acute pancreatitis (AP) is one kind of acute surgical abdominal disease in the world. It causes intestinal damage with subsequent bacterial migration, endotoxemia and secondary pancreatic infections. In this investigation, we determined that edaravone (EDA) reduces pancreatic and intestinal injury after AP in mice. Th...

journal_title：Biological & pharmaceutical bulletin

authors： Wang B,Lin W

更新日期：2020-01-01 00:00:00

abstract：:Apoptotic cells must be recognized early for phagocytosis to ensure that their toxic contents do not damage neighboring cells. In some cases this is achieved via CD43-capped membrane glycoproteins, the sialylpolylactosaminyl chains of which serve as ligands for phagocytosis by macrophages. However, because many additi...

journal_title：Biological & pharmaceutical bulletin

authors： Oguri E,Miki Y,Hirano K,Yamanaka M,Beppu M

更新日期：2012-01-01 00:00:00

abstract：:The effect of 4-(4-chlorobenzyl)pyridine (4-CBP) on rat hepatic microsomal cytochrome P450 (P450) and its molecular species (CYP2B1, 2E1, 3A2, 2C11, and 2C12), and on drug-metabolizing enzyme activities were examined in vivo and in vitro. Treatment of rats with 4-CBP resulted in the induction of P450 and drug-metaboli...

journal_title：Biological & pharmaceutical bulletin

authors： Kobayashi Y,Ohshiro N,Sasaki T,Tokuyama S,Tobe T,Yoshida T,Yamamoto T

更新日期：2001-05-01 00:00:00

abstract：:Among the calcium-binding proteins from chicken gizzard smooth muscle, smooth muscle calcium-binding protein 11 (SMCaBP 11), which is an EF-hand type calcium-binding protein, can prevent Ca2+ dependent histamine release from permeabilized rat peritoneal mast cells. This activity appears to be specific since other calc...

journal_title：Biological & pharmaceutical bulletin

authors： Fujii T,Kuzumaki N,Ogoma Y,Kondo Y

更新日期：1994-05-01 00:00:00

abstract：:The utility of using a multifunctional envelope-type nano device (MEND) for delivering a gene to the liver was examined. Lipotrust, a commercially available transfection reagent whose lipid composition is DC6- 14 :DOPE: cholesterol=4 : 3 : 3, was used as a reference. When Lipotrust was administrated intravenously, luc...

journal_title：Biological & pharmaceutical bulletin

authors： Yamauchi J,Hayashi Y,Kajimoto K,Akita H,Harashima H

更新日期：2010-01-01 00:00:00

abstract：:Morinda citrifolia L., known as noni, originated from Indonesia exhibits various pharmacological activities including anti-inflammatory properties. However, the validity of noni fruit juice as a treatment for rheumatoid arthritis (RA), an autoimmune disorder, has not been confirmed yet. Therefore, the main purpose of ...

journal_title：Biological & pharmaceutical bulletin

authors： Kustiarini DA,Nishigaki T,Kanno H,To H

更新日期：2019-01-01 00:00:00

abstract：:Japanese allergic subjects are commonly sensitized to both house dust mite (HDM) and Japanese cedar pollen (JCP) and combined treatment with sublingual immunotherapy (SLIT) tablets is desirable. However, mixing extracts of two non-homologous allergens may compromise allergen stability and affect the clinical outcome. ...

journal_title：Biological & pharmaceutical bulletin

authors： Watanabe A,Yamamoto T,Matsuhara H,Matsui H,Nakazawa H,Lund K,Ohashi-Doi K

更新日期：2020-10-01 00:00:00

abstract：:B-type natriuretic peptide (BNP) is one peptide hormone released in response to myocyte stretch, whose functions play significant roles in health and disease. Its physiologic effects result in improved loading conditions and have led to the development of recombinant BNP as a therapeutic agent for heart failure. Previ...

journal_title：Biological & pharmaceutical bulletin

authors： Sun Y,Zhang Y,Yan M,Wu Y,Zheng X

更新日期：2009-09-01 00:00:00

abstract：:Recently, Banhabackchulchunmatang (HMC05) has been implicated as a preventive and/or therapeutic candidate for cardiovascular diseases due to its inhibition of atherosclerosis lesions and its reduction of neointima formation. Knowledge of the mechanism of HMC05 in smooth muscle cells (SMC) is limited. However, SMC may...

journal_title：Biological & pharmaceutical bulletin

authors： Gum SI,Shin HM,Cho MK

更新日期：2014-01-01 00:00:00

abstract：:Sentinel lymph nodes (SLN) are the first lymph nodes (LN) where cancer cells metastasize from the primary tumor. We designed fluorophore-quencher-based activatable nanoparticles for SLN imaging. We selected TAMRA as a fluorophore and BHQ2 or QSY7 as a quencher. Ternary anionic complexes were constructed with generatio...

journal_title：Biological & pharmaceutical bulletin

authors： Hagimori M,Hatabe E,Sano K,Miyazaki H,Sasaki H,Saji H,Mukai T

更新日期：2017-01-01 00:00:00

abstract：:Cisplatin chemotherapy is the standard treatment for metastatic urothelial carcinoma. Although there are second-line chemotherapeutic agents approved by the U.S. Food and Drug Administration (FDA) such as those targeting programmed death-ligand 1 (PD-L1), more effective pharmacotherapy is required for cisplatin-resist...

journal_title：Biological & pharmaceutical bulletin

authors： Ryu H,Jin H,Ho JN,Bae J,Lee E,Lee SE,Lee S

更新日期：2019-01-01 00:00:00

abstract：:Cisplatin-induced nephrotoxicity is related to an increase in lipid peroxidation and oxygen free radicals in a kidney. In the present study, we investigated the effect of the dietary antioxidants, capsaicin (Cap), against cisplatin-induced lipid peroxidation and nephrotoxicity in rats. Nephrotoxicity induced by treatm...

journal_title：Biological & pharmaceutical bulletin

authors： Shimeda Y,Hirotani Y,Akimoto Y,Shindou K,Ijiri Y,Nishihori T,Tanaka K

更新日期：2005-09-01 00:00:00

abstract：:Acetohexamide (AH) is reduced to its alcohol metabolite by carbonyl reductase. We have previously shown that carbonyl reductase present in the liver microsomes of rats is a male-specific and androgen-dependent enzyme. In the present study, the role of microsomal carbonyl reductase in the pharmacokinetics of AH was exa...

journal_title：Biological & pharmaceutical bulletin

authors： Imamura Y,Shimada H

更新日期：2005-01-01 00:00:00

abstract：:The relation between degranulation and rapid metabolic responses (acidification rate changes) in RBL-2H3 cells was studied using a cytosensor microphysiometer, a silicon-based biosensor system. The metabolic responses in RBL-2H3 cells by antigen stimulation were compared with those by inhibitors of Ca2+ -ATPase. The f...

journal_title：Biological & pharmaceutical bulletin

authors： Furuno T,Ohyama N,Nakanishi M

更新日期：1999-03-01 00:00:00

abstract：:To elucidate molecular mechanisms of adipocyte differentiation, we previously isolated TC10-like/TC10betaLong (TCL/TC10betaL), regulators of G protein signaling 2 (RGS2), factor for adipocyte differentiation (fad) 104 and fad158, which were transiently expressed in the early phase of adipogenesis. These four genes see...

journal_title：Biological & pharmaceutical bulletin

authors： Kawaji A,Nishizuka M,Osada S,Imagawa M

更新日期：2010-01-01 00:00:00

abstract：:Lysosomal trapping was investigated in the retinal capillary endothelial cells that are responsible for the inner blood-retinal barrier (BRB) using LysoTracker(®) Red (LTR). Using confocal microscopy on TR-iBRB2 cells, an in vitro model of the inner BRB, the presence of lysosomal trapping in retinal capillary endothel...

journal_title：Biological & pharmaceutical bulletin

authors： Kubo Y,Seko N,Usui T,Akanuma S,Hosoya K

更新日期：2016-01-01 00:00:00

abstract：:The intestinal expression of the CYP3A subfamily was investigated in female rats, and the intestinal metabolism of two CYP3A substrates, testosterone and rifabutin, was examined and compared between males and females. CYP3A1/23 and CYP3A2 intestinal expression was barely detected in male and female rats. Although CYP3...

journal_title：Biological & pharmaceutical bulletin

authors： Aiba T,Yoshinaga M,Ishida K,Takehara Y,Hashimoto Y

更新日期：2005-02-01 00:00:00

abstract：:The effect of insulin administration on bone formation was investigated in the femoral diaphysis of rats with skeletal unloading. When the femoral-diaphyseal tissues from normal rats were cultured in the presence of insulin (10(-9) and 10(-8) M) for 48 h, the hormone produced a significant increase of alkaline phospha...

journal_title：Biological & pharmaceutical bulletin

authors： Yamaguchi M,Kishi S,Hoshi T

更新日期：1993-11-01 00:00:00